Alzheimer’s disease(AD)is a slow,progressive neurodegenerative disease with clinical symptoms that typically emerge in the elderly,leading to deterioration of cognitive functions over time.Memory loss is the primary ...Alzheimer’s disease(AD)is a slow,progressive neurodegenerative disease with clinical symptoms that typically emerge in the elderly,leading to deterioration of cognitive functions over time.Memory loss is the primary symptom,eventually leading to significant declines in executive and cognitive functions,along with psychiatric and behavioral changes,and alterations in personality.展开更多
We consider a subclass of quantum Turing machines (QTM), named stationary rotational quantum Turing machine (SR-QTM), which halts deterministically and has deterministic tape head position. A quantum state transition ...We consider a subclass of quantum Turing machines (QTM), named stationary rotational quantum Turing machine (SR-QTM), which halts deterministically and has deterministic tape head position. A quantum state transition diagram (QSTD) is proposed to describe SR-QTM. With QSTD, we construct a SR-QTM which is universal for all near-trivial transformations. This indicates there exists a QTM which is universal for the above subclass. Finally we show that SR-QTM is computational equivalent with ordinary QTM in the bounded error setting. It can be seen that SR-QTMs have deterministic tape head position and halt deterministically, and thus the halting scheme problem will not exist for this class of QTMs.展开更多
The field of neurodegeneration research has long been focused on finding therapeutic strategies to effectively decrease or halt neuronal loss while minimizing side effects.A recent study titled“Inhibiting acute,axona...The field of neurodegeneration research has long been focused on finding therapeutic strategies to effectively decrease or halt neuronal loss while minimizing side effects.A recent study titled“Inhibiting acute,axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition”(Zhang et al.,2025),describes an innovative approach to achieve this goal.The authors target a specific post-translational modification of dual leucine-zipper kinase(DLK),palmitoylation,to selectively inhibit DLK-dependent pro-degenerative signaling and protect neurons,thereby revealing a new way to intervene and block neurodegeneration.This Perspective aims to explore the significance of these findings and propose directions for future research.展开更多
A new policy on performance-based pay for teachers aims to attract and retain talented people on December 21, 2008, the State Council executive meeting approved a policy to adopt a per- formance-based pay system
基金supported by the National Natural Science Foundation of China(82120108010 and 81930028).
文摘Alzheimer’s disease(AD)is a slow,progressive neurodegenerative disease with clinical symptoms that typically emerge in the elderly,leading to deterioration of cognitive functions over time.Memory loss is the primary symptom,eventually leading to significant declines in executive and cognitive functions,along with psychiatric and behavioral changes,and alterations in personality.
基金supported by the National Natural Science Foundation of China (Grant No.61173157)the Strategy Pilot Project of Chinese Academy of Sciences (Grant No.project XDA06010702)IIE’s Cryptography Research Project
文摘We consider a subclass of quantum Turing machines (QTM), named stationary rotational quantum Turing machine (SR-QTM), which halts deterministically and has deterministic tape head position. A quantum state transition diagram (QSTD) is proposed to describe SR-QTM. With QSTD, we construct a SR-QTM which is universal for all near-trivial transformations. This indicates there exists a QTM which is universal for the above subclass. Finally we show that SR-QTM is computational equivalent with ordinary QTM in the bounded error setting. It can be seen that SR-QTMs have deterministic tape head position and halt deterministically, and thus the halting scheme problem will not exist for this class of QTMs.
基金supported by NIH(R01 NS094402 and R21 EY029386)Shriners Children’s(#85190 PHI and#87400 PHI)by BrightFocus Foundation(G2019267)(to GMT).
文摘The field of neurodegeneration research has long been focused on finding therapeutic strategies to effectively decrease or halt neuronal loss while minimizing side effects.A recent study titled“Inhibiting acute,axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition”(Zhang et al.,2025),describes an innovative approach to achieve this goal.The authors target a specific post-translational modification of dual leucine-zipper kinase(DLK),palmitoylation,to selectively inhibit DLK-dependent pro-degenerative signaling and protect neurons,thereby revealing a new way to intervene and block neurodegeneration.This Perspective aims to explore the significance of these findings and propose directions for future research.
文摘A new policy on performance-based pay for teachers aims to attract and retain talented people on December 21, 2008, the State Council executive meeting approved a policy to adopt a per- formance-based pay system
