In response to the increasing demand for hadron therapy facilities,significant efforts have been directed toward enhancing the performance of high-gradient and high-transmission injectors for light ion beams.For carbo...In response to the increasing demand for hadron therapy facilities,significant efforts have been directed toward enhancing the performance of high-gradient and high-transmission injectors for light ion beams.For carbon ion irradiations,which offer greater radiobiological efficiency in tumor treatment,recent research has focused on developing high-production sources of fully stripped C^(6+)ions and highly compact,high-frequency RFQ cavities.This study explores the design possibilities of a carbon ion acceleration section using 750 MHz Interdigital H-mode Drift Tube Linacs(IH-DTLs)as a high-efficiency solution for accelerating ions in the 5-10 MeV per nucleon energy range.A particle-tracking routine based on the TRAVEL code was developed to design the acceleration line through a tailored KONUS-type configuration.Three design solutions were proposed and compared,exploring different alternatives regarding the use of a MEBT to match the output beam phase space of the RFQ to the optics of the line,as well as varying considerations for magnetic systems to focus the beam.Additionally,the compatibility of the proposed solutions with the existing design of the carbon ion bent-linac for hadron therapy was assessed.展开更多
A conception design of the Advanced Proton Therapy Facility （APTF） has been carried out. The system intentionally employs a slow-cycling synchrotron with a maximum energy of 250 MeV, two rotating gantries and two fi...A conception design of the Advanced Proton Therapy Facility （APTF） has been carried out. The system intentionally employs a slow-cycling synchrotron with a maximum energy of 250 MeV, two rotating gantries and two fixed beam nozzles for the treatment. In this paper, we try to compare the strength and weaknesses between the two treatment methods： the beam spreading and the pencil beam scanning. The application of the pencil beam scanning method and the double-scattering method together with the related nozzle design at APTF is also given. The simulation results of employing the double-scattering method have been given during the preliminary design.展开更多
A proton therapy facility based on a linac injector and a slow-cycling synchrotron is proposed. To obtain good treatments for different cancer types, both the spot scanning method and the double-scattering method are ...A proton therapy facility based on a linac injector and a slow-cycling synchrotron is proposed. To obtain good treatments for different cancer types, both the spot scanning method and the double-scattering method are adopted in the facility, whereas the nozzles include both gantry and fixed beam types. The proton accelerator chain includes a synchrotron of 250 MeV in maximum energy, an injector of 7 MeV consisting of an RFQ and a DTL linac, with a repetition rate of 0.5 Hz. The slow extraction using the third-order resonance and together with the RFKO method is considered to be a good method to obtain a stable and more-or-less homogenous beam spill. To benefit the spot scanning 200 between 60 MeV and 230 MeV. A new method method, the extraction energy can be as many as about - the emittance balancing technique of using a solenoid or a quadrupole rotator is proposed to solve the problem of unequal emittance in the two transverse planes with a beam slowly extracted from a synchrotron. The facility has been designed to keep the potential to be upgraded to include the carbon therapy in the future.展开更多
During carbon ion therapy, lots of positron emitters such as 11C, 15O, 11C are generated in irradiated tissues by nuclear reactions, and can be used to track the carbon beam in the tissue by a positron emission tomogr...During carbon ion therapy, lots of positron emitters such as 11C, 15O, 11C are generated in irradiated tissues by nuclear reactions, and can be used to track the carbon beam in the tissue by a positron emission tomography （PET） scanner. In this study, an dual-plate in-room PET scanner has been designed and evaluated based on the GATE simulation platform to monitor patient dose in carbon ion therapy. The dual-plate PET is designed to avoid interference with the carbon beamline and with patient positioning. Its performance was compared with that of four-head and full-ring PET scanners. The dual-plate, four-head and full-ring PET scanners consisted of 30, 60, 60 detector modules, respectively, with a 36 cm distance measurements. Each detector module consisted of a between directly opposite detector modules for dose deposition 24~24 array of 2 mm×2 mm×18 mm LYSO pixels coupled to a Hamamatsu H8500 PMT. To estimate the production yield of positron emitters, a 10 cm×15 cm×15 cm cuboid PMMA phantom was irradiated with 172, 200, 250 MeV/u 12C beams. 3D images of the activity distribution measured by the three types of scanner are produced by an iterative reconstruction algorithm. By comparing the longitudinal profile of positron emitters along the carbon beam path, it is indicated that use of the dual-plate PET scanner is feasible for monitoring the dose distribution in carbon ion therapy.展开更多
基金Project co-funded by European Union in the context of the precommercial public procurement of RD services managed by CDTI E.P.Eco-funded by the European Regional Development Fund(ERDF)as part of the project for the development of a Compact Linear Accelerator for Hadrontherapy,Exp.CPP 03/2023 AB(DCCPI/OCPI)。
文摘In response to the increasing demand for hadron therapy facilities,significant efforts have been directed toward enhancing the performance of high-gradient and high-transmission injectors for light ion beams.For carbon ion irradiations,which offer greater radiobiological efficiency in tumor treatment,recent research has focused on developing high-production sources of fully stripped C^(6+)ions and highly compact,high-frequency RFQ cavities.This study explores the design possibilities of a carbon ion acceleration section using 750 MHz Interdigital H-mode Drift Tube Linacs(IH-DTLs)as a high-efficiency solution for accelerating ions in the 5-10 MeV per nucleon energy range.A particle-tracking routine based on the TRAVEL code was developed to design the acceleration line through a tailored KONUS-type configuration.Three design solutions were proposed and compared,exploring different alternatives regarding the use of a MEBT to match the output beam phase space of the RFQ to the optics of the line,as well as varying considerations for magnetic systems to focus the beam.Additionally,the compatibility of the proposed solutions with the existing design of the carbon ion bent-linac for hadron therapy was assessed.
文摘A conception design of the Advanced Proton Therapy Facility （APTF） has been carried out. The system intentionally employs a slow-cycling synchrotron with a maximum energy of 250 MeV, two rotating gantries and two fixed beam nozzles for the treatment. In this paper, we try to compare the strength and weaknesses between the two treatment methods： the beam spreading and the pencil beam scanning. The application of the pencil beam scanning method and the double-scattering method together with the related nozzle design at APTF is also given. The simulation results of employing the double-scattering method have been given during the preliminary design.
文摘A proton therapy facility based on a linac injector and a slow-cycling synchrotron is proposed. To obtain good treatments for different cancer types, both the spot scanning method and the double-scattering method are adopted in the facility, whereas the nozzles include both gantry and fixed beam types. The proton accelerator chain includes a synchrotron of 250 MeV in maximum energy, an injector of 7 MeV consisting of an RFQ and a DTL linac, with a repetition rate of 0.5 Hz. The slow extraction using the third-order resonance and together with the RFKO method is considered to be a good method to obtain a stable and more-or-less homogenous beam spill. To benefit the spot scanning 200 between 60 MeV and 230 MeV. A new method method, the extraction energy can be as many as about - the emittance balancing technique of using a solenoid or a quadrupole rotator is proposed to solve the problem of unequal emittance in the two transverse planes with a beam slowly extracted from a synchrotron. The facility has been designed to keep the potential to be upgraded to include the carbon therapy in the future.
基金Supported by National Natural Science Foundation of China(11205222)West Light Foundation of the Chinese Academy of Sciences(210340XBO)+1 种基金National Major Scientific Instruments and Equipment Development Projects(2011YQ12009604)Youth Innovation Promotion Association,CAS(201330YQO)
文摘During carbon ion therapy, lots of positron emitters such as 11C, 15O, 11C are generated in irradiated tissues by nuclear reactions, and can be used to track the carbon beam in the tissue by a positron emission tomography （PET） scanner. In this study, an dual-plate in-room PET scanner has been designed and evaluated based on the GATE simulation platform to monitor patient dose in carbon ion therapy. The dual-plate PET is designed to avoid interference with the carbon beamline and with patient positioning. Its performance was compared with that of four-head and full-ring PET scanners. The dual-plate, four-head and full-ring PET scanners consisted of 30, 60, 60 detector modules, respectively, with a 36 cm distance measurements. Each detector module consisted of a between directly opposite detector modules for dose deposition 24~24 array of 2 mm×2 mm×18 mm LYSO pixels coupled to a Hamamatsu H8500 PMT. To estimate the production yield of positron emitters, a 10 cm×15 cm×15 cm cuboid PMMA phantom was irradiated with 172, 200, 250 MeV/u 12C beams. 3D images of the activity distribution measured by the three types of scanner are produced by an iterative reconstruction algorithm. By comparing the longitudinal profile of positron emitters along the carbon beam path, it is indicated that use of the dual-plate PET scanner is feasible for monitoring the dose distribution in carbon ion therapy.
