Background:Statins,a first-line therapeutic option for atherosclerotic cardiovascular disease(ASCVD),have prompted concerns regarding dysglycemia and diabetes,thus posing a dilemma in treating patients with prediabete...Background:Statins,a first-line therapeutic option for atherosclerotic cardiovascular disease(ASCVD),have prompted concerns regarding dysglycemia and diabetes,thus posing a dilemma in treating patients with prediabetes.Xuezhikang(XZK)decreases blood cholesterol levels without affecting glucose metabolism,and may serve as a potential substitute.Methods:The XTREME study is a prospective,randomized,open-label,multi-center trial evaluating whether XZK 1200 mg/d,compared with atorvastatin 20 mg/d,has favorable effects on HbA1c levels after 24 weeks of treatment in patients with dyslipidemia and prediabetes.After a 1-week run-in period for adherence assessment,the study will ran-domly assign(1:1)392 patients meeting the protocol inclusion criteria to one of two treatment groups:an experimental group(XZK 1200 mg/day)or a control group(atorvastatin 20 mg/day).All participants will be recruited from approxi-mately 20 Chinese medical centers.The last participant is planned to be recruited before December 2023.The primary endpoint will be change in HbA1c level from baseline to 24 weeks,or before anti-diabetic therapy initiation within 24 weeks.The key secondary outcomes will include other biomarkers reflecting blood glucose or lipid metabolism.Discussion:Delaying diabetes is desirable for individuals with prediabetes.The XTREME trial presents a unique oppor-tunity to demonstrate whether XZK might provide an alternative to statins for patients with dyslipidemia and prediabetes.展开更多
The current recommendation to avoid non-steroidal anti-inflammatory drugs(NSAIDs)in the management of dengue virus disease(DVD)is scientifically considered of very low to low certainty,despite being widely adopted wor...The current recommendation to avoid non-steroidal anti-inflammatory drugs(NSAIDs)in the management of dengue virus disease(DVD)is scientifically considered of very low to low certainty,despite being widely adopted worldwide.The same recommendation,initially made during the coronavirus disease 2019(COVID-19)pandemic,was subsequently proven incorrect.In this clinical report,we present evidence,for the first time globally,from a real-life practice that NSAIDs may actually be lifesaving in the early management of DVD as they have proved to be in COVID-19.Moreover,we propose that the personalized immunemodulatory Kelleni’s protocol,which includes nitazoxanide as a key component,can be safely and effectively used to manage various separate or concomitant viral infections and co-infections,including DVD.Importantly,this article contributes to the current medical knowledge in the global pursuit of a safe and effective broad-spectrum antiviral protocol that can be used to early manage multiple highly infectious viruses.However,it’s crucial that sufficiently powered controlled randomized clinical trials be conducted to thoroughly assess and evaluate the safety of NSAIDs in the early management of DVD as well as the efficacy of nitazoxanide with or without NSAIDs in its management.展开更多
Broadcasting is a basic technique in Mobile ad-hoc network(MANET),and it refers to sending a packet from one node to every other node within the transmission range.Flooding is a type of broadcast where the received pa...Broadcasting is a basic technique in Mobile ad-hoc network(MANET),and it refers to sending a packet from one node to every other node within the transmission range.Flooding is a type of broadcast where the received packet is retransmitted once by every node.The naive flooding technique,floods the network with query messages,while the random walk technique operates by contacting the subsets of every node’s neighbors at each step,thereby restricting the search space.One of the key challenges in an ad-hoc network is the resource or content discovery problem which is about locating the queried resource.Many earlier works have mainly focused on the simulation-based analysis of flooding,and its variants under a wired network.Although,there have been some empirical studies in peer-to-peer(P2P)networks,the analytical results are still lacking,especially in the context of P2P systems running over MANET.In this paper,we describe how P2P resource discovery protocols perform badly over MANETs.To address the limitations,we propose a new protocol named ABRW(Address Broadcast Random Walk),which is a lightweight search approach,designed considering the underlay topology aimed to better suit the unstructured architecture.We provide the mathematical model,measuring the performance of our proposed search scheme with different widely popular benchmarked search techniques.Further,we also derive three relevant search performance metrics,i.e.,mean no.of steps needed to find a resource,the probability of finding a resource,and the mean no.of message overhead.We validated the analytical expressions through simulations.The simulation results closely matched with our analyticalmodel,justifying our findings.Our proposed search algorithm under such highly dynamic self-evolving networks performed better,as it reduced the search latency,decreased the overall message overhead,and still equally had a good success rate.展开更多
Most of the public key algorithms used in the exchange of information for power data transmission protocols are RSA. The core of the key part of this kind of algorithm system has not been announced. For the domestic s...Most of the public key algorithms used in the exchange of information for power data transmission protocols are RSA. The core of the key part of this kind of algorithm system has not been announced. For the domestic sensitive information data field, there are threats such as preset backdoors and security vulnerabilities. In response to the above problems, the article introduces a secure communication protocol based on the optimized Secret SM2 algorithm, which uses socket programming to achieve two-way encrypted communication between clients and services, and is able to complete the security protection of data encryption transmission, authentication, data tampering, etc., and proves through experiments that the security protocol is more secure than traditional methods, can effectively identify each other, carry out stable and controllable data encryption transmission, and has good applicability.展开更多
3D （Three-dimensional） Caco-2 spheroids closely recapitulating in vivo physiological organization of intestinal epithelial cells, provide an excellent in vitro model system to study their pathophysiology and their r...3D （Three-dimensional） Caco-2 spheroids closely recapitulating in vivo physiological organization of intestinal epithelial cells, provide an excellent in vitro model system to study their pathophysiology and their response to stressful stimuli. The objective of this technical note is to provide optimized in vitro experimental protocols for culturing 3D Caco-2 spheroids and for analyzing their cell growth features. An optimized 3D Caco-2 spheroid culturing technique based on a new configuration of the culture medium is provided A methodological approach to determine the distribution of the cell cycle phases in disaggregated Caco-2 spheroids by using cytofluorimetric analysis is also described. The optimized culturing protocol favors 3D Caco-2 spheroid differentiation process, as evaluated by the number of well-differentiated spheroids with a single hollow lumen. The cytofluorimetric analysis allows rapid collection of cell cycle phase data from high numbers of spheroid samples, thus, permitting to estimate their growth dynamics in a relatively short time. The optimized technical approaches described here can be applied in systematic manner to a variety of research activities utilizing 3D Caco-2 spheroids. Ease of use, time and economic saving advantages deriving from these protocols further highlight their potential.展开更多
In recent years, Hyper Text Transfer Protocol （HTTP） spreads quickly and steadily in the usage of mobile applications as a common web protocol, so that the mobile applications can also benefit from HTTP/2, which is ...In recent years, Hyper Text Transfer Protocol （HTTP） spreads quickly and steadily in the usage of mobile applications as a common web protocol, so that the mobile applications can also benefit from HTTP/2, which is the new version of HTTP based on SPDY developed by Google to speed up the Internet transmission speed. HTTP/2 enables a more efficient use of network resources and a reduced perception of latency by in- troducing header field compression and allowing multiple concurrent exchanges on the same connection. However, what H3TP/2 focuses on is visiting websites through a browser, and mobile applications are not considered much. In this paper, firstly, mobile applications are classified based on the da- ta flow characteristics. Based on the classification, we propose an optimization of HTTP/2 for mobile applications, called HTTP/2-Advance, which uses multiple Transmission Control Protocol （TCP） connections to multiplex HTYP requests and responses. Then we build a tiny system which simulates actu- al requests and responses between mobile applications and servers. We figure out the best choice of the number of multiple TCP connections for mobile applications, and compare the performance of HTTP, HTTP/2 and HTrP/2-Advance in both simulated and in-situ experiments in our system.展开更多
视频流量逐渐在网络中占据主导地位,且视频平台大多对其进行加密传输。虽然加密传输视频可以有效保护用户隐私,但是也增加了监管有害视频传播的难度.现有的加密视频识别方法基于TCP(Transmission Control Protocol)传输协议头部信息和HT...视频流量逐渐在网络中占据主导地位,且视频平台大多对其进行加密传输。虽然加密传输视频可以有效保护用户隐私,但是也增加了监管有害视频传播的难度.现有的加密视频识别方法基于TCP(Transmission Control Protocol)传输协议头部信息和HTTP/1.1(Hypertext Transfer Protocol Version1.1)的传输模式,提取应用层音视频数据单元传输长度序列来实现视频识别.但是随着基于UDP(User Datagram Protocol)的QUIC(Quick UDP Internet Connections)协议及基于QUIC实现的HTTP/3(Hypertext Transfer Protocol Version 3)协议应用于视频传输,已有方法不再适用.HTTP/3协议缺少类似TCP的头部信息,且使用了多路复用机制,并对几乎所有数据进行了加密,此外,视频平台开始使用多片段合并分发技术,这给从网络流量中精准识别加密视频带来了巨大挑战。本文基于HTTP/3协议中的控制信息特征,提出了从HTTP/3加密视频流中提取数据传输特征并进行修正的方法,最大程度复原出应用层音视频长度特征.面向多片段合并分发导致的海量匹配问题,本文基于明文指纹库设计了键值数据库来实现视频的快速识别.实验结果表明,本文提出的基于HTTP/3传输特性的加密视频识别方法能够在包含36万个真实视频指纹的YouTube大规模指纹库中达到接近99%的准确率,100%的精确率以及99.32%的F1得分,对传输过程中加人了填充顿的Facebook平台,在包含28万个真实视频指纹的大规模指纹库中达到95%的准确率、100%的精确率以及96.45%的F1得分,在具有同样特性的Instagram平台中,最高可达到97.57%的F1得分,且本方法在所有指纹库中的平均视频识别时间均低于0.4秒.本文的方法首次解决了使用HTTP/3传输的加密视频在大规模指纹库场景中的识别问题,具有很强的实用性和通用性.展开更多
The electronic system in a comprehensive shipboard has a extremely wide bandwidth. It supports synchronized and asynchronous data transmission, muhimedia correspondence, and videophone conferencing. In order to guaran...The electronic system in a comprehensive shipboard has a extremely wide bandwidth. It supports synchronized and asynchronous data transmission, muhimedia correspondence, and videophone conferencing. In order to guarantee the security and correspondent real time of the communication, choosing a multicast routing protocol based on different applications is a key problem in terms of the complexity of the system. A simulation model was first designed for existing multicast routing protocols in NS-2 and analysis was performed on their corresponding application environments. The experiments proved that PIM-DM based on the shortest-path tree protocol is suitable for communication in the field of comprehensive shipboard. Further work that is necessary is also discussed.展开更多
文摘Background:Statins,a first-line therapeutic option for atherosclerotic cardiovascular disease(ASCVD),have prompted concerns regarding dysglycemia and diabetes,thus posing a dilemma in treating patients with prediabetes.Xuezhikang(XZK)decreases blood cholesterol levels without affecting glucose metabolism,and may serve as a potential substitute.Methods:The XTREME study is a prospective,randomized,open-label,multi-center trial evaluating whether XZK 1200 mg/d,compared with atorvastatin 20 mg/d,has favorable effects on HbA1c levels after 24 weeks of treatment in patients with dyslipidemia and prediabetes.After a 1-week run-in period for adherence assessment,the study will ran-domly assign(1:1)392 patients meeting the protocol inclusion criteria to one of two treatment groups:an experimental group(XZK 1200 mg/day)or a control group(atorvastatin 20 mg/day).All participants will be recruited from approxi-mately 20 Chinese medical centers.The last participant is planned to be recruited before December 2023.The primary endpoint will be change in HbA1c level from baseline to 24 weeks,or before anti-diabetic therapy initiation within 24 weeks.The key secondary outcomes will include other biomarkers reflecting blood glucose or lipid metabolism.Discussion:Delaying diabetes is desirable for individuals with prediabetes.The XTREME trial presents a unique oppor-tunity to demonstrate whether XZK might provide an alternative to statins for patients with dyslipidemia and prediabetes.
文摘The current recommendation to avoid non-steroidal anti-inflammatory drugs(NSAIDs)in the management of dengue virus disease(DVD)is scientifically considered of very low to low certainty,despite being widely adopted worldwide.The same recommendation,initially made during the coronavirus disease 2019(COVID-19)pandemic,was subsequently proven incorrect.In this clinical report,we present evidence,for the first time globally,from a real-life practice that NSAIDs may actually be lifesaving in the early management of DVD as they have proved to be in COVID-19.Moreover,we propose that the personalized immunemodulatory Kelleni’s protocol,which includes nitazoxanide as a key component,can be safely and effectively used to manage various separate or concomitant viral infections and co-infections,including DVD.Importantly,this article contributes to the current medical knowledge in the global pursuit of a safe and effective broad-spectrum antiviral protocol that can be used to early manage multiple highly infectious viruses.However,it’s crucial that sufficiently powered controlled randomized clinical trials be conducted to thoroughly assess and evaluate the safety of NSAIDs in the early management of DVD as well as the efficacy of nitazoxanide with or without NSAIDs in its management.
文摘Broadcasting is a basic technique in Mobile ad-hoc network(MANET),and it refers to sending a packet from one node to every other node within the transmission range.Flooding is a type of broadcast where the received packet is retransmitted once by every node.The naive flooding technique,floods the network with query messages,while the random walk technique operates by contacting the subsets of every node’s neighbors at each step,thereby restricting the search space.One of the key challenges in an ad-hoc network is the resource or content discovery problem which is about locating the queried resource.Many earlier works have mainly focused on the simulation-based analysis of flooding,and its variants under a wired network.Although,there have been some empirical studies in peer-to-peer(P2P)networks,the analytical results are still lacking,especially in the context of P2P systems running over MANET.In this paper,we describe how P2P resource discovery protocols perform badly over MANETs.To address the limitations,we propose a new protocol named ABRW(Address Broadcast Random Walk),which is a lightweight search approach,designed considering the underlay topology aimed to better suit the unstructured architecture.We provide the mathematical model,measuring the performance of our proposed search scheme with different widely popular benchmarked search techniques.Further,we also derive three relevant search performance metrics,i.e.,mean no.of steps needed to find a resource,the probability of finding a resource,and the mean no.of message overhead.We validated the analytical expressions through simulations.The simulation results closely matched with our analyticalmodel,justifying our findings.Our proposed search algorithm under such highly dynamic self-evolving networks performed better,as it reduced the search latency,decreased the overall message overhead,and still equally had a good success rate.
文摘Most of the public key algorithms used in the exchange of information for power data transmission protocols are RSA. The core of the key part of this kind of algorithm system has not been announced. For the domestic sensitive information data field, there are threats such as preset backdoors and security vulnerabilities. In response to the above problems, the article introduces a secure communication protocol based on the optimized Secret SM2 algorithm, which uses socket programming to achieve two-way encrypted communication between clients and services, and is able to complete the security protection of data encryption transmission, authentication, data tampering, etc., and proves through experiments that the security protocol is more secure than traditional methods, can effectively identify each other, carry out stable and controllable data encryption transmission, and has good applicability.
文摘3D （Three-dimensional） Caco-2 spheroids closely recapitulating in vivo physiological organization of intestinal epithelial cells, provide an excellent in vitro model system to study their pathophysiology and their response to stressful stimuli. The objective of this technical note is to provide optimized in vitro experimental protocols for culturing 3D Caco-2 spheroids and for analyzing their cell growth features. An optimized 3D Caco-2 spheroid culturing technique based on a new configuration of the culture medium is provided A methodological approach to determine the distribution of the cell cycle phases in disaggregated Caco-2 spheroids by using cytofluorimetric analysis is also described. The optimized culturing protocol favors 3D Caco-2 spheroid differentiation process, as evaluated by the number of well-differentiated spheroids with a single hollow lumen. The cytofluorimetric analysis allows rapid collection of cell cycle phase data from high numbers of spheroid samples, thus, permitting to estimate their growth dynamics in a relatively short time. The optimized technical approaches described here can be applied in systematic manner to a variety of research activities utilizing 3D Caco-2 spheroids. Ease of use, time and economic saving advantages deriving from these protocols further highlight their potential.
文摘In recent years, Hyper Text Transfer Protocol （HTTP） spreads quickly and steadily in the usage of mobile applications as a common web protocol, so that the mobile applications can also benefit from HTTP/2, which is the new version of HTTP based on SPDY developed by Google to speed up the Internet transmission speed. HTTP/2 enables a more efficient use of network resources and a reduced perception of latency by in- troducing header field compression and allowing multiple concurrent exchanges on the same connection. However, what H3TP/2 focuses on is visiting websites through a browser, and mobile applications are not considered much. In this paper, firstly, mobile applications are classified based on the da- ta flow characteristics. Based on the classification, we propose an optimization of HTTP/2 for mobile applications, called HTTP/2-Advance, which uses multiple Transmission Control Protocol （TCP） connections to multiplex HTYP requests and responses. Then we build a tiny system which simulates actu- al requests and responses between mobile applications and servers. We figure out the best choice of the number of multiple TCP connections for mobile applications, and compare the performance of HTTP, HTTP/2 and HTrP/2-Advance in both simulated and in-situ experiments in our system.
文摘视频流量逐渐在网络中占据主导地位,且视频平台大多对其进行加密传输。虽然加密传输视频可以有效保护用户隐私,但是也增加了监管有害视频传播的难度.现有的加密视频识别方法基于TCP(Transmission Control Protocol)传输协议头部信息和HTTP/1.1(Hypertext Transfer Protocol Version1.1)的传输模式,提取应用层音视频数据单元传输长度序列来实现视频识别.但是随着基于UDP(User Datagram Protocol)的QUIC(Quick UDP Internet Connections)协议及基于QUIC实现的HTTP/3(Hypertext Transfer Protocol Version 3)协议应用于视频传输,已有方法不再适用.HTTP/3协议缺少类似TCP的头部信息,且使用了多路复用机制,并对几乎所有数据进行了加密,此外,视频平台开始使用多片段合并分发技术,这给从网络流量中精准识别加密视频带来了巨大挑战。本文基于HTTP/3协议中的控制信息特征,提出了从HTTP/3加密视频流中提取数据传输特征并进行修正的方法,最大程度复原出应用层音视频长度特征.面向多片段合并分发导致的海量匹配问题,本文基于明文指纹库设计了键值数据库来实现视频的快速识别.实验结果表明,本文提出的基于HTTP/3传输特性的加密视频识别方法能够在包含36万个真实视频指纹的YouTube大规模指纹库中达到接近99%的准确率,100%的精确率以及99.32%的F1得分,对传输过程中加人了填充顿的Facebook平台,在包含28万个真实视频指纹的大规模指纹库中达到95%的准确率、100%的精确率以及96.45%的F1得分,在具有同样特性的Instagram平台中,最高可达到97.57%的F1得分,且本方法在所有指纹库中的平均视频识别时间均低于0.4秒.本文的方法首次解决了使用HTTP/3传输的加密视频在大规模指纹库场景中的识别问题,具有很强的实用性和通用性.
基金Supported by the Performance Simulation and Computation Complexity on Computer Network Foundation (No.F2004060)
文摘The electronic system in a comprehensive shipboard has a extremely wide bandwidth. It supports synchronized and asynchronous data transmission, muhimedia correspondence, and videophone conferencing. In order to guarantee the security and correspondent real time of the communication, choosing a multicast routing protocol based on different applications is a key problem in terms of the complexity of the system. A simulation model was first designed for existing multicast routing protocols in NS-2 and analysis was performed on their corresponding application environments. The experiments proved that PIM-DM based on the shortest-path tree protocol is suitable for communication in the field of comprehensive shipboard. Further work that is necessary is also discussed.
