目的 探究穴位贴敷按摩联合5-羟色胺(5-HT3)受体拮抗剂对恶性肿瘤患者化疗后呕吐及血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平的影响.方法 选取无锡市中医医院2016年1月至2019年7月收治的60例恶性肿瘤化疗患者为研究对象,按照随...目的 探究穴位贴敷按摩联合5-羟色胺(5-HT3)受体拮抗剂对恶性肿瘤患者化疗后呕吐及血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平的影响.方法 选取无锡市中医医院2016年1月至2019年7月收治的60例恶性肿瘤化疗患者为研究对象,按照随机数字表法分为对照组和观察组,各30例.对照组予以5-HT3受体拮抗剂治疗,观察组则联合穴位贴敷治疗,治疗周期均为6周.比较2组治疗前后血清TNF-α、IL-6水平与呕吐生活功能指数(FLIE)、国际指南推荐的罗德恶心及呕吐指数评估量表[Rhods Index of CINV(R-INVR)]评分以及治疗后呕吐有效控制率.结果 与治疗前相比,2组治疗后血清TNF-α、IL-6水平及R-INVR评分降低,且观察组低于对照组(P<0.05);2组治疗后FLIE升高,且观察组高于对照组(P<0.05);治疗后观察组有效控制率100%高于对照组62.50%(P<0.05).结论 采用穴位贴敷按摩联合5-HT3受体拮抗剂治疗可通过降低TNF-α、IL-6水平有效缓解恶性肿瘤患者的化疗性呕吐,值得推广.展开更多
Poly(3-hexylthiophene)(P3HT)is one of the most promising hole-transporting materials in the pursuit of efficient and stable perovskite solar cells due to its outstanding stability and low cost.However,the intrinsic lo...Poly(3-hexylthiophene)(P3HT)is one of the most promising hole-transporting materials in the pursuit of efficient and stable perovskite solar cells due to its outstanding stability and low cost.However,the intrinsic low carrier density of P3 HT and poor contact between the P3HT/perovskite interface always lead to a low performance of the solar cell,while conventional chemical doping always makes the films unstable and limits the scalability.In this work,for the first time,we simultaneously enhanced the hole transporting properties of P3HT film and the interface of perovskite by doping it with a judiciously designed oxidized small molecule organic semiconductor.The organic salt not only can promote the lamellar crystallinity of P3HT to obtain better charge transport properties,but also reduce the defects of perovskite.As a result,we achieved champion efficiencies of 23.0%for small-area solar cells and 18.8%for larger-area modules(48.0 cm^(2)).This efficiency is the highest value for P3HT-based perovskite modules.Moreover,the solar cells show excellent operational stability,retaining over 95%of their initial efficiencies after1200 h of continuous operation.展开更多
文摘目的 探究穴位贴敷按摩联合5-羟色胺(5-HT3)受体拮抗剂对恶性肿瘤患者化疗后呕吐及血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平的影响.方法 选取无锡市中医医院2016年1月至2019年7月收治的60例恶性肿瘤化疗患者为研究对象,按照随机数字表法分为对照组和观察组,各30例.对照组予以5-HT3受体拮抗剂治疗,观察组则联合穴位贴敷治疗,治疗周期均为6周.比较2组治疗前后血清TNF-α、IL-6水平与呕吐生活功能指数(FLIE)、国际指南推荐的罗德恶心及呕吐指数评估量表[Rhods Index of CINV(R-INVR)]评分以及治疗后呕吐有效控制率.结果 与治疗前相比,2组治疗后血清TNF-α、IL-6水平及R-INVR评分降低,且观察组低于对照组(P<0.05);2组治疗后FLIE升高,且观察组高于对照组(P<0.05);治疗后观察组有效控制率100%高于对照组62.50%(P<0.05).结论 采用穴位贴敷按摩联合5-HT3受体拮抗剂治疗可通过降低TNF-α、IL-6水平有效缓解恶性肿瘤患者的化疗性呕吐,值得推广.
基金financially supported by the National Natural Science Foundation of China(52472248 and 22075221)the Key Research and Development Project of Shanxi Province(202202060301003 and 202202060301015)the Innovation Program of Wuhan-Shuguang Project(2023010201020367)。
文摘Poly(3-hexylthiophene)(P3HT)is one of the most promising hole-transporting materials in the pursuit of efficient and stable perovskite solar cells due to its outstanding stability and low cost.However,the intrinsic low carrier density of P3 HT and poor contact between the P3HT/perovskite interface always lead to a low performance of the solar cell,while conventional chemical doping always makes the films unstable and limits the scalability.In this work,for the first time,we simultaneously enhanced the hole transporting properties of P3HT film and the interface of perovskite by doping it with a judiciously designed oxidized small molecule organic semiconductor.The organic salt not only can promote the lamellar crystallinity of P3HT to obtain better charge transport properties,but also reduce the defects of perovskite.As a result,we achieved champion efficiencies of 23.0%for small-area solar cells and 18.8%for larger-area modules(48.0 cm^(2)).This efficiency is the highest value for P3HT-based perovskite modules.Moreover,the solar cells show excellent operational stability,retaining over 95%of their initial efficiencies after1200 h of continuous operation.
