目的:研究HSIL患者进行不同手术方式的处理,随后对患者进行随访,对患者后期HPV的转归结果进行分析。方法:搜集2023年1月至2024年1月就诊于我院的HSIL并接受手术治疗的患者90名,其中按手术方式的不同分为3组,分别是CKC组、LEEP组、锐扶...目的:研究HSIL患者进行不同手术方式的处理,随后对患者进行随访,对患者后期HPV的转归结果进行分析。方法:搜集2023年1月至2024年1月就诊于我院的HSIL并接受手术治疗的患者90名,其中按手术方式的不同分为3组,分别是CKC组、LEEP组、锐扶刀组各30名。对于不同手术方式的患者3、6、12个月进行HPV的检测。结果:① 三组患者一般资料对比,年龄、孕次、产次、是否绝经、有无阴道炎、HPV的感染情况对比,差异无统计学意义(P > 0.05);② 三组患者手术资料的对比,术后切缘状态、是否累腺,三组间比较差异无统计学意义(P > 0.05),锥切深度的不同在三组间比较差异有统计学意义(P 0.05);④ 将HPV的转阴情况进行多因素分析,可得出是否有阴道炎、是否累及腺体、是否绝经与HPV转阴情况有相关性(P 0.05)。结论:HSIL患者不同手术方式均有一定的治疗效果,且术后HPV转阴率与绝经、阴道炎、累腺因素相关。Study of HSIL patients who underwent different surgical modalities and were subsequently followed up to analyze the outcome of late HPV regression in patients. Methods: Ninety patients with HSIL who attended our hospital from January 2023 to January 2024 and underwent surgical treatment were collected, of which 30 patients were divided into three groups according to the different surgical methods, namely, 30 patients each in the CKC group, the LEEP group, and the Sharp Knife group. HPV testing was performed at 3, 6, and 12 months for patients with different surgical procedures. In the end ① Comparison of the general information of the three groups of patients, age, pregnancy, delivery, whether menopause, the presence of vaginitis, HPV infection comparison, the difference is not statistically significant (P > 0.05);② Comparison of the three groups of patients’ surgical data, postoperative margin status, whether the gland is tired, the difference is not statistically significant among the three groups (P > 0.05), the difference between the three groups of the cone depth of the different comparison of the three groups statistically significant (P 0.05);④ A multifactorial analysis of the HPV conversion status can be concluded that there is a correlation between whether or not there is vaginitis, whether or not there is gland involvement, and whether or not there is menopause, and the HPV conversion status (P 0.05). Conclude: The different surgical modalities in HSIL patients were effective, and the postoperative HPV conversion rate was correlated with menopause, vaginitis, and tired gland factors.展开更多
High-grade squamous intraepithelial lesion(HSIL)is regarded as a serious precancerous state of cervix,and it is easy to progress into cervical invasive carcinoma which highlights the importance of earlier diagnosis an...High-grade squamous intraepithelial lesion(HSIL)is regarded as a serious precancerous state of cervix,and it is easy to progress into cervical invasive carcinoma which highlights the importance of earlier diagnosis and treatment of cervical lesions.Pathologists examine the biopsied cervical epithelial tissue through a microscope.The pathological examination will take a long time and sometimes results in high inter-and intra-observer variability in outcomes.Polarization imaging techniques have broad application prospects for biomedical diagnosis such as breast,liver,colon,thyroid and so on.In our team,we have derived polarimetry feature parameters(PFPs)to characterize microstructural features in histological sections of breast tissues,and the accuracy for PFPs ranges from 0.82 to 0.91.Therefore,the aim of this paper is to distinguish automatically microstructural features between HSIL and cervical squamous cell carcinoma(CSCC)by means of polarization imaging techniques,and try to provide quantitative reference index for patho-logical diagnosis which can alleviate the workload of pathologists.Polarization images of the H&E stained histological slices were obtained by Mueller matrix microscope.The typical path-ological structure area was labeled by two experienced pathologists.Calculate the polarimetry basis parameter(PBP)statistics for this region.The PBP statistics(stat PBPs)are screened by mutual information(MI)method.The training method is based on a linear discriminant analysis(LDA)classier whichnds the most simplied linear combination from these stat PBPs and the accuracy remains constant to characterize the specic microstructural feature quantitatively in cervical squamous epithelium.We present results from 37 clinical patients with analysis regions of cervical squamous epithelium.The accuracy of PFP for recognizing HSIL and CSCC was 83.8%and 87.5%,respectively.This work demonstrates the ability of PFP to quantitatively charac-terize the cervical squamous epithelial lesions in the H&E pathological sections.Signicance:Polarization detection technology provides an effcient method for digital pathological diagnosis and points out a new way for automatic screening of pathological sections.展开更多
文摘目的:研究HSIL患者进行不同手术方式的处理,随后对患者进行随访,对患者后期HPV的转归结果进行分析。方法:搜集2023年1月至2024年1月就诊于我院的HSIL并接受手术治疗的患者90名,其中按手术方式的不同分为3组,分别是CKC组、LEEP组、锐扶刀组各30名。对于不同手术方式的患者3、6、12个月进行HPV的检测。结果:① 三组患者一般资料对比,年龄、孕次、产次、是否绝经、有无阴道炎、HPV的感染情况对比,差异无统计学意义(P > 0.05);② 三组患者手术资料的对比,术后切缘状态、是否累腺,三组间比较差异无统计学意义(P > 0.05),锥切深度的不同在三组间比较差异有统计学意义(P 0.05);④ 将HPV的转阴情况进行多因素分析,可得出是否有阴道炎、是否累及腺体、是否绝经与HPV转阴情况有相关性(P 0.05)。结论:HSIL患者不同手术方式均有一定的治疗效果,且术后HPV转阴率与绝经、阴道炎、累腺因素相关。Study of HSIL patients who underwent different surgical modalities and were subsequently followed up to analyze the outcome of late HPV regression in patients. Methods: Ninety patients with HSIL who attended our hospital from January 2023 to January 2024 and underwent surgical treatment were collected, of which 30 patients were divided into three groups according to the different surgical methods, namely, 30 patients each in the CKC group, the LEEP group, and the Sharp Knife group. HPV testing was performed at 3, 6, and 12 months for patients with different surgical procedures. In the end ① Comparison of the general information of the three groups of patients, age, pregnancy, delivery, whether menopause, the presence of vaginitis, HPV infection comparison, the difference is not statistically significant (P > 0.05);② Comparison of the three groups of patients’ surgical data, postoperative margin status, whether the gland is tired, the difference is not statistically significant among the three groups (P > 0.05), the difference between the three groups of the cone depth of the different comparison of the three groups statistically significant (P 0.05);④ A multifactorial analysis of the HPV conversion status can be concluded that there is a correlation between whether or not there is vaginitis, whether or not there is gland involvement, and whether or not there is menopause, and the HPV conversion status (P 0.05). Conclude: The different surgical modalities in HSIL patients were effective, and the postoperative HPV conversion rate was correlated with menopause, vaginitis, and tired gland factors.
基金the Guangming District Economic Development Special Fund(2020R01043)。
文摘High-grade squamous intraepithelial lesion(HSIL)is regarded as a serious precancerous state of cervix,and it is easy to progress into cervical invasive carcinoma which highlights the importance of earlier diagnosis and treatment of cervical lesions.Pathologists examine the biopsied cervical epithelial tissue through a microscope.The pathological examination will take a long time and sometimes results in high inter-and intra-observer variability in outcomes.Polarization imaging techniques have broad application prospects for biomedical diagnosis such as breast,liver,colon,thyroid and so on.In our team,we have derived polarimetry feature parameters(PFPs)to characterize microstructural features in histological sections of breast tissues,and the accuracy for PFPs ranges from 0.82 to 0.91.Therefore,the aim of this paper is to distinguish automatically microstructural features between HSIL and cervical squamous cell carcinoma(CSCC)by means of polarization imaging techniques,and try to provide quantitative reference index for patho-logical diagnosis which can alleviate the workload of pathologists.Polarization images of the H&E stained histological slices were obtained by Mueller matrix microscope.The typical path-ological structure area was labeled by two experienced pathologists.Calculate the polarimetry basis parameter(PBP)statistics for this region.The PBP statistics(stat PBPs)are screened by mutual information(MI)method.The training method is based on a linear discriminant analysis(LDA)classier whichnds the most simplied linear combination from these stat PBPs and the accuracy remains constant to characterize the specic microstructural feature quantitatively in cervical squamous epithelium.We present results from 37 clinical patients with analysis regions of cervical squamous epithelium.The accuracy of PFP for recognizing HSIL and CSCC was 83.8%and 87.5%,respectively.This work demonstrates the ability of PFP to quantitatively charac-terize the cervical squamous epithelial lesions in the H&E pathological sections.Signicance:Polarization detection technology provides an effcient method for digital pathological diagnosis and points out a new way for automatic screening of pathological sections.
