In this study,the evidence-based design(EBD)of naturalized decoration in hematopoietic stem cell transplantation(HSCT)wards of Peking University First Hospital was explored to improve patients’psychological state and...In this study,the evidence-based design(EBD)of naturalized decoration in hematopoietic stem cell transplantation(HSCT)wards of Peking University First Hospital was explored to improve patients’psychological state and rehabilitation environment by introducing natural elements.Based on questionnaire surveys and literature research,the EBD method was adopted to propose a naturalized decoration scheme for HSCT wards,and a satisfaction evaluation was conducted after construction and use.The research results show that naturalized decoration can effectively enhance the satisfaction and comfort of patients and medical staff,verifying its positive effects in HSCT wards.展开更多
Objective To evaluate the outcome of combination of intensive preconditioning regimen allo - HSCT with imatinib for treatment of Ph chromosome positive acute lymphocyte leukemia ( ALL) . Methods Between 2009 and 2010,...Objective To evaluate the outcome of combination of intensive preconditioning regimen allo - HSCT with imatinib for treatment of Ph chromosome positive acute lymphocyte leukemia ( ALL) . Methods Between 2009 and 2010,8 patients diagnosed as Ph + ALL received展开更多
The haematopoietic stem cell transplantation(HSCT)ward serves as a temporary residence for patients following their surgical procedures,necessitating adherence to rigorous aseptic standards.However,the current atmosph...The haematopoietic stem cell transplantation(HSCT)ward serves as a temporary residence for patients following their surgical procedures,necessitating adherence to rigorous aseptic standards.However,the current atmosphere within these wards frequently contributes to feelings of depression among patients.Research indicates that a restorative environment has the potential to alleviate negative emotional states in individuals.This study utilized the HSCT ward of Peking University First Hospital as a case study to examine the decorative preferences.This investigation was conducted through a questionnaire that was informed by the patients’inherent preferences and insights derived from research on restorative environments.The results indicated that the incorporation of floral decorations,particularly those resembling sunflowers,in ward corridors,communal activity areas,and walls can significantly enhance patients’sense of hope.Additionally,it is essential to improve the environmental visual experience in the nurses’lounge and demonstration rooms for medical staff.展开更多
Allogeneic hematopoietic stem cell transplantation(allo-HSCT)represents a curative therapy for hematological malignancies,with T-cell immune reconstitution playing a pivotal role in determining clinical outcomes.This ...Allogeneic hematopoietic stem cell transplantation(allo-HSCT)represents a curative therapy for hematological malignancies,with T-cell immune reconstitution playing a pivotal role in determining clinical outcomes.This review comprehensively illustrates the processes and influencing factors of T-cell recovery post-HSCT,highlighting the dual pathways of reconstitution:thymus-independent peripheral expansion and thymus-dependent central regeneration.Key factors such as recipient and donor age,human leukocyte antigen disparity,conditioning regimens,immunosuppressive therapies,cytomegalovirus reactivation,and graft-versus-host disease(GVHD)significantly impact T-cell reconstitution dynamics and functional recovery.Furthermore,the article discusses the critical balance between graft-versus-leukemia(GVL)effects and GVHD,emphasizing how T-cell exhaustion,inhibitory receptor overexpression,and clonal dynamics contribute to relapse.Emerging technologies,including single-cell multi-omics,spatially resolved proteomics,T cell receptor repertoire analysis,and artificial intelligence-driven modeling,are explored for their potential to deepen mechanistic understanding and enable personalized therapeutic strategies.Ultimately,enhancing T-cell reconstitution through optimized transplantation protocols and targeted interventions is essential for reducing complications and improving long-term survival.展开更多
基金Sponsored by the National Natural Science Foundation of China:Visual Perception Based Natural Intervention for Patients in HSCT Wards(52278045)Innovation and Entrepreneurship Training Programme for Students in 2024(10805136024XN139-91).
文摘In this study,the evidence-based design(EBD)of naturalized decoration in hematopoietic stem cell transplantation(HSCT)wards of Peking University First Hospital was explored to improve patients’psychological state and rehabilitation environment by introducing natural elements.Based on questionnaire surveys and literature research,the EBD method was adopted to propose a naturalized decoration scheme for HSCT wards,and a satisfaction evaluation was conducted after construction and use.The research results show that naturalized decoration can effectively enhance the satisfaction and comfort of patients and medical staff,verifying its positive effects in HSCT wards.
文摘Objective To evaluate the outcome of combination of intensive preconditioning regimen allo - HSCT with imatinib for treatment of Ph chromosome positive acute lymphocyte leukemia ( ALL) . Methods Between 2009 and 2010,8 patients diagnosed as Ph + ALL received
文摘 对急性白血病(AL)患者自体造血干细胞移植(Auto＿HSCT)前进行大剂量化疗,移植后给白细胞介素 2(IL 2)免疫治疗以降低AL患者Auto＿HSCT后的复发率,延长患者的生存期.10例AL第一次缓解期(CR 1)的患者进入研究.移植前急性淋巴细胞白血病(ALL)患者3例均接受大剂量甲氨碟呤1疗程及大剂量阿糖胞苷(HD Ara C)加蒽环类抗肿瘤药1疗程.急性非淋巴细胞白血病(ANLL)患者7例接受HD Ara C加蒽环类抗肿瘤药2疗程.化疗结束后给患者行Auto＿HSCT治疗.预处理方案为:CY/TBI;MAC或EAC方案.移植的CD34+细胞5.5×106～12.2×106/kg.患者造血重建后给IL 21×106～2×106μ治疗每天1次,5d为1疗程.患者均接受3～5疗程的治疗.经以上序惯治疗后,1例ALL患者14月后复发,经化疗无效死亡.9/10(90.00%)例无病生存至今,平均生存期37.10月(37.1±24.98),明显延长.可见对AL患者Auto＿HSCT前大剂量化疗,最大限度降低患者体内白血病负荷;移植后免疫治疗清除微小残留病,可能是降低AL患者Auto＿HSCT后复发,延长患者生存期的有效途径.
基金Sponsored by National Natural Science Foundation of China(52278045).
文摘The haematopoietic stem cell transplantation(HSCT)ward serves as a temporary residence for patients following their surgical procedures,necessitating adherence to rigorous aseptic standards.However,the current atmosphere within these wards frequently contributes to feelings of depression among patients.Research indicates that a restorative environment has the potential to alleviate negative emotional states in individuals.This study utilized the HSCT ward of Peking University First Hospital as a case study to examine the decorative preferences.This investigation was conducted through a questionnaire that was informed by the patients’inherent preferences and insights derived from research on restorative environments.The results indicated that the incorporation of floral decorations,particularly those resembling sunflowers,in ward corridors,communal activity areas,and walls can significantly enhance patients’sense of hope.Additionally,it is essential to improve the environmental visual experience in the nurses’lounge and demonstration rooms for medical staff.
基金supported by grants from the Ministry of Science and Technology of China(2021YFA1100902)the National Natural Science Foundation of China(NSFC)(82370222,92368202)+3 种基金the Haihe Laboratory of Cell Ecosystem Innovation Fund(HH24KYZX0001)CAMS Innovation Fund for Medical Sciences(CIFMS)(2024-I2M-ZD-010)Science,Technology&Innovation Project of Xiong’an New Area(2022XAGG0142)Tianjin Municipal Science and Technology Commission Grant(24ZXRKSY00030,24ZXZSSS00250).
文摘Allogeneic hematopoietic stem cell transplantation(allo-HSCT)represents a curative therapy for hematological malignancies,with T-cell immune reconstitution playing a pivotal role in determining clinical outcomes.This review comprehensively illustrates the processes and influencing factors of T-cell recovery post-HSCT,highlighting the dual pathways of reconstitution:thymus-independent peripheral expansion and thymus-dependent central regeneration.Key factors such as recipient and donor age,human leukocyte antigen disparity,conditioning regimens,immunosuppressive therapies,cytomegalovirus reactivation,and graft-versus-host disease(GVHD)significantly impact T-cell reconstitution dynamics and functional recovery.Furthermore,the article discusses the critical balance between graft-versus-leukemia(GVL)effects and GVHD,emphasizing how T-cell exhaustion,inhibitory receptor overexpression,and clonal dynamics contribute to relapse.Emerging technologies,including single-cell multi-omics,spatially resolved proteomics,T cell receptor repertoire analysis,and artificial intelligence-driven modeling,are explored for their potential to deepen mechanistic understanding and enable personalized therapeutic strategies.Ultimately,enhancing T-cell reconstitution through optimized transplantation protocols and targeted interventions is essential for reducing complications and improving long-term survival.
