The globe faces an urgent need to close the energy demand-supply gap.Addressing this difficulty requires constructing a Hybrid Renewable Energy System(HRES),which has proven to be the most appropriate solution.HRES al...The globe faces an urgent need to close the energy demand-supply gap.Addressing this difficulty requires constructing a Hybrid Renewable Energy System(HRES),which has proven to be the most appropriate solution.HRES allows for integrating two or more renewable energy resources,successfully addressing the issue of intermittent availability of non-conventional energy resources.Optimization is critical for improving the HRES’s performance parameters during implementation.This study focuses on HRES using solar and biomass as renewable energy supplies and appropriate energy storage technologies.However,energy fluctuations present a problem with the power quality of HRES.To address this issue,the research paper introduces the Generalized Dynamic Progressive Neural Fuzzy Controller(GDPNFC),which regulates power flow within the proposed HRES.Furthermore,a unique approach called Enhanced Multi-Objective Monarch Butterfly Optimization(EMMBO)is used to optimize technical parameters.The simulation tool used in the research work is HOMER(Hybrid Optimization of Multiple Energy Resources)-PRO,and the system’s power quality is assessed using MATLAB 2016.The research paper concludes with comparing the performance of existing systems to the proposed system in terms of power loss and Total Harmonic Distortion(THD).It was established that the proposed technique involving EMMBO outperformed existing methods in technical optimization.展开更多
实体瘤中乏氧区的存在是影响放疗效果最主要的因素之一[1].在一个基因启动子内利用乏氧和射线应答元件联合,限制治疗基因仅在乏氧和/或受照组织激活,可提高治疗比率.该文研究目的是构建包含HREs和CArG元件的乏氧-辐射嵌合性基因启动子,...实体瘤中乏氧区的存在是影响放疗效果最主要的因素之一[1].在一个基因启动子内利用乏氧和射线应答元件联合,限制治疗基因仅在乏氧和/或受照组织激活,可提高治疗比率.该文研究目的是构建包含HREs和CArG元件的乏氧-辐射嵌合性基因启动子,并观察乏氧及照射时该启动子诱导增强的绿色荧光蛋白(enhanced green fluorescent protein,EGFP)在BEL7402肝癌细胞中的表达变化.展开更多
目的探讨在Co Cl2模拟低氧条件下,低氧诱导因子1α(HIF-1α)对于过氧化物酶体增殖物激活受体γ2(PPARγ2)是否具有调控作用。方法用real time PCR和Western blot检测Co Cl2模拟低氧条件下PPARγ2和低氧诱导因子1α(HIF-1α)mRNA及蛋白...目的探讨在Co Cl2模拟低氧条件下,低氧诱导因子1α(HIF-1α)对于过氧化物酶体增殖物激活受体γ2(PPARγ2)是否具有调控作用。方法用real time PCR和Western blot检测Co Cl2模拟低氧条件下PPARγ2和低氧诱导因子1α(HIF-1α)mRNA及蛋白表达。用双荧光报告系统检测HIF-1α对于PPARγ调控的剂量依赖性,并通过染色质免疫共沉淀技术进一步验证。结果 Co Cl2模拟低氧条件下PPARγ2和HIF-1α的mRNA及蛋白表达水平均随着诱导时间的增加而增加。过表达HIF-1α导致PPARγ2表达上调(P<0.01),而抑制HIF-1α则导致PPARγ2表达下调(P<0.05)。HIF-1α对PPARγ2基因的表达具有正调控作用,通过结合于PPARγ2上游调控区特定的低氧应答元件(HRE)而调控其表达。结论 PPARγ2通过HIF-1α依赖的途径在Co Cl2模拟的低氧条件下发挥低氧适应作用。展开更多
文摘The globe faces an urgent need to close the energy demand-supply gap.Addressing this difficulty requires constructing a Hybrid Renewable Energy System(HRES),which has proven to be the most appropriate solution.HRES allows for integrating two or more renewable energy resources,successfully addressing the issue of intermittent availability of non-conventional energy resources.Optimization is critical for improving the HRES’s performance parameters during implementation.This study focuses on HRES using solar and biomass as renewable energy supplies and appropriate energy storage technologies.However,energy fluctuations present a problem with the power quality of HRES.To address this issue,the research paper introduces the Generalized Dynamic Progressive Neural Fuzzy Controller(GDPNFC),which regulates power flow within the proposed HRES.Furthermore,a unique approach called Enhanced Multi-Objective Monarch Butterfly Optimization(EMMBO)is used to optimize technical parameters.The simulation tool used in the research work is HOMER(Hybrid Optimization of Multiple Energy Resources)-PRO,and the system’s power quality is assessed using MATLAB 2016.The research paper concludes with comparing the performance of existing systems to the proposed system in terms of power loss and Total Harmonic Distortion(THD).It was established that the proposed technique involving EMMBO outperformed existing methods in technical optimization.
文摘实体瘤中乏氧区的存在是影响放疗效果最主要的因素之一[1].在一个基因启动子内利用乏氧和射线应答元件联合,限制治疗基因仅在乏氧和/或受照组织激活,可提高治疗比率.该文研究目的是构建包含HREs和CArG元件的乏氧-辐射嵌合性基因启动子,并观察乏氧及照射时该启动子诱导增强的绿色荧光蛋白(enhanced green fluorescent protein,EGFP)在BEL7402肝癌细胞中的表达变化.
文摘目的探讨在Co Cl2模拟低氧条件下,低氧诱导因子1α(HIF-1α)对于过氧化物酶体增殖物激活受体γ2(PPARγ2)是否具有调控作用。方法用real time PCR和Western blot检测Co Cl2模拟低氧条件下PPARγ2和低氧诱导因子1α(HIF-1α)mRNA及蛋白表达。用双荧光报告系统检测HIF-1α对于PPARγ调控的剂量依赖性,并通过染色质免疫共沉淀技术进一步验证。结果 Co Cl2模拟低氧条件下PPARγ2和HIF-1α的mRNA及蛋白表达水平均随着诱导时间的增加而增加。过表达HIF-1α导致PPARγ2表达上调(P<0.01),而抑制HIF-1α则导致PPARγ2表达下调(P<0.05)。HIF-1α对PPARγ2基因的表达具有正调控作用,通过结合于PPARγ2上游调控区特定的低氧应答元件(HRE)而调控其表达。结论 PPARγ2通过HIF-1α依赖的途径在Co Cl2模拟的低氧条件下发挥低氧适应作用。
