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HPLC-Q-Exactive-MS/MS快速鉴定三子散在体外人工胃液、肠液中代谢转化研究
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作者 夏慧敏 孙丽君 +5 位作者 何春龙 李若凡 许佳绮 董馨 张慧文 王焕芸 《中南药学》 2025年第6期1584-1590,共7页
目的通过研究三子散在人工胃液、肠液中的代谢转化情况,推测其在体内的代谢物及代谢转化途径。方法采用高效液相色谱-四极杆/静电场轨道阱高分辨质谱(HPLC-Q-Exactive-MS/MS)法,色谱柱为SHIMADZU GIST C18(4.6 mm×150 mm,5μm),柱... 目的通过研究三子散在人工胃液、肠液中的代谢转化情况,推测其在体内的代谢物及代谢转化途径。方法采用高效液相色谱-四极杆/静电场轨道阱高分辨质谱(HPLC-Q-Exactive-MS/MS)法,色谱柱为SHIMADZU GIST C18(4.6 mm×150 mm,5μm),柱温为30℃,流动相为0.1%甲酸水-甲醇溶液(梯度洗脱),流速为0.5 mL·min^(-1),检测波长为270 nm;离子源为电喷雾离子源,质荷比(m/z)为100→1500;在正、负离子模式下,对三子散在人工胃液、肠液中的代谢成分进行鉴定分析,对照三子散中已鉴定出的化学成分并结合文献推测三子散在人工胃液和肠液中的代谢途径。结果三子散经人工胃液代谢后,共推测出人工胃液中26个原形成分,其中19个来自诃子,6个来自栀子,1个来自川楝子;人工肠液中31个原形成分,其中21个来自诃子,9个来自栀子,1个来自川楝子;对比人工胃液、肠液中的代谢物分析结果,26个成分在胃液和肠液中均检出,5个成分(没食子酸甲酯、Jaminiside B/D/G、咖啡酸、反苯基丙烯酸、6''-O-trans-p-coumaroylgenipin gentiobioside)仅在肠液中检出。结论本研究初步推测三子散在人工胃液、肠液中多以原形存在,胃肠道成分代谢有所不同,可为三子散的体内代谢转化研究提供参考。 展开更多
关键词 三子散 代谢 人工胃液 人工肠液 hplc-q-exactive-ms/ms 成分分析
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A New Inversion-free Iterative Method for Solving the Nonlinear Matrix Equation and Its Application in Optimal Control
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作者 GAO Xiangyu XIE Weiwei ZHANG Lina 《应用数学》 北大核心 2026年第1期143-150,共8页
In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to ... In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method. 展开更多
关键词 Nonlinear matrix equation Maximal positive definite solution Inversion-free iterative method Optimal control
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Crushing evolution in pebble bed based on a novel method:a crushable DEM study
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作者 Jian Wang Ming‑Zhun Lei +4 位作者 Ming‑Zong Liu Qi‑Gang Wu Zi‑Cong Cai Kai‑Song Wang Hai‑Shun Deng 《Nuclear Science and Techniques》 2026年第1期212-224,共13页
In this paper,a novel method for investigating the particle-crushing behavior of breeding particles in a fusion blanket is proposed.The fractal theory and Weibull distribution are combined to establish a theoretical m... In this paper,a novel method for investigating the particle-crushing behavior of breeding particles in a fusion blanket is proposed.The fractal theory and Weibull distribution are combined to establish a theoretical model,and its validity was verified using a simple impact test.A crushable discrete element method(DEM)framework is built based on the previously established theoretical model.The tensile strength,which considers the fractal theory,size effect,and Weibull variation,was assigned to each generated particle.The assigned strength is then used for crush detection by comparing it with its maximum tensile stress.Mass conservation is ensured by inserting a series of sub-particles whose total mass was equal to the quality loss.Based on the crushable DEM framework,a numerical simulation of the crushing behavior of a pebble bed with hollow cylindrical geometry under a uniaxial compression test was performed.The results of this investigation showed that the particle withstands the external load by contact and sliding at the beginning of the compression process,and the results confirmed that crushing can be considered an important method of resisting the increasing external load.A relatively regular particle arrangement aids in resisting the load and reduces the occurrence of particle crushing.However,a limit exists to the promotion of resistance.When the strain increases beyond this limit,the distribution of the crushing position tends to be isotropic over the entire pebble bed.The theoretical model and crushable DEM framework provide a new method for exploring the pebble bed in a fusion reactor,considering particle crushing. 展开更多
关键词 Crushing behavior Granular material Discrete element method Pebble bed Fractal theory
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A Deep Reinforcement Learning-Based Partitioning Method for Power System Parallel Restoration
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作者 Changcheng Li Weimeng Chang +1 位作者 Dahai Zhang Jinghan He 《Energy Engineering》 2026年第1期243-264,共22页
Effective partitioning is crucial for enabling parallel restoration of power systems after blackouts.This paper proposes a novel partitioning method based on deep reinforcement learning.First,the partitioning decision... Effective partitioning is crucial for enabling parallel restoration of power systems after blackouts.This paper proposes a novel partitioning method based on deep reinforcement learning.First,the partitioning decision process is formulated as a Markov decision process(MDP)model to maximize the modularity.Corresponding key partitioning constraints on parallel restoration are considered.Second,based on the partitioning objective and constraints,the reward function of the partitioning MDP model is set by adopting a relative deviation normalization scheme to reduce mutual interference between the reward and penalty in the reward function.The soft bonus scaling mechanism is introduced to mitigate overestimation caused by abrupt jumps in the reward.Then,the deep Q network method is applied to solve the partitioning MDP model and generate partitioning schemes.Two experience replay buffers are employed to speed up the training process of the method.Finally,case studies on the IEEE 39-bus test system demonstrate that the proposed method can generate a high-modularity partitioning result that meets all key partitioning constraints,thereby improving the parallelism and reliability of the restoration process.Moreover,simulation results demonstrate that an appropriate discount factor is crucial for ensuring both the convergence speed and the stability of the partitioning training. 展开更多
关键词 Partitioning method parallel restoration deep reinforcement learning experience replay buffer partitioning modularity
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An improved open-top dynamic chambers method for measuring the exchange fluxes of N_(2)O,NO and NH_(3) from farmland
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作者 Minhang Tan Yining Hu +6 位作者 Yifei Song Zixuan Huang Yujing Mu Junfeng Liu Chenglong Zhang Pengfei Liu Yuanyuan Zhang 《Journal of Environmental Sciences》 2026年第1期535-545,共11页
The application of nitrogen fertilizers in agricultural fields can lead to the release of nitrogen-containing gases(NCGs),such as NO_(x),NH_(3) and N_(2)O,which can significantly impact regional atmospheric environmen... The application of nitrogen fertilizers in agricultural fields can lead to the release of nitrogen-containing gases(NCGs),such as NO_(x),NH_(3) and N_(2)O,which can significantly impact regional atmospheric environment and con-tribute to global climate change.However,there remain considerable research gaps in the accurate measurement of NCGs emissions from agricultural fields,hindering the development of effective emission reduction strategies.We improved an open-top dynamic chambers(OTDCs)system and evaluated the performance by comparing the measured and given fluxes of the NCGs.The results showed that the measured fluxes of NO,N_(2)O and NH_(3)were 1%,2%and 7%lower than the given fluxes,respectively.For the determination of NH_(3) concentration,we employed a stripping coil-ion chromatograph(SC-IC)analytical technique,which demonstrated an absorption efficiency for atmospheric NH_(3) exceeding 96.1%across sampling durations of 6 to 60 min.In the summer maize season,we utilized the OTDCs system to measure the exchange fluxes of NO,NH_(3),and N_(2)O from the soil in the North China Plain.Substantial emissions of NO,NH_(3) and N_(2)O were recorded following fertilization,with peaks of 107,309,1239 ng N/(m^(2)·s),respectively.Notably,significant NCGs emissions were observed following sus-tained heavy rainfall one month after fertilization,particularly with NH_(3) peak being 4.5 times higher than that observed immediately after fertilization.Our results demonstrate that the OTDCs system accurately reflects the emission characteristics of soil NCGs and meets the requirements for long-term and continuous flux observation. 展开更多
关键词 Open-top dynamic chambers Nitrogen-containing gases Soil emissions North China Plain method evaluation
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Numerical Simulation of the Welding Deformation of Marine Thin Plates Based on a Temperature Gradient-thermal Strain Method
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作者 Lin Wang Yugang Miao +3 位作者 Zhenjian Zhuo Chunxiang Lin Benshun Zhang Duanfeng Han 《哈尔滨工程大学学报(英文版)》 2026年第1期122-135,共14页
Marine thin plates are susceptible to welding deformation owing to their low structural stiffness.Therefore,the efficient and accurate prediction of welding deformation is essential for improving welding quality.The t... Marine thin plates are susceptible to welding deformation owing to their low structural stiffness.Therefore,the efficient and accurate prediction of welding deformation is essential for improving welding quality.The traditional thermal elastic-plastic finite element method(TEP-FEM)can accurately predict welding deformation.However,its efficiency is low because of the complex nonlinear transient computation,making it difficult to meet the needs of rapid engineering evaluation.To address this challenge,this study proposes an efficient prediction method for welding deformation in marine thin plate butt welds.This method is based on the coupled temperature gradient-thermal strain method(TG-TSM)that integrates inherent strain theory with a shell element finite element model.The proposed method first extracts the distribution pattern and characteristic value of welding-induced inherent strain through TEP-FEM analysis.This strain is then converted into the equivalent thermal load applied to the shell element model for rapid computation.The proposed method-particularly,the gradual temperature gradient-thermal strain method(GTG-TSM)-achieved improved computational efficiency and consistent precision.Furthermore,the proposed method required much less computation time than the traditional TEP-FEM.Thus,this study lays the foundation for future prediction of welding deformation in more complex marine thin plates. 展开更多
关键词 Marine thin plate Welding deformation Numerical simulation Temperature gradient-thermal strain method Shell element
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Precision and trueness of a method for determing antimony content in groundwater using hydride generation-atomic fluorescence spectrometry
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作者 Bing-bing Liu Lin Zhang Ke Li 《Journal of Groundwater Science and Engineering》 2026年第1期49-58,共10页
At present,there is currently a lack of unified standard methods for the determination of antimony content in groundwater in China.The precision and trueness of related detection technologies have not yet been systema... At present,there is currently a lack of unified standard methods for the determination of antimony content in groundwater in China.The precision and trueness of related detection technologies have not yet been systematically and quantitatively evaluated,which limits the effective implementation of environmental monitoring.In response to this key technical gap,this study aimed to establish a standardized method for determining antimony in groundwater using Hydride Generation–Atomic Fluorescence Spectrometry(HG-AFS).Ten laboratories participated in inter-laboratory collaborative tests,and the statistical analysis of the test data was carried out in strict accordance with the technical specifications of GB/T 6379.2—2004 and GB/T 6379.4—2006.The consistency and outliers of the data were tested by Mandel's h and k statistics,the Grubbs test and the Cochran test,and the outliers were removed to optimize the data,thereby significantly improving the reliability and accuracy.Based on the optimized data,parameters such as the repeatability limit(r),reproducibility limit(R),and method bias value(δ)were determined,and the trueness of the method was statistically evaluated.At the same time,precision-function relationships were established,and all results met the requirements.The results show that the lower the antimony content,the lower the repeatability limit(r)and reproducibility limit(R),indicating that the measurement error mainly originates from the detection limit of the method and instrument sensitivity.Therefore,improving the instrument sensitivity and reducing the detection limit are the keys to controlling the analytical error and improving precision.This study provides reliable data support and a solid technical foundation for the establishment and evaluation of standardized methods for the determination of antimony content in groundwater. 展开更多
关键词 Mandel's h and k statistics Grubbs test Cochran test Repeatability limit Reproducibility limit method bias value
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基于HPLC-Q-Exactive-MS/MS整合网络药理学研究加味塔布森-2有效成分及其抗骨质疏松机制 被引量:8
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作者 田显庭 薛培凤 +5 位作者 张廉居 董睿 封千喜 李春燕 陆景坤 董馨 《中国现代应用药学》 CAS CSCD 北大核心 2022年第13期1668-1676,共9页
目的鉴定加味塔布森-2入血成分,并结合网络药理学阐述其治疗骨质疏松的作用机制。方法采用HPLC-Q-Exactive-MS/MS对加味塔布森-2入血成分进行鉴定;在此基础上结合SwissTarget Prediction与SuperPred数据库进行入血成分的靶点预测,同时在... 目的鉴定加味塔布森-2入血成分,并结合网络药理学阐述其治疗骨质疏松的作用机制。方法采用HPLC-Q-Exactive-MS/MS对加味塔布森-2入血成分进行鉴定;在此基础上结合SwissTarget Prediction与SuperPred数据库进行入血成分的靶点预测,同时在DisGeNET数据库中搜索骨质疏松相关的疾病靶点,利用Cytoscape软件构建“入血成分-靶点-疾病”网络模型,运用String数据分析平台进行蛋白互作网络分析,并且利用David数据库对核心靶点进行GO富集分析和KEGG通路分析,最后使用分子对接对网络药理学内容进行初步验证。结果最终确定入血成分21个,通过网络药理分析得到加味塔布森-2抗骨质疏松的核心靶点11个。对11个核心靶点进行GO功能注释和KEGG通路分析后,发现加味塔布森-2抗骨质疏松的信号通路主要包括HIF-1、雌激素、MAPK、甲状腺素、TNF、mTOR、PI3K/AKT等。结论该方法初步明确了加味塔布森-2的入血成分及潜在作用机制,为加味塔布森-2药理作用机制的进一步研究提供科学依据。 展开更多
关键词 hplc-q-exactive-ms/ms 加味塔布森-2 入血成分 网络药理 骨质疏松 分子对接
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HPLC-Q-Exactive-MS/MS快速鉴定蒙药三子散化学成分 被引量:7
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作者 夏慧敏 张慧文 +2 位作者 刘宏 梁越 王焕芸 《中国现代应用药学》 CAS CSCD 北大核心 2023年第21期3005-3014,共10页
目的采用HPLC-Q-Exactive-MS/MS对三子散复方中化学成分进行快速定性分析。方法SHIMADZU GIST C18色谱柱(4.6 mm×150 mm,5μm),以0.1%甲酸水-甲醇为流动相,梯度洗脱,流速0.5 mL·min^(–1),柱温30℃,正、负离子模式下扫描三子... 目的采用HPLC-Q-Exactive-MS/MS对三子散复方中化学成分进行快速定性分析。方法SHIMADZU GIST C18色谱柱(4.6 mm×150 mm,5μm),以0.1%甲酸水-甲醇为流动相,梯度洗脱,流速0.5 mL·min^(–1),柱温30℃,正、负离子模式下扫描三子散的一级、二级质谱信息。以总离子流图分析的分子离子峰和碎片离子的质谱信息、分子式、保留时间,结合Chemspider数据库及参考文献查找的分子式和结构式,对三子散中各成分进行定性归属。结果通过分析各类成分的质谱裂解规律和文献信息,初步推测出95个可能的化学成分,包括39个酚酸类成分、20个鞣质成分、9个有机酸酯类成分、5个单萜类成分、12个环烯醚萜类成分、8个三萜类成分和2个黄酮类成分。其中,57个来自诃子,30个来自栀子,10个来自川楝子,其中芦丁同时来源于诃子、栀子和川楝子。结论HPLC-Q-Exactive-MS/MS检测方法分离度好、灵敏度高,可快速、高效地推测出三子散中各类成分,为鉴定三子散中的化学成分建立了一种快速、高效的分析方法。 展开更多
关键词 三子散 hplc-q-exactive-ms/ms 化学成分
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基于HPLC-Q-Exactive-MS法的蒙药蓝盆花血清图谱研究 被引量:4
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作者 韩盟帝 石佳欣 +3 位作者 董馨 马飞祥 布仁 薛培凤 《中药材》 CAS 北大核心 2019年第12期2843-2849,共7页
目的:采用四极杆-静电场轨道阱高分辨质谱联用(HPLC-Q-Exactive-MS)技术建立蒙药蓝盆花含药血清色谱图并分析其入血成分。方法:采用ACE EXCEL 3 C18-PFP(100 mm×3 mm,3μm)色谱柱;以乙腈-0.1%甲酸溶液为流动相,梯度洗脱;柱温为45℃... 目的:采用四极杆-静电场轨道阱高分辨质谱联用(HPLC-Q-Exactive-MS)技术建立蒙药蓝盆花含药血清色谱图并分析其入血成分。方法:采用ACE EXCEL 3 C18-PFP(100 mm×3 mm,3μm)色谱柱;以乙腈-0.1%甲酸溶液为流动相,梯度洗脱;柱温为45℃;流速为0.5 mL/min;热电喷雾(HESI)质谱离子源,负离子全扫描模式下采集数据,建立15批蓝盆花含药血清和空白血清色谱图;采用SIMCA-P+14.0软件进行模式识别及多维统计分析。结果:建立了蒙药蓝盆花血清图谱,共确定17个成分,聚类分析结果表明15批蓝盆花样品分为3类,与主成分分析结果一致;正交偏最小二乘判别分析法筛选出绿原酸、新绿原酸及芹菜素3种差异较大药源性成分。结论:本研究首次采用HPLC-Q-Exactive-MS技术建立蒙药蓝盆花血清图谱,该方法可较全面地反映蓝盆花口服给药后吸收入血情况,为其体内药效物质研究及质量控制奠定基础。 展开更多
关键词 蓝盆花 hplc-q-exactive-ms 血清图谱
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HPLC-Q-Exactive-MS/MS快速分析蒙药材悬钩子木中的化学成分 被引量:1
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作者 李晶 李娜 +2 位作者 包保全 韩东宁 张屏 《中国现代应用药学》 CAS CSCD 北大核心 2024年第11期1447-1455,共9页
目的采用高效液相色谱串联四极杆-静电场轨道阱高分辨质谱(HPLC-Q-Exactive-MS/MS)法快速分析蒙药材悬钩子木化学成分。方法采用CAPCELL PAK MGII C_(18)(4.6 mm×250 mm,5μm)色谱柱,以乙腈(A)-0.1%甲酸水溶液(B)为流动相进行梯度... 目的采用高效液相色谱串联四极杆-静电场轨道阱高分辨质谱(HPLC-Q-Exactive-MS/MS)法快速分析蒙药材悬钩子木化学成分。方法采用CAPCELL PAK MGII C_(18)(4.6 mm×250 mm,5μm)色谱柱,以乙腈(A)-0.1%甲酸水溶液(B)为流动相进行梯度洗脱,体积流量1.0 mL·min^(-1),进样体积20μL,柱温30℃,热电喷雾(HESI)质谱离子源,在负离子模式下采集数据。结果依据精确质量数和Chem Spider、Pub Chem数据库确定化合物分子式及结构式,通过比较对照品及文献报道的保留时间、一级质谱以及二级碎片离子,结合此类化合物的裂解规律,从悬钩子木中共鉴定出71个化学成分,包括30个有机酸类、22个黄酮类、7个三萜皂苷类、5个香豆素类、1个木质素类、1个没食子鞣质和2个芳香族化合物。结论该方法可快捷、准确地鉴定悬钩子木中复杂化学成分,为悬钩子木的药效物质基础研究提供科学依据。 展开更多
关键词 悬钩子木 hplc-q-exactive-ms/ms 化学成分 成分归属
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基于HPLC-Q-Exactive-MS/MS和GC-MS联用技术的蒙药通拉嘎-5化学成分研究 被引量:1
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作者 徐才猛 董馨 +4 位作者 胡少男 王智 王坤 任艾 薛培凤 《中医药导报》 2024年第6期57-65,共9页
目的:系统分析蒙药通拉嘎-5化学成分,明确其化学物质组成。方法:采用HPLC-Q-Exactive-MS/MS和GC-MS联用技术对通拉嘎-5固有成分进行分析。结果:通过二级质谱结合CD软件和文献检索,共鉴定出105个化学成份,包括27个生物碱类,26个黄酮类,1... 目的:系统分析蒙药通拉嘎-5化学成分,明确其化学物质组成。方法:采用HPLC-Q-Exactive-MS/MS和GC-MS联用技术对通拉嘎-5固有成分进行分析。结果:通过二级质谱结合CD软件和文献检索,共鉴定出105个化学成份,包括27个生物碱类,26个黄酮类,15个挥发油类,11个酚酸类,5个瑞诺烷类二萜类,5个有机酸类,3个多酚类,3个鞣质类,3个香豆素类和7个其他类。通过GC-MS法结合NIST数据库,共鉴定57个化合物,包括30个萜类、14个烃类、6个醛类、2个脂肪醇类、2个羧酸酯类、1个酮类、1个生物碱类和1个甾醇。结论:建立的HPLC-Q-Exactive-MS/MS和GC-MS分析方法可对通拉嘎-5中化学成分进行快速识别和鉴定,可为系统阐明药效物质基础和质量控制提供实验参考。 展开更多
关键词 通拉嘎-5 hplc-q-exactive-ms/ms GC-MS 化学成分
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Structural Modal Parameter Recognition and Related Damage Identification Methods under Environmental Excitations:A Review 被引量:5
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作者 Chao Zhang Shang-Xi Lai Hua-Ping Wang 《Structural Durability & Health Monitoring》 EI 2025年第1期25-54,共30页
Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters accordi... Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientific basis for structural damage identification and dynamic model modification.In view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and briefly describes how to identify structural damages based on the derived modal parameters.The paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),briefly describes damage identification methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artificial intelligence(AI)methods in the direction of modal parameter recognition and damage identification is further discussed.Based on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identification methods are given to provide scientific references for the optimized design and functional upgrading of SHM systems. 展开更多
关键词 Structural health monitoring data information modal parameters damage identification AI method
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Study of the Transport Behavior of Multispherical Proppant in Intersecting Fracture Based on Discrete Element Method 被引量:1
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作者 Chengyong Peng JianshuWu +2 位作者 Mao Jiang Biao Yin Yishan Lou 《Energy Engineering》 EI 2025年第1期185-201,共17页
To analyze the differences in the transport and distribution of different types of proppants and to address issues such as the short effective support of proppant and poor placement in hydraulically intersecting fract... To analyze the differences in the transport and distribution of different types of proppants and to address issues such as the short effective support of proppant and poor placement in hydraulically intersecting fractures,this study considered the combined impact of geological-engineering factors on conductivity.Using reservoir production parameters and the discrete elementmethod,multispherical proppants were constructed.Additionally,a 3D fracture model,based on the specified conditions of the L block,employed coupled(Computational Fluid Dynamics)CFD-DEM(Discrete ElementMethod)for joint simulations to quantitatively analyze the transport and placement patterns of multispherical proppants in intersecting fractures.Results indicate that turbulent kinetic energy is an intrinsic factor affecting proppant transport.Moreover,the efficiency of placement and migration distance of low-sphericity quartz sand constructed by the DEM in the main fracture are significantly reduced compared to spherical ceramic proppants,with a 27.7%decrease in the volume fraction of the fracture surface,subsequently affecting the placement concentration and damaging fracture conductivity.Compared to small-angle fractures,controlling artificial and natural fractures to expand at angles of 45°to 60°increases the effective support length by approximately 20.6%.During hydraulic fracturing of gas wells,ensuring the fracture support area and post-closure conductivity can be achieved by controlling the sphericity of proppants and adjusting the perforation direction to control the direction of artificial fractures. 展开更多
关键词 Hydraulic fracturing discrete element method PROPPANT SPHERICITY CFD-DEM
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Combing the Entropy Weight Method with Fuzzy Mathematics for Assessing the Quality and Post-Ripening Mechanism of High-Temperature Daqu during Storage 被引量:1
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作者 YANG Junlin YANG Shaojuan +8 位作者 WU Cheng YIN Yanshun YOU Xiaolong ZHAO Wenyu ZHU Anran WANG Jia HU Feng HU Jianfeng WANG Diqiang 《食品科学》 北大核心 2025年第9期48-62,共15页
This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standar... This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standard system was established for comprehensive quality evaluation of HTD.There were obvious changes in the physicochemical properties,enzyme activities,and volatile flavor components at different storage periods,which affected the sensory evaluation of HTD to a certain extent.The results of high-throughput sequencing revealed significant microbial diversity,and showed that the bacterial community changed significantly more than did the fungal community.During the storage process,the dominant bacterial genera were Kroppenstedtia and Thermoascus.The correlation between dominant microorganisms and quality indicators highlighted their role in HTD quality.Lactococcus,Candida,Pichia,Paecilomyces,and protease activity played a crucial role in the formation of isovaleraldehyde.Acidic protease activity had the greatest impact on the microbial community.Moisture promoted isobutyric acid generation.Furthermore,the comprehensive quality evaluation standard system was established by the entropy weight method combined with multi-factor fuzzy mathematics.Consequently,this study provides innovative insights for comprehensive quality evaluation of HTD during storage and establishes a groundwork for scientific and rational storage of HTD and quality control of sauce-flavor Baijiu. 展开更多
关键词 microbial community high-temperature Daqu comprehensive quality evaluation entropy weight method maturation process
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In situ stress inversion using nonlinear stress boundaries achieved by the bubbling method 被引量:1
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作者 Xige Liu Chenchun Huang +3 位作者 Wancheng Zhu Joung Oh Chengguo Zhang Guangyao Si 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第3期1510-1527,共18页
Due to the heterogeneity of rock masses and the variability of in situ stress,the traditional linear inversion method is insufficiently accurate to achieve high accuracy of the in situ stress field.To address this cha... Due to the heterogeneity of rock masses and the variability of in situ stress,the traditional linear inversion method is insufficiently accurate to achieve high accuracy of the in situ stress field.To address this challenge,nonlinear stress boundaries for a numerical model are determined through regression analysis of a series of nonlinear coefficient matrices,which are derived from the bubbling method.Considering the randomness and flexibility of the bubbling method,a parametric study is conducted to determine recommended ranges for these parameters,including the standard deviation(σb)of bubble radii,the non-uniform coefficient matrix number(λ)for nonlinear stress boundaries,and the number(m)and positions of in situ stress measurement points.A model case study provides a reference for the selection of these parameters.Additionally,when the nonlinear in situ stress inversion method is employed,stress distortion inevitably occurs near model boundaries,aligning with the Saint Venant's principle.Two strategies are proposed accordingly:employing a systematic reduction of nonlinear coefficients to achieve high inversion accuracy while minimizing significant stress distortion,and excluding regions with severe stress distortion near the model edges while utilizing the central part of the model for subsequent simulations.These two strategies have been successfully implemented in the nonlinear in situ stress inversion of the Xincheng Gold Mine and have achieved higher inversion accuracy than the linear method.Specifically,the linear and nonlinear inversion methods yield root mean square errors(RMSE)of 4.15 and 3.2,and inversion relative errors(δAve)of 22.08%and 17.55%,respectively.Therefore,the nonlinear inversion method outperforms the traditional multiple linear regression method,even in the presence of a systematic reduction in the nonlinear stress boundaries. 展开更多
关键词 In situ stress field Inversion method The bubbling method Nonlinear stress boundary Multiple linear regression method
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An efficient and accurate numerical method for simulating close-range blast loads of cylindrical charges based on neural network 被引量:1
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作者 Ting Liu Changhai Chen +2 位作者 Han Li Yaowen Yu Yuansheng Cheng 《Defence Technology(防务技术)》 2025年第2期257-271,共15页
To address the problems of low accuracy by the CONWEP model and poor efficiency by the Coupled Eulerian-Lagrangian(CEL)method in predicting close-range air blast loads of cylindrical charges,a neural network-based sim... To address the problems of low accuracy by the CONWEP model and poor efficiency by the Coupled Eulerian-Lagrangian(CEL)method in predicting close-range air blast loads of cylindrical charges,a neural network-based simulation(NNS)method with higher accuracy and better efficiency was proposed.The NNS method consisted of three main steps.First,the parameters of blast loads,including the peak pressures and impulses of cylindrical charges with different aspect ratios(L/D)at different stand-off distances and incident angles were obtained by two-dimensional numerical simulations.Subsequently,incident shape factors of cylindrical charges with arbitrary aspect ratios were predicted by a neural network.Finally,reflected shape factors were derived and implemented into the subroutine of the ABAQUS code to modify the CONWEP model,including modifications of impulse and overpressure.The reliability of the proposed NNS method was verified by related experimental results.Remarkable accuracy improvement was acquired by the proposed NNS method compared with the unmodified CONWEP model.Moreover,huge efficiency superiority was obtained by the proposed NNS method compared with the CEL method.The proposed NNS method showed good accuracy when the scaled distance was greater than 0.2 m/kg^(1/3).It should be noted that there is no need to generate a new dataset again since the blast loads satisfy the similarity law,and the proposed NNS method can be directly used to simulate the blast loads generated by different cylindrical charges.The proposed NNS method with high efficiency and accuracy can be used as an effective method to analyze the dynamic response of structures under blast loads,and it has significant application prospects in designing protective structures. 展开更多
关键词 Close-range air blast load Cylindrical charge Numerical method Neural network CEL method CONWEP model
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Insight Into the Separation-of-Variable Methods for the Closed-Form Solutions of Free Vibration of Rectangular Thin Plates
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作者 Yufeng Xing Ye Yuan Gen Li 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期329-355,共27页
The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytica... The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytical solutions for free vibration and eigenbuckling of rectangular plates and circular cylindrical shells.By taking the free vibration of rectangular thin plates as an example,this work presents the theoretical framework of the SOV methods in an instructive way,and the bisection–based solution procedures for a group of nonlinear eigenvalue equations.Besides,the explicit equations of nodal lines of the SOV methods are presented,and the relations of nodal line patterns and frequency orders are investigated.It is concluded that the highly accurate SOV methods have the same accuracy for all frequencies,the mode shapes about repeated frequencies can also be precisely captured,and the SOV methods do not have the problem of missing roots as well. 展开更多
关键词 Separation-of-variable method Rayleigh quotient nodal line eigenvalue equation bisection method
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Improved methods,properties,applications and prospects of microbial induced carbonate precipitation(MICP)treated soil:A review 被引量:2
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作者 Xuanshuo Zhang Hongyu Wang +3 位作者 Ya Wang Jinghui Wang Jing Cao Gang Zhang 《Biogeotechnics》 2025年第1期34-54,共21页
Soil improvement is one of the most important issues in geotechnical engineering practice.The wide application of traditional improvement techniques(cement/chemical materials)are limited due to damage ecological en-vi... Soil improvement is one of the most important issues in geotechnical engineering practice.The wide application of traditional improvement techniques(cement/chemical materials)are limited due to damage ecological en-vironment and intensify carbon emissions.However,the use of microbially induced calcium carbonate pre-cipitation(MICP)to obtain bio-cement is a novel technique with the potential to induce soil stability,providing a low-carbon,environment-friendly,and sustainable integrated solution for some geotechnical engineering pro-blems in the environment.This paper presents a comprehensive review of the latest progress in soil improvement based on the MICP strategy.It systematically summarizes and overviews the mineralization mechanism,influ-encing factors,improved methods,engineering characteristics,and current field application status of the MICP.Additionally,it also explores the limitations and correspondingly proposes prospective applications via the MICP approach for soil improvement.This review indicates that the utilization of different environmental calcium-based wastes in MICP and combination of materials and MICP are conducive to meeting engineering and market demand.Furthermore,we recommend and encourage global collaborative study and practice with a view to commercializing MICP technique in the future.The current review purports to provide insights for engineers and interdisciplinary researchers,and guidance for future engineering applications. 展开更多
关键词 Soil improvement Bio-cement MICP Improved methods Field application cases
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一种基于Least Square Method算法的城轨车辆车门动作时间精准判断的研究
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作者 李宏菱 宋华杰 +3 位作者 马仲智 周辉 李晴 陈龙 《时代汽车》 2025年第3期190-192,共3页
为研究城市轨道交通车辆客室车门动作时间精准性,门的动作主要依靠直流无刷电机的驱动,所以门动作判断的根本,是对电机运动状态的判读,门运动过程中由于电机码盘线受杂波干扰,系统无法准确寻找计时点从而影响系统判断门运动时间;建立波... 为研究城市轨道交通车辆客室车门动作时间精准性,门的动作主要依靠直流无刷电机的驱动,所以门动作判断的根本,是对电机运动状态的判读,门运动过程中由于电机码盘线受杂波干扰,系统无法准确寻找计时点从而影响系统判断门运动时间;建立波形矫正模型,利用数学方法校准波形,让MCU找出最佳计时点并处理(误差不超过10ms),采用最小二乘法模型,通过最小化误差的平方和找到一组数据的最佳函数匹配,求得未知的数据,并使得这些求得的数据与实际数据之间误差的平方和为最小,可精准地得到门动作时间。模拟测试结果表明,门动作时间测算误差所示其误差为7.42ms,小于10ms。 展开更多
关键词 城轨车辆 客室车门 电机码盘 Least Square method算法 门动作时间精准
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