Halogenated polycyclic aromatic hydrocarbons(HPAHs)and polycyclic aromatic hydrocarbons(PAHs)were determined in human serum samples pooled by donor age(<20,20–29,30–39,40–49 and≥50 y).The pooled samples were co...Halogenated polycyclic aromatic hydrocarbons(HPAHs)and polycyclic aromatic hydrocarbons(PAHs)were determined in human serum samples pooled by donor age(<20,20–29,30–39,40–49 and≥50 y).The pooled samples were collected from four Chinese cities,Yantai(Shandong Province),Ganzi(Sichuan Province),Huaihua(Hunan Province),and Lingshui(Hainan Province).The concentrations of HPAHs and PAHs were in the range of 4.26–633 ng/g lipid and 249–1642 ng/g lipid from the different cities.Although the levels of HPAHs in blood samples varied among the populations of the four cities,1,5-dichloroanthracene(1,5-Cl_(2)Ant)was the predominant contributor to HPAHs in the serum samples,accounting for over 85.7%of its total concentration.Furthermore,1,5-Cl_(2)Ant serum concentrations increased significantly with age.Notably,molecular docking results show that 1,5-Cl_(2)Ant not only ac-quires the ability to bind d-AhR PAS-B domain,but also binds at the similar sites as 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)and benzo[a]pyrene(BaP),suggesting that 1,5-Cl_(2)Ant,like TCDD and BaP,may cause a wide variety of toxicity via AhR-mediated signaling pathways.The bio-accumulation potential of 1,5-Cl_(2)Ant in the human body and its associated toxicity observed in this study need special attention.展开更多
基金supported by Beijing Natural Science Foundation grant 8232043Fundamental Research Funds for the Central Universities grant 2022QNPY57.
文摘Halogenated polycyclic aromatic hydrocarbons(HPAHs)and polycyclic aromatic hydrocarbons(PAHs)were determined in human serum samples pooled by donor age(<20,20–29,30–39,40–49 and≥50 y).The pooled samples were collected from four Chinese cities,Yantai(Shandong Province),Ganzi(Sichuan Province),Huaihua(Hunan Province),and Lingshui(Hainan Province).The concentrations of HPAHs and PAHs were in the range of 4.26–633 ng/g lipid and 249–1642 ng/g lipid from the different cities.Although the levels of HPAHs in blood samples varied among the populations of the four cities,1,5-dichloroanthracene(1,5-Cl_(2)Ant)was the predominant contributor to HPAHs in the serum samples,accounting for over 85.7%of its total concentration.Furthermore,1,5-Cl_(2)Ant serum concentrations increased significantly with age.Notably,molecular docking results show that 1,5-Cl_(2)Ant not only ac-quires the ability to bind d-AhR PAS-B domain,but also binds at the similar sites as 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)and benzo[a]pyrene(BaP),suggesting that 1,5-Cl_(2)Ant,like TCDD and BaP,may cause a wide variety of toxicity via AhR-mediated signaling pathways.The bio-accumulation potential of 1,5-Cl_(2)Ant in the human body and its associated toxicity observed in this study need special attention.
