In order to satisfy a satellite horizontality requirement in an experiment, it is indispensable to monitor and adjust the horizontality of a large platform loading the satellite under the condition of ultra-low temper...In order to satisfy a satellite horizontality requirement in an experiment, it is indispensable to monitor and adjust the horizontality of a large platform loading the satellite under the condition of ultra-low temperature with real time. So the control system design and control strategy are described in detail to accomplish the horizontality monitoring and adjusting. The system adopts the industry control computer as the upper computer and the SIEMENS S7-300 PLC as the lower computer. The upper computer that bases on industry configuration software IFIX takes charge of monitoring the platform and puts forward the control strategy. PLC takes charge of receiving the adjusting instructions and controlling the legs moving to accomplish the horizontality adjusting. The horizontality adjusting strategy is emphasized and the concept of grads is introduced to establish a mathematics model of the platform inclined state, so the adjusting method is obtained. Accordingly the key question of the automatic horizontality adjusting is solved in this control system.展开更多
A horizontality adjusting system of the earth drill's platform is designed todeal with the operation difficulty of the platform which appeared while the earth drill is used.The proportional-impulse control to elim...A horizontality adjusting system of the earth drill's platform is designed todeal with the operation difficulty of the platform which appeared while the earth drill is used.The proportional-impulse control to eliminate the over-adjustment andelectricity-hydraulic-proportional control to drive the adjusting mechanism are adopted in thesystem. The control scheme and control algorithm are introduced in detail. The software flow chartis given.展开更多
Dear Editor,Dorsal pontine lesions may cause a variety of complex neuro-ophthalmic deficits,including horizontal gaze palsy(HGP),internuclear ophthalmoplegia,one-and-ahalf syndrome,abducens nerve palsy,skew deviation,...Dear Editor,Dorsal pontine lesions may cause a variety of complex neuro-ophthalmic deficits,including horizontal gaze palsy(HGP),internuclear ophthalmoplegia,one-and-ahalf syndrome,abducens nerve palsy,skew deviation,or any combination of these.Here we present a rare case of an adult patient who developed multiple complicated clinical manifestations after surgical removal of a pontine cavernous hemangioma(PCH).Our case highlights a single pontine lesion may involve complicated neural pathways and result in complicated symptoms and signs,in which abducens nerve palsy or skew deviation is easily missed when combined with HGP.展开更多
Identifying geohazards such as landslides and methane leakage is crucial during gas extraction from natural gas hydrate(NGH)reservoirs,and understanding reservoir settlement behavior is central to this assessment.Hori...Identifying geohazards such as landslides and methane leakage is crucial during gas extraction from natural gas hydrate(NGH)reservoirs,and understanding reservoir settlement behavior is central to this assessment.Horizontal wells can enlarge the pressure relief zone within the formation,improving single-well productivity,and are therefore considered a promising approach for NGH development.This study examines the settlement response of hydrate-bearing sediments during depressurization using horizontal wells.A fully coupled thermal,hydraulic,mechanical,and chemical(THMC)model with representative reservoir properties(Shenhu region in the South China Sea)is presented accordingly.The simulations show that lower production pressures,while increasing gas output,also intensify formation settlement.The maximum difference in settlement between the lowest and highest production pressures reaches 0.016 m,contributing to more pronounced differential subsidence.Optimal well placement,specifically targeting a low-saturation hydrate zone containing free gas and situated adjacent to a high-saturation hydrate layer,markedly improves both gas production rate and cumulative yield,while reducing overall settlement and limiting changes in effective stress.展开更多
Significant differences exist between deep and medium-shallow coalbed methane(CBM)reservoirs.The unclear understanding of flowback and production behavior severely constrains the development of deep CBM resources.To a...Significant differences exist between deep and medium-shallow coalbed methane(CBM)reservoirs.The unclear understanding of flowback and production behavior severely constrains the development of deep CBM resources.To address this challenge,guided by the gas-liquid two-phase flow theory in ultra-low permeability reservoirs,and integrating theoretical analysis,numerical simulation,and insights from production practices,this study classifies the flowback and production stages of deep CBM well considering the Daning-Jixian Block,Eastern Ordos Basin as a representative case.We summarize the flowback characteristics for each stage and establish a standard flowback production type curve,aiming to guide field operations.The results indicate that:(a)The production process of deep CBM horizontal wells can be divided into five distinct stages:initial single-phase water dewatering stage,initial gas appearance to peak water production stage,gas breakthrough to peak gas production stage,stable production and decline stage,and low-rate production stage.(b)Based on reservoir energy,two standard type curves for horizontal well flowback production are established:the‘Sufficient Reservoir Energy’type and the‘Insufficient Reservoir Energy’type.The former achieves a higher initial gas rate(up to 12×10^(4)m^(3)/d)but exhibits poorer stability,while the latter achieves a lower stable rate(up to 8×10^(4)m^(3)/d)but demonstrates stronger stability.Numerical simulation confirms these behavioral patterns and reveals the underlying mechanisms related to the effectively drained area where pressure is significantly depleted.The findings from this study have guided the flowback production operations in 53 deep CBM wells with positive results,demonstrating high potential for broad application.展开更多
The shale gas development in China faces challenges such as complex reservoir conditions and high development costs.Based on the pore pressure and geostress coupling theory,this paper studies the geostress evolution l...The shale gas development in China faces challenges such as complex reservoir conditions and high development costs.Based on the pore pressure and geostress coupling theory,this paper studies the geostress evolution laws and fracture network characteristics of shale gas infill wells.A mechanism model of CN platform logging data and geomechanical parameters is established to simulate the influence of parent well’s production on the geostress in the infill well area.It is suggested that with the increase of production time,normal fault stress state and horizontal stress deflection will occur.The smaller the parent well spacing and the longer the production time,the earlier the normal fault stress state appears and the larger the range.Based on the model,the fracture network morphology and construction parameters of infill wells are optimized.parentparentparentparent The results indicate that:1:A well spacing of 500 m achieves a Pareto optimum between“full reserve coverage”and“stress barrier”;2:A parent well recovery degree of 30%corresponds to the critical point of stress reversal,where the lateral deflection rate of the infill fracture is less than 8%and the SRV loss is minimized;3:6-cluster intensive completion with twice the liquid intensity increases the fracture complexity index by 1.7 times,enhances well group EUR by 15.4%,and reduces single-well cost by 22%.This research fills the theoretical gap in the collaborative optimization of“multi-parameter,multi-objective and multi-constraint”and provide parameter optimization basis for shale gas infill well development in China and help to improve the development efficiency and economic benefits.展开更多
Antibiotic resistance genes(ARGs) are recognized as a primary threat to the sustainability of environment and human health in the 21^(st) century.Nanomaterials(NMs) have attracted substantial attention due to their un...Antibiotic resistance genes(ARGs) are recognized as a primary threat to the sustainability of environment and human health in the 21^(st) century.Nanomaterials(NMs) have attracted substantial attention due to their unique dimensions and structures.Unfortunately,emerging evidence suggests that NMs may facilitate the transmission of ARGs.It is crucial to elucidate how NMs affect the evolution and dissemination of ARGs.The current review comprehensively examines the role of NMs in the widespread transmission of ARGs in aquatic environments and the underlying mechanisms involved in the process.It aims to clarify the effects and mechanisms of NMs on the horizontal gene transfer processes that are associated with ARGs,including the enhancement of cell membrane permeability,the formation of nanopores on membranes,promotion of mutagenesis,and the generation of reactive oxygen species(ROSs).Furthermore,the trade-off between the removal of ARGs and horizontal transfer has been elucidated.The review aspires to guide future research directions,advance knowledge on the implications of NMs in the field of ARGs' transmission,and provide a theoretical foundation for the development of safer and more effective applications of NMs.展开更多
The current inertial measurement unit(IMU)and odometry fusion navigation algorithms often incorporate non-holonomic constraints(NHC)to obtain three-dimensional velocity in the navigation frame.However,due to the integ...The current inertial measurement unit(IMU)and odometry fusion navigation algorithms often incorporate non-holonomic constraints(NHC)to obtain three-dimensional velocity in the navigation frame.However,due to the integral nature of the dead reckoning algorithm,the attitude errors of the IMU accumulate over time,causing the velocity transformation results to fail to accurately reflect the threedimensional velocity in the navigation frame.Based on the fact that during a vehicle??s horizontal and uniform motion,the vertical acceleration is consistent with gravitational acceleration,this paper proposes an IMU/odometry fusion navigation algorithm based on horizontal attitude constraints(HAC).Building on non-holonomic constraints,this algorithm determines the motion state of the vehicle through accelerometer output and zeroes out the pitch and roll angles during horizontal and uniform motion.Verified through two sets of real-world vehicle test data,this algorithm improves horizontal positioning accuracy by approximately 63%and 70%,and vertical positioning accuracy by 98%and 97%,compared with the traditional NHC IMU/odometer fusion algorithm.展开更多
Preserving beam quality during the transport of high-brightness electron bunches is crucial for advanced accelerator applications,such as particle colliders,free-electron lasers,and recirculating linacs.However,cohere...Preserving beam quality during the transport of high-brightness electron bunches is crucial for advanced accelerator applications,such as particle colliders,free-electron lasers,and recirculating linacs.However,coherent synchrotron radiation(CSR)significantly degrades beam quality when electron bunches pass through multi-bend isochronous beamlines,particularly for short bunches with non-ideal longitudinal profiles.Although several methods have been proposed to mitigate CSR effects,most rely on small-angle approximations or are limited to idealized bunch profiles.In this study,we present two improved methods for designing isochronous triple-bend achromat(TBA)beamlines that effectively mitigate CSR-induced emittance growth and longitudinal profile distortion without relying on small-angle approximations.The first method,an enhanced integral optimization approach,simplifies numerical optimization and can accurately handle larger deflection angles,making it suitable for practical applications that require flexible lattice configurations.The second method,an optimized I-matrix approach,completely cancels steady-state and transient CSR kicks through specific matrix constraints and higher-order dispersion optimization,enabling effective CSR suppression even with very large deflection angles.Systematic simulations demonstrate that both methods achieve excellent preservation of transverse emittance and longitudinal profiles.展开更多
With the continuous development of the offshore wind industry,the design concept of composite foundation has been given attention in the past decade.This paper presents an accurate method for investigating the horizon...With the continuous development of the offshore wind industry,the design concept of composite foundation has been given attention in the past decade.This paper presents an accurate method for investigating the horizontal vibration of monopile-friction wheel composite foundations in layered saturated soil.Firstly,the three-dimensional continuum mechanics theory with the range of linear elasticity is introduced to calculate the frictional resistance distributed on the upper soil surface.Then,the resistances of multilayered soils and inviscid seawater to the pile shaft under horizontal harmonic excitation are obtained using Novak's plane strain model,Biot's porous media theory and radiationwave theory.Thirdly,the expressions for the deformation,bending moment and internal force of the Euler-Bernoulli pile are derived using the boundary conditions with definitephysical meaning and transfer matrix method.By comparing with the results of 1g laboratory test and the idealized formula reported by the literature,the rationality and accuracy of the developed dynamical model can be verified.Finally,this paper conducts a series of worked examples to investigate the influencesof the elastic modulus and thickness of three-layer saturated soil and the location of interlayer soil on the horizontal dynamic vibration of composite foundation.The results show that an increase in elastic modulus of the surface soil is an effective way to improve the dynamic stability of the composite foundation in service conditions.The conclusions drawn from the numerical examples can develop some guidelines for the current foundation design of offshore wind turbines.展开更多
AIM:To evaluate the clinical outcomes of a new minimally invasive technique using horizontal mattress sutures and Hoffman pockets for four-point refixation of dislocated fourhaptic intraocular lenses(IOLs).METHODS:Thi...AIM:To evaluate the clinical outcomes of a new minimally invasive technique using horizontal mattress sutures and Hoffman pockets for four-point refixation of dislocated fourhaptic intraocular lenses(IOLs).METHODS:This retrospective consecutive case series included eyes with dislocated Akreos AO60 IOLs underwent scleral refixation using a horizontal mattress doubleneedle suture technique with intralamellar knot burial via Hoffman pockets.Clinical outcomes assessed included pre-and postoperative best-corrected visual acuity(BCVA),intraocular pressure(IOP),spherical equivalent(SE),suture duration,IOL centration,and perioperative complications.RESULTS:A total of 10 eyes from 10 patients(6 males)were included.The mean age at the time of IOL refixation was 53.10±13.07y(range:28-68y).The mean interval between initial IOL implantation and dislocation was 8.44±3.54y.The mean postoperative follow-up duration was 11.45±10.30mo.Surgical time averaged 15.3±1.77min,with no intraoperative complications.The mean axial length was 27.16±4.35 mm,with high myopia(HM)as the leading comorbidity(4/10 eyes).Postoperative BCVA significantly improved compared to preoperative values(P=0.025).Postoperative SE was significantly improved compared with preoperative(P=0.01).All IOLs remained centered throughout follow-up.CONCLUSION:This minimally invasive four-point scleral fixation technique offers a safe and effective refixation strategy for dislocated four-haptic IOLs.The horizontal mattress suture configuration combined with Hoffman pockets facilitates durable centration,avoids conjunctival dissection,and could be adopted into routine surgical practice.展开更多
Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(...Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)].展开更多
With the rapid advancement of optoelectronic technology,high-performance photodetectors are increasingly in demand in fields such as environmental monitoring,optical communication,and defense systems,where ultraviolet...With the rapid advancement of optoelectronic technology,high-performance photodetectors are increasingly in demand in fields such as environmental monitoring,optical communication,and defense systems,where ultraviolet detection is critical.However,conventional semiconductor materials suffer from limited UV-visible detection capabilities owing to their narrow bandgaps and high dark currents.To address these challenges,wide-bandgap semiconductors have emerged as promising alternatives.Here,we fabricated a horizontally structured n–n heterojunction photodetector by growingβ-Ga_(2)O_(3) on Si–GaN via plasma-enhanced chemical vapor deposition.The device exhibits a self-powered photocurrent of 3.5 nA at zero bias,enabled by the photovoltaic effect of the space charge region.Under 254-nm and 365-nm illumination,it exhibits rectification behavior,achieving a responsivity of 0.475 m A/W(0 V,220??W/cm~2 at 254 nm)and 257.6 mA/W(-5 V),respectively.Notably,the photodetector demonstrates a high photocurrent-to-dark current ratio of 10~5 under-5-V bias,highlighting its potential for self-powered and high-performance UV detection applications.展开更多
Federated Learning(FL)has become a leading decentralized solution that enables multiple clients to train a model in a collaborative environment without directly sharing raw data,making it suitable for privacy-sensitiv...Federated Learning(FL)has become a leading decentralized solution that enables multiple clients to train a model in a collaborative environment without directly sharing raw data,making it suitable for privacy-sensitive applications such as healthcare,finance,and smart systems.As the field continues to evolve,the research field has become more complex and scattered,covering different system designs,training methods,and privacy techniques.This survey is organized around the three core challenges:how the data is distributed,how models are synchronized,and how to defend against attacks.It provides a structured and up-to-date review of FL research from 2023 to 2025,offering a unified taxonomy that categorizes works by data distribution(Horizontal FL,Vertical FL,Federated Transfer Learning,and Personalized FL),training synchronization(synchronous and asynchronous FL),optimization strategies,and threat models(data leakage and poisoning attacks).In particular,we summarize the latest contributions in Vertical FL frameworks for secure multi-party learning,communication-efficient Horizontal FL,and domain-adaptive Federated Transfer Learning.Furthermore,we examine synchronization techniques addressing system heterogeneity,including straggler mitigation in synchronous FL and staleness management in asynchronous FL.The survey covers security threats in FL,such as gradient inversion,membership inference,and poisoning attacks,as well as their defense strategies that include privacy-preserving aggregation and anomaly detection.The paper concludes by outlining unresolved issues and highlighting challenges in handling personalized models,scalability,and real-world adoption.展开更多
Predicting the productivity of multistage fractured horizontal wells plays an important role in exploiting unconventional resources.In recent years,machine learning(ML)models have emerged as a new approach for such st...Predicting the productivity of multistage fractured horizontal wells plays an important role in exploiting unconventional resources.In recent years,machine learning(ML)models have emerged as a new approach for such studies.However,the scarcity of sufficient real data for model training often leads to imprecise predictions,even though the models trained with real data better characterize geological and engineering features.To tackle this issue,we propose an ML model that can obtain reliable results even with a small amount of data samples.Our model integrates the synthetic minority oversampling technique(SMOTE)to expand the data volume,the support vector machine(SVM)for model training,and the particle swarm optimization(PSO)algorithm for optimizing hyperparameters.To enhance the model performance,we conduct feature fusion and dimensionality reduction.Additionally,we examine the influences of different sample sizes and ML models for training.The proposed model demonstrates higher prediction accuracy and generalization ability,achieving a predicted R^(2)value of up to 0.9 for the test set,compared to the traditional ML techniques with an R^(2)of 0.13.This model accurately predicts the production of fractured horizontal wells even with limited samples,supplying an efficient tool for optimizing the production of unconventional resources.Importantly,the model holds the potential applicability to address similar challenges in other fields constrained by scarce data samples.展开更多
Objective Poxviruses are zoonotic pathogens that infect humans,mammals,vertebrates,and arthropods.However,the specific role of ticks in transmission and evolution of these viruses remains unclear.Methods Transcriptomi...Objective Poxviruses are zoonotic pathogens that infect humans,mammals,vertebrates,and arthropods.However,the specific role of ticks in transmission and evolution of these viruses remains unclear.Methods Transcriptomic and metatranscriptomic raw data from 329 sampling pools of seven tick species across five continents were mined to assess the diversity and abundance of poxviruses.Chordopoxviral sequences were assembled and subjected to phylogenetic analysis to trace the origins of the unblasted fragments within these sequences.Results Fifty-eight poxvirus species,representing two subfamilies and 20 genera,were identified,with 212 poxviral sequences assembled.A substantial proportion of AT-rich fragments were detected in the assembled poxviral genomes.These genomic sequences contained fragments originating from rodents,archaea,and arthropods.Conclusion Our findings indicate that ticks play a significant role in the transmission and evolution of poxviruses.These viruses demonstrate the capacity to modulate virulence and adaptability through horizontal gene transfer,gene recombination,and gene mutations,thereby promoting co-existence and co-evolution with their hosts.This study advances understanding of the ecological dynamics of poxvirus transmission and evolution and highlights the potential role of ticks as vectors and vessels in these processes.展开更多
Zika virus(ZIKV)is a mosquito-borne virus belonging to the genus Orthoflavivirus,and the family Flaviviridae.It commonly presents with febrile-like symptoms,neurological issues,and pregnancy complications in humans.Cu...Zika virus(ZIKV)is a mosquito-borne virus belonging to the genus Orthoflavivirus,and the family Flaviviridae.It commonly presents with febrile-like symptoms,neurological issues,and pregnancy complications in humans.Currently,there is no commercial vaccine or specific treatment available to prevent ZIKV infection.Therefore,controlling the epidemic's spread relies on preventing mosquitoes from transmitting the virus.Although various studies have explored the transmission of ZIKV between mosquitoes and vertebrate hosts,comprehensive research on potential mosquito-to-mosquito transmission of ZIKV remains limited.In this study,we conducted systematic laboratory investigations to assess the ability of ZIKV to spread among mosquitoes,and to evaluate the impact of ZIKV infection on mosquito development.Our findings revealed that ZIKV can be transmitted between Aedes aegypti mosquitoes both vertically and horizontally,through oviposition and contact between mosquitoes of the same or opposite sex.Additionally,we observed that ZIKV infection resulted in a reduction in the number of mosquito eggs but an increase in their size.The widespread distribution of ZIKV in infected mosquitoes and the altered levels of hormone related genes following viral infection were noted,which may contribute to viral transmission among mosquitoes and affect mosquito development.This research provides systematic experimental evidence of ZIKV transmission among mosquitoes,which is crucial for developing novel strategies to disrupt the spread of orthoflaviviruses and other mosquitoborne pathogens.展开更多
The Carter model is used to characterize the dynamic behaviors of fracture growth and fracturing fluid leakoff.A thermo-fluid coupling temperature response forward model is built considering the fluid flow and heat tr...The Carter model is used to characterize the dynamic behaviors of fracture growth and fracturing fluid leakoff.A thermo-fluid coupling temperature response forward model is built considering the fluid flow and heat transfer in wellbore,fracture and reservoir.The influences of fracturing parameters and fracture parameters on the responses of distributed temperature sensing(DTS)are analyzed,and a diagnosis method of fracture parameters is presented based on the simulated annealing algorithm.A field case study is introduced to verify the model’s reliability.Typical V-shaped characteristics can be observed from the DTS responses in the multi-cluster fracturing process,with locations corresponding to the hydraulic fractures.The V-shape depth is shallower for a higher injection rate and longer fracturing and shut-in time.Also,the V-shape is wider for a higher fracture-surface leakoff coefficient,longer fracturing time and smaller fracture width.Additionally,the cooling effect near the wellbore continues to spread into the reservoir during the shut-in period,causing the DTS temperature to decrease instead of rise.Real-time monitoring and interpretation of DTS temperature data can help understand the fracture propagation during fracturing operation,so that immediate measures can be taken to improve the fracturing performance.展开更多
The horizontal ecological compensation plays an important role in balancing the interests of all parties and coordinating regional development in the basin.However,the mechanism of ecological compensation based on emb...The horizontal ecological compensation plays an important role in balancing the interests of all parties and coordinating regional development in the basin.However,the mechanism of ecological compensation based on embodied carbon emissions is still poorly understood.Here,taking the Yellow River Basin as the research area,we use the multi-regional input-output(MRIO)model to measure the embodied carbon transfers between its seven urban agglomerations in 2012 and 2017 from the viewpoint of value-added trade benefits.Further,for the first time,the green trade benefits and ecological compensation amounts are analyzed.The results indicate that:(1)The transfer of trade-embodied carbon among the urban agglomerations in the basin showed obvious spatial heterogeneity and geographic proximity effects,and trade-embodied carbon outflows(inflows)had a pattern of"highest in the midstream,second in the downstream,and lowest in the upstream".(2)The industry composition of the urban agglomerations in relation to embodied carbon outflows(inflows)was similar,mainly in the service and heavy manufacturing industries.(3)The spatial pattern of green trade benefits in the basin had shifted from"high in the north and low in the surrounding area"to"high in the east-central part and low in the west".(4)The pattern of ecological compensation in the basin had shifted from the upstream surplus,the middle and downstream deficit to the midstream deficit,and the upstream and downstream surplus.Therefore,we recommend improving energy structures in high-demand urban agglomerations by adopting clean energy,focusing on decarbonization and energy efficiency in resource-rich regions.Additionally,promoting low-carbon economies,especially in the service and heavy manufacturing industries,implementing differentiated emission reduction strategies,and optimizing carbon compensation mechanisms considering regional disparities and resource endowments are crucial.It is expected that the study can enrich the scientific basis of horizontal ecological compensation and increase the fairness of regional carbon emission rights allocation.展开更多
文摘In order to satisfy a satellite horizontality requirement in an experiment, it is indispensable to monitor and adjust the horizontality of a large platform loading the satellite under the condition of ultra-low temperature with real time. So the control system design and control strategy are described in detail to accomplish the horizontality monitoring and adjusting. The system adopts the industry control computer as the upper computer and the SIEMENS S7-300 PLC as the lower computer. The upper computer that bases on industry configuration software IFIX takes charge of monitoring the platform and puts forward the control strategy. PLC takes charge of receiving the adjusting instructions and controlling the legs moving to accomplish the horizontality adjusting. The horizontality adjusting strategy is emphasized and the concept of grads is introduced to establish a mathematics model of the platform inclined state, so the adjusting method is obtained. Accordingly the key question of the automatic horizontality adjusting is solved in this control system.
文摘A horizontality adjusting system of the earth drill's platform is designed todeal with the operation difficulty of the platform which appeared while the earth drill is used.The proportional-impulse control to eliminate the over-adjustment andelectricity-hydraulic-proportional control to drive the adjusting mechanism are adopted in thesystem. The control scheme and control algorithm are introduced in detail. The software flow chartis given.
文摘Dear Editor,Dorsal pontine lesions may cause a variety of complex neuro-ophthalmic deficits,including horizontal gaze palsy(HGP),internuclear ophthalmoplegia,one-and-ahalf syndrome,abducens nerve palsy,skew deviation,or any combination of these.Here we present a rare case of an adult patient who developed multiple complicated clinical manifestations after surgical removal of a pontine cavernous hemangioma(PCH).Our case highlights a single pontine lesion may involve complicated neural pathways and result in complicated symptoms and signs,in which abducens nerve palsy or skew deviation is easily missed when combined with HGP.
基金supported by the State Key Research Development Program of China(Grant No.2021YFC2800905-02)the National Natural Science Foundation of China(Grant No.52304208)。
文摘Identifying geohazards such as landslides and methane leakage is crucial during gas extraction from natural gas hydrate(NGH)reservoirs,and understanding reservoir settlement behavior is central to this assessment.Horizontal wells can enlarge the pressure relief zone within the formation,improving single-well productivity,and are therefore considered a promising approach for NGH development.This study examines the settlement response of hydrate-bearing sediments during depressurization using horizontal wells.A fully coupled thermal,hydraulic,mechanical,and chemical(THMC)model with representative reservoir properties(Shenhu region in the South China Sea)is presented accordingly.The simulations show that lower production pressures,while increasing gas output,also intensify formation settlement.The maximum difference in settlement between the lowest and highest production pressures reaches 0.016 m,contributing to more pronounced differential subsidence.Optimal well placement,specifically targeting a low-saturation hydrate zone containing free gas and situated adjacent to a high-saturation hydrate layer,markedly improves both gas production rate and cumulative yield,while reducing overall settlement and limiting changes in effective stress.
基金supported by the National Science and Technology Major Project of China(No.2025ZD1405702)the Scientific Research and Technology Development Project of PetroChina Coalbed Methane Co.,Ltd.(Project No.25MQCTSG010)Applied Science and Technology Project of PetroChina Company Limited(2023ZZ18YJ04).
文摘Significant differences exist between deep and medium-shallow coalbed methane(CBM)reservoirs.The unclear understanding of flowback and production behavior severely constrains the development of deep CBM resources.To address this challenge,guided by the gas-liquid two-phase flow theory in ultra-low permeability reservoirs,and integrating theoretical analysis,numerical simulation,and insights from production practices,this study classifies the flowback and production stages of deep CBM well considering the Daning-Jixian Block,Eastern Ordos Basin as a representative case.We summarize the flowback characteristics for each stage and establish a standard flowback production type curve,aiming to guide field operations.The results indicate that:(a)The production process of deep CBM horizontal wells can be divided into five distinct stages:initial single-phase water dewatering stage,initial gas appearance to peak water production stage,gas breakthrough to peak gas production stage,stable production and decline stage,and low-rate production stage.(b)Based on reservoir energy,two standard type curves for horizontal well flowback production are established:the‘Sufficient Reservoir Energy’type and the‘Insufficient Reservoir Energy’type.The former achieves a higher initial gas rate(up to 12×10^(4)m^(3)/d)but exhibits poorer stability,while the latter achieves a lower stable rate(up to 8×10^(4)m^(3)/d)but demonstrates stronger stability.Numerical simulation confirms these behavioral patterns and reveals the underlying mechanisms related to the effectively drained area where pressure is significantly depleted.The findings from this study have guided the flowback production operations in 53 deep CBM wells with positive results,demonstrating high potential for broad application.
文摘The shale gas development in China faces challenges such as complex reservoir conditions and high development costs.Based on the pore pressure and geostress coupling theory,this paper studies the geostress evolution laws and fracture network characteristics of shale gas infill wells.A mechanism model of CN platform logging data and geomechanical parameters is established to simulate the influence of parent well’s production on the geostress in the infill well area.It is suggested that with the increase of production time,normal fault stress state and horizontal stress deflection will occur.The smaller the parent well spacing and the longer the production time,the earlier the normal fault stress state appears and the larger the range.Based on the model,the fracture network morphology and construction parameters of infill wells are optimized.parentparentparentparent The results indicate that:1:A well spacing of 500 m achieves a Pareto optimum between“full reserve coverage”and“stress barrier”;2:A parent well recovery degree of 30%corresponds to the critical point of stress reversal,where the lateral deflection rate of the infill fracture is less than 8%and the SRV loss is minimized;3:6-cluster intensive completion with twice the liquid intensity increases the fracture complexity index by 1.7 times,enhances well group EUR by 15.4%,and reduces single-well cost by 22%.This research fills the theoretical gap in the collaborative optimization of“multi-parameter,multi-objective and multi-constraint”and provide parameter optimization basis for shale gas infill well development in China and help to improve the development efficiency and economic benefits.
基金supported by the State Key Laboratory of Urban Water Resource and Environment (Harbin Institute of Technology) (No.2022TS13)the key projects of National Natural Science Foundation of China (No.2019YFC0408503)the Key Research Program of Wuhan (No.2022022202015015)。
文摘Antibiotic resistance genes(ARGs) are recognized as a primary threat to the sustainability of environment and human health in the 21^(st) century.Nanomaterials(NMs) have attracted substantial attention due to their unique dimensions and structures.Unfortunately,emerging evidence suggests that NMs may facilitate the transmission of ARGs.It is crucial to elucidate how NMs affect the evolution and dissemination of ARGs.The current review comprehensively examines the role of NMs in the widespread transmission of ARGs in aquatic environments and the underlying mechanisms involved in the process.It aims to clarify the effects and mechanisms of NMs on the horizontal gene transfer processes that are associated with ARGs,including the enhancement of cell membrane permeability,the formation of nanopores on membranes,promotion of mutagenesis,and the generation of reactive oxygen species(ROSs).Furthermore,the trade-off between the removal of ARGs and horizontal transfer has been elucidated.The review aspires to guide future research directions,advance knowledge on the implications of NMs in the field of ARGs' transmission,and provide a theoretical foundation for the development of safer and more effective applications of NMs.
基金from the National Key Research and Development Program project"Adaptive Navigation Software and Hardware Technology(2018YFB0505200)."。
文摘The current inertial measurement unit(IMU)and odometry fusion navigation algorithms often incorporate non-holonomic constraints(NHC)to obtain three-dimensional velocity in the navigation frame.However,due to the integral nature of the dead reckoning algorithm,the attitude errors of the IMU accumulate over time,causing the velocity transformation results to fail to accurately reflect the threedimensional velocity in the navigation frame.Based on the fact that during a vehicle??s horizontal and uniform motion,the vertical acceleration is consistent with gravitational acceleration,this paper proposes an IMU/odometry fusion navigation algorithm based on horizontal attitude constraints(HAC).Building on non-holonomic constraints,this algorithm determines the motion state of the vehicle through accelerometer output and zeroes out the pitch and roll angles during horizontal and uniform motion.Verified through two sets of real-world vehicle test data,this algorithm improves horizontal positioning accuracy by approximately 63%and 70%,and vertical positioning accuracy by 98%and 97%,compared with the traditional NHC IMU/odometer fusion algorithm.
基金supported by the Natural Science Foundation of Shanghai(No.22ZR1470200)National Natural Science Foundation of China(Nos.12125508,12122514,12541503,12241501)Shanghai Pilot Program for Basic Research—Chinese Academy of Sciences,Shanghai Branch(JCYJ-SHFY-2021-010)。
文摘Preserving beam quality during the transport of high-brightness electron bunches is crucial for advanced accelerator applications,such as particle colliders,free-electron lasers,and recirculating linacs.However,coherent synchrotron radiation(CSR)significantly degrades beam quality when electron bunches pass through multi-bend isochronous beamlines,particularly for short bunches with non-ideal longitudinal profiles.Although several methods have been proposed to mitigate CSR effects,most rely on small-angle approximations or are limited to idealized bunch profiles.In this study,we present two improved methods for designing isochronous triple-bend achromat(TBA)beamlines that effectively mitigate CSR-induced emittance growth and longitudinal profile distortion without relying on small-angle approximations.The first method,an enhanced integral optimization approach,simplifies numerical optimization and can accurately handle larger deflection angles,making it suitable for practical applications that require flexible lattice configurations.The second method,an optimized I-matrix approach,completely cancels steady-state and transient CSR kicks through specific matrix constraints and higher-order dispersion optimization,enabling effective CSR suppression even with very large deflection angles.Systematic simulations demonstrate that both methods achieve excellent preservation of transverse emittance and longitudinal profiles.
基金supported by the National Natural Science Foundation of China(Grant No.52178329),the China Scholarship Council(Grant No.202306130155)the Postgraduate Scientific Research Innovation Project of Hunan Province,China(Grant No.CX20230442).
文摘With the continuous development of the offshore wind industry,the design concept of composite foundation has been given attention in the past decade.This paper presents an accurate method for investigating the horizontal vibration of monopile-friction wheel composite foundations in layered saturated soil.Firstly,the three-dimensional continuum mechanics theory with the range of linear elasticity is introduced to calculate the frictional resistance distributed on the upper soil surface.Then,the resistances of multilayered soils and inviscid seawater to the pile shaft under horizontal harmonic excitation are obtained using Novak's plane strain model,Biot's porous media theory and radiationwave theory.Thirdly,the expressions for the deformation,bending moment and internal force of the Euler-Bernoulli pile are derived using the boundary conditions with definitephysical meaning and transfer matrix method.By comparing with the results of 1g laboratory test and the idealized formula reported by the literature,the rationality and accuracy of the developed dynamical model can be verified.Finally,this paper conducts a series of worked examples to investigate the influencesof the elastic modulus and thickness of three-layer saturated soil and the location of interlayer soil on the horizontal dynamic vibration of composite foundation.The results show that an increase in elastic modulus of the surface soil is an effective way to improve the dynamic stability of the composite foundation in service conditions.The conclusions drawn from the numerical examples can develop some guidelines for the current foundation design of offshore wind turbines.
文摘AIM:To evaluate the clinical outcomes of a new minimally invasive technique using horizontal mattress sutures and Hoffman pockets for four-point refixation of dislocated fourhaptic intraocular lenses(IOLs).METHODS:This retrospective consecutive case series included eyes with dislocated Akreos AO60 IOLs underwent scleral refixation using a horizontal mattress doubleneedle suture technique with intralamellar knot burial via Hoffman pockets.Clinical outcomes assessed included pre-and postoperative best-corrected visual acuity(BCVA),intraocular pressure(IOP),spherical equivalent(SE),suture duration,IOL centration,and perioperative complications.RESULTS:A total of 10 eyes from 10 patients(6 males)were included.The mean age at the time of IOL refixation was 53.10±13.07y(range:28-68y).The mean interval between initial IOL implantation and dislocation was 8.44±3.54y.The mean postoperative follow-up duration was 11.45±10.30mo.Surgical time averaged 15.3±1.77min,with no intraoperative complications.The mean axial length was 27.16±4.35 mm,with high myopia(HM)as the leading comorbidity(4/10 eyes).Postoperative BCVA significantly improved compared to preoperative values(P=0.025).Postoperative SE was significantly improved compared with preoperative(P=0.01).All IOLs remained centered throughout follow-up.CONCLUSION:This minimally invasive four-point scleral fixation technique offers a safe and effective refixation strategy for dislocated four-haptic IOLs.The horizontal mattress suture configuration combined with Hoffman pockets facilitates durable centration,avoids conjunctival dissection,and could be adopted into routine surgical practice.
文摘Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)].
基金Project supported by the Joints Fund of the National Natural Science Foundation of China(Grant No.U23A20349)the Young Scientists Fund of the National Natural Science Foundation of China(Grant Nos.62204126,62305171,62304113)。
文摘With the rapid advancement of optoelectronic technology,high-performance photodetectors are increasingly in demand in fields such as environmental monitoring,optical communication,and defense systems,where ultraviolet detection is critical.However,conventional semiconductor materials suffer from limited UV-visible detection capabilities owing to their narrow bandgaps and high dark currents.To address these challenges,wide-bandgap semiconductors have emerged as promising alternatives.Here,we fabricated a horizontally structured n–n heterojunction photodetector by growingβ-Ga_(2)O_(3) on Si–GaN via plasma-enhanced chemical vapor deposition.The device exhibits a self-powered photocurrent of 3.5 nA at zero bias,enabled by the photovoltaic effect of the space charge region.Under 254-nm and 365-nm illumination,it exhibits rectification behavior,achieving a responsivity of 0.475 m A/W(0 V,220??W/cm~2 at 254 nm)and 257.6 mA/W(-5 V),respectively.Notably,the photodetector demonstrates a high photocurrent-to-dark current ratio of 10~5 under-5-V bias,highlighting its potential for self-powered and high-performance UV detection applications.
文摘Federated Learning(FL)has become a leading decentralized solution that enables multiple clients to train a model in a collaborative environment without directly sharing raw data,making it suitable for privacy-sensitive applications such as healthcare,finance,and smart systems.As the field continues to evolve,the research field has become more complex and scattered,covering different system designs,training methods,and privacy techniques.This survey is organized around the three core challenges:how the data is distributed,how models are synchronized,and how to defend against attacks.It provides a structured and up-to-date review of FL research from 2023 to 2025,offering a unified taxonomy that categorizes works by data distribution(Horizontal FL,Vertical FL,Federated Transfer Learning,and Personalized FL),training synchronization(synchronous and asynchronous FL),optimization strategies,and threat models(data leakage and poisoning attacks).In particular,we summarize the latest contributions in Vertical FL frameworks for secure multi-party learning,communication-efficient Horizontal FL,and domain-adaptive Federated Transfer Learning.Furthermore,we examine synchronization techniques addressing system heterogeneity,including straggler mitigation in synchronous FL and staleness management in asynchronous FL.The survey covers security threats in FL,such as gradient inversion,membership inference,and poisoning attacks,as well as their defense strategies that include privacy-preserving aggregation and anomaly detection.The paper concludes by outlining unresolved issues and highlighting challenges in handling personalized models,scalability,and real-world adoption.
基金supported by the National Natural Science Foundation of China(52274055)the Shandong Provincial Natural Science Foundation(ZR2022YQ50)the Taishan Scholar Program of Shandong Province(tsqn202408088)。
文摘Predicting the productivity of multistage fractured horizontal wells plays an important role in exploiting unconventional resources.In recent years,machine learning(ML)models have emerged as a new approach for such studies.However,the scarcity of sufficient real data for model training often leads to imprecise predictions,even though the models trained with real data better characterize geological and engineering features.To tackle this issue,we propose an ML model that can obtain reliable results even with a small amount of data samples.Our model integrates the synthetic minority oversampling technique(SMOTE)to expand the data volume,the support vector machine(SVM)for model training,and the particle swarm optimization(PSO)algorithm for optimizing hyperparameters.To enhance the model performance,we conduct feature fusion and dimensionality reduction.Additionally,we examine the influences of different sample sizes and ML models for training.The proposed model demonstrates higher prediction accuracy and generalization ability,achieving a predicted R^(2)value of up to 0.9 for the test set,compared to the traditional ML techniques with an R^(2)of 0.13.This model accurately predicts the production of fractured horizontal wells even with limited samples,supplying an efficient tool for optimizing the production of unconventional resources.Importantly,the model holds the potential applicability to address similar challenges in other fields constrained by scarce data samples.
基金financially supported by the Shanghai New Three-Year Action Plan for Public Health(Grant No.GWVI-11.1-03)National Natural Science Foundation of China(Grant No.81872673).
文摘Objective Poxviruses are zoonotic pathogens that infect humans,mammals,vertebrates,and arthropods.However,the specific role of ticks in transmission and evolution of these viruses remains unclear.Methods Transcriptomic and metatranscriptomic raw data from 329 sampling pools of seven tick species across five continents were mined to assess the diversity and abundance of poxviruses.Chordopoxviral sequences were assembled and subjected to phylogenetic analysis to trace the origins of the unblasted fragments within these sequences.Results Fifty-eight poxvirus species,representing two subfamilies and 20 genera,were identified,with 212 poxviral sequences assembled.A substantial proportion of AT-rich fragments were detected in the assembled poxviral genomes.These genomic sequences contained fragments originating from rodents,archaea,and arthropods.Conclusion Our findings indicate that ticks play a significant role in the transmission and evolution of poxviruses.These viruses demonstrate the capacity to modulate virulence and adaptability through horizontal gene transfer,gene recombination,and gene mutations,thereby promoting co-existence and co-evolution with their hosts.This study advances understanding of the ecological dynamics of poxvirus transmission and evolution and highlights the potential role of ticks as vectors and vessels in these processes.
基金supported by National Key Research and Development Program of China,China(2024YFD1800102,2022YFD1800105 and 2022YFD1801500)National Natural Science Foundation of China,China(32372993 and 32030107)Fundamental Research Funds for the Central Universities,China(2662023PY005).
文摘Zika virus(ZIKV)is a mosquito-borne virus belonging to the genus Orthoflavivirus,and the family Flaviviridae.It commonly presents with febrile-like symptoms,neurological issues,and pregnancy complications in humans.Currently,there is no commercial vaccine or specific treatment available to prevent ZIKV infection.Therefore,controlling the epidemic's spread relies on preventing mosquitoes from transmitting the virus.Although various studies have explored the transmission of ZIKV between mosquitoes and vertebrate hosts,comprehensive research on potential mosquito-to-mosquito transmission of ZIKV remains limited.In this study,we conducted systematic laboratory investigations to assess the ability of ZIKV to spread among mosquitoes,and to evaluate the impact of ZIKV infection on mosquito development.Our findings revealed that ZIKV can be transmitted between Aedes aegypti mosquitoes both vertically and horizontally,through oviposition and contact between mosquitoes of the same or opposite sex.Additionally,we observed that ZIKV infection resulted in a reduction in the number of mosquito eggs but an increase in their size.The widespread distribution of ZIKV in infected mosquitoes and the altered levels of hormone related genes following viral infection were noted,which may contribute to viral transmission among mosquitoes and affect mosquito development.This research provides systematic experimental evidence of ZIKV transmission among mosquitoes,which is crucial for developing novel strategies to disrupt the spread of orthoflaviviruses and other mosquitoborne pathogens.
基金Supported by the National High-Tech Research Project(GJSCB-HFGDY-2024-004)National Natural Science Foundation of China(12402305)+2 种基金Postdoctoral Fellowship Program of CPSF(GZC20232200)China Postdoctoral Science Foundation(2024M762703)Sichuan Science and Technology Program(2025ZNSFSC1352)。
文摘The Carter model is used to characterize the dynamic behaviors of fracture growth and fracturing fluid leakoff.A thermo-fluid coupling temperature response forward model is built considering the fluid flow and heat transfer in wellbore,fracture and reservoir.The influences of fracturing parameters and fracture parameters on the responses of distributed temperature sensing(DTS)are analyzed,and a diagnosis method of fracture parameters is presented based on the simulated annealing algorithm.A field case study is introduced to verify the model’s reliability.Typical V-shaped characteristics can be observed from the DTS responses in the multi-cluster fracturing process,with locations corresponding to the hydraulic fractures.The V-shape depth is shallower for a higher injection rate and longer fracturing and shut-in time.Also,the V-shape is wider for a higher fracture-surface leakoff coefficient,longer fracturing time and smaller fracture width.Additionally,the cooling effect near the wellbore continues to spread into the reservoir during the shut-in period,causing the DTS temperature to decrease instead of rise.Real-time monitoring and interpretation of DTS temperature data can help understand the fracture propagation during fracturing operation,so that immediate measures can be taken to improve the fracturing performance.
基金supported by the National Natural Science Foundation of China(Grant number 42201302)the"Double First-Class"University Construction Project of Lanzhou University(Grant number:561120213)。
文摘The horizontal ecological compensation plays an important role in balancing the interests of all parties and coordinating regional development in the basin.However,the mechanism of ecological compensation based on embodied carbon emissions is still poorly understood.Here,taking the Yellow River Basin as the research area,we use the multi-regional input-output(MRIO)model to measure the embodied carbon transfers between its seven urban agglomerations in 2012 and 2017 from the viewpoint of value-added trade benefits.Further,for the first time,the green trade benefits and ecological compensation amounts are analyzed.The results indicate that:(1)The transfer of trade-embodied carbon among the urban agglomerations in the basin showed obvious spatial heterogeneity and geographic proximity effects,and trade-embodied carbon outflows(inflows)had a pattern of"highest in the midstream,second in the downstream,and lowest in the upstream".(2)The industry composition of the urban agglomerations in relation to embodied carbon outflows(inflows)was similar,mainly in the service and heavy manufacturing industries.(3)The spatial pattern of green trade benefits in the basin had shifted from"high in the north and low in the surrounding area"to"high in the east-central part and low in the west".(4)The pattern of ecological compensation in the basin had shifted from the upstream surplus,the middle and downstream deficit to the midstream deficit,and the upstream and downstream surplus.Therefore,we recommend improving energy structures in high-demand urban agglomerations by adopting clean energy,focusing on decarbonization and energy efficiency in resource-rich regions.Additionally,promoting low-carbon economies,especially in the service and heavy manufacturing industries,implementing differentiated emission reduction strategies,and optimizing carbon compensation mechanisms considering regional disparities and resource endowments are crucial.It is expected that the study can enrich the scientific basis of horizontal ecological compensation and increase the fairness of regional carbon emission rights allocation.
