The thermal strati?cation of the lakes impedes the transfer of atmospheric oxygen into the lower layers of the lake. In lakes which are af fected by diverse anthropogenic in?uences, the increasing organic matter amoun...The thermal strati?cation of the lakes impedes the transfer of atmospheric oxygen into the lower layers of the lake. In lakes which are af fected by diverse anthropogenic in?uences, the increasing organic matter amounts lead to a sharp decrease in hypolimnetic oxygen amounts, aided by thermal strati?cation,and anaerobic conditions arise. The determination of hypolimnetic oxygen demand(HOD) and areal hypolimnetic oxygen demand(AHOD) and their monitoring represent an integrated approach to investigate the oxygenation of lakes, the nutrient conditions, and the physicochemical dynamics. In this study, two lakes dif fering by size and af fected by dif ferent anthropogenic sources, are investigated in this respect. At?rst, bathymetric studies were conducted to determine the depth, surface area, and volume relationships.Then, based on monitoring studies conducted in 2013 and 2014, the thermal strati?cation dynamics and layer properties were established using the relative thermal resistance to mixing(RTRM) index based on temperature and density pro?les. Following this, the oxygen depletion rates were determined by oxygen and temperature pro?ling in the hypolimnion. For the years of 2013 and 2014, the AHOD values for the Borabey Pond which is far from anthropogenic in?uences, were found to be 0.848 and 0.569 g O 2/(m·d), respectively.The AHOD values for the Porsuk Reservoir which was overburdened for years by industrial and domestic pollution were found to be 4.263 and 5.099 g O 2/(m·d), larger than its counterpart by almost sevenfold. The HOD and AHOD monitoring can be considered to a valuable tool for assessing the ecological and chemical status of lakes within Annex 5 of the Water Framework Directive and as an integrated approach to assess and monitor the status of lakes.展开更多
Reactivation of hepatitis B virus(HBV)can occur in lymphoma patients infected with HBV when they receive chemotherapy or immunotherapy.Prophylactic administration of lamivudine(LAM)reduces the morbidity and mortality ...Reactivation of hepatitis B virus(HBV)can occur in lymphoma patients infected with HBV when they receive chemotherapy or immunotherapy.Prophylactic administration of lamivudine(LAM)reduces the morbidity and mortality associated with HBV reactivation.However,what defines HBV reactivation and the optimal duration of treatment with LAM have not yet been clearly established.HBV reactivation may occur due to the cessation of prophylactic LAM,although re-treatment with nucleoside analogs may sometimes result in hepatitis B surface antigen(HBsAg)seroconversion,which is a satisfactory endpoint for the management of HBV infection.We report a case of HBV reactivation in a 68-year-old HBsAg-positive patient who received rituximab-based immunochemotherapy for follicular lymphoma.HBV reactivation developed following cessation of prophylactic LAM therapy.The patient subsequently received treatment with entecavir(ETV),which led to a rapid and sustained suppression of HBV replication and HBsAg seroconversion.We also appraised the literature concerning HBV reactivation and the role of ETV in the management of HBV reactivation in lymphoma patients.A total of 28 cases of HBV reactivation have been reported as having been treated with ETV during or after immunosuppressive chemotherapy in lymphoma patients.We conclude that ETV is an efficacious and safe treatment for HBV reactivation following LAM cessation in lymphoma patients treated with rituximab-based immunochemotherapy.展开更多
An improved interpolating complex variable element-frees Galerkin(IICVEFG)method for the two-dimensional elastic problems is developed.This method is based on the improved interpolating complex variable moving least-s...An improved interpolating complex variable element-frees Galerkin(IICVEFG)method for the two-dimensional elastic problems is developed.This method is based on the improved interpolating complex variable moving least-squares(IICVMLS)method and the integral form of the elastic problems.In the IICVEFG method,the proposed shape function has the interpolating feature.Therefore,the essential boundary conditions can be exerted directly.Additionally,the unnecessary t erms in the discrete mat rices are removed,which resul ts in a set of concise formulas.This method is verified by analyzing three elastic examples under different constraints and loads.The numerical results show that the IICVEFG method is superior in precision and efficiency to other non-interpolating meshless methods.展开更多
The potential based low order surface panel method is used to predict the hydrodynamic performance of marine propellers. In present method the hyperboloidal quadrilateral panels are employed to avoid the gap between t...The potential based low order surface panel method is used to predict the hydrodynamic performance of marine propellers. In present method the hyperboloidal quadrilateral panels are employed to avoid the gap between the panels. The influence coefficients of panels are calculated by Morino’s analytical formulations for increasing numerically calculating speed. The pressure Kutta condition is satisfied on the trailing edge of propeller blade by Newton-Raphson iterative procedure. Therefore the pressure coefficients of the suction and pressure faces of blade are equal on trailing edge. The method developed by Yanagizawa is used to determine the velocities on propeller surface, and to avoid the singularity in the numerical differentiation. The predicted pressure distributions and open water performances of general propellers and highly skewed propellers have a good agreement with experimental dat and other calculation results.展开更多
Let Ω CR^d,1≤d≤3, be a bounded d-polytope. Consider the parabolic equation on Q with the Dirac delta function on the right hand side. We study the well-posedness, regularity, and the interior error estimate of semi...Let Ω CR^d,1≤d≤3, be a bounded d-polytope. Consider the parabolic equation on Q with the Dirac delta function on the right hand side. We study the well-posedness, regularity, and the interior error estimate of semidiscrete finite element approximations of the equation. In particular, we derive that the interior error is bounded by the best local approximation error, the negative norms of the error, and the negative norms of the time derivative of the error. This result implies different convergence rates for the numerical solution in different interior regions, especially when the region is close to the singular point. Numerical test results are reported to support the theoretical prediction.展开更多
This paper presents a 2D simulation of transient heat transfer in the human eye using appropriate boundary conditions.The mathematical model governing bioheat transfer in the human eye is discussed and the existence a...This paper presents a 2D simulation of transient heat transfer in the human eye using appropriate boundary conditions.The mathematical model governing bioheat transfer in the human eye is discussed and the existence and uniqueness of the solution are proven.Four methods based on finite element method and nonoverlapping domain decomposition method to obtain transient heat transfer in the human eye are presented and described in details.After conducting numerous simulations using realistic parameters obtained from the open literature and after comparison with measurements reported by previous experimental studies,all proposed methods gave an accurate representation of transient heat transfer in the human eye.The results obtained by the domain decomposition of the human eye into four subdomains are found to be the closest to reality.展开更多
基金Supported by the Anadolu University Scientific Research Project(No.1208F129)(Project Coordinator:S.GONCü)
文摘The thermal strati?cation of the lakes impedes the transfer of atmospheric oxygen into the lower layers of the lake. In lakes which are af fected by diverse anthropogenic in?uences, the increasing organic matter amounts lead to a sharp decrease in hypolimnetic oxygen amounts, aided by thermal strati?cation,and anaerobic conditions arise. The determination of hypolimnetic oxygen demand(HOD) and areal hypolimnetic oxygen demand(AHOD) and their monitoring represent an integrated approach to investigate the oxygenation of lakes, the nutrient conditions, and the physicochemical dynamics. In this study, two lakes dif fering by size and af fected by dif ferent anthropogenic sources, are investigated in this respect. At?rst, bathymetric studies were conducted to determine the depth, surface area, and volume relationships.Then, based on monitoring studies conducted in 2013 and 2014, the thermal strati?cation dynamics and layer properties were established using the relative thermal resistance to mixing(RTRM) index based on temperature and density pro?les. Following this, the oxygen depletion rates were determined by oxygen and temperature pro?ling in the hypolimnion. For the years of 2013 and 2014, the AHOD values for the Borabey Pond which is far from anthropogenic in?uences, were found to be 0.848 and 0.569 g O 2/(m·d), respectively.The AHOD values for the Porsuk Reservoir which was overburdened for years by industrial and domestic pollution were found to be 4.263 and 5.099 g O 2/(m·d), larger than its counterpart by almost sevenfold. The HOD and AHOD monitoring can be considered to a valuable tool for assessing the ecological and chemical status of lakes within Annex 5 of the Water Framework Directive and as an integrated approach to assess and monitor the status of lakes.
基金Supported by National Natural Science Foundation of China,Grant No.81241073Peking University Cancer Hospital Foundation for Scientific Research,Grant No.2013-Autonomous-9
文摘Reactivation of hepatitis B virus(HBV)can occur in lymphoma patients infected with HBV when they receive chemotherapy or immunotherapy.Prophylactic administration of lamivudine(LAM)reduces the morbidity and mortality associated with HBV reactivation.However,what defines HBV reactivation and the optimal duration of treatment with LAM have not yet been clearly established.HBV reactivation may occur due to the cessation of prophylactic LAM,although re-treatment with nucleoside analogs may sometimes result in hepatitis B surface antigen(HBsAg)seroconversion,which is a satisfactory endpoint for the management of HBV infection.We report a case of HBV reactivation in a 68-year-old HBsAg-positive patient who received rituximab-based immunochemotherapy for follicular lymphoma.HBV reactivation developed following cessation of prophylactic LAM therapy.The patient subsequently received treatment with entecavir(ETV),which led to a rapid and sustained suppression of HBV replication and HBsAg seroconversion.We also appraised the literature concerning HBV reactivation and the role of ETV in the management of HBV reactivation in lymphoma patients.A total of 28 cases of HBV reactivation have been reported as having been treated with ETV during or after immunosuppressive chemotherapy in lymphoma patients.We conclude that ETV is an efficacious and safe treatment for HBV reactivation following LAM cessation in lymphoma patients treated with rituximab-based immunochemotherapy.
基金The authors sincerely acknowledge the financial support from the National Science Foundation of China(No.12002240)the National Science and Technology Major Project(No.2017-IV-0003-0040).
文摘An improved interpolating complex variable element-frees Galerkin(IICVEFG)method for the two-dimensional elastic problems is developed.This method is based on the improved interpolating complex variable moving least-squares(IICVMLS)method and the integral form of the elastic problems.In the IICVEFG method,the proposed shape function has the interpolating feature.Therefore,the essential boundary conditions can be exerted directly.Additionally,the unnecessary t erms in the discrete mat rices are removed,which resul ts in a set of concise formulas.This method is verified by analyzing three elastic examples under different constraints and loads.The numerical results show that the IICVEFG method is superior in precision and efficiency to other non-interpolating meshless methods.
文摘The potential based low order surface panel method is used to predict the hydrodynamic performance of marine propellers. In present method the hyperboloidal quadrilateral panels are employed to avoid the gap between the panels. The influence coefficients of panels are calculated by Morino’s analytical formulations for increasing numerically calculating speed. The pressure Kutta condition is satisfied on the trailing edge of propeller blade by Newton-Raphson iterative procedure. Therefore the pressure coefficients of the suction and pressure faces of blade are equal on trailing edge. The method developed by Yanagizawa is used to determine the velocities on propeller surface, and to avoid the singularity in the numerical differentiation. The predicted pressure distributions and open water performances of general propellers and highly skewed propellers have a good agreement with experimental dat and other calculation results.
基金Li Guo was supported in part by the National Natural Science Foundation of China under the grant 11601536.Hengguang Li was supported in part by the National Science Foundation Grant DMS-1418853,by the Natural Science Foundation of China Grant 11628104,and by the Wayne State University Grants Plus Program.Yang Yang was supported in part by the National Natural Science Foundation of China under the grants 11571367&11601536 and the Fundamental Research Funds for the Central Universities 18CX05003A.
文摘Let Ω CR^d,1≤d≤3, be a bounded d-polytope. Consider the parabolic equation on Q with the Dirac delta function on the right hand side. We study the well-posedness, regularity, and the interior error estimate of semidiscrete finite element approximations of the equation. In particular, we derive that the interior error is bounded by the best local approximation error, the negative norms of the error, and the negative norms of the time derivative of the error. This result implies different convergence rates for the numerical solution in different interior regions, especially when the region is close to the singular point. Numerical test results are reported to support the theoretical prediction.
文摘This paper presents a 2D simulation of transient heat transfer in the human eye using appropriate boundary conditions.The mathematical model governing bioheat transfer in the human eye is discussed and the existence and uniqueness of the solution are proven.Four methods based on finite element method and nonoverlapping domain decomposition method to obtain transient heat transfer in the human eye are presented and described in details.After conducting numerous simulations using realistic parameters obtained from the open literature and after comparison with measurements reported by previous experimental studies,all proposed methods gave an accurate representation of transient heat transfer in the human eye.The results obtained by the domain decomposition of the human eye into four subdomains are found to be the closest to reality.
