Lung cancer has become one of the most common types of cancer,and has the highest morbidity and mortality rates.We herein performed a bioinformatic analysis to explore the gene expression of hexokinase domain containi...Lung cancer has become one of the most common types of cancer,and has the highest morbidity and mortality rates.We herein performed a bioinformatic analysis to explore the gene expression of hexokinase domain containing 1(HKDC1)to further illuminate the molecular mechanisms involved in non-small cell lung cancer(NSCLC).We also examined the relationship between HKDC1 expression and patient survival.The Oncomine and cBioPortal cancer genomics databases were used to investigate the expression of HKDC1 in NSCLC.Then the protein-protein interaction network and protein expression intensity of HKDC1 were examined with the Gene MANIA and The Human Protein Atlas databases.Finally,the prognostic impact of HKDC1 was evaluated via the GEPIA,Oncolnc and Kaplan-Meier Plotter online tools.HKDC1 was significantly up-regulated in NSCLC patients.In addition,the mutation frequency of HKDC1 in NSCLC was high in a large number of studies.Moreover,HKDC1 expression was correlated with a poor prognosis in NSCLC patients.These findings suggest that HKDC1 represents a novel therapeutic target for NSCLC.展开更多
A metabolic switch favoring glycolysis over aerobic oxidative phosphorylation,termed the“Warburg effect”,is a hallmark of cancer cells[1].Hexokinase(HK)catalyzes the first and irreversible step of glycolysis,thereby...A metabolic switch favoring glycolysis over aerobic oxidative phosphorylation,termed the“Warburg effect”,is a hallmark of cancer cells[1].Hexokinase(HK)catalyzes the first and irreversible step of glycolysis,thereby limiting overall glycolytic activity.Mammals encode five HK family members:HK1-4 and HKDC1(HK domain containing 1).HKDC1 has an exceptionally low glucose affinity and,therefore,low hexokinase activity under physiological conditions[2],raising questions about its function.A recent study indicated that HKDC1 functions as a glucose sensor within the tumor microenvironment[3],and its dysregulated expression has been associated with chronic inflammation[4]and various cancers[5].展开更多
基金the National Natural Science Foundation of China(No.81860494).
文摘Lung cancer has become one of the most common types of cancer,and has the highest morbidity and mortality rates.We herein performed a bioinformatic analysis to explore the gene expression of hexokinase domain containing 1(HKDC1)to further illuminate the molecular mechanisms involved in non-small cell lung cancer(NSCLC).We also examined the relationship between HKDC1 expression and patient survival.The Oncomine and cBioPortal cancer genomics databases were used to investigate the expression of HKDC1 in NSCLC.Then the protein-protein interaction network and protein expression intensity of HKDC1 were examined with the Gene MANIA and The Human Protein Atlas databases.Finally,the prognostic impact of HKDC1 was evaluated via the GEPIA,Oncolnc and Kaplan-Meier Plotter online tools.HKDC1 was significantly up-regulated in NSCLC patients.In addition,the mutation frequency of HKDC1 in NSCLC was high in a large number of studies.Moreover,HKDC1 expression was correlated with a poor prognosis in NSCLC patients.These findings suggest that HKDC1 represents a novel therapeutic target for NSCLC.
基金supported by the German Research Foundation(DFG)through the individual grant SO1141/10-1,the Research Unit FOR5042“miTarget-The Microbiome as a Target in Inflammatory Bowel Diseases”(project P5)the Excellence Cluster EXS2167“Precision Medicine in Chronic Inflammation”,an intramural grant of the medical faculty of Kiel University(grant no K126408)Felix Sommer and ZMB Young Scientist Award 2021,category doctoral students(grant no F384430)to Lea Järke.
文摘A metabolic switch favoring glycolysis over aerobic oxidative phosphorylation,termed the“Warburg effect”,is a hallmark of cancer cells[1].Hexokinase(HK)catalyzes the first and irreversible step of glycolysis,thereby limiting overall glycolytic activity.Mammals encode five HK family members:HK1-4 and HKDC1(HK domain containing 1).HKDC1 has an exceptionally low glucose affinity and,therefore,low hexokinase activity under physiological conditions[2],raising questions about its function.A recent study indicated that HKDC1 functions as a glucose sensor within the tumor microenvironment[3],and its dysregulated expression has been associated with chronic inflammation[4]and various cancers[5].
