This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV i...This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV infection model has a susceptible class,a recovered class,along with a case of infection divided into three sub-different levels or categories and the recovered class.The total time interval is converted into two,which are further investigated for ordinary and fractional order operators of the AB derivative,respectively.The proposed model is tested separately for unique solutions and existence on bi intervals.The numerical solution of the proposed model is treated by the piece-wise numerical iterative scheme of Newtons Polynomial.The proposed method is established for piece-wise derivatives under natural order and non-singular Mittag-Leffler Law.The cross-over or bending characteristics in the dynamical system of HIV are easily examined by the aspect of this research having a memory effect for controlling the said disease.This study uses the neural network(NN)technique to obtain a better set of weights with low residual errors,and the epochs number is considered 1000.The obtained figures represent the approximate solution and absolute error which are tested with NN to train the data accurately.展开更多
This paper shows how mathematical methods can be implemented to formulate guidelines for clinical testing and monitoring of HIV/AIDS disease. First, a mathematical model for HIV infection is presented which the measur...This paper shows how mathematical methods can be implemented to formulate guidelines for clinical testing and monitoring of HIV/AIDS disease. First, a mathematical model for HIV infection is presented which the measurement of the CD4+T cells and the viral load counts are needed to estimate all its parameters. Next, through an analysis of model properties, the minimal number of measurement samples is obtained. In the sequel, the effect of Reverse Transcriptase enzyme Inhibitor (RTI) on HIV progression is demonstrated by using a control function. Also the total cost of treatment by this kind of drugs has been minimized. The numerical results are obtained by a numerical method in discretization issue, called AVK.展开更多
An HIV model was considered. The parameters of the model are estimated by adjoint dada assimilation method. The results showed the method is valid. This method has potential application to a wide variety of models in ...An HIV model was considered. The parameters of the model are estimated by adjoint dada assimilation method. The results showed the method is valid. This method has potential application to a wide variety of models in biomathematics.展开更多
Considering the antiviral drugs can act on the fusion,reverse transcription,and budding stages of HIV infected cells,in this paper,we formulate a two-periodic delay heterogeneous space diffusion HIV model with three-s...Considering the antiviral drugs can act on the fusion,reverse transcription,and budding stages of HIV infected cells,in this paper,we formulate a two-periodic delay heterogeneous space diffusion HIV model with three-stage infection process to study the effects of periodic antiviral treatment and spatial heterogeneity on HIV infection process.We first study the well-posedness of the full system and then derive the basic reproduction number R_(0),which is defined as the spectral radius of the next generation operator.We further prove that R_(0) is a threshold for the elimination and persistence of HIV infection by comparison principle and persistence theory for non-autonomous system.In the spatial homogeneous case,the explicit expression of R_(0) is derived and the global attractivity of the positive steady state is proved by using the fluctuation method.Some numerical simulations are conducted to illustrate the theoretical results and our works suggest that both spatial heterogeneity and periodic delays caused by periodic antiviral therapy have a remarkable impact on the progression of HIV infection and should not be overlooked in clinical treatment process.展开更多
Biologically,because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells,time delay and spatial heterogeneity should be considered.In this paper,we establish an HIV infection model with n...Biologically,because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells,time delay and spatial heterogeneity should be considered.In this paper,we establish an HIV infection model with nonlocal dispersal and infection age.Moreover,applying the theory of Fourier transformation and von Foerster rule,we transform the model to an integrodifferential equation with nonlocal time delay and dispersal.The well-posedness,positivity,and boundedness of the solution for the model are studied.展开更多
HIV is a retrovirus that infects and impairs the cells and functions of the immune system. It has caused a great challenge to global public health systems and leads to Acquired Immunodeficiency Syndrome (AIDS), if not...HIV is a retrovirus that infects and impairs the cells and functions of the immune system. It has caused a great challenge to global public health systems and leads to Acquired Immunodeficiency Syndrome (AIDS), if not attended to in good time. Antiretroviral therapy is used for managing the virus in a patient’s lifetime. Some of the symptoms of the disease include lean body mass and many opportunistic infections. This study has developed a SIAT mathematical model to investigate the impact of inconsistency in treatment of the disease. The arising non-linear differential equations have been obtained and analyzed. The DFE and its stability have been obtained and the study found that it is locally asymptotically stable when the basic reproduction number is less than unity. The endemic equilibrium has been obtained and found to be globally asymptotically stable when the basic reproduction number is greater than unity. Numerical solutions have been obtained and analyzed to give the trends in the spread dynamics. The inconsistency in treatment uptake has been analyzed through the numerical solutions. The study found that when the treatment rate of those infected increases, it leads to an increase in treatment population, which slows down the spread of HIV and vice versa. An increase in the rate of treatment of those with AIDS leads to a decrease in the AIDS population, the reverse happens when this rate decreases. The study recommends that the community involvement in advocating for consistent treatment of HIV to curb the spread of the disease.展开更多
构建一类具有VCT(voluntary counseling and testing)意识及媒体报道影响的HIV/AIDS感染动力学模型.首先得到模型解的适定性,并给出模型的基本再生数.其次,借助Hurwitz判别法及Lyapunov函数分析模型的阈值动力学,当R_(0)<1时无病平...构建一类具有VCT(voluntary counseling and testing)意识及媒体报道影响的HIV/AIDS感染动力学模型.首先得到模型解的适定性,并给出模型的基本再生数.其次,借助Hurwitz判别法及Lyapunov函数分析模型的阈值动力学,当R_(0)<1时无病平衡点局部渐近稳定且当R_(0)≤1时全局渐近稳定;当R_(0)>1时,地方病平衡点局部渐近稳定.进一步,结合持续生存理论给出疾病的一致持续性.最后,数值模拟表明随着VCT意识比例的提高,艾滋病患者人数的峰值逐渐降低,而随着信息失效率的增大,艾滋病患者人数的峰值将有所提高.展开更多
In this study,a numerical method based on the Pell-Lucas polynomials(PLPs)is developed to solve the fractional order HIV/AIDS epidemic model with a treatment compartment.The HIV/AIDS mathematical model with a treatmen...In this study,a numerical method based on the Pell-Lucas polynomials(PLPs)is developed to solve the fractional order HIV/AIDS epidemic model with a treatment compartment.The HIV/AIDS mathematical model with a treatment compartment is divided into five classes,namely,susceptible patients(S),HIV-positive individuals(I),individuals with full-blown AIDS but not receiving ARV treatment(A),individuals being treated(T),and individuals who have changed their sexual habits sufficiently(R).According to the method,by utilizing the PLPs and the collocation points,we convert the fractional order HIV/AIDS epidemic model with a treatment compartment into a nonlinear system of the algebraic equations.Also,the error analysis is presented for the Pell-Lucas approximation method.The aim of this study is to observe the behavior of five populations after 200 days when drug treatment is applied to HIV-infectious and full-blown AIDS people.To demonstrate the usefulness of this method,the applications are made on the numerical example with the help of MATLAB.In addition,four cases of the fractional order derivative(p=1,p=0.95,p=0.9,p=0.85)are examined in the range[0,200].Owing to applications,we figured out that the outcomes have quite decent errors.Also,we understand that the errors decrease when the value of N increases.The figures in this study are created in MATLAB.The outcomes indicate that the presented method is reasonably sufficient and correct.展开更多
A non-linear HIV-TB co-infection has been formulated and analyzed. The positivity and invariant region has been established. The disease free equilibrium and its stability has been determined. The local stability was ...A non-linear HIV-TB co-infection has been formulated and analyzed. The positivity and invariant region has been established. The disease free equilibrium and its stability has been determined. The local stability was determined and found to be stable under given conditions. The basic reproduction number was obtained and according to findings, co-infection diminishes when this number is less than unity, and persists when the number is greater than unity. The global stability of the endemic equilibrium was calculated. The impact of HIV on TB was established as well as the impact of TB on HIV. Numerical solution was also done and the findings indicate that when the rate of HIV treatment increases the latent TB increases while the co-infected population decreases. When the rate of HIV treatment decreases the latent TB population decreases and the co-infected population increases. Encouraging communities to prioritize the consistent treatment of HIV infected individuals must be emphasized in order to reduce the scourge of HIV-TB co-infection.展开更多
目的了解凉山州新报告HIV感染者或艾滋病病人(简称HIV/AIDS病例)性别比的特征,并探索性别比的影响因素。方法通过中国艾滋病综合防治信息系统收集2019—2022年凉山州新报告的报告年龄15岁及以上、传播途径为异性传播HIV/AIDS病例的基本...目的了解凉山州新报告HIV感染者或艾滋病病人(简称HIV/AIDS病例)性别比的特征,并探索性别比的影响因素。方法通过中国艾滋病综合防治信息系统收集2019—2022年凉山州新报告的报告年龄15岁及以上、传播途径为异性传播HIV/AIDS病例的基本信息,分析凉山州不同地区、人口学特征、疾病特征的男女性别比差异;采用SPSS 22.0软件进行卡方检验、Fisher确切概率法、linear by linear association检验,并建立线性混合模型,分析男女性别比的影响因素。结果2019—2022年凉山州新报告15周岁及以上异性传播HIV/AIDS病例9963例,占全部新报告病例的76.08%,其中非婚非商业性传播病例占71.55%。凉山州四年新报告异性传播HIV/AIDS病例的男女性别比为1.19∶1,布拖、昭觉、金阳和美姑连续4年的性别比均小于1∶1。多因素分析结果显示:年龄越小,民族为彝族,文化程度越低,婚姻状态为离异或丧偶、已婚有配偶,常住人口,异性传播表现形式为非婚非商、配偶阳性,首次CD4^(+)T淋巴细胞计数越高,性别比越小,倒置越明显。结论2019—2022年凉山州新报告HIV/AIDS病例以非婚非商业性传播为主,布拖、昭觉、金阳和美姑等县女性的HIV感染风险高于男性。应进一步发挥学校、多媒体的作用,做好宣传教育工作;加强育龄妇女管理、单阳家庭管理和抗病毒治疗等工作,降低当地女性的艾滋病传播风险,控制艾滋病的传播。展开更多
基金supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University(IMSIU)(grant number IMSIU-RP23066).
文摘This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV infection model has a susceptible class,a recovered class,along with a case of infection divided into three sub-different levels or categories and the recovered class.The total time interval is converted into two,which are further investigated for ordinary and fractional order operators of the AB derivative,respectively.The proposed model is tested separately for unique solutions and existence on bi intervals.The numerical solution of the proposed model is treated by the piece-wise numerical iterative scheme of Newtons Polynomial.The proposed method is established for piece-wise derivatives under natural order and non-singular Mittag-Leffler Law.The cross-over or bending characteristics in the dynamical system of HIV are easily examined by the aspect of this research having a memory effect for controlling the said disease.This study uses the neural network(NN)technique to obtain a better set of weights with low residual errors,and the epochs number is considered 1000.The obtained figures represent the approximate solution and absolute error which are tested with NN to train the data accurately.
文摘This paper shows how mathematical methods can be implemented to formulate guidelines for clinical testing and monitoring of HIV/AIDS disease. First, a mathematical model for HIV infection is presented which the measurement of the CD4+T cells and the viral load counts are needed to estimate all its parameters. Next, through an analysis of model properties, the minimal number of measurement samples is obtained. In the sequel, the effect of Reverse Transcriptase enzyme Inhibitor (RTI) on HIV progression is demonstrated by using a control function. Also the total cost of treatment by this kind of drugs has been minimized. The numerical results are obtained by a numerical method in discretization issue, called AVK.
文摘An HIV model was considered. The parameters of the model are estimated by adjoint dada assimilation method. The results showed the method is valid. This method has potential application to a wide variety of models in biomathematics.
基金supported by the National Natural Science Foundation of China(No.12201557)the Foundation of Zhejiang Provincial Education Department(No.Y202249921).
文摘Considering the antiviral drugs can act on the fusion,reverse transcription,and budding stages of HIV infected cells,in this paper,we formulate a two-periodic delay heterogeneous space diffusion HIV model with three-stage infection process to study the effects of periodic antiviral treatment and spatial heterogeneity on HIV infection process.We first study the well-posedness of the full system and then derive the basic reproduction number R_(0),which is defined as the spectral radius of the next generation operator.We further prove that R_(0) is a threshold for the elimination and persistence of HIV infection by comparison principle and persistence theory for non-autonomous system.In the spatial homogeneous case,the explicit expression of R_(0) is derived and the global attractivity of the positive steady state is proved by using the fluctuation method.Some numerical simulations are conducted to illustrate the theoretical results and our works suggest that both spatial heterogeneity and periodic delays caused by periodic antiviral therapy have a remarkable impact on the progression of HIV infection and should not be overlooked in clinical treatment process.
基金Supported by Funding for the National Natural Science Foundation of China(12201557,12001483,61807006)。
文摘Biologically,because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells,time delay and spatial heterogeneity should be considered.In this paper,we establish an HIV infection model with nonlocal dispersal and infection age.Moreover,applying the theory of Fourier transformation and von Foerster rule,we transform the model to an integrodifferential equation with nonlocal time delay and dispersal.The well-posedness,positivity,and boundedness of the solution for the model are studied.
文摘HIV is a retrovirus that infects and impairs the cells and functions of the immune system. It has caused a great challenge to global public health systems and leads to Acquired Immunodeficiency Syndrome (AIDS), if not attended to in good time. Antiretroviral therapy is used for managing the virus in a patient’s lifetime. Some of the symptoms of the disease include lean body mass and many opportunistic infections. This study has developed a SIAT mathematical model to investigate the impact of inconsistency in treatment of the disease. The arising non-linear differential equations have been obtained and analyzed. The DFE and its stability have been obtained and the study found that it is locally asymptotically stable when the basic reproduction number is less than unity. The endemic equilibrium has been obtained and found to be globally asymptotically stable when the basic reproduction number is greater than unity. Numerical solutions have been obtained and analyzed to give the trends in the spread dynamics. The inconsistency in treatment uptake has been analyzed through the numerical solutions. The study found that when the treatment rate of those infected increases, it leads to an increase in treatment population, which slows down the spread of HIV and vice versa. An increase in the rate of treatment of those with AIDS leads to a decrease in the AIDS population, the reverse happens when this rate decreases. The study recommends that the community involvement in advocating for consistent treatment of HIV to curb the spread of the disease.
文摘构建一类具有VCT(voluntary counseling and testing)意识及媒体报道影响的HIV/AIDS感染动力学模型.首先得到模型解的适定性,并给出模型的基本再生数.其次,借助Hurwitz判别法及Lyapunov函数分析模型的阈值动力学,当R_(0)<1时无病平衡点局部渐近稳定且当R_(0)≤1时全局渐近稳定;当R_(0)>1时,地方病平衡点局部渐近稳定.进一步,结合持续生存理论给出疾病的一致持续性.最后,数值模拟表明随着VCT意识比例的提高,艾滋病患者人数的峰值逐渐降低,而随着信息失效率的增大,艾滋病患者人数的峰值将有所提高.
文摘In this study,a numerical method based on the Pell-Lucas polynomials(PLPs)is developed to solve the fractional order HIV/AIDS epidemic model with a treatment compartment.The HIV/AIDS mathematical model with a treatment compartment is divided into five classes,namely,susceptible patients(S),HIV-positive individuals(I),individuals with full-blown AIDS but not receiving ARV treatment(A),individuals being treated(T),and individuals who have changed their sexual habits sufficiently(R).According to the method,by utilizing the PLPs and the collocation points,we convert the fractional order HIV/AIDS epidemic model with a treatment compartment into a nonlinear system of the algebraic equations.Also,the error analysis is presented for the Pell-Lucas approximation method.The aim of this study is to observe the behavior of five populations after 200 days when drug treatment is applied to HIV-infectious and full-blown AIDS people.To demonstrate the usefulness of this method,the applications are made on the numerical example with the help of MATLAB.In addition,four cases of the fractional order derivative(p=1,p=0.95,p=0.9,p=0.85)are examined in the range[0,200].Owing to applications,we figured out that the outcomes have quite decent errors.Also,we understand that the errors decrease when the value of N increases.The figures in this study are created in MATLAB.The outcomes indicate that the presented method is reasonably sufficient and correct.
文摘A non-linear HIV-TB co-infection has been formulated and analyzed. The positivity and invariant region has been established. The disease free equilibrium and its stability has been determined. The local stability was determined and found to be stable under given conditions. The basic reproduction number was obtained and according to findings, co-infection diminishes when this number is less than unity, and persists when the number is greater than unity. The global stability of the endemic equilibrium was calculated. The impact of HIV on TB was established as well as the impact of TB on HIV. Numerical solution was also done and the findings indicate that when the rate of HIV treatment increases the latent TB increases while the co-infected population decreases. When the rate of HIV treatment decreases the latent TB population decreases and the co-infected population increases. Encouraging communities to prioritize the consistent treatment of HIV infected individuals must be emphasized in order to reduce the scourge of HIV-TB co-infection.
文摘目的了解凉山州新报告HIV感染者或艾滋病病人(简称HIV/AIDS病例)性别比的特征,并探索性别比的影响因素。方法通过中国艾滋病综合防治信息系统收集2019—2022年凉山州新报告的报告年龄15岁及以上、传播途径为异性传播HIV/AIDS病例的基本信息,分析凉山州不同地区、人口学特征、疾病特征的男女性别比差异;采用SPSS 22.0软件进行卡方检验、Fisher确切概率法、linear by linear association检验,并建立线性混合模型,分析男女性别比的影响因素。结果2019—2022年凉山州新报告15周岁及以上异性传播HIV/AIDS病例9963例,占全部新报告病例的76.08%,其中非婚非商业性传播病例占71.55%。凉山州四年新报告异性传播HIV/AIDS病例的男女性别比为1.19∶1,布拖、昭觉、金阳和美姑连续4年的性别比均小于1∶1。多因素分析结果显示:年龄越小,民族为彝族,文化程度越低,婚姻状态为离异或丧偶、已婚有配偶,常住人口,异性传播表现形式为非婚非商、配偶阳性,首次CD4^(+)T淋巴细胞计数越高,性别比越小,倒置越明显。结论2019—2022年凉山州新报告HIV/AIDS病例以非婚非商业性传播为主,布拖、昭觉、金阳和美姑等县女性的HIV感染风险高于男性。应进一步发挥学校、多媒体的作用,做好宣传教育工作;加强育龄妇女管理、单阳家庭管理和抗病毒治疗等工作,降低当地女性的艾滋病传播风险,控制艾滋病的传播。
