Preserving genetic diversity is crucial for the long-term survival of wild plant species,yet many remain at risk of genetic erosion due to small population sizes and habitat fragmentation.Here,we present a comparative...Preserving genetic diversity is crucial for the long-term survival of wild plant species,yet many remain at risk of genetic erosion due to small population sizes and habitat fragmentation.Here,we present a comparative genomic study of the critically endangered Oreocharis esquirolii(Gesneriaceae)and its widespread congener O.maximowiczii.We assembled and annotated chromosome-level reference genomes for both species and generated whole-genome resequencing data from 28 O.esquirolii and 79 O.maximowiczii individuals.Our analyses reveal substantially lower genetic diversity and higher inbreeding in O.esquirolii,despite its overall reduced mutational burden.Notably,O.esquirolii exhibits an elevated proportion of strongly deleterious mutations relative to O.maximowiczii,suggesting that limited opportunities for purging have allowed these variants to accumulate.These contrasting genomic profileslikely reflectdivergent demographic histories,with O.esquirolii having experienced severe bottlenecks and protracted population decline.Collectively,our findingshighlight the critically endangered status of O.esquirolii,characterized by diminished genetic diversity,pronounced inbreeding,and reduced ability to eliminate deleterious alleles.This study provides valuable genomic resources for the Gesneriaceae family and underscores the urgent need for targeted conservation measures,including habitat protection and ex situ preservation efforts,to mitigate the extinction risk facing O.esquirolii and potentially other threatened congeners.展开更多
The present investigation aims at unveiling the main causes of the recorded disparate phylogeographic patterning among the two highly dispersive coastal crab species Carcinus aestuarii and Pachygrapsus marmoratus in t...The present investigation aims at unveiling the main causes of the recorded disparate phylogeographic patterning among the two highly dispersive coastal crab species Carcinus aestuarii and Pachygrapsus marmoratus in the Mediterranean Sea.For this purpose,available mitochondrial and nuclear data for both species were re-analyzed and investigated for genetic polymorphism and differentiation patterns across three defined geographic scales in their distribution ranges,but also across the same locations in the Mediterranean Sea.The temporal frame of genetic diversification was also determined for both species in order to check whether observed differences in phylogeographic patterns among these coastal decapods could be attributed to different evolutionary histories.The obtained results revealed a more variable and diversified gene pool in the green crab C.aestuarii than the one recorded in the marbled crab P.marmoratus.Lack of significant correlation between pairwise genetic dissimilarities observed among C.aestuarii populations and those detected for P.marmoratus was notably discerned across the same defined Mediterranean locations.This finding indicates that the pattern of pairwise genetic differentiation does not vary in the same way in both examined crab species.Significant outputs of population genetic differentiation,retrieved within both species,were shown to be differently associated with the potential effects of various kinds of isolation processes(related to geography,environment and biogeographic boundary).Evolutionary history reconstruction showed older genetic diversification event in C.aestuarii than the one recorded in P.marmoratus.These recorded temporal frames suggest different modes of genetic diversification in both crab species(glacial vicariance for C.aestuarii and interglacial dispersal for P.marmoratus).They may also provide an explanation for the recorded differences in variation of patterns of population genetic diversity and structure,when integrated with species ecological requirements and life-history traits.展开更多
Genome size changes significantly among taxonomic levels,and this variation is often related to the patterns shaped by the phylogeny,life histories and ecological factors.However,there are mixed evidences on the main ...Genome size changes significantly among taxonomic levels,and this variation is often related to the patterns shaped by the phylogeny,life histories and ecological factors.However,there are mixed evidences on the main factors affecting molecular evolution in animals.In this study,we used phylogenetic comparative analysis to investigate the evolutionary rate of genome size and the relationships between genome size and life histories(i.e.,hatchling mass,clutch size,clutches per year,age at sexual maturity,lifespan and body mass)among 199 squamata species.Our results showed that the evolutionary rate of genome size in Lacertilia was significantly faster than Serpentes.Moreover,we also found that larger species showed larger hatchling mass,more clutches per year and clutch size and longer lifespan.However,genome size was negatively associated with clutch size and clutches per year,but not associated with body mass we looked at.The findings suggest that larger species do not possess the evolution of large genomes in squamata.展开更多
The collisional Himalayan orogen is commonly presented as largely laterally uniform from the NW–to NE–Himalaya,with almost similar geological and tectonic settings.Despite active continuous convergence and precipita...The collisional Himalayan orogen is commonly presented as largely laterally uniform from the NW–to NE–Himalaya,with almost similar geological and tectonic settings.Despite active continuous convergence and precipitation since many million years in the Himalaya,thermochronological/cooling age pattern,uplift and exhumation rates vary in different parts of NW–and NE–Himalaya as a function of structural positions such as dome/window/synform,klippen/nappe structures and thrusting/back-thrusting along different major faults.展开更多
This study focuses on Hong Kong youth,recognizing them as a vital subject within the context of“four histories”education.From the perspective of the integration of Lingnan culture,it explores the rich resources of L...This study focuses on Hong Kong youth,recognizing them as a vital subject within the context of“four histories”education.From the perspective of the integration of Lingnan culture,it explores the rich resources of Lingnan culture,innovates the narrative system,and explores the path of positive guidance in history education.Responding to the demands of the times,it seeks to alleviate the pressing concerns of Hong Kong society,help Hong Kong youth break down prejudices,gain a comprehensive understanding of China,grasp the development context of modern China,recognize historical trends,undertake national responsibilities,and take on the mission of the times.展开更多
The Taihu Lake,a large shallow lake in the floodplain of the Changjiang(Yangtze) River in the eastern China,is faced with challenging ecological problems resulting from eutrophication,which has affected the regional f...The Taihu Lake,a large shallow lake in the floodplain of the Changjiang(Yangtze) River in the eastern China,is faced with challenging ecological problems resulting from eutrophication,which has affected the regional freshwater supply of a large population.Although efforts have been made to assess the nutrient evolution histories in the northern bays,little is known regarding nutrient histories in different parts across the entire lake basin.In this paper,we present nutrient histories for different parts of the lake based on chironomid transfer functions applied to four short cores obtained from the northern,western and eastern regions of the lake.The chironomid-inferred total phosphorus(CI-TP) concentrations were compared with the phosphorus concentrations obtained by using instrumental and sedimentary data.The results suggest that trophic evolution histories were asynchronous throughout the lake during the past decades in response to different ecological regimes controlled by the nutrient input,wind direction and shoreline topography.The restoration of aquatic plants may be an effective option for the management of lake rehabilitation to ′natural′ conditions.Given the multiple factors controlling the biotic communities in such a large and complex lake,combined analyses among the multi-proxies encountered in the sediments are necessary for comprehensive insight into paleolimnological studies.The spatial heterogeneity in the ecological trajectories within this complicated ecosystem suggests that different management practices should be undertaken for specific lake zones in the Taihu Lake.展开更多
Medicine and knowledge of medical practice have been exchanged along the Silk Road since antiquity.Medical texts provide the vast majority of information about the drugs,techniques,and ideas that passed from foreign l...Medicine and knowledge of medical practice have been exchanged along the Silk Road since antiquity.Medical texts provide the vast majority of information about the drugs,techniques,and ideas that passed from foreign lands into China and became part of Chinese medicine.In addition to the medical corpus,historical works provide the backdrop for how,when,and from where these ideas and medicines entered and influenced Chinese medical practice.Examining the historical texts and the information pertaining to medical exchange can allow us to better understand how foreign cultures and practices of medicine along the Silk Road entered and influenced Chinese Medicine.展开更多
The electroencephalogram(EEG)rhythm and functional near-infrared spectroscopy(fNIRS)activation levels have not been compared between a healthy control group(HCG)and methamphetamine user group(MUG)with different addict...The electroencephalogram(EEG)rhythm and functional near-infrared spectroscopy(fNIRS)activation levels have not been compared between a healthy control group(HCG)and methamphetamine user group(MUG)with different addiction histories.This study used 64-electrode EEG and fNIRS to conduct an experiment that analyzed the resting and craving states.The EEG and fNIRS data of 56 participants were collected,including 14 healthy participants,14 methamphetamine users with an addiction history of 0.5–5 years,14 users with an addiction history of 5–10 years,and 14 users with an addiction history of 10–15 years.Isolated effective coherence(iCoh)within the brain network was used to process the EEG data.Statistical analysis was performed to compare differences in iCoh among the delta,theta,alpha,beta,and gamma bands and explore oxyhemoglobin activation levels in the ventrolateral prefrontal cortex,dorsolateral prefrontal cortex,orbitofrontal cortex,and frontopolar prefrontal cortex(FPC)of the control group.Finally,the Kmeans,Gaussian mixed model(GMM),linear discriminant analysis(LDA),support vector machine(SVM),Bayes,and convolutional neural networks(CNN)algorithms were used to classify methamphetamine users based on drug and neutral images.A 3-class accuracy was achieved.Changes in EEG and fNIRS activation levels of HCG and MUG with varied addiction histories were demonstrated.展开更多
After decades of low year classes,the stock of Japanese sardine(Sardinops melanostictus)has begun to recover since the mid-2000s.The hatch dates and otolith growth rates of age-0 juvenile sardine,which were collected ...After decades of low year classes,the stock of Japanese sardine(Sardinops melanostictus)has begun to recover since the mid-2000s.The hatch dates and otolith growth rates of age-0 juvenile sardine,which were collected in the subarctic Oyashio waters in autumn 2018,were determined from an otolith microstructure analysis.The sardines were hatched from late January to late April,while mostly in February and March.The otolith growth rate increased continuously up to 60 d after hatching and thereafter de-creased.The revealed growth rate in a crucial growth period is faster than that reported for juvenile sardines collected in the 1990s,which is coincided with the recent recovery trend of the sardine stock.Two groups with different hatch dates,growth histories,and migration routes were identified using unsupervised random forest clustering analysis.They were considered inshore and offshore migration individuals in accordance with recent researches.In the offshore group,a high proportion of sardine juveniles hatched late and grew faster in the Kuroshio-Oyashio transitional waters,a finding consistent with the hypothesis of growth-rate-dependent re-cruitment.This finding on the population composition and growth rate of juvenile sardine in the Oyashio waters can be a basis for an improved prediction of their survival and provides us with valuable information on the recruitment processes of this stock during the period of stock recovery.展开更多
Analysis of space shifting of geodetic center of China and the West,reveals that the China's geodetic center has been in coincidence with its political center. Furthermore the development of the maps in Europe was...Analysis of space shifting of geodetic center of China and the West,reveals that the China's geodetic center has been in coincidence with its political center. Furthermore the development of the maps in Europe was controlled by developmat of economy. Thereupon, maps in China and the West were developing in their own ways, and thus formed two different cartographic systems.Although China has a splendid cartogrphic history, it has not yet got many great breakthroughs. The reasons are as follows : 1. The theory of round earth has never occupied the ruling place, instead, the theory of flat earth took the dominant position. Thus the geodetic frameworks of China are not scientific. 2. Owing to the trammels of the theory that China is the whole earth, the Chinese geodetic workers have been limited in China's area. 3. Exchange between the East and the Weat is too late. The Chinese geodetic workers took a long time to accept the West geodetic technology. on the contrary, the West has absorbed the geodetic technology and results of China. 4. China's anciat gcodotic workers usually stopped after getting a little knowledge of a subject. They should have made great breakthroughs in geodetic area. Nevertheless, they failed.展开更多
Background: While brain imaging studies show that reward regions in the human brain that regulate reward-guided behavior and integrate sensory modalities of smell, taste, and texture respond preferentially to high cal...Background: While brain imaging studies show that reward regions in the human brain that regulate reward-guided behavior and integrate sensory modalities of smell, taste, and texture respond preferentially to high calorie foods, few studies account for dietary histories or account for recent behavioral evidence showing preferential responding for fruits (a low calorie food that tastes sweet). To address these concerns, the present study tested the hypothesis that images of high/low fat and sugar foods, even sugary foods that are low calorie (i.e., fruits), will enhance emotional responsiveness and that these changes may be related to dietary histories with fat and sugar intake. Method: Participants were shown 4 sets of 15 food images with each food image automatically timed every 9 s to transition to a new food image;participant pre-post mood and arousal was measured. The 4 sets of food images were high fat-high sugar (HFHS;desserts), high fat-low sugar (HFLS;fried foods), low fat-high sugar (LFHS;fruits), or low fat-low sugar (LFLS;vegetables) foods. To account for dietary histories, participants also completed estimated daily intake scales (EDIS) for sugar and fat. Results: Mood and arousal significantly increased in all groups, except Group LFLS, and even in a group that was low calorie but shown foods that taste sweet, i.e., Group LFHS. Interestingly, changes in arousal, but not mood, were dependent on participant histories with sugar and fat intake. Conclusion: Changes in emotional responsiveness to food images were nutrient-specific, which can be a more detailed level of analysis for assessing responsiveness to food images. Also, participant histories with sugar and fat should be taken into account as these histories can explain the changes in arousal observed here.展开更多
It has been a period of time since the concept of scenario earthquake was proposed, but this concept has rarely been used in seismic safety evaluation in China since then. Meanwhile, because of the uncertainties of ma...It has been a period of time since the concept of scenario earthquake was proposed, but this concept has rarely been used in seismic safety evaluation in China since then. Meanwhile, because of the uncertainties of magnitudes-distances pairs, there is large arbitrariness while determining the envelope function of time histories in seismic hazard analysis. In this paper, we describe a method to control the envelope functions of the time histories by introducing the most-likely combinations of magnitude and distance of the scenario earthquakes based on a probabilistic method, revise the software of the ellipse model for seismic hazard analysis, and give a computation example.展开更多
Via investigating typical Palaeozoic and Mesozoic petroleum-bearing basins in China by using thermal maturation theories of organic matter to improve the conventional Karweil’s method, a new method to reconstruct hyd...Via investigating typical Palaeozoic and Mesozoic petroleum-bearing basins in China by using thermal maturation theories of organic matter to improve the conventional Karweil’s method, a new method to reconstruct hydrocarbon-generating histories of source rocks has been suggested. This method, combining geological background with geochemical information makes the calculated VRo closer to the measured one. Moreover, it enables us to make clear the hydrocarbon generation trend of source rocks during geological history. The method has the merits of simple calculation and objective presentation, especially suitable to basins whose sedimentation and tectonic movements are complicated.展开更多
Background:Drama therapy as a discipline in clinical and public health areas dates back to movements in the Netherlands,Great Britain and the United States of America in the 1960s.Today,drama therapy comprises a huge ...Background:Drama therapy as a discipline in clinical and public health areas dates back to movements in the Netherlands,Great Britain and the United States of America in the 1960s.Today,drama therapy comprises a huge variety of methods and is applied in numerous medical domains such as psychiatry,pediatrics and neurogeriatrics.Nonetheless,historical and philosophical considerations suggest that at all times dramatic arts have encompassed curative potential and helped to promote mental health.Regarding this perspective,the present article aims to explore the spirit of drama therapy in ancient Chinese and Greek cultures.Methods:Involving cross-cultural psychiatry and medical anthropology,comparative research centred around salutary momentums inhering in drama and dramatic practices in Ancient China and Greece.The entire research process consisted of three phases:(i)screening of ancient Chinese and Greek dramatic rituals and arts to select phenomena and genres with pathological,therapeutic and mental health relevance;(ii)medical ontological processing,in particular from a psychopathological,psychiatric,psychotherapeutic and mental health scientific point of view,to explore and elucidate their curative and preventative features;(iii)transdisciplinary considerations about the evolution of drama therapy,as well as their diverse modes of artistic and medical reasoning.Results:The research process resulted in the identification of five(functional)roots of drama therapy,as well as public health benefits of dramatic arts:(i)dramatic rituals,stage-trance settings and spiritual immersion,(ii)mise-en-scène of divine spheres and alternative worlds,as well as scenic imagination and creative fusion of reality and fantasy,desire and satisfaction,(iii)anthropologic ontology,search of meaning and self-actualisation‘beyond codes and conventions’,(iv)personality traits and differential psychological symbolism,aesthetic self-exploration and auxiliary egos,(v)introjection and role-identity,inventive ways to tackle life problems,‘working through’and catharsis.Conclusion:Interdisciplinary constructivist reasoning suggests that dramatic arts and drama therapy share similar health promoting potential and innate therapeutic power.This calls for further research(i)to explore the entire spectrum of curative factors inhering in dramatic entities,(ii)to explain how drama-based interventions may alleviate mental-health issues alongside culturally sensitive differential diagnostic guidelines,and(iii)to optimise beneficial effects through advanced drama therapeutic settings.The present study suggests that dramatic arts shall also be studied with regard to public health challenges,self-regulation and self-care,mental resilience,well-being and quality of life,and emphatically advocates intensified collaboration between drama theory and drama therapy.展开更多
Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide ...Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide technology for good and prevent and control technological risks has become an important issue of global concern.Research on science and technology ethics is dedicated to integrating ethical theories into governance practices and constructing ethical models that adapt to the development of the times.Methods:This article systematically reviews the six core approaches of scientific and technological ethics thought,including technological autonomy and political philosophy criticism,responsibility ethics and intergenerational obligations,technological intermediation and the integration of life and the world,ethical principles and normative frameworks,participatory governance and ethical practice innovation,as well as domain-specific ethical norms,thereby constructing an ethical analysis framework applicable to medical technology risks.And cross-analysis was conducted by taking medical events such as gene editing and xenotransplantation as examples.Results:Research shows that a single ethical approach has limitations in addressing complex medical ethical challenges,while the six approaches are complementary and synergistic.By criticizing technological autonomy,establishing a responsibility ethics orientation,setting the bottom line of ethical principles,promoting participatory governance,formulating domain norms,and continuously reflecting on the intermediary nature of technology,a multi-level and dynamically adaptive governance system for scientific and technological ethics can be constructed.Conclusion:The key to addressing contemporary medical ethics challenges lies in the comprehensive application of science and technology ethics theories and the integration of ethical considerations throughout the entire process of scientific and technological research and development.In the future,a governance framework that adapts to the development of new technologies should be established to promote cross-cultural and cross-disciplinary ethical dialogue and public participation,ensuring that scientific and technological innovation always serves the dignity of human life and overall well-being.展开更多
This essay uses the notion of a symptom to examine the ways in which temporality is deployed in Hong Kong author Dung Kai-Cheung＇s 2007 novel, Histories o^Time. In particular, the essay follows Dung＇s own lead, in H...This essay uses the notion of a symptom to examine the ways in which temporality is deployed in Hong Kong author Dung Kai-Cheung＇s 2007 novel, Histories o^Time. In particular, the essay follows Dung＇s own lead, in Histories of Time, and considers the peculiar temporality implicit in the concept of figuration in Biblical hermeneutics, wherein the ＂figure＂ mediates between the two distinct--yet structurally related--temporalities of the Old and the New Testaments： the ＂prefiguration＂ of the Old Testament and the ＂fulfillment of figuration＂ of the New Testament. I propose that a literary ＂figure,＂ in Dung＇s work, similarly mediates between the different temporal planes within his novel, while at the same time mediating between the fictional space of the novel and the historical era within which the work is positioned. Just as a symptom is simultaneously a function of--but also structurally external to--the underlying condition that it signifies, this sort of literary figure may similarly be seen as a function of--but simultaneously external to--the historical era to which it corresponds. This sort of literary figure, accordingly, marks a point of rupture within the temporality of the novel and its corresponding era, while at the same time providing the ground on which that temporal continuum is established in the first place.展开更多
The Great Mosque of Quanzhou, as a distinctive community center, bound its residents through religious, professional, and educational ties; it also linked the mosque community to other communities with bonds of shared...The Great Mosque of Quanzhou, as a distinctive community center, bound its residents through religious, professional, and educational ties; it also linked the mosque community to other communities with bonds of shared Muslim identity and minority status. The Great Mosque was rebuilt in 1609 under the supervision of the Confucian scholar Li Guangjin. This significant event is evidence of a local elite fellowship in seventeenth-century Quanzhou consisting of three well-known Confucian scholars--Li Zhi, Li Guangjin, and He Qiaoyuan--who had close ties to their Muslim neighbors. They left meticulous records of merchants, particularly Muslim traders. This paper focuses on the fellowship among the three men in order to investigate Quanzhou＇s connections to the broader world of global commercial and religious networks and to look more closely at local community life.展开更多
Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.Recent evidence has challenged the classical view of the functio...Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.Recent evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to axons.Despite the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is lacking.We delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature oligodendrocytes.Indeed,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination preferences.Furthermore,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system region.Age and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric disorders.Nevertheless,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined investigations.Future studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte heterogeneity.Such research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,hold promise for the development of therapeutic interventions targeting varied central nervous system pathology.展开更多
基金supported by National Key R&D Program of China(2024YFF1307400)Guangdong S&T Program(2022B1111230001).
文摘Preserving genetic diversity is crucial for the long-term survival of wild plant species,yet many remain at risk of genetic erosion due to small population sizes and habitat fragmentation.Here,we present a comparative genomic study of the critically endangered Oreocharis esquirolii(Gesneriaceae)and its widespread congener O.maximowiczii.We assembled and annotated chromosome-level reference genomes for both species and generated whole-genome resequencing data from 28 O.esquirolii and 79 O.maximowiczii individuals.Our analyses reveal substantially lower genetic diversity and higher inbreeding in O.esquirolii,despite its overall reduced mutational burden.Notably,O.esquirolii exhibits an elevated proportion of strongly deleterious mutations relative to O.maximowiczii,suggesting that limited opportunities for purging have allowed these variants to accumulate.These contrasting genomic profileslikely reflectdivergent demographic histories,with O.esquirolii having experienced severe bottlenecks and protracted population decline.Collectively,our findingshighlight the critically endangered status of O.esquirolii,characterized by diminished genetic diversity,pronounced inbreeding,and reduced ability to eliminate deleterious alleles.This study provides valuable genomic resources for the Gesneriaceae family and underscores the urgent need for targeted conservation measures,including habitat protection and ex situ preservation efforts,to mitigate the extinction risk facing O.esquirolii and potentially other threatened congeners.
文摘The present investigation aims at unveiling the main causes of the recorded disparate phylogeographic patterning among the two highly dispersive coastal crab species Carcinus aestuarii and Pachygrapsus marmoratus in the Mediterranean Sea.For this purpose,available mitochondrial and nuclear data for both species were re-analyzed and investigated for genetic polymorphism and differentiation patterns across three defined geographic scales in their distribution ranges,but also across the same locations in the Mediterranean Sea.The temporal frame of genetic diversification was also determined for both species in order to check whether observed differences in phylogeographic patterns among these coastal decapods could be attributed to different evolutionary histories.The obtained results revealed a more variable and diversified gene pool in the green crab C.aestuarii than the one recorded in the marbled crab P.marmoratus.Lack of significant correlation between pairwise genetic dissimilarities observed among C.aestuarii populations and those detected for P.marmoratus was notably discerned across the same defined Mediterranean locations.This finding indicates that the pattern of pairwise genetic differentiation does not vary in the same way in both examined crab species.Significant outputs of population genetic differentiation,retrieved within both species,were shown to be differently associated with the potential effects of various kinds of isolation processes(related to geography,environment and biogeographic boundary).Evolutionary history reconstruction showed older genetic diversification event in C.aestuarii than the one recorded in P.marmoratus.These recorded temporal frames suggest different modes of genetic diversification in both crab species(glacial vicariance for C.aestuarii and interglacial dispersal for P.marmoratus).They may also provide an explanation for the recorded differences in variation of patterns of population genetic diversity and structure,when integrated with species ecological requirements and life-history traits.
基金Financial support was provided by the National Natural Sciences Foundation of China(31772451,31970393)the Science and Technology Youth Innovation Team of Sichuan Province(2019JDTD0012)。
文摘Genome size changes significantly among taxonomic levels,and this variation is often related to the patterns shaped by the phylogeny,life histories and ecological factors.However,there are mixed evidences on the main factors affecting molecular evolution in animals.In this study,we used phylogenetic comparative analysis to investigate the evolutionary rate of genome size and the relationships between genome size and life histories(i.e.,hatchling mass,clutch size,clutches per year,age at sexual maturity,lifespan and body mass)among 199 squamata species.Our results showed that the evolutionary rate of genome size in Lacertilia was significantly faster than Serpentes.Moreover,we also found that larger species showed larger hatchling mass,more clutches per year and clutch size and longer lifespan.However,genome size was negatively associated with clutch size and clutches per year,but not associated with body mass we looked at.The findings suggest that larger species do not possess the evolution of large genomes in squamata.
基金financially supported by Department of Science and Technology,Government of India’s research project no.IR/S4/ESF-15/2009 awarded to R.C.Patel.
文摘The collisional Himalayan orogen is commonly presented as largely laterally uniform from the NW–to NE–Himalaya,with almost similar geological and tectonic settings.Despite active continuous convergence and precipitation since many million years in the Himalaya,thermochronological/cooling age pattern,uplift and exhumation rates vary in different parts of NW–and NE–Himalaya as a function of structural positions such as dome/window/synform,klippen/nappe structures and thrusting/back-thrusting along different major faults.
基金2021 Guangdong Provincial Education Science Planning Project(Moral Education Special)“Constructing Situation to Narrate:Exploring Lingnan Cultural Resources for Telling the China Story Well”(2021JKDY064)2021 Shenzhen Education Science Key Funding Project(14th Five-Year Plan)“Contradiction,Motivation,and Purpose:An Exploration of the Needs for a Better Life for Cross-Border Schoolchildren between Shenzhen and Hong Kong”(SZIIT2022SK037)。
文摘This study focuses on Hong Kong youth,recognizing them as a vital subject within the context of“four histories”education.From the perspective of the integration of Lingnan culture,it explores the rich resources of Lingnan culture,innovates the narrative system,and explores the path of positive guidance in history education.Responding to the demands of the times,it seeks to alleviate the pressing concerns of Hong Kong society,help Hong Kong youth break down prejudices,gain a comprehensive understanding of China,grasp the development context of modern China,recognize historical trends,undertake national responsibilities,and take on the mission of the times.
基金Under the auspices of National Basic Research Program of China(No.2012CB9561002008CB418103)National Natural Science Foundation of China(No.41072267)
文摘The Taihu Lake,a large shallow lake in the floodplain of the Changjiang(Yangtze) River in the eastern China,is faced with challenging ecological problems resulting from eutrophication,which has affected the regional freshwater supply of a large population.Although efforts have been made to assess the nutrient evolution histories in the northern bays,little is known regarding nutrient histories in different parts across the entire lake basin.In this paper,we present nutrient histories for different parts of the lake based on chironomid transfer functions applied to four short cores obtained from the northern,western and eastern regions of the lake.The chironomid-inferred total phosphorus(CI-TP) concentrations were compared with the phosphorus concentrations obtained by using instrumental and sedimentary data.The results suggest that trophic evolution histories were asynchronous throughout the lake during the past decades in response to different ecological regimes controlled by the nutrient input,wind direction and shoreline topography.The restoration of aquatic plants may be an effective option for the management of lake rehabilitation to ′natural′ conditions.Given the multiple factors controlling the biotic communities in such a large and complex lake,combined analyses among the multi-proxies encountered in the sediments are necessary for comprehensive insight into paleolimnological studies.The spatial heterogeneity in the ecological trajectories within this complicated ecosystem suggests that different management practices should be undertaken for specific lake zones in the Taihu Lake.
文摘Medicine and knowledge of medical practice have been exchanged along the Silk Road since antiquity.Medical texts provide the vast majority of information about the drugs,techniques,and ideas that passed from foreign lands into China and became part of Chinese medicine.In addition to the medical corpus,historical works provide the backdrop for how,when,and from where these ideas and medicines entered and influenced Chinese medical practice.Examining the historical texts and the information pertaining to medical exchange can allow us to better understand how foreign cultures and practices of medicine along the Silk Road entered and influenced Chinese Medicine.
基金supported by Shanghai Municipal Science and Technology Plan Project(No.22010502400)National Natural Science Foundation of China(Nos.82072228,92048205,and 62376149).
文摘The electroencephalogram(EEG)rhythm and functional near-infrared spectroscopy(fNIRS)activation levels have not been compared between a healthy control group(HCG)and methamphetamine user group(MUG)with different addiction histories.This study used 64-electrode EEG and fNIRS to conduct an experiment that analyzed the resting and craving states.The EEG and fNIRS data of 56 participants were collected,including 14 healthy participants,14 methamphetamine users with an addiction history of 0.5–5 years,14 users with an addiction history of 5–10 years,and 14 users with an addiction history of 10–15 years.Isolated effective coherence(iCoh)within the brain network was used to process the EEG data.Statistical analysis was performed to compare differences in iCoh among the delta,theta,alpha,beta,and gamma bands and explore oxyhemoglobin activation levels in the ventrolateral prefrontal cortex,dorsolateral prefrontal cortex,orbitofrontal cortex,and frontopolar prefrontal cortex(FPC)of the control group.Finally,the Kmeans,Gaussian mixed model(GMM),linear discriminant analysis(LDA),support vector machine(SVM),Bayes,and convolutional neural networks(CNN)algorithms were used to classify methamphetamine users based on drug and neutral images.A 3-class accuracy was achieved.Changes in EEG and fNIRS activation levels of HCG and MUG with varied addiction histories were demonstrated.
基金supported by the National Natural Science Foundation of China(Nos.41930534,41861134-037,and 41876177)funding to the Third Institute of Oceanography through the National Program on Global Change and Air-Sea Interaction(No.GASI-02-PAC-YDaut).
文摘After decades of low year classes,the stock of Japanese sardine(Sardinops melanostictus)has begun to recover since the mid-2000s.The hatch dates and otolith growth rates of age-0 juvenile sardine,which were collected in the subarctic Oyashio waters in autumn 2018,were determined from an otolith microstructure analysis.The sardines were hatched from late January to late April,while mostly in February and March.The otolith growth rate increased continuously up to 60 d after hatching and thereafter de-creased.The revealed growth rate in a crucial growth period is faster than that reported for juvenile sardines collected in the 1990s,which is coincided with the recent recovery trend of the sardine stock.Two groups with different hatch dates,growth histories,and migration routes were identified using unsupervised random forest clustering analysis.They were considered inshore and offshore migration individuals in accordance with recent researches.In the offshore group,a high proportion of sardine juveniles hatched late and grew faster in the Kuroshio-Oyashio transitional waters,a finding consistent with the hypothesis of growth-rate-dependent re-cruitment.This finding on the population composition and growth rate of juvenile sardine in the Oyashio waters can be a basis for an improved prediction of their survival and provides us with valuable information on the recruitment processes of this stock during the period of stock recovery.
文摘Analysis of space shifting of geodetic center of China and the West,reveals that the China's geodetic center has been in coincidence with its political center. Furthermore the development of the maps in Europe was controlled by developmat of economy. Thereupon, maps in China and the West were developing in their own ways, and thus formed two different cartographic systems.Although China has a splendid cartogrphic history, it has not yet got many great breakthroughs. The reasons are as follows : 1. The theory of round earth has never occupied the ruling place, instead, the theory of flat earth took the dominant position. Thus the geodetic frameworks of China are not scientific. 2. Owing to the trammels of the theory that China is the whole earth, the Chinese geodetic workers have been limited in China's area. 3. Exchange between the East and the Weat is too late. The Chinese geodetic workers took a long time to accept the West geodetic technology. on the contrary, the West has absorbed the geodetic technology and results of China. 4. China's anciat gcodotic workers usually stopped after getting a little knowledge of a subject. They should have made great breakthroughs in geodetic area. Nevertheless, they failed.
文摘Background: While brain imaging studies show that reward regions in the human brain that regulate reward-guided behavior and integrate sensory modalities of smell, taste, and texture respond preferentially to high calorie foods, few studies account for dietary histories or account for recent behavioral evidence showing preferential responding for fruits (a low calorie food that tastes sweet). To address these concerns, the present study tested the hypothesis that images of high/low fat and sugar foods, even sugary foods that are low calorie (i.e., fruits), will enhance emotional responsiveness and that these changes may be related to dietary histories with fat and sugar intake. Method: Participants were shown 4 sets of 15 food images with each food image automatically timed every 9 s to transition to a new food image;participant pre-post mood and arousal was measured. The 4 sets of food images were high fat-high sugar (HFHS;desserts), high fat-low sugar (HFLS;fried foods), low fat-high sugar (LFHS;fruits), or low fat-low sugar (LFLS;vegetables) foods. To account for dietary histories, participants also completed estimated daily intake scales (EDIS) for sugar and fat. Results: Mood and arousal significantly increased in all groups, except Group LFLS, and even in a group that was low calorie but shown foods that taste sweet, i.e., Group LFHS. Interestingly, changes in arousal, but not mood, were dependent on participant histories with sugar and fat intake. Conclusion: Changes in emotional responsiveness to food images were nutrient-specific, which can be a more detailed level of analysis for assessing responsiveness to food images. Also, participant histories with sugar and fat should be taken into account as these histories can explain the changes in arousal observed here.
基金sponsored under the keyresearch project of social development of Zhejiang Province(2005C23075)
文摘It has been a period of time since the concept of scenario earthquake was proposed, but this concept has rarely been used in seismic safety evaluation in China since then. Meanwhile, because of the uncertainties of magnitudes-distances pairs, there is large arbitrariness while determining the envelope function of time histories in seismic hazard analysis. In this paper, we describe a method to control the envelope functions of the time histories by introducing the most-likely combinations of magnitude and distance of the scenario earthquakes based on a probabilistic method, revise the software of the ellipse model for seismic hazard analysis, and give a computation example.
文摘Via investigating typical Palaeozoic and Mesozoic petroleum-bearing basins in China by using thermal maturation theories of organic matter to improve the conventional Karweil’s method, a new method to reconstruct hydrocarbon-generating histories of source rocks has been suggested. This method, combining geological background with geochemical information makes the calculated VRo closer to the measured one. Moreover, it enables us to make clear the hydrocarbon generation trend of source rocks during geological history. The method has the merits of simple calculation and objective presentation, especially suitable to basins whose sedimentation and tectonic movements are complicated.
文摘Background:Drama therapy as a discipline in clinical and public health areas dates back to movements in the Netherlands,Great Britain and the United States of America in the 1960s.Today,drama therapy comprises a huge variety of methods and is applied in numerous medical domains such as psychiatry,pediatrics and neurogeriatrics.Nonetheless,historical and philosophical considerations suggest that at all times dramatic arts have encompassed curative potential and helped to promote mental health.Regarding this perspective,the present article aims to explore the spirit of drama therapy in ancient Chinese and Greek cultures.Methods:Involving cross-cultural psychiatry and medical anthropology,comparative research centred around salutary momentums inhering in drama and dramatic practices in Ancient China and Greece.The entire research process consisted of three phases:(i)screening of ancient Chinese and Greek dramatic rituals and arts to select phenomena and genres with pathological,therapeutic and mental health relevance;(ii)medical ontological processing,in particular from a psychopathological,psychiatric,psychotherapeutic and mental health scientific point of view,to explore and elucidate their curative and preventative features;(iii)transdisciplinary considerations about the evolution of drama therapy,as well as their diverse modes of artistic and medical reasoning.Results:The research process resulted in the identification of five(functional)roots of drama therapy,as well as public health benefits of dramatic arts:(i)dramatic rituals,stage-trance settings and spiritual immersion,(ii)mise-en-scène of divine spheres and alternative worlds,as well as scenic imagination and creative fusion of reality and fantasy,desire and satisfaction,(iii)anthropologic ontology,search of meaning and self-actualisation‘beyond codes and conventions’,(iv)personality traits and differential psychological symbolism,aesthetic self-exploration and auxiliary egos,(v)introjection and role-identity,inventive ways to tackle life problems,‘working through’and catharsis.Conclusion:Interdisciplinary constructivist reasoning suggests that dramatic arts and drama therapy share similar health promoting potential and innate therapeutic power.This calls for further research(i)to explore the entire spectrum of curative factors inhering in dramatic entities,(ii)to explain how drama-based interventions may alleviate mental-health issues alongside culturally sensitive differential diagnostic guidelines,and(iii)to optimise beneficial effects through advanced drama therapeutic settings.The present study suggests that dramatic arts shall also be studied with regard to public health challenges,self-regulation and self-care,mental resilience,well-being and quality of life,and emphatically advocates intensified collaboration between drama theory and drama therapy.
基金supported by the National Key Research and Development Program(Grant No.2024YFA0917200)the Projects of the Chinese Center for Disease Control and Prevention(Grant No.BB2110240093)World Medical History under the Education Innovation Plan of the University of Science and Technology of China(Grant No.2024YCHX07).
文摘Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide technology for good and prevent and control technological risks has become an important issue of global concern.Research on science and technology ethics is dedicated to integrating ethical theories into governance practices and constructing ethical models that adapt to the development of the times.Methods:This article systematically reviews the six core approaches of scientific and technological ethics thought,including technological autonomy and political philosophy criticism,responsibility ethics and intergenerational obligations,technological intermediation and the integration of life and the world,ethical principles and normative frameworks,participatory governance and ethical practice innovation,as well as domain-specific ethical norms,thereby constructing an ethical analysis framework applicable to medical technology risks.And cross-analysis was conducted by taking medical events such as gene editing and xenotransplantation as examples.Results:Research shows that a single ethical approach has limitations in addressing complex medical ethical challenges,while the six approaches are complementary and synergistic.By criticizing technological autonomy,establishing a responsibility ethics orientation,setting the bottom line of ethical principles,promoting participatory governance,formulating domain norms,and continuously reflecting on the intermediary nature of technology,a multi-level and dynamically adaptive governance system for scientific and technological ethics can be constructed.Conclusion:The key to addressing contemporary medical ethics challenges lies in the comprehensive application of science and technology ethics theories and the integration of ethical considerations throughout the entire process of scientific and technological research and development.In the future,a governance framework that adapts to the development of new technologies should be established to promote cross-cultural and cross-disciplinary ethical dialogue and public participation,ensuring that scientific and technological innovation always serves the dignity of human life and overall well-being.
文摘This essay uses the notion of a symptom to examine the ways in which temporality is deployed in Hong Kong author Dung Kai-Cheung＇s 2007 novel, Histories o^Time. In particular, the essay follows Dung＇s own lead, in Histories of Time, and considers the peculiar temporality implicit in the concept of figuration in Biblical hermeneutics, wherein the ＂figure＂ mediates between the two distinct--yet structurally related--temporalities of the Old and the New Testaments： the ＂prefiguration＂ of the Old Testament and the ＂fulfillment of figuration＂ of the New Testament. I propose that a literary ＂figure,＂ in Dung＇s work, similarly mediates between the different temporal planes within his novel, while at the same time mediating between the fictional space of the novel and the historical era within which the work is positioned. Just as a symptom is simultaneously a function of--but also structurally external to--the underlying condition that it signifies, this sort of literary figure may similarly be seen as a function of--but simultaneously external to--the historical era to which it corresponds. This sort of literary figure, accordingly, marks a point of rupture within the temporality of the novel and its corresponding era, while at the same time providing the ground on which that temporal continuum is established in the first place.
文摘The Great Mosque of Quanzhou, as a distinctive community center, bound its residents through religious, professional, and educational ties; it also linked the mosque community to other communities with bonds of shared Muslim identity and minority status. The Great Mosque was rebuilt in 1609 under the supervision of the Confucian scholar Li Guangjin. This significant event is evidence of a local elite fellowship in seventeenth-century Quanzhou consisting of three well-known Confucian scholars--Li Zhi, Li Guangjin, and He Qiaoyuan--who had close ties to their Muslim neighbors. They left meticulous records of merchants, particularly Muslim traders. This paper focuses on the fellowship among the three men in order to investigate Quanzhou＇s connections to the broader world of global commercial and religious networks and to look more closely at local community life.
基金supported by a grant from the Progressive MS Alliance(BRAVE in MS)Le Grand Portage Fund。
文摘Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.Recent evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to axons.Despite the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is lacking.We delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature oligodendrocytes.Indeed,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination preferences.Furthermore,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system region.Age and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric disorders.Nevertheless,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined investigations.Future studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte heterogeneity.Such research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,hold promise for the development of therapeutic interventions targeting varied central nervous system pathology.
