Purpose To investigate the feasibility of a municipality-based 16-week group-based HIFT-program(e.g.CrossFit)as a part of the physical rehabilitation of cancer survivors at different stages of cancer treatment.Methods...Purpose To investigate the feasibility of a municipality-based 16-week group-based HIFT-program(e.g.CrossFit)as a part of the physical rehabilitation of cancer survivors at different stages of cancer treatment.Methods Non-randomised clinical feasibility study.Younger adult patients(age 18-44 years)diagnosed with cancer who were referred to rehabilitation between August 2019 to December 2019 were eligible for inclusion.The group-based HIFT intervention was designed as a 16-week program with two sessions weekly(1.25 h each).The intervention program was not developed with pre-defined progression in terms of gradually added resistance,intensity,or volume during the 16 weeks period but the physiotherapist leading the sessions was trained in scalability.Feasibility was evaluated as retention,adher-ence,and accrual rates.Data on quality of life and cancer-related fatigue were measured EORTC QLQ-C-30 and evaluated using paired t-tests or Wilcoxon signed-rank test.Results Eighty-three percent of the eligible patients were included and initiated the HIFT program.However,25%of the patients were not adherent to the intervention and only 34% of the patients were still adherent to the intervention after 4 months.Nonetheless,a significant improvement in cancer specific HRQoL was found from baseline[Mean=53.4,95%CI(47.6,59.1)]to the end of the intervention[Mean=66.3,95%CI(60.8,71.9)].Conclusion It is possible to recruit patients diagnosed with cancer to a municipality-based HIFT rehabilitation program,however,adherence to the intervention is found to be difficult for the majority of the patients.展开更多
Exercise has been shown to influence gut microbiota composition,but the specific effects of different exercise modalities on microbial diversity remain unclear.Understanding these differences is essential for optimizi...Exercise has been shown to influence gut microbiota composition,but the specific effects of different exercise modalities on microbial diversity remain unclear.Understanding these differences is essential for optimizing exercise programs to enhance both physical fitness and gut health.This study compared the gut microbiota profiles of participants undergoing moderate-intensity continuous training(MICT),high-intensity interval training(HIIT),and high-intensity functional training(HIFT)using 16S rRNA gene sequencing.Thirty-one previously untrained healthy university students were randomly assigned into MICT(n=7),HIIT(n=12)and HIFT(n=12).The results revealed that distinct gut microbiome profiles in participants under different exercise modes.Notably,the alpha-diversity gradually increased from the MICT group to the HIFT group.In addition,there was a progressive shift towards a Faecalibacterium-dominated microbial type from HIIT to HIFT group compared to MICT group.Individuals in the HIFT group were identified to be enriched with Lactobacillus and Limosilactobacillus,along with reduced Actinomyces and Anaeromassilibacillus.Functionally,the KEGG pathway and enzyme analysis using PICRUST2 revealed that the HIFT group exhibited prominence in muscle function-related pathways and enzymes,specifically ko00280(valine,leucine,and isoleucine degradation),as well as the enzyme EC:3.4.11.14(alanine aminopeptidase).In conclusion,these findings highlight how exercise modality influences gut microbial diversity,with HIFT promoting a more favorable microbial profile compared to traditional endurance training.Understanding these effects can help tailor exercise programs to improve both fitness and gut health.展开更多
基金Open access funding provided by National Hospital.
文摘Purpose To investigate the feasibility of a municipality-based 16-week group-based HIFT-program(e.g.CrossFit)as a part of the physical rehabilitation of cancer survivors at different stages of cancer treatment.Methods Non-randomised clinical feasibility study.Younger adult patients(age 18-44 years)diagnosed with cancer who were referred to rehabilitation between August 2019 to December 2019 were eligible for inclusion.The group-based HIFT intervention was designed as a 16-week program with two sessions weekly(1.25 h each).The intervention program was not developed with pre-defined progression in terms of gradually added resistance,intensity,or volume during the 16 weeks period but the physiotherapist leading the sessions was trained in scalability.Feasibility was evaluated as retention,adher-ence,and accrual rates.Data on quality of life and cancer-related fatigue were measured EORTC QLQ-C-30 and evaluated using paired t-tests or Wilcoxon signed-rank test.Results Eighty-three percent of the eligible patients were included and initiated the HIFT program.However,25%of the patients were not adherent to the intervention and only 34% of the patients were still adherent to the intervention after 4 months.Nonetheless,a significant improvement in cancer specific HRQoL was found from baseline[Mean=53.4,95%CI(47.6,59.1)]to the end of the intervention[Mean=66.3,95%CI(60.8,71.9)].Conclusion It is possible to recruit patients diagnosed with cancer to a municipality-based HIFT rehabilitation program,however,adherence to the intervention is found to be difficult for the majority of the patients.
基金supported by the National Natural Science Foundation of China(82300496)Beijing Hospitals Authority Clinical medicine Development of special funding support(XMLX202135)Capital’s Funds for Health Improvement and Research(Key Research Program)NO.CFH 2024-1-4061.
文摘Exercise has been shown to influence gut microbiota composition,but the specific effects of different exercise modalities on microbial diversity remain unclear.Understanding these differences is essential for optimizing exercise programs to enhance both physical fitness and gut health.This study compared the gut microbiota profiles of participants undergoing moderate-intensity continuous training(MICT),high-intensity interval training(HIIT),and high-intensity functional training(HIFT)using 16S rRNA gene sequencing.Thirty-one previously untrained healthy university students were randomly assigned into MICT(n=7),HIIT(n=12)and HIFT(n=12).The results revealed that distinct gut microbiome profiles in participants under different exercise modes.Notably,the alpha-diversity gradually increased from the MICT group to the HIFT group.In addition,there was a progressive shift towards a Faecalibacterium-dominated microbial type from HIIT to HIFT group compared to MICT group.Individuals in the HIFT group were identified to be enriched with Lactobacillus and Limosilactobacillus,along with reduced Actinomyces and Anaeromassilibacillus.Functionally,the KEGG pathway and enzyme analysis using PICRUST2 revealed that the HIFT group exhibited prominence in muscle function-related pathways and enzymes,specifically ko00280(valine,leucine,and isoleucine degradation),as well as the enzyme EC:3.4.11.14(alanine aminopeptidase).In conclusion,these findings highlight how exercise modality influences gut microbial diversity,with HIFT promoting a more favorable microbial profile compared to traditional endurance training.Understanding these effects can help tailor exercise programs to improve both fitness and gut health.
