Hereditary hemochromatosis (HH) is defined as an autosomal recessive iron metabolism disorder, typically characterized by excessive iron absorption leading to iron overload in multiple organs, particularly the liver, ...Hereditary hemochromatosis (HH) is defined as an autosomal recessive iron metabolism disorder, typically characterized by excessive iron absorption leading to iron overload in multiple organs, particularly the liver, heart, and endocrine glands. Clinical manifestations commonly include diabetes, skin pigmentation, cirrhosis, abdominal pain, arthralgia, and fatigue. Mutations in the HFEgene, located on chromosome 6p22, have been identified as the primary genetic basis of HH. This gene encodes a protein critical for iron absorption and metabolism. Studies indicate that HH is most prevalent in European populations but rare in Asians. Due to reduced iron accumulation from menstrual blood loss in females, the disease predominantly affects adult males, with females often developing symptoms post-menopause. This article reports a rare case of HHin a premenopausal Chinese female caused by a homozygous HFE gene mutation (c.340 + 4T > C). The patient presented with chronic fatigue, abdominal pain, and lower limb petechiae. Diagnosis was confirmed via clinical evaluation, laboratory tests, and genetic analysis. This study identifies a novel pathogenic mutation in the Chinese population, contributing to early diagnosis and treatment of HH.展开更多
为了获得氢氟醚HFE7100、HFE7500的热物理性质参数,补充现有数据不足,为其作为电子元器件的冷却介质、工业清洗剂等工程应用提供技术支持,利用瞬态热线法测量了常压下HFE7100和HFE7500的热导率,并用表面光散射法测量了HFE7100和HFE7500...为了获得氢氟醚HFE7100、HFE7500的热物理性质参数,补充现有数据不足,为其作为电子元器件的冷却介质、工业清洗剂等工程应用提供技术支持,利用瞬态热线法测量了常压下HFE7100和HFE7500的热导率,并用表面光散射法测量了HFE7100和HFE7500的液相黏度和表面张力。HFE7100和HFE7500的热导率和液相黏度均关联成温度的多项式函数,HFE7100热导率和黏度的实验值和关联式的平均绝对偏差分别为0.37%和1.19%,HFE7500热导率和黏度的实验值和关联式的平均绝对偏差分别0.08%和1.10%。利用改进的van der Waals关联表面张力和温度的关系,HFE7100和HFE7500的表面张力的实验值和关联式的平均绝对偏差分别为0.03 m N·m-1和0.02 m N·m-1。获得的HFE7100和HFE7500的热导率、黏度和表面张力实验数据及方程,可为其工程应用提出数据支持。展开更多
纠错密码是一种利用纠错码体制来实现纠错和加密双重功能的一种密码体制。大部分已知的纠错密码从变换的角度看是一种对明文的线性变换。从密码分析的角度看,由于不具有非线性变换,密码的混淆能力不强,容易被攻击。利用纠错码(Error-Cor...纠错密码是一种利用纠错码体制来实现纠错和加密双重功能的一种密码体制。大部分已知的纠错密码从变换的角度看是一种对明文的线性变换。从密码分析的角度看,由于不具有非线性变换,密码的混淆能力不强,容易被攻击。利用纠错码(Error-Correction Code,ECC)改造基本HFE(Hidden Field Equations)密码算法,所得的新密码算法具有纠错和加密功能,而且因其具有概率密码特性以及建立在MQ困难问题之上,具有很高的安全强度。展开更多
目的采用Meta分析方法评价HFE基因C28Y与H63D突变型与肝癌发生的相关性。方法计算机检索PubMed、CNKI、中国知网和万方数据库HFE基因型与肝癌发生相关的病例对照研究,相关文献的查找采用文献追溯方法。检索时限是从建库至2016年1月。按...目的采用Meta分析方法评价HFE基因C28Y与H63D突变型与肝癌发生的相关性。方法计算机检索PubMed、CNKI、中国知网和万方数据库HFE基因型与肝癌发生相关的病例对照研究,相关文献的查找采用文献追溯方法。检索时限是从建库至2016年1月。按照纳入和排除标准选择文献,并进行提取资料和评价质量,用RevMan 5.0软件进行Meta分析及评估文献的发表偏倚。结果最终纳入14篇文章,C282Y研究组共纳入病例组2418人,对照组9022人;H63D研究组病例组2208人,对照组6170人。Meta分析结果显示,C282Y研究组等位基因(C vs Y)Y基因的表达为肝癌发生的危险因素[OR=1.58,95%CI(1.06,2.33)],对基因分型进行的分层研究,结果表明与携带CC基因型人群相比,携带YY基因型(YY vs CC)患肿瘤风险增高[OR=5.71,95%CI(2.81,11.62)]。携带隐性基因型YY与另外两种基因型(YY vs CC+CY)同样增高患肿瘤的风险[OR=5.71,95%CI(2.81,11.38)]。结论HFE基因型C282Y突变基因的表达是肝癌发生的危险因素。展开更多
文摘Hereditary hemochromatosis (HH) is defined as an autosomal recessive iron metabolism disorder, typically characterized by excessive iron absorption leading to iron overload in multiple organs, particularly the liver, heart, and endocrine glands. Clinical manifestations commonly include diabetes, skin pigmentation, cirrhosis, abdominal pain, arthralgia, and fatigue. Mutations in the HFEgene, located on chromosome 6p22, have been identified as the primary genetic basis of HH. This gene encodes a protein critical for iron absorption and metabolism. Studies indicate that HH is most prevalent in European populations but rare in Asians. Due to reduced iron accumulation from menstrual blood loss in females, the disease predominantly affects adult males, with females often developing symptoms post-menopause. This article reports a rare case of HHin a premenopausal Chinese female caused by a homozygous HFE gene mutation (c.340 + 4T > C). The patient presented with chronic fatigue, abdominal pain, and lower limb petechiae. Diagnosis was confirmed via clinical evaluation, laboratory tests, and genetic analysis. This study identifies a novel pathogenic mutation in the Chinese population, contributing to early diagnosis and treatment of HH.
文摘为了获得氢氟醚HFE7100、HFE7500的热物理性质参数,补充现有数据不足,为其作为电子元器件的冷却介质、工业清洗剂等工程应用提供技术支持,利用瞬态热线法测量了常压下HFE7100和HFE7500的热导率,并用表面光散射法测量了HFE7100和HFE7500的液相黏度和表面张力。HFE7100和HFE7500的热导率和液相黏度均关联成温度的多项式函数,HFE7100热导率和黏度的实验值和关联式的平均绝对偏差分别为0.37%和1.19%,HFE7500热导率和黏度的实验值和关联式的平均绝对偏差分别0.08%和1.10%。利用改进的van der Waals关联表面张力和温度的关系,HFE7100和HFE7500的表面张力的实验值和关联式的平均绝对偏差分别为0.03 m N·m-1和0.02 m N·m-1。获得的HFE7100和HFE7500的热导率、黏度和表面张力实验数据及方程,可为其工程应用提出数据支持。
文摘纠错密码是一种利用纠错码体制来实现纠错和加密双重功能的一种密码体制。大部分已知的纠错密码从变换的角度看是一种对明文的线性变换。从密码分析的角度看,由于不具有非线性变换,密码的混淆能力不强,容易被攻击。利用纠错码(Error-Correction Code,ECC)改造基本HFE(Hidden Field Equations)密码算法,所得的新密码算法具有纠错和加密功能,而且因其具有概率密码特性以及建立在MQ困难问题之上,具有很高的安全强度。
文摘目的采用Meta分析方法评价HFE基因C28Y与H63D突变型与肝癌发生的相关性。方法计算机检索PubMed、CNKI、中国知网和万方数据库HFE基因型与肝癌发生相关的病例对照研究,相关文献的查找采用文献追溯方法。检索时限是从建库至2016年1月。按照纳入和排除标准选择文献,并进行提取资料和评价质量,用RevMan 5.0软件进行Meta分析及评估文献的发表偏倚。结果最终纳入14篇文章,C282Y研究组共纳入病例组2418人,对照组9022人;H63D研究组病例组2208人,对照组6170人。Meta分析结果显示,C282Y研究组等位基因(C vs Y)Y基因的表达为肝癌发生的危险因素[OR=1.58,95%CI(1.06,2.33)],对基因分型进行的分层研究,结果表明与携带CC基因型人群相比,携带YY基因型(YY vs CC)患肿瘤风险增高[OR=5.71,95%CI(2.81,11.62)]。携带隐性基因型YY与另外两种基因型(YY vs CC+CY)同样增高患肿瘤的风险[OR=5.71,95%CI(2.81,11.38)]。结论HFE基因型C282Y突变基因的表达是肝癌发生的危险因素。
