Recently,Prevotella spp.,a major genus of gram-negative commensal bacteria in humans,have emerged as a key microbial contributor to host metabolism due to its ability to ferment dietary fibers,produce beneficial short...Recently,Prevotella spp.,a major genus of gram-negative commensal bacteria in humans,have emerged as a key microbial contributor to host metabolism due to its ability to ferment dietary fibers,produce beneficial short-chain fatty acids,and influence immune responses.However,their diversity and functional differences have created challenges for their development and therapeutic use.Recent studies have shown that specific Prevotella species,such as P.copri,P.intestinalis,and P.histicola,can strengthen gut barrier integrity and reduce metabolic imbalances.Notably,Prevotella populations can be increased through high-fiber or herbal-based treatments.Traditional herbal medicines,including fiber-rich decoctions,also demonstrate the potential to boost endogenous Prevotella communities,enhance microbial fermentation,and improve glucose and lipid balance.This perspective examines the context-dependent roles of Prevotella spp.,with emphasis on the functional heterogeneity of key species such as P.copri,suggests a framework for combining herbal modulation with species-level microbiota profiling,and outlines a research plan to explore microbe-herb synergy in treating obesity,type 2 diabetes,and related metabolic disorders.This strategy offers a new,ecology-based approach to complement standard metabolic interventions.展开更多
Objective:To evaluate the nursing effects of auricular seed therapy combined with Chinese herbal poultice treatment for patients with lumbar disc herniation(LDH).Method:A total of 80 patients with LDH were randomly di...Objective:To evaluate the nursing effects of auricular seed therapy combined with Chinese herbal poultice treatment for patients with lumbar disc herniation(LDH).Method:A total of 80 patients with LDH were randomly divided into two groups.The combined group received auricular acupuncture with seed application combined with Chinese herbal poultice therapy,while the reference group received auricular acupuncture with seed application alone.The therapeutic outcomes of both groups were compared.Results:The combined intervention group demonstrated decreased sleep quality scores,reduced pain neurotransmitter levels,and improved lumbar spine function scores post-intervention,with significant intergroup differences(p<0.05).Conclusion:Auricular seed therapy combined with Chinese herbal poultice care effectively improves sleep quality and lumbar spine function while alleviating pain perception in patients with lumbar disc herniation,indicating superior therapeutic efficacy.展开更多
Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi...Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi-cine for a long time to prevent diseases and as nutrient supplements to improve the product quality.This experi-ment explored the effects of adding 1.0%Chinese herbal formula(CHF,including 0.30%Leonurus japonicus Houtt.,0.20%Salvia miltiorrhiza Bge.,0.25%Ligustrum lucidum Ait.,and 0.25%Taraxacum mongolicum Hand.-Mazz.)for 120 d to the spent hens’diet through metabolomics,network pharmacology,and microbiome strategies.Results The results indicated that CHF supplementation improved the meat quality by reducing drip loss(P<0.05),b*value(P=0.058),and shear force(P=0.099)and increasing cooked meat percentage(P=0.054)and dry matter(P<0.05)of breast muscle.The addition of CHF improved the nutritional value of breast muscle by increasing(P<0.05)the content of C18:2n-6,n-6/n-3 polyunsaturated fatty acids(PUFA),total PUFA,PUFA-to-saturated fatty acids(SFA)ratio,and hypocholesterolemic-to-hypercholesterolemic ratio,and tending to increase serine content(P=0.069).The targeted metabolomics analysis revealed that the biosynthesis of SFA,linoleic acid metabolism,fatty acid degradation,fatty acid elongation,and fatty acid biosynthesis pathways were enriched by CHF supplementation.Furthermore,the network pharmacology analysis indicated that CHF was closely associated with oxidative stress and lipid metabo-lism.The CHF supplementation increased the glutathione peroxidase level(P<0.05)and upregulated gene expres-sion related to the Nrf2 pathway(including HO-1,P<0.05;Nrf2,P=0.098;CAT,P=0.060;GPX1,P=0.063;and SOD2,P=0.052)and lipid metabolism(including PPARγ,P<0.05;SREBP1,P=0.059;and CPT1A,P=0.058).Additionally,CHF supplementation increased Firmicutes and decreased Bacteroidetes,Spirochaetes,and Synergistetes abundances(P<0.05),which may contribute to better meat quality.Conclusions Our results suggest that CHF supplementation improved the quality and nutritional value of meat,which will provide a theoretical basis for the utilization of CHF as a feed additive in spent hens’diets.展开更多
BACKGROUND Cold exposure has traditionally been considered a pathological factor that can easily impair gastrointestinal(GI)digestion.Shihosogan-tang(ST),Yijung-tang(YT),and Pyeongwi-san(PS)are well-known herbal formu...BACKGROUND Cold exposure has traditionally been considered a pathological factor that can easily impair gastrointestinal(GI)digestion.Shihosogan-tang(ST),Yijung-tang(YT),and Pyeongwi-san(PS)are well-known herbal formulas frequently used to treat GI disorders in East Asia.AIM To compare the effects of these herbal formulas on GI motility and investigate their mechanisms of action using a cold stress(CS)-induced dyspepsia mouse model.METHODS C57BL/6J mice were exposed to CS by immersion in cold water(10±1℃)while being restrained in conical tubes for 1 hour.This procedure was repeated six times over 2 weeks.Herbal formulas or mosapride(positive control)were administered orally five times per week over a 2-week period.RESULTS The pre-test results revealed that CS,rather than restraint stress,significantly delayed gut motility in mice.However,PS and ST notably improved gastric emptying and intestinal transit,surpassing YT.Additionally,PS and ST significantly reduced gastric potential of hydrogen and increased pepsin and lipase gene expression compared to CS.The observed mechanisms likely involved increased gastric acidity and enhanced levels of digestive enzymes,such as pepsin and lipase.Furthermore,PS administration elevated GI hormone levels and metabolites related to the gut microbiota(5-hydroxytryptamine and short-chain fatty acid)more effectively than ST and YT treatments.CONCLUSION PS more effectively alleviated CS-induced GI dysfunction than both YT and ST.These comparative findings offer valuable insights for clinical applications in the treatment of cold-related digestive disorders.展开更多
Non-alcoholic fatty liver disease(NAFLD)is a metabolic disease characterized by abnormal deposition of lipid in hepatocytes.If not intervened in time,NAFLD may develop into liver fibrosis or liver cancer,and ultimatel...Non-alcoholic fatty liver disease(NAFLD)is a metabolic disease characterized by abnormal deposition of lipid in hepatocytes.If not intervened in time,NAFLD may develop into liver fibrosis or liver cancer,and ultimately threatening life.NAFLD has complicated etiology and pathogenesis,and there are no effective therapeutic means and specific drugs.Currently,insulin sensitizers,lipid-lowering agents and hepatoprotective agents are often used for clinical intervention,but these drugs have obvious side effects,and their effectiveness and safety need to be further confirmed.Adenosine monophosphate(AMP)-activated protein kinase(AMPK)plays a central role in maintaining energy homeostasis.Activated AMPK can enhance lipid degradation,alleviate insulin resistance(IR),suppress oxidative stress and inflammatory response,and regulate autophagy,thereby alleviating NAFLD.Natural herbal medicines have received extensive attention recently because of their regulatory effects on AMPK and low side effects.In this article,we reviewed the biologically active natural herbal medicines(such as natural herbal medicine formulas,extracts,polysaccharides,andmonomers)that reported in recent years to treatNAFLD via regulating AMPK,which can serve as a foundation for subsequent development of candidate drugs for NAFLD.展开更多
Depression manifests as an enduring experience of sorrow and a loss of interest,appetite,and engagement.Currently,no study has systematically reviewed the efficacy of Chinese herbal medicine Banxia-Houpo-Tang(BHT)for ...Depression manifests as an enduring experience of sorrow and a loss of interest,appetite,and engagement.Currently,no study has systematically reviewed the efficacy of Chinese herbal medicine Banxia-Houpo-Tang(BHT)for the treatment of depression in animal experimental research.This systematic review sought to provide evidence regarding the efficacy and molecular mechanism of BHT for depression.Fifteen electronic databases were searched until November 23,2023.Two researchers individually screened abstracts and full texts for inclusion,extracted data,and assessed the quality of included studies using the risk of bias tool from the Systematic Review Center for Laboratory Animal Experimentation.We conducted the meta-analysis for behavior and biological outcomes.Network pharmacology and molecular docking analyses were conducted to predict the key contributors to BHT’s antidepressant effects.We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.This review included 23 studies.The meta-analysis indicated that BHT considerably reduced immobility time in the forced swim test(SMD=−2.89,95%CI:−3.92 to−1.87,P<0.00001,I2=93%),and tail suspended swim test(SMD=−2.70,95%CI:−3.64 to−1.76,P<0.00001,I2=90%),and increased movement in open field tests(SMD=0.62,95%CI:0.25–1.00,P=0.28,I2=21%).Also,BHT markedly increased 5-hydroxytryptamine(SMD=1.39,95%CI=0.61–2.18,P<0.00001,I2=92%),5-hydroxyindoleacetic acid(SMD=1.06,95%CI=0.22–1.90,P<0.00001,I2=93%),and dopamine(SMD=2.07,95%CI=0.35–3.79,P<0.00001,I2=96%).Silico analysis revealed that honokiol,magnolol,and rosmarinic acid were valuable components associated with the mechanisms of BHT.Our study demonstrated that BHT may relieve depression by regulating neurotransmitters,neuro-inflammation,the hypothalamic-pituitary-adrenal axis,and other biological mechanisms.Well-designed pre-clinical studies should be conducted to provide robust evidence for the mechanism and efficacy of BHT.展开更多
Non-alcoholic fatty liver disease(NAFLD)has emerged as a global public health concern,affecting over one-quarter of the global population.It is closely associated with the prevalence of obesity and metabolic syndrome....Non-alcoholic fatty liver disease(NAFLD)has emerged as a global public health concern,affecting over one-quarter of the global population.It is closely associated with the prevalence of obesity and metabolic syndrome.Current treatment options for NAFLD are limited and often have side effects.Traditional Chinese medicine(TCM)offers a promising alternative with its holistic approach and use of multi-component herbal formulations.A recent study explored the potential of the TCM formula,"Fanlian Huazhuo Formula(FLHZF)",to alleviate high-fat dietinduced NAFLD by regulating autophagy and lipid synthesis signaling pathways.TCM has shown advantages in the prevention and treatment of NAFLD due to its efficacy and minimal side effects.However,the complex multicomponent and multitarget characteristics of formulas such as FLHZF present challenges in research.Future studies should focus on utilizing modern techniques to deepen our understanding of the mechanisms of action and active ingredients of Chinese herbal medicines,thereby promoting their modernization.展开更多
This paper first analyzes the complexity of pathological processes involved in acute hemorrhagic or ischemic stroke,including primary and secondary brain injury manifestations and mechanisms,potential transformations ...This paper first analyzes the complexity of pathological processes involved in acute hemorrhagic or ischemic stroke,including primary and secondary brain injury manifestations and mechanisms,potential transformations between hemorrhage and infarction,and the impact of postbrain injury inflammation on disease progression.Based on decades of extensive clinical and pharmacological research on the usage of Chinese herbal medicine(CHM)monomers or formulas that promote blood circulation and remove blood stasis(such as Angong Niuhuang Wan,Buyang Huanwu Tang,Dahuoluo Wan,and Dushen Tang)for stroke treatment,it proposes that tonifying qi,promoting blood circulation,removing blood stasis,and detoxifying are rational treatment principles of CHM.These principles correspond to the following Western medical implications:tonifying qi corresponds to neuroprotection effects,promoting blood circulation corresponds to anticoagulation and thrombolysis,removing blood stasis addresses hematoma absorption and cerebral edema reduction,and detoxifying corresponds to anti-inflammatory actions.This paper further proposes from a systems medicine perspective that acute stroke is a complex disease requiring individualized CHM treatment with timely modifications rather than a one-sizefits-all approach.CHM monomers or formulas for promoting blood circulation and removing blood stasis,which have various effects such as lowering blood pressure,hemostasis,anticoagulation,antiplatelet,anti-inflammatory,promoting fibrinolysis,and edema reduction,must align with disease progression and be applied within appropriate therapeutic time windows to ensure efficacy and safety.Finally,this paper suggests that a combined use of acupuncture and CHM can potentially synergistically leverage their respective therapeutic strengths.Additionally,acupuncture shows clear benefits in the acute phase of intracerebral hemorrhage(ICH),such as stimulating the vagus nerve to enhance cerebral blood flow,reducing inflammation,as well as triggering hemostatic effects.By applying these rational treatment principles in an integrated approach,better CHM treatment outcomes and higher efficacy of stroke management may be attained.展开更多
The use of traditional herbal drugs derived from natural sources is on the rise due to their minimal side effects and numerous health benefits.However,a major limitation is the lack of standardized knowledge for ident...The use of traditional herbal drugs derived from natural sources is on the rise due to their minimal side effects and numerous health benefits.However,a major limitation is the lack of standardized knowledge for identifying and mapping the quality of these herbal medicines.This article aims to provide practical insights into the application of artificial intelligence for quality-based commercialization of raw herbal drugs.It focuses on feature extraction methods,image processing techniques,and the preparation of herbal images for compatibility with machine learning models.The article discusses commonly used image processing tools such as normalization,slicing,cropping,and augmentation to prepare images for artificial intelligence-based models.It also provides an overview of global herbal image databases and the models employed for herbal plant/drug identification.Readers will gain a comprehensive understanding of the potential application of various machine learning models,including artificial neural networks and convolutional neural networks.The article delves into suitable validation parameters like true positive rates,accuracy,precision,and more for the development of artificial intelligence-based identification and authentication techniques for herbal drugs.This article offers valuable insights and a conclusive platform for the further exploration of artificial intelligence in the field of herbal drugs,paving the way for smarter identification and authentication methods.展开更多
The herbal drink “Attoté” has been widely used in the Abidjan district to treat a number of illnesses, notably erectile dysfunction. Despite the popularity of its therapeutic effects, very few studies have been...The herbal drink “Attoté” has been widely used in the Abidjan district to treat a number of illnesses, notably erectile dysfunction. Despite the popularity of its therapeutic effects, very few studies have been carried out on its effects on the health of users. The aim of this study was to identify the constituents contained in the phytomedicinal product and to assess their potential adverse effects in vivo. Phytochemical screening was conducted to identify the bioactive molecules in “Attoté” and to evaluate its hepatic effects in vivo. Forty (40) Wistar rats, randomly divided into 4 groups, with 10 animals per group (5 males and 5 females) were used to study potential hepatotoxic effects. Group 1 animals (control group) received distilled water. Batches I, II and III received by gavage a volume of Attoté extract corresponding to 1 ml/100 g body weight at 200 mg/kg, 400 mg/kg and 800 mg/kg, respectively. Attoté extract was administered daily at the same time for 28 days, and serum was collected every two weeks to assess hepatic biochemical markers by spectrophotometry using a Cobas C311® HITACHI biochemistry system. After one month of study, the rats were euthanized by ether overdose and the livers were harvested for morphological and histopathological analysis. Phytochemical screening revealed the presence of alkaloids, polyphenols, leucoanthocyanes, anthraquinones and quinones. Hepatic biochemical and hematological parameters such as red globular, hemoglobin, alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), alkaline phosphatase (ALPs) and gamma glutamyl transferase (GGT) showed no significant change (p > 0.05) in the treated rat group compared with controls. However, these variations were moderate and transient, with values remaining almost within their standard limits. Microscopic observations of liver tissue sections from treated rats showed no liver damage or dysfunction. This study merits further investigation, with a view to gaining a better understanding of the cytotoxic mechanisms of herbal medicinal beverages, with a view to their reformulation as improved traditional medicines (ITMs).展开更多
[Objectives]To systematically evaluate the clinical efficacy of head massage combined with Chinese herbal bath in treating insomnia and analyze its herbal medication patterns.[Methods]Clinical data of 200 chronic inso...[Objectives]To systematically evaluate the clinical efficacy of head massage combined with Chinese herbal bath in treating insomnia and analyze its herbal medication patterns.[Methods]Clinical data of 200 chronic insomnia patients treated at the Sleep Disorder Center of Taihe Hospital from January 2020 to December 2024 were retrospectively analyzed.Patients were randomly divided into observation group and control group(n=100 each).The observation group received head massage combined with Chinese herbal bath therapy,while the control group received Chinese herbal bath alone.The Pittsburgh Sleep Quality Index(PSQI)was used for efficacy evaluation,and statistical analysis was performed on the frequency of herbal medications in herbal herbal bath formulas.[Results]The PSQI score improvement in the observation group(8.44±1.87)was significantly better than that in the control group(5.74±1.93)(P<0.01).Herbal formulas for external bath primarily contained mind-calming and heart-nourishing herbs(fried Ziziphi Spinosae Semen,Concha Margaritifera)and heat-clearing herbs(Rhizoma Coptidis,Radix Scutellariae).[Conclusions]The combination of head massage and Chinese herbal bath can significantly improve sleep quality in insomnia patients,demonstrating superior clinical efficacy compared with Chinese herbal bath alone.This combined therapy shows good safety and operability,warranting promotion in primary and specialized medical institutions.展开更多
This review examines the distinct mechanisms of Tuina massage and topical herbal medicine in pediatric diarrhea management,focusing on their independent regulation of gastrointestinal metabolism and barrier function.T...This review examines the distinct mechanisms of Tuina massage and topical herbal medicine in pediatric diarrhea management,focusing on their independent regulation of gastrointestinal metabolism and barrier function.Tuina therapy primarily enhances gastrointestinal motility through the stimulation of targeted acupoints such as Tianshu(ST25)and Shenque(CV8),activating vagal efferent pathways to normalize motility hormones including motilin while suppressing pro-inflammatory cytokines such interleukin-6 and tumor necrosis factor-alpha.It further reinforces mucosal defense by inhibiting mast cell degranulation and augmenting microcirculation via nitric oxide-mediated vasodilation.Herbal medicine containing bioactive compounds from Atractylodes macrocephala and Poria cocos directly restores intestinal barrier integrity by upregulating tight junction proteins occludin and zonula occludens-1,inhibiting epithelial apoptosis,and stimulating MUC2 production.These formulations additionally reprogram enterocyte metabolism by reactivating mitochondrial tricarboxylic acid cycle flux and modulating short-chain fatty acid profiles,with the independent prebiotic effects enhancing commensal butyrate production.Tuina primarily modulates neuroimmune pathways and motility,and herbal medicine directly targets epithelial repair and metabolism.These therapeutic pathways may address core diarrhea pathophysiology,providing holistic complementary therapies.Standardized protocols and interdisciplinary research are urgently needed for clinical translation.展开更多
基金supported by the National Research Foundation of Korea(2020R1F1A1074155).
文摘Recently,Prevotella spp.,a major genus of gram-negative commensal bacteria in humans,have emerged as a key microbial contributor to host metabolism due to its ability to ferment dietary fibers,produce beneficial short-chain fatty acids,and influence immune responses.However,their diversity and functional differences have created challenges for their development and therapeutic use.Recent studies have shown that specific Prevotella species,such as P.copri,P.intestinalis,and P.histicola,can strengthen gut barrier integrity and reduce metabolic imbalances.Notably,Prevotella populations can be increased through high-fiber or herbal-based treatments.Traditional herbal medicines,including fiber-rich decoctions,also demonstrate the potential to boost endogenous Prevotella communities,enhance microbial fermentation,and improve glucose and lipid balance.This perspective examines the context-dependent roles of Prevotella spp.,with emphasis on the functional heterogeneity of key species such as P.copri,suggests a framework for combining herbal modulation with species-level microbiota profiling,and outlines a research plan to explore microbe-herb synergy in treating obesity,type 2 diabetes,and related metabolic disorders.This strategy offers a new,ecology-based approach to complement standard metabolic interventions.
文摘Objective:To evaluate the nursing effects of auricular seed therapy combined with Chinese herbal poultice treatment for patients with lumbar disc herniation(LDH).Method:A total of 80 patients with LDH were randomly divided into two groups.The combined group received auricular acupuncture with seed application combined with Chinese herbal poultice therapy,while the reference group received auricular acupuncture with seed application alone.The therapeutic outcomes of both groups were compared.Results:The combined intervention group demonstrated decreased sleep quality scores,reduced pain neurotransmitter levels,and improved lumbar spine function scores post-intervention,with significant intergroup differences(p<0.05).Conclusion:Auricular seed therapy combined with Chinese herbal poultice care effectively improves sleep quality and lumbar spine function while alleviating pain perception in patients with lumbar disc herniation,indicating superior therapeutic efficacy.
基金supported by the National Key Research and Development Project(2022YFC3400700)the City-School Cooperation Project of the Fuyang Science and Technology Special Fund undertaken by Fuyang Normal University(SXHZ2020007)+1 种基金the Basic Research Program of Shenzhen Municipal Government(JCYJ20200109114242138)the Special Commissioner for Rural Science and Technology of Guangdong Province(KTP20210345).
文摘Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi-cine for a long time to prevent diseases and as nutrient supplements to improve the product quality.This experi-ment explored the effects of adding 1.0%Chinese herbal formula(CHF,including 0.30%Leonurus japonicus Houtt.,0.20%Salvia miltiorrhiza Bge.,0.25%Ligustrum lucidum Ait.,and 0.25%Taraxacum mongolicum Hand.-Mazz.)for 120 d to the spent hens’diet through metabolomics,network pharmacology,and microbiome strategies.Results The results indicated that CHF supplementation improved the meat quality by reducing drip loss(P<0.05),b*value(P=0.058),and shear force(P=0.099)and increasing cooked meat percentage(P=0.054)and dry matter(P<0.05)of breast muscle.The addition of CHF improved the nutritional value of breast muscle by increasing(P<0.05)the content of C18:2n-6,n-6/n-3 polyunsaturated fatty acids(PUFA),total PUFA,PUFA-to-saturated fatty acids(SFA)ratio,and hypocholesterolemic-to-hypercholesterolemic ratio,and tending to increase serine content(P=0.069).The targeted metabolomics analysis revealed that the biosynthesis of SFA,linoleic acid metabolism,fatty acid degradation,fatty acid elongation,and fatty acid biosynthesis pathways were enriched by CHF supplementation.Furthermore,the network pharmacology analysis indicated that CHF was closely associated with oxidative stress and lipid metabo-lism.The CHF supplementation increased the glutathione peroxidase level(P<0.05)and upregulated gene expres-sion related to the Nrf2 pathway(including HO-1,P<0.05;Nrf2,P=0.098;CAT,P=0.060;GPX1,P=0.063;and SOD2,P=0.052)and lipid metabolism(including PPARγ,P<0.05;SREBP1,P=0.059;and CPT1A,P=0.058).Additionally,CHF supplementation increased Firmicutes and decreased Bacteroidetes,Spirochaetes,and Synergistetes abundances(P<0.05),which may contribute to better meat quality.Conclusions Our results suggest that CHF supplementation improved the quality and nutritional value of meat,which will provide a theoretical basis for the utilization of CHF as a feed additive in spent hens’diets.
基金Supported by the National Research Foundation of Korea,No.2022M3A9E4017033。
文摘BACKGROUND Cold exposure has traditionally been considered a pathological factor that can easily impair gastrointestinal(GI)digestion.Shihosogan-tang(ST),Yijung-tang(YT),and Pyeongwi-san(PS)are well-known herbal formulas frequently used to treat GI disorders in East Asia.AIM To compare the effects of these herbal formulas on GI motility and investigate their mechanisms of action using a cold stress(CS)-induced dyspepsia mouse model.METHODS C57BL/6J mice were exposed to CS by immersion in cold water(10±1℃)while being restrained in conical tubes for 1 hour.This procedure was repeated six times over 2 weeks.Herbal formulas or mosapride(positive control)were administered orally five times per week over a 2-week period.RESULTS The pre-test results revealed that CS,rather than restraint stress,significantly delayed gut motility in mice.However,PS and ST notably improved gastric emptying and intestinal transit,surpassing YT.Additionally,PS and ST significantly reduced gastric potential of hydrogen and increased pepsin and lipase gene expression compared to CS.The observed mechanisms likely involved increased gastric acidity and enhanced levels of digestive enzymes,such as pepsin and lipase.Furthermore,PS administration elevated GI hormone levels and metabolites related to the gut microbiota(5-hydroxytryptamine and short-chain fatty acid)more effectively than ST and YT treatments.CONCLUSION PS more effectively alleviated CS-induced GI dysfunction than both YT and ST.These comparative findings offer valuable insights for clinical applications in the treatment of cold-related digestive disorders.
基金funded by the Chongqing Clinical Pharmacy Key Specialties Construction Project,Central Guidance for Local Scientific and Technological Development Special Project of Sichuan Province,China(Grant No.:2023ZYD0283)Natural Science Foundation of Chongqing Municipality,China(Grant No.:CSTB2024NSCQ-MSX1180).
文摘Non-alcoholic fatty liver disease(NAFLD)is a metabolic disease characterized by abnormal deposition of lipid in hepatocytes.If not intervened in time,NAFLD may develop into liver fibrosis or liver cancer,and ultimately threatening life.NAFLD has complicated etiology and pathogenesis,and there are no effective therapeutic means and specific drugs.Currently,insulin sensitizers,lipid-lowering agents and hepatoprotective agents are often used for clinical intervention,but these drugs have obvious side effects,and their effectiveness and safety need to be further confirmed.Adenosine monophosphate(AMP)-activated protein kinase(AMPK)plays a central role in maintaining energy homeostasis.Activated AMPK can enhance lipid degradation,alleviate insulin resistance(IR),suppress oxidative stress and inflammatory response,and regulate autophagy,thereby alleviating NAFLD.Natural herbal medicines have received extensive attention recently because of their regulatory effects on AMPK and low side effects.In this article,we reviewed the biologically active natural herbal medicines(such as natural herbal medicine formulas,extracts,polysaccharides,andmonomers)that reported in recent years to treatNAFLD via regulating AMPK,which can serve as a foundation for subsequent development of candidate drugs for NAFLD.
基金supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI)funded by the Ministry of Health&Welfare,Republic of Korea(grant number:HF21C0036).
文摘Depression manifests as an enduring experience of sorrow and a loss of interest,appetite,and engagement.Currently,no study has systematically reviewed the efficacy of Chinese herbal medicine Banxia-Houpo-Tang(BHT)for the treatment of depression in animal experimental research.This systematic review sought to provide evidence regarding the efficacy and molecular mechanism of BHT for depression.Fifteen electronic databases were searched until November 23,2023.Two researchers individually screened abstracts and full texts for inclusion,extracted data,and assessed the quality of included studies using the risk of bias tool from the Systematic Review Center for Laboratory Animal Experimentation.We conducted the meta-analysis for behavior and biological outcomes.Network pharmacology and molecular docking analyses were conducted to predict the key contributors to BHT’s antidepressant effects.We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.This review included 23 studies.The meta-analysis indicated that BHT considerably reduced immobility time in the forced swim test(SMD=−2.89,95%CI:−3.92 to−1.87,P<0.00001,I2=93%),and tail suspended swim test(SMD=−2.70,95%CI:−3.64 to−1.76,P<0.00001,I2=90%),and increased movement in open field tests(SMD=0.62,95%CI:0.25–1.00,P=0.28,I2=21%).Also,BHT markedly increased 5-hydroxytryptamine(SMD=1.39,95%CI=0.61–2.18,P<0.00001,I2=92%),5-hydroxyindoleacetic acid(SMD=1.06,95%CI=0.22–1.90,P<0.00001,I2=93%),and dopamine(SMD=2.07,95%CI=0.35–3.79,P<0.00001,I2=96%).Silico analysis revealed that honokiol,magnolol,and rosmarinic acid were valuable components associated with the mechanisms of BHT.Our study demonstrated that BHT may relieve depression by regulating neurotransmitters,neuro-inflammation,the hypothalamic-pituitary-adrenal axis,and other biological mechanisms.Well-designed pre-clinical studies should be conducted to provide robust evidence for the mechanism and efficacy of BHT.
文摘Non-alcoholic fatty liver disease(NAFLD)has emerged as a global public health concern,affecting over one-quarter of the global population.It is closely associated with the prevalence of obesity and metabolic syndrome.Current treatment options for NAFLD are limited and often have side effects.Traditional Chinese medicine(TCM)offers a promising alternative with its holistic approach and use of multi-component herbal formulations.A recent study explored the potential of the TCM formula,"Fanlian Huazhuo Formula(FLHZF)",to alleviate high-fat dietinduced NAFLD by regulating autophagy and lipid synthesis signaling pathways.TCM has shown advantages in the prevention and treatment of NAFLD due to its efficacy and minimal side effects.However,the complex multicomponent and multitarget characteristics of formulas such as FLHZF present challenges in research.Future studies should focus on utilizing modern techniques to deepen our understanding of the mechanisms of action and active ingredients of Chinese herbal medicines,thereby promoting their modernization.
文摘This paper first analyzes the complexity of pathological processes involved in acute hemorrhagic or ischemic stroke,including primary and secondary brain injury manifestations and mechanisms,potential transformations between hemorrhage and infarction,and the impact of postbrain injury inflammation on disease progression.Based on decades of extensive clinical and pharmacological research on the usage of Chinese herbal medicine(CHM)monomers or formulas that promote blood circulation and remove blood stasis(such as Angong Niuhuang Wan,Buyang Huanwu Tang,Dahuoluo Wan,and Dushen Tang)for stroke treatment,it proposes that tonifying qi,promoting blood circulation,removing blood stasis,and detoxifying are rational treatment principles of CHM.These principles correspond to the following Western medical implications:tonifying qi corresponds to neuroprotection effects,promoting blood circulation corresponds to anticoagulation and thrombolysis,removing blood stasis addresses hematoma absorption and cerebral edema reduction,and detoxifying corresponds to anti-inflammatory actions.This paper further proposes from a systems medicine perspective that acute stroke is a complex disease requiring individualized CHM treatment with timely modifications rather than a one-sizefits-all approach.CHM monomers or formulas for promoting blood circulation and removing blood stasis,which have various effects such as lowering blood pressure,hemostasis,anticoagulation,antiplatelet,anti-inflammatory,promoting fibrinolysis,and edema reduction,must align with disease progression and be applied within appropriate therapeutic time windows to ensure efficacy and safety.Finally,this paper suggests that a combined use of acupuncture and CHM can potentially synergistically leverage their respective therapeutic strengths.Additionally,acupuncture shows clear benefits in the acute phase of intracerebral hemorrhage(ICH),such as stimulating the vagus nerve to enhance cerebral blood flow,reducing inflammation,as well as triggering hemostatic effects.By applying these rational treatment principles in an integrated approach,better CHM treatment outcomes and higher efficacy of stroke management may be attained.
文摘The use of traditional herbal drugs derived from natural sources is on the rise due to their minimal side effects and numerous health benefits.However,a major limitation is the lack of standardized knowledge for identifying and mapping the quality of these herbal medicines.This article aims to provide practical insights into the application of artificial intelligence for quality-based commercialization of raw herbal drugs.It focuses on feature extraction methods,image processing techniques,and the preparation of herbal images for compatibility with machine learning models.The article discusses commonly used image processing tools such as normalization,slicing,cropping,and augmentation to prepare images for artificial intelligence-based models.It also provides an overview of global herbal image databases and the models employed for herbal plant/drug identification.Readers will gain a comprehensive understanding of the potential application of various machine learning models,including artificial neural networks and convolutional neural networks.The article delves into suitable validation parameters like true positive rates,accuracy,precision,and more for the development of artificial intelligence-based identification and authentication techniques for herbal drugs.This article offers valuable insights and a conclusive platform for the further exploration of artificial intelligence in the field of herbal drugs,paving the way for smarter identification and authentication methods.
文摘The herbal drink “Attoté” has been widely used in the Abidjan district to treat a number of illnesses, notably erectile dysfunction. Despite the popularity of its therapeutic effects, very few studies have been carried out on its effects on the health of users. The aim of this study was to identify the constituents contained in the phytomedicinal product and to assess their potential adverse effects in vivo. Phytochemical screening was conducted to identify the bioactive molecules in “Attoté” and to evaluate its hepatic effects in vivo. Forty (40) Wistar rats, randomly divided into 4 groups, with 10 animals per group (5 males and 5 females) were used to study potential hepatotoxic effects. Group 1 animals (control group) received distilled water. Batches I, II and III received by gavage a volume of Attoté extract corresponding to 1 ml/100 g body weight at 200 mg/kg, 400 mg/kg and 800 mg/kg, respectively. Attoté extract was administered daily at the same time for 28 days, and serum was collected every two weeks to assess hepatic biochemical markers by spectrophotometry using a Cobas C311® HITACHI biochemistry system. After one month of study, the rats were euthanized by ether overdose and the livers were harvested for morphological and histopathological analysis. Phytochemical screening revealed the presence of alkaloids, polyphenols, leucoanthocyanes, anthraquinones and quinones. Hepatic biochemical and hematological parameters such as red globular, hemoglobin, alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), alkaline phosphatase (ALPs) and gamma glutamyl transferase (GGT) showed no significant change (p > 0.05) in the treated rat group compared with controls. However, these variations were moderate and transient, with values remaining almost within their standard limits. Microscopic observations of liver tissue sections from treated rats showed no liver damage or dysfunction. This study merits further investigation, with a view to gaining a better understanding of the cytotoxic mechanisms of herbal medicinal beverages, with a view to their reformulation as improved traditional medicines (ITMs).
文摘[Objectives]To systematically evaluate the clinical efficacy of head massage combined with Chinese herbal bath in treating insomnia and analyze its herbal medication patterns.[Methods]Clinical data of 200 chronic insomnia patients treated at the Sleep Disorder Center of Taihe Hospital from January 2020 to December 2024 were retrospectively analyzed.Patients were randomly divided into observation group and control group(n=100 each).The observation group received head massage combined with Chinese herbal bath therapy,while the control group received Chinese herbal bath alone.The Pittsburgh Sleep Quality Index(PSQI)was used for efficacy evaluation,and statistical analysis was performed on the frequency of herbal medications in herbal herbal bath formulas.[Results]The PSQI score improvement in the observation group(8.44±1.87)was significantly better than that in the control group(5.74±1.93)(P<0.01).Herbal formulas for external bath primarily contained mind-calming and heart-nourishing herbs(fried Ziziphi Spinosae Semen,Concha Margaritifera)and heat-clearing herbs(Rhizoma Coptidis,Radix Scutellariae).[Conclusions]The combination of head massage and Chinese herbal bath can significantly improve sleep quality in insomnia patients,demonstrating superior clinical efficacy compared with Chinese herbal bath alone.This combined therapy shows good safety and operability,warranting promotion in primary and specialized medical institutions.
基金Supported by the Key Research and Development Program of Zhejiang Province,No.2024C03211the Traditional Chinese Medicine Science and Technology Plan Project of Zhejiang Province,No.2023ZL498.
文摘This review examines the distinct mechanisms of Tuina massage and topical herbal medicine in pediatric diarrhea management,focusing on their independent regulation of gastrointestinal metabolism and barrier function.Tuina therapy primarily enhances gastrointestinal motility through the stimulation of targeted acupoints such as Tianshu(ST25)and Shenque(CV8),activating vagal efferent pathways to normalize motility hormones including motilin while suppressing pro-inflammatory cytokines such interleukin-6 and tumor necrosis factor-alpha.It further reinforces mucosal defense by inhibiting mast cell degranulation and augmenting microcirculation via nitric oxide-mediated vasodilation.Herbal medicine containing bioactive compounds from Atractylodes macrocephala and Poria cocos directly restores intestinal barrier integrity by upregulating tight junction proteins occludin and zonula occludens-1,inhibiting epithelial apoptosis,and stimulating MUC2 production.These formulations additionally reprogram enterocyte metabolism by reactivating mitochondrial tricarboxylic acid cycle flux and modulating short-chain fatty acid profiles,with the independent prebiotic effects enhancing commensal butyrate production.Tuina primarily modulates neuroimmune pathways and motility,and herbal medicine directly targets epithelial repair and metabolism.These therapeutic pathways may address core diarrhea pathophysiology,providing holistic complementary therapies.Standardized protocols and interdisciplinary research are urgently needed for clinical translation.
