A novel method for HDDA-derived benzyne trapped by nitrone was developed.This research described a simple and efficient pathway for the synthesis of benzisoxazoles from arynes and PTIO(2-phenyl-4,4,5,5-tetramethylimid...A novel method for HDDA-derived benzyne trapped by nitrone was developed.This research described a simple and efficient pathway for the synthesis of benzisoxazoles from arynes and PTIO(2-phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl),C-C and C-O bonds were formed in a single step without catalyst under mild conditions.The unexpected cleavage of C-N bond contributed to the formation of isoxazole ring,as indicated by DFT studies.Furthermore,we obtained the structure of benzoxazolopyrrolidine when the trapping agent is DMPO(5,5-dimethyl-1-pyrroline N-oxide).展开更多
This study presents a facile strategy for the formation of highly substituted butterfly 1,4-adducts/9,10-adducts via the Diels-Alder reaction of benzyne intermediates.The method achieves very good to excellent yields ...This study presents a facile strategy for the formation of highly substituted butterfly 1,4-adducts/9,10-adducts via the Diels-Alder reaction of benzyne intermediates.The method achieves very good to excellent yields of the respective anthracene derivative s under mild conditions.This practical protocol is compatible with a variety of sensitive functional groups and provides access to difunctionalized bridge 1,4-adducts/9,10-adducts.展开更多
基金the National Natural Science Foundation of China(No.22071001)The Research Culture Funds of Anhui Normal UniversityDepartment of Human Resources of Anhui Province for financial support。
文摘A novel method for HDDA-derived benzyne trapped by nitrone was developed.This research described a simple and efficient pathway for the synthesis of benzisoxazoles from arynes and PTIO(2-phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl),C-C and C-O bonds were formed in a single step without catalyst under mild conditions.The unexpected cleavage of C-N bond contributed to the formation of isoxazole ring,as indicated by DFT studies.Furthermore,we obtained the structure of benzoxazolopyrrolidine when the trapping agent is DMPO(5,5-dimethyl-1-pyrroline N-oxide).
基金the National Natural Science Foundation of China(Nos.21572002,21272005)The Research Culture Funds of Anhui Normal UniversityDepartment of Human Resources of Anhui Province for financial support。
文摘This study presents a facile strategy for the formation of highly substituted butterfly 1,4-adducts/9,10-adducts via the Diels-Alder reaction of benzyne intermediates.The method achieves very good to excellent yields of the respective anthracene derivative s under mild conditions.This practical protocol is compatible with a variety of sensitive functional groups and provides access to difunctionalized bridge 1,4-adducts/9,10-adducts.
