Targeted protein degradation(TPD)technology mainly utilizes the natural degradation systems within cells to specific and efficient degradation of disease-related proteins1.The ubiquitin-proteasome system(UPS)is the mo...Targeted protein degradation(TPD)technology mainly utilizes the natural degradation systems within cells to specific and efficient degradation of disease-related proteins1.The ubiquitin-proteasome system(UPS)is the most important way of protein degradation in eukaryotic cells,which is involved in more than 80%of degradation processes2.Molecular glues are mostly small molecules to stabilize existing interactions between two proteins or induce new protein-protein interactions3.In the case of molecular glues between the target protein and an E3 ligase.展开更多
基金supported by grants from the National Key Research and Development Program of China (No.2018YFC1003701, 2018YFC1003801)the National Natural Science Foundation of China (No.31872792)Institution of Higher Education Projects of Building First-class Discipline Construction in Ningxia Region (Biology),China (No.NXYLXK2017B05)。
文摘Targeted protein degradation(TPD)technology mainly utilizes the natural degradation systems within cells to specific and efficient degradation of disease-related proteins1.The ubiquitin-proteasome system(UPS)is the most important way of protein degradation in eukaryotic cells,which is involved in more than 80%of degradation processes2.Molecular glues are mostly small molecules to stabilize existing interactions between two proteins or induce new protein-protein interactions3.In the case of molecular glues between the target protein and an E3 ligase.
