Primary liver cancer(PLC)is a fatal disease that affects millions of lives worldwide.PLC is the leading cause of cancer-related deaths and the incidence rate is predicted to rise in the coming decades.PLC can be categ...Primary liver cancer(PLC)is a fatal disease that affects millions of lives worldwide.PLC is the leading cause of cancer-related deaths and the incidence rate is predicted to rise in the coming decades.PLC can be categorized into three major histological subtypes:hepatocellular carcinoma(HCC),intrahepatic cholangiocarcinoma(ICC),and combined HCC-ICC.These subtypes are distinct with respect to epidemiology,clinicopathological features,genetic alterations,and clinical managements,which are thoroughly summarized in this review.The state of treatment strategies for each subtype,including the currently approved drugs and the potential novel therapies,are also discussed.展开更多
基金We thank Zichen Xu for assistance in the preparation of the figures.This work was supported by the National Natural Science Foundation of China(81972735,31671452,81970459)Clinical Medicine Plus X-Young Scholars Project of Peking University(71006Y2435).
文摘Primary liver cancer(PLC)is a fatal disease that affects millions of lives worldwide.PLC is the leading cause of cancer-related deaths and the incidence rate is predicted to rise in the coming decades.PLC can be categorized into three major histological subtypes:hepatocellular carcinoma(HCC),intrahepatic cholangiocarcinoma(ICC),and combined HCC-ICC.These subtypes are distinct with respect to epidemiology,clinicopathological features,genetic alterations,and clinical managements,which are thoroughly summarized in this review.The state of treatment strategies for each subtype,including the currently approved drugs and the potential novel therapies,are also discussed.
