It is important to improve the comprehensive performance of the ductile iron bars(DIBs)for the cylinder block of the extra high pressure hydraulic plunger pump and accelerate the industrial application.In this work,th...It is important to improve the comprehensive performance of the ductile iron bars(DIBs)for the cylinder block of the extra high pressure hydraulic plunger pump and accelerate the industrial application.In this work,the LZQT600-3 DIBs with the diameter of 145 mm were prepared by the horizontal continuous casting(HCC)process,that is,LZQT600-3 HCCDIBs.The microstructure and room temperature tensile properties of different sections[left-edge(surface layer),left-1/2R(left half of the radius),and the center of the HCCDIBs]were studied.The results show that the spheroidization of LZQT600-3 HCCDIBs matrix from the left-edge,left-1/2R to the center is at nodulizing grade II and above.As the cooling rate gradually decreases from surface to the center of the HCCIBs,the number of spheroidized graphite is gradually reduced,the size is gradually increased,the shape factor is decreased,and the pearlite content and lamellate spacing are increased.Along the horizontal direction of the section,the hardness of the material is distributed symmetrically around the center of the HCCDIBs.In the vertical direction,the hardness distribution in the center of the HCCDIBs is asymmetrical due to the gravity during the solidification process.Therefore,the microstructure in the lower part of the section solidifies relatively quickly.The left-edge has the best tensile mechanical properties,and the ultimate tensile strength,yield tensile strength and elongation are 597.3 MPa,418.5 MPa and 9.6%,respectively.The tensile fracture belongs to the ductile-brittle hybrid fracture.The comprehensive performances of LZQT600-3 HCCDIBs meet the actual application requirements of ultra-high pressure hydraulic plunger pump cylinder.展开更多
Hepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rates worldwide. In the various treatment methods for HCC, the lack of cancer cell specificity and the development of multidrug resistance (...Hepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rates worldwide. In the various treatment methods for HCC, the lack of cancer cell specificity and the development of multidrug resistance (MDR) are two major obstacles in the treatment of HCC. P-glycoprotein (P-gp) is an ATP-dependent drug efflux pump that can reduce the accumulation of drugs in cells and make cancer cells acquire drug resistance. D-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) can inhibit the activity of ATP-dependent P-gp and serves as an effective excipient for overcoming tumor multidrug resistance (MDR). TPGS has been approved by the FDA as a safe adjuvant and is widely used in drug delivery systems. The biological and physicochemical properties of TPGS provide multiple advantages for its application in drug delivery, such as high biocompatibility, enhanced drug solubility, improved drug permeation, and selective antitumor activity. In recent years, more and more studies have found that using TPGS-modified nanomaterials to load chemotherapy drugs to treat tumors can effectively reverse the drug resistance of tumors, including HCC. This review summarizes and discusses the role of TPGS in reversing tumor drug resistance and the therapeutic effects of TPGS-based drugs on drug-resistant HCC.展开更多
目的探讨肝细胞癌(hepatocellular carcinoma,HCC)患者接受免疫治疗与肝移植术后排斥反应风险的关联性。方法回顾性分析2019—2025年首都医科大学附属北京友谊医院11例移植前接受免疫治疗的HCC患者,并纳入文献报道的70例病例,分析排斥...目的探讨肝细胞癌(hepatocellular carcinoma,HCC)患者接受免疫治疗与肝移植术后排斥反应风险的关联性。方法回顾性分析2019—2025年首都医科大学附属北京友谊医院11例移植前接受免疫治疗的HCC患者,并纳入文献报道的70例病例,分析排斥反应发生率及影响因素。结果本中心队列排斥率为9.1%(1/11人),低于文献中新辅助治疗队列(25.0%)和移植后队列(30.8%)。免疫治疗的末次用药与移植时间间隔>2个半衰期者排斥率显著降低。移植物中程序性死亡配体1(programmed death ligand 1,PD-L1)的表达可能与排斥风险相关,可作为预测排斥反应发生的潜在生物标志物。结论建议免疫治疗后至少等待8周(2个半衰期)再行肝移植。移植物组织中程序性死亡受体1(programmed death receptor 1,PD-1)/PD-L1的表达水平可作为潜在生物标志物,但需进一步研究其机制及安全时间间隔。展开更多
基金the support from the International Science and Technology Cooperation Program of Shaanxi Province(No.2023-GHZD-50)the Projects of Major Innovation Platforms for Scientific and Technological and Local Transformation of Scientific and Technological Achievements of Xi’an(No.20GXSF0003)+1 种基金the Projects of Major Scientific and Technological Achievements Local Transformation of Xi’an(No.2022JH-ZDZH-0039)the Higher Education Institution Discipline Innovation and Intelligence Base of Shaanxi Provincial(No.S2021-ZC-GXYZ-0011)。
文摘It is important to improve the comprehensive performance of the ductile iron bars(DIBs)for the cylinder block of the extra high pressure hydraulic plunger pump and accelerate the industrial application.In this work,the LZQT600-3 DIBs with the diameter of 145 mm were prepared by the horizontal continuous casting(HCC)process,that is,LZQT600-3 HCCDIBs.The microstructure and room temperature tensile properties of different sections[left-edge(surface layer),left-1/2R(left half of the radius),and the center of the HCCDIBs]were studied.The results show that the spheroidization of LZQT600-3 HCCDIBs matrix from the left-edge,left-1/2R to the center is at nodulizing grade II and above.As the cooling rate gradually decreases from surface to the center of the HCCIBs,the number of spheroidized graphite is gradually reduced,the size is gradually increased,the shape factor is decreased,and the pearlite content and lamellate spacing are increased.Along the horizontal direction of the section,the hardness of the material is distributed symmetrically around the center of the HCCDIBs.In the vertical direction,the hardness distribution in the center of the HCCDIBs is asymmetrical due to the gravity during the solidification process.Therefore,the microstructure in the lower part of the section solidifies relatively quickly.The left-edge has the best tensile mechanical properties,and the ultimate tensile strength,yield tensile strength and elongation are 597.3 MPa,418.5 MPa and 9.6%,respectively.The tensile fracture belongs to the ductile-brittle hybrid fracture.The comprehensive performances of LZQT600-3 HCCDIBs meet the actual application requirements of ultra-high pressure hydraulic plunger pump cylinder.
文摘Hepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rates worldwide. In the various treatment methods for HCC, the lack of cancer cell specificity and the development of multidrug resistance (MDR) are two major obstacles in the treatment of HCC. P-glycoprotein (P-gp) is an ATP-dependent drug efflux pump that can reduce the accumulation of drugs in cells and make cancer cells acquire drug resistance. D-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) can inhibit the activity of ATP-dependent P-gp and serves as an effective excipient for overcoming tumor multidrug resistance (MDR). TPGS has been approved by the FDA as a safe adjuvant and is widely used in drug delivery systems. The biological and physicochemical properties of TPGS provide multiple advantages for its application in drug delivery, such as high biocompatibility, enhanced drug solubility, improved drug permeation, and selective antitumor activity. In recent years, more and more studies have found that using TPGS-modified nanomaterials to load chemotherapy drugs to treat tumors can effectively reverse the drug resistance of tumors, including HCC. This review summarizes and discusses the role of TPGS in reversing tumor drug resistance and the therapeutic effects of TPGS-based drugs on drug-resistant HCC.
文摘目的探讨肝细胞癌(hepatocellular carcinoma,HCC)患者接受免疫治疗与肝移植术后排斥反应风险的关联性。方法回顾性分析2019—2025年首都医科大学附属北京友谊医院11例移植前接受免疫治疗的HCC患者,并纳入文献报道的70例病例,分析排斥反应发生率及影响因素。结果本中心队列排斥率为9.1%(1/11人),低于文献中新辅助治疗队列(25.0%)和移植后队列(30.8%)。免疫治疗的末次用药与移植时间间隔>2个半衰期者排斥率显著降低。移植物中程序性死亡配体1(programmed death ligand 1,PD-L1)的表达可能与排斥风险相关,可作为预测排斥反应发生的潜在生物标志物。结论建议免疫治疗后至少等待8周(2个半衰期)再行肝移植。移植物组织中程序性死亡受体1(programmed death receptor 1,PD-1)/PD-L1的表达水平可作为潜在生物标志物,但需进一步研究其机制及安全时间间隔。
