探究2型糖尿病(diabetes mellitus type 2,T2DM)患者血清C肽、糖化血红蛋白(glycosylated hemoglobin,HbA1c)以及葡萄糖(glucose,GLU)水平表达及其同并发症发生风险的相关性。选取甘肃省陇南市第一人民医院(2024年1月—2025年4月)收治的...探究2型糖尿病(diabetes mellitus type 2,T2DM)患者血清C肽、糖化血红蛋白(glycosylated hemoglobin,HbA1c)以及葡萄糖(glucose,GLU)水平表达及其同并发症发生风险的相关性。选取甘肃省陇南市第一人民医院(2024年1月—2025年4月)收治的180例T2DM患者为观察组,根据是否发生并发症分为非并发症组(50例)和并发症组(130例)。同时选取同期体检的180例健康人群为对照组。对比C肽、HbA1c、GLU水平,并经Spearman相关性分析C肽、HbA1c、GLU水平与T2DM患者并发症发生风险的相关性。结果显示,观察组血清C肽水平低于对照组,HbA1c水平、GLU高于对照组(P<0.05)。并发症组血清C肽水平低于非并发症组,HbA1c水平、GLU高于非并发症组(P<0.05)。HbA1c、GLU水平与T2DM患者并发症的发生风险呈正相关,C肽水平与T2DM患者并发症的发生风险呈负相关(P<0.05)。研究发现,通过监测血清C肽、HbA1c以及GLU水平,可评估T2DM患者的并发症发生风险。展开更多
目的探究老年糖尿病治疗中采用甘精胰岛素联合阿卡波糖的价值。方法选取上海市嘉定区迎园医院于2022年6月—2023年9月收治的106例糖尿病老年患者作为研究对象,按随机数表法分为对照组(53例,给予阿卡波糖治疗)、观察组(53例,给予甘精胰...目的探究老年糖尿病治疗中采用甘精胰岛素联合阿卡波糖的价值。方法选取上海市嘉定区迎园医院于2022年6月—2023年9月收治的106例糖尿病老年患者作为研究对象,按随机数表法分为对照组(53例,给予阿卡波糖治疗)、观察组(53例,给予甘精胰岛素联合阿卡波糖治疗)。比较两组临床疗效、血糖指标、体质指数(Body Mass Index,BMI)、不良反应发生情况以及胰岛功能。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组空腹血糖(Fasting Blood Glucose,FBG)、餐后2 h血糖(2 Hour Post⁃prandial Blood Glucose,2 hBG)以及糖化血红蛋白(Hemoglobin A1c,HbA1c)均低于对照组,差异有统计学意义(P均<0.05);观察组体质指数高于对照组,差异有统计学意义(P<0.05);观察组不良反应总发生率与对照组比较,差异无统计学意义(P>0.05);观察组胰岛素抵抗指数(Homeostatic Model Assessment of Insulin Resis⁃tance,HOMA-IR)低于对照组,胰岛β细胞功能指数(Homeostasis Model Assessment-β,HOMA-β)高于对照组,差异有统计学意义(P均<0.05)。结论在老年糖尿病治疗中选择甘精胰岛素与阿卡波糖联合方案可降低血糖水平,改善体质指数及胰岛素功能,确保治疗有效性。展开更多
Objective:To study the application effect of standardized nutritional care combined with exercise intervention in patients with gestational diabetes mellitus and the effect on fasting blood glucose(FPG),2-hour postpra...Objective:To study the application effect of standardized nutritional care combined with exercise intervention in patients with gestational diabetes mellitus and the effect on fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),and glycated hemoglobin(HbA1c)levels.Methods:Ninety cases of gestational diabetes mellitus diagnosed between June 2022 and June 2023 were selected and randomly divided into two groups of 45 cases each.The control group received conventional intervention,while the observation group received combined standardized nutritional care and exercise intervention.Blood glucose levels,adverse pregnancy outcomes,and adverse neonatal outcomes were compared.Results:On the day before delivery,the FPG,2hPG,and HbA1c levels of patients in the observation group were lower than those of patients in the control group(P<0.05).The incidence of adverse pregnancy outcomes(4.44%)and adverse neonatal outcomes(2.22%)in the observation group was lower than in the control group(P<0.05).Conclusion:The blood glucose levels of gestational diabetes mellitus patients can be controlled through standardized nutritional care and exercise interventions,leading to improved pregnancy and neonatal outcomes.展开更多
Background: Prognosis in Mucormycosis is poor, secondary to the nature of such opportunistic angioinvasive fungal infection that affects immuno-compromised patients with uncontrolled diabetes which is a common risk fa...Background: Prognosis in Mucormycosis is poor, secondary to the nature of such opportunistic angioinvasive fungal infection that affects immuno-compromised patients with uncontrolled diabetes which is a common risk factors in most of the cases. Objectives: Patients with post-Covid Mucormycosis presenting to the ENT OPD were included and evaluated for HbA1c, extent of disease, and subsequently underwent the required modality of management. Methods: A prospective observational study was done in 154 patients of mucormycosis and according to the extent of disease such as sinonasal involvement, orbital extension or intracranial extension, the HbA1c values were compared among themselves. Results: In our study, out of 154 patients, 86 (55.8%) patients have only sinonasal involvement, 30 (19.4%) patients have extension into orbit and 38 (24.6%) patients have intracranial spread. In patients with sinonasal involvement, mean HbA1c was 9.8 ± 2.41;in orbital extension, mean HbA1c was 12.7 ± 2.31 and in intracranial extension, mean HbA1c was 13.4 ± 1.98. Conclusion: In our study, elevated HbA1c is indicative of poor glycaemic control and positively correlated with increased invasiveness and aggressive fungal disease.展开更多
文摘探究2型糖尿病(diabetes mellitus type 2,T2DM)患者血清C肽、糖化血红蛋白(glycosylated hemoglobin,HbA1c)以及葡萄糖(glucose,GLU)水平表达及其同并发症发生风险的相关性。选取甘肃省陇南市第一人民医院(2024年1月—2025年4月)收治的180例T2DM患者为观察组,根据是否发生并发症分为非并发症组(50例)和并发症组(130例)。同时选取同期体检的180例健康人群为对照组。对比C肽、HbA1c、GLU水平,并经Spearman相关性分析C肽、HbA1c、GLU水平与T2DM患者并发症发生风险的相关性。结果显示,观察组血清C肽水平低于对照组,HbA1c水平、GLU高于对照组(P<0.05)。并发症组血清C肽水平低于非并发症组,HbA1c水平、GLU高于非并发症组(P<0.05)。HbA1c、GLU水平与T2DM患者并发症的发生风险呈正相关,C肽水平与T2DM患者并发症的发生风险呈负相关(P<0.05)。研究发现,通过监测血清C肽、HbA1c以及GLU水平,可评估T2DM患者的并发症发生风险。
文摘目的探究老年糖尿病治疗中采用甘精胰岛素联合阿卡波糖的价值。方法选取上海市嘉定区迎园医院于2022年6月—2023年9月收治的106例糖尿病老年患者作为研究对象,按随机数表法分为对照组(53例,给予阿卡波糖治疗)、观察组(53例,给予甘精胰岛素联合阿卡波糖治疗)。比较两组临床疗效、血糖指标、体质指数(Body Mass Index,BMI)、不良反应发生情况以及胰岛功能。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组空腹血糖(Fasting Blood Glucose,FBG)、餐后2 h血糖(2 Hour Post⁃prandial Blood Glucose,2 hBG)以及糖化血红蛋白(Hemoglobin A1c,HbA1c)均低于对照组,差异有统计学意义(P均<0.05);观察组体质指数高于对照组,差异有统计学意义(P<0.05);观察组不良反应总发生率与对照组比较,差异无统计学意义(P>0.05);观察组胰岛素抵抗指数(Homeostatic Model Assessment of Insulin Resis⁃tance,HOMA-IR)低于对照组,胰岛β细胞功能指数(Homeostasis Model Assessment-β,HOMA-β)高于对照组,差异有统计学意义(P均<0.05)。结论在老年糖尿病治疗中选择甘精胰岛素与阿卡波糖联合方案可降低血糖水平,改善体质指数及胰岛素功能,确保治疗有效性。
文摘Objective:To study the application effect of standardized nutritional care combined with exercise intervention in patients with gestational diabetes mellitus and the effect on fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),and glycated hemoglobin(HbA1c)levels.Methods:Ninety cases of gestational diabetes mellitus diagnosed between June 2022 and June 2023 were selected and randomly divided into two groups of 45 cases each.The control group received conventional intervention,while the observation group received combined standardized nutritional care and exercise intervention.Blood glucose levels,adverse pregnancy outcomes,and adverse neonatal outcomes were compared.Results:On the day before delivery,the FPG,2hPG,and HbA1c levels of patients in the observation group were lower than those of patients in the control group(P<0.05).The incidence of adverse pregnancy outcomes(4.44%)and adverse neonatal outcomes(2.22%)in the observation group was lower than in the control group(P<0.05).Conclusion:The blood glucose levels of gestational diabetes mellitus patients can be controlled through standardized nutritional care and exercise interventions,leading to improved pregnancy and neonatal outcomes.
文摘Background: Prognosis in Mucormycosis is poor, secondary to the nature of such opportunistic angioinvasive fungal infection that affects immuno-compromised patients with uncontrolled diabetes which is a common risk factors in most of the cases. Objectives: Patients with post-Covid Mucormycosis presenting to the ENT OPD were included and evaluated for HbA1c, extent of disease, and subsequently underwent the required modality of management. Methods: A prospective observational study was done in 154 patients of mucormycosis and according to the extent of disease such as sinonasal involvement, orbital extension or intracranial extension, the HbA1c values were compared among themselves. Results: In our study, out of 154 patients, 86 (55.8%) patients have only sinonasal involvement, 30 (19.4%) patients have extension into orbit and 38 (24.6%) patients have intracranial spread. In patients with sinonasal involvement, mean HbA1c was 9.8 ± 2.41;in orbital extension, mean HbA1c was 12.7 ± 2.31 and in intracranial extension, mean HbA1c was 13.4 ± 1.98. Conclusion: In our study, elevated HbA1c is indicative of poor glycaemic control and positively correlated with increased invasiveness and aggressive fungal disease.
