[Objective] The paper was to compare the infrared spectra of straight guard hairs of leopard cat and golden cat. [Method] The straight guard hairs of leopard cat and golden cat were detected and analyzed by FTIR （Fou...[Objective] The paper was to compare the infrared spectra of straight guard hairs of leopard cat and golden cat. [Method] The straight guard hairs of leopard cat and golden cat were detected and analyzed by FTIR （Fourier Transform Infrared Spectroscopy）. [Result] There was significant interspecific difference in the infrared spectra and second derivative spectra for the middle part of guard hair. An evident M-shaped bimodal absorption peak appeared in golden cat at 648 and 654 cm-1, respectively, while did not appear in leopard cat. The second derivative spec-tra of golden cat at wave numbers from 709 to 763 cm -1 were mainly unimodal peaks with strong peak intensity, while that of leopard cat mainly was M-shaped bi-modal absorption peak with weak peak intensity. It indicated that there was obvious difference in the structure of protein side chain in guard hairs of these two animals. [Conclusion] The FTIR analysis showed great application foreground in the study of animal hairs for interspecific identification.展开更多
The taxonomic status of long-tailed field mouse (Apodemus orestes) is still uncertain up to now.Some scholars regarded it as a subspecies or a synonym of dragon field mouse (A.draco),while other scholars considered it...The taxonomic status of long-tailed field mouse (Apodemus orestes) is still uncertain up to now.Some scholars regarded it as a subspecies or a synonym of dragon field mouse (A.draco),while other scholars considered it a valid species.In the study,five specimens of adult long-tailed field mouse,dragon field mouse and Chevrier's field mouse (A.chevrieri) (as a contrast) were chosen respectively.After treated,with the eyepiece micrometer in the inverted microscope,we made measurements of the widths of hairs and medullas and then calculated the medullary indexes of straight guard hairs from around the mouth,head,back,abdomen and forelimb of each species.The results indicate that,viewing at each of the five parts and the mixture of the five parts,there are no significant differences between A.orestes and A.draco,Significant differences can be found between A.orestes & A.chevrieri and A.draco & A.chevrieri though.The standpoint that A.orestes was listed as a valid species is not supported by this study.展开更多
In recent times,there had been reported cases of Pb poisoning in Anka gold mining area,Northwest Nigeria.Therefore,this study was carried out to determine the extent of bioaccumulation of heavy metals in the hairs and...In recent times,there had been reported cases of Pb poisoning in Anka gold mining area,Northwest Nigeria.Therefore,this study was carried out to determine the extent of bioaccumulation of heavy metals in the hairs and nails of children in the area.Forty samples(twenty nails and twenty hairs)samples were collected from ten boys and ten girls of ages 5–9 residing in the area.To ascertain the sources of heavy metals in children,15 soils samples,15 groundwater samples,5 samples of mine tailings,and 5 plants samples were collected.Hair and nails of the subjects were collected using internationally acceptable techniques.All samples were kept in uncontaminated ziplock bags prior to laboratory preparation and analysis.The samples were cleaned using nonionic detergent(triton X-100)and deionized water.The hairs and nails were digested with 10 mL of 6:1 mixture of nitric acid and perchloric acid.The soils,mine tailings,and plants were air-dried at room temperature,sieved,and chemically digested using the aqua regia method.The concentrations of metals in all the samples were determined using highperformance liquid chromatography–inductively coupled plasma–mass spectrometry.Statistical analysis was employed to unravel potential sources of metals in the media.Results showed that heavy metals in children of the area are above results from similar studies and pathological ranges for heavy metals in hairs and nails.Also,heavy metals in environmental media are above the recommended standards.Multivariate analysis showed that the metals are mainly from mining and other anthropogenic sources.Results of correlation between heavy metals in hairs and nails with those in geological samples revealed that heavy metal that bioaccumulates in the children of this area are mostly from contaminated environmental media.It is recommended that complete remediation and effective health education be carried out in the area.展开更多
In polymorphic mammalian species that display multiple color forms, those with dark, or melanic pelage would be prone to overheating, especially if they live in warm climates, because their fur absorbs solar energy at...In polymorphic mammalian species that display multiple color forms, those with dark, or melanic pelage would be prone to overheating, especially if they live in warm climates, because their fur absorbs solar energy at a higher rate. However, experimental studies indicate that certain physical properties of fur of dark individuals appear to prevent, or minimize heat stress, although it is not clear what properties do so. Here, we tested the possibility that black-furred individuals simply have shorter or thinner hair fibers, which would create a lighter （in terms of weight） coat or one that allows greater air flow for evaporative coo- ling. We examined museum specimens of eastern fox squirrels Sciurus niger, a species native to the United States and one that displays brown, grey or all-black pelage color, and used image analysis procedures to quantify hairs from the dorsal surface and tail. From examination of 43 specimens （19 brown, 9 black and 15 grey）, and 1,720 hairs, we found no significant difference in hair lengths across color morphs, but significant differences in hair fiber widths. Black squirrels had thinner body hairs than other forms （7% thinner）, but thicker tail hairs （9% thicker） than the others. Given that the dorsal surface would be directly exposed to solar radiation, we interpret this to be an adaptation to prevent heat stress during the day. The thicker tail hairs may be an adapta- tion for nighttime thermoregulation, since squirrels sleep with their tails wrapped around their bodies. These results add to a growing literature body of the functional significance of mammalian pelage [Current Zoology 57 （6）： 731-736, 2011].展开更多
The contents of total and methyl mercury in scalp hair samples of 1179 fishermenliving at a typical Hg-polluted region in Northeast China and 27 lying-in womenand their new born babies in Beijing have been determined ...The contents of total and methyl mercury in scalp hair samples of 1179 fishermenliving at a typical Hg-polluted region in Northeast China and 27 lying-in womenand their new born babies in Beijing have been determined by illstrumental neutronactivation analysis, gas chromatography (electron coupling) and other techniqlles.Only 18 of all fishermen have the Hg contents above 5 ig/g, which indicates that theHg pollution there has been substantially alleviated. The longitudinal Hg patternsof the lying-in women show a gradually lowering tendency during pregnant period.Further, the Hg contents of the new-born babies are generally above or close to those oftheir mothers, confirming the mechanism that the methyl Hg, an organic species of Hgwith high toxicity, is readily able to penetrate the placental barrier and accumulatedin fetus. Thus, the mercury poison hajs occurred at the early stage of pregnancy.展开更多
The presumed hairs of Holy Maria-Magdalena are studied here for mineral particles found on their surfaces, by the techniques of scanning electron microscopy coupled with energy dispersive X-ray. Exploration by these t...The presumed hairs of Holy Maria-Magdalena are studied here for mineral particles found on their surfaces, by the techniques of scanning electron microscopy coupled with energy dispersive X-ray. Exploration by these techniques of the hair surfaces allows us to observe and study some marble fragments that can originate from the walls of the sarcophagus in which Maria-Magdalena’s remains were kept. These new findings support the authenticity of the hair as traditionally reported in the French “tradition des Saints de Provence”.展开更多
Mammalian hair,as a key feature related to endothermy,physical protection,and camouflage,has a long geohistorical record that dates back even to the Mesozoic.However,the limited information on the taphonomy of hair hi...Mammalian hair,as a key feature related to endothermy,physical protection,and camouflage,has a long geohistorical record that dates back even to the Mesozoic.However,the limited information on the taphonomy of hair hinders the understanding of its evolutionary significance in deep time.To address this,we conducted taphonomic experiments to simulate the transformation process of black hair.The changes in the morphological structure,microscopic characteristics,and chemical composition of hair during the simulated fossilization process were documented by scanning electron microscopy,Fourier transform infrared(FTIR)spectroscopy,and Raman spectroscopy.Our results revealed that damage to the morphology of hair began at a mild temperature(150–175℃),and hair transformed into a fluid-like mass at a relatively high temperature(200℃).In addition,the morphological structure of melanosomes had relatively greater preservation potential than keratins did,and the microscopic features of melanosomes were persistently stable.The Raman and FTIR spectra indicated that the characteristic melanin and keratin peaks changed as the temperature increased.Although the chemical signals were not lost completely,the variations in the characteristic amide bands in the FTIR spectra indicate that the keratins severely degraded at high temperatures(>200℃),whereas the characteristic melanin bands in the Raman spectra suggested that melanin signals were still recognizable,even at high temperatures(>200℃).These results were confirmed by principal component analysis(PCA)and principal component analysis linear discriminant analysis(PCA–LDA).In addition,the Raman signals of all the samples in the simulated experiments were distinguished from the signals of common geological carbonaceous materials(humic acid),which suggested that Raman spectroscopy can be used to detect melanin in fossils.展开更多
Take care of your hair to help it stay clean,strong and healthy.Wash your hair when it gets dirty,but not too often.For most people,that means every two to three days.People with oily hair wash it every one to two day...Take care of your hair to help it stay clean,strong and healthy.Wash your hair when it gets dirty,but not too often.For most people,that means every two to three days.People with oily hair wash it every one to two days.Use a brush or comb to keep your hair neat and smooth.It's also important to be gentle so you don't pull or break your hair.Never go to bed with wet hair.It can break easily when you sleep.Dry it before bed!展开更多
Peripheral nerve defect repair is a complex process that involves multiple cell types;perineurial cells play a pivotal role.Hair follicle neural crest stem cells promote perineurial cell proliferation and migration vi...Peripheral nerve defect repair is a complex process that involves multiple cell types;perineurial cells play a pivotal role.Hair follicle neural crest stem cells promote perineurial cell proliferation and migration via paracrine signaling;however,their clinical applications are limited by potential risks such as tumorigenesis and xenogeneic immune rejection,which are similar to the risks associated with other stem cell transplantations.The present study therefore focuses on small extracellular vesicles derived from hair follicle neural crest stem cells,which preserve the bioactive properties of the parent cells while avoiding the transplantation-associated risks.In vitro,small extracellular vesicles derived from hair follicle neural crest stem cells significantly enhanced the proliferation,migration,tube formation,and barrier function of perineurial cells,and subsequently upregulated the expression of tight junction proteins.Furthermore,in a rat model of sciatic nerve defects bridged with silicon tubes,treatment with small extracellular vesicles derived from hair follicle neural crest stem cells resulted in higher tight junction protein expression in perineurial cells,thus facilitating neural tissue regeneration.At 10 weeks post-surgery,rats treated with small extracellular vesicles derived from hair follicle neural crest stem cells exhibited improved nerve function recovery and reduced muscle atrophy.Transcriptomic and micro RNA analyses revealed that small extracellular vesicles derived from hair follicle neural crest stem cells deliver mi R-21-5p,which inhibits mothers against decapentaplegic homolog 7 expression,thereby activating the transforming growth factor-β/mothers against decapentaplegic homolog signaling pathway and upregulating hyaluronan synthase 2 expression,and further enhancing tight junction protein expression.Together,our findings indicate that small extracellular vesicles derived from hair follicle neural crest stem cells promote the proliferation,migration,and tight junction protein formation of perineurial cells.These results provide new insights into peripheral nerve regeneration from the perspective of perineurial cells,and present a novel approach for the clinical treatment of peripheral nerve defects.展开更多
Mechanosensors,as the core component of a proprioceptive system,can detect many types of mechanical signals in their surroundings,such as force signals,displacement signals,and vibration signals.It is understandable t...Mechanosensors,as the core component of a proprioceptive system,can detect many types of mechanical signals in their surroundings,such as force signals,displacement signals,and vibration signals.It is understandable that the development of an all-new mechanosensory structure that can be widely used is highly desirable.This is because it can markedly improve the detection performance of mechanosensors.Coincidentally,in nature,optimized microscale trigger hairs of Venus flytrap are ingeniously used as a mechanosensory structure.These trigger hairs are utilized for tactile mechanosensilla to efficiently detect external mechanical stimuli.Biological trigger hair-based mechanosensilla offer an all-new bio-inspired strategy.This strategy utilizes the notch structure and variable stiffness to enhance the perceptual performance of mechanosensors.In this study,the structure-performance-application coupling relationship of trigger hair-based mechanosensors is explored through experiment and analysis.An artificial trigger hair-based mechanosensor is developed by mimicking the deformation properties of the Venus flytrap trigger hair.This bio-inspired mechanosensor shows excellent performance in terms of mechanical stability,response time,and sensitivity to mechanical signals.展开更多
From June 7-10 hair and beauty specialists from 20 countries in Asia gathered in Beijing to take part in the 1994 ⅩⅧ Asian Hairstyling and Make-up Competition. This was the first time the event was held in China. At...From June 7-10 hair and beauty specialists from 20 countries in Asia gathered in Beijing to take part in the 1994 ⅩⅧ Asian Hairstyling and Make-up Competition. This was the first time the event was held in China. At the same time an international cosmetic, hair and skin care products oriental beauty exposition also was taking place. Throughout history men and women have paid attention to physical beauty, both in the West and the East,展开更多
The genetic identities of Ca2+ channels in root hair (RH) tips essential for constitutive RH growth have remained elusive for decades. Here, we report the identification and characterization of three cyclicnucleotide-...The genetic identities of Ca2+ channels in root hair (RH) tips essential for constitutive RH growth have remained elusive for decades. Here, we report the identification and characterization of three cyclicnucleotide-gated channel (CNGC) family members, CNGC5, CNGC6, and CNGC9, as Ca2+ channels essential for constitutive RH growth in Arabidopsis. We found that the cngc5-1cngc6-2cngc9-1 triple mutant(designated shrh1) showed significantly shorter and branching RH phenotypes as compared with thewild type. The defective RH growth phenotype of shrh1 could be rescued by either the expression ofCNGC5, CNGC6, or CNGC9 single gene or by the supply of high external Ca2+, but could not be rescuedby external K+ supply. Cytosolic Ca2+ imaging and patch-clamp data in HEK293T cells showed that thesethree CNGCs all function as Ca2+-permeable channels. Cytosolic Ca2+ imaging in growing RHs furthershowed that the Ca2+ gradients and their oscillation in RH tips were dramatically attenuated in shrh1compared with those in the wild type. Phenotypic analysis revealed that these three CNGCs are Ca2+ channels essential for constitutive RH growth, with different roles in RHs from the conditional player CNGC14.Moreover, we found that these three CNGCs are involved in auxin signaling in RHs. Taken together, ourstudy identified CNGC5, CNGC6, and CNGC9 as three key Ca2+ channels essential for constitutive RHgrowth and auxin signaling in Arabidopsis.展开更多
The availability in the soil of potassium(K^(+)),a poorly mobile macronutrient required in large quantities for plant growth,is generally suboptimal for crop production in the absence of fertilization,making improveme...The availability in the soil of potassium(K^(+)),a poorly mobile macronutrient required in large quantities for plant growth,is generally suboptimal for crop production in the absence of fertilization,making improvement of the ability of crops to adapt to K^(+)deficiency stress a major issue.Increasing the uptake capacity of the root system is among the main strategies to achieve this goal.Here,we report an integrative approach to examine the effect of K^(+)deficiency on the development of young plant entire root system,including root hairs which are known to provide a significant contribution to the uptake of poorly mobile nutrients such as K^(+),in two genetically distant wheat varieties.A rhizobox-type methodology was developed to obtain highly-resolved images of root and root hairs,allowing to describe global root and root hair traits over the whole root system via image analysis procedures.The two wheat varieties responded differently to the K^(+)shortage:Escandia,a wheat ancestor,reduced shoot biomass in condition of K^(+)shortage and substantially increased the surface area of its root system,specifically by increasing the total root hair area.Oued Zenati,a landrace,conversely appeared unresponsive to the K^(+)shortage but was shown to constitutively express,independently of the external K^(+)availability,favorable traits to cope with reduced K^(+)availability,among which a high total root hair area.Thus,valuable information on root system adaptation to K^(+)deficiency was provided by global analyses including root hairs,which should also be relevant for other nutrient stresses.展开更多
The coupled SU(5) Einstein-Yang-Mills-Higgs system of fields is investigated. A familyof static spherically symmetric and stationary axisymmetric black hole solutions is obtained.Our result shows that the black hole c...The coupled SU(5) Einstein-Yang-Mills-Higgs system of fields is investigated. A familyof static spherically symmetric and stationary axisymmetric black hole solutions is obtained.Our result shows that the black hole can carry not only the abelian electric and magneticcharges but also the non-Abelian SU(3)_c color charge.展开更多
Growth-and health-promoting bacteria can boost crop productivity in a sustainable way.Pseudomonas simiae WCS417is sucha bacterium that efficiently colonizes roots,modifiesthe architecture of the root systemto increase...Growth-and health-promoting bacteria can boost crop productivity in a sustainable way.Pseudomonas simiae WCS417is sucha bacterium that efficiently colonizes roots,modifiesthe architecture of the root systemto increase its size,and induces systemic resistance to make plants more resistant to pests and pathogens.Our previous work suggested that WCS417-induced phenotypes are controlled by root cell-type-specific mechanisms.However,it remains unclear how WCS417 affects these mechanisms.In this study,we transcriptionally profiled five Arabidopsis thaliana root cell types following WCS417 colonization.We found that the cortex and endodermis have the most differentially expressed genes,even though they are not in direct contact with this epiphytic bacterium.Many of these genes are associated with reduced cell wall biogenesis,and mutant analysis suggests that this downregulation facilitates WCS417-driven root architectural changes.Furthermore,we observed elevated expression of suberin biosynthesis genes and increased deposition of suberin in the endodermis of WCS417-colonized roots.Using an endodermal barrier mutant,we showed the importance of endodermal barrier integrity for optimal plant-beneficial bacterium association.Comparison of the transcriptome profiles in the two epidermal cell types that are in direct contact with WcS417-trichoblasts that form root hairs and atrichoblasts that do not-implies a difference in potential for defense gene activation.While both cell types respond to WCS417,trichoblasts displayed both higher basal and WCS417-dependent activation of defense-related genes compared with atrichoblasts.This suggests that root hairs may activate root immunity,a hypothesis that is supported by differential immune responses in root hair mutants.Taken together,these results highlight the strength of cell-type-specific transcriptional profiling to uncover"masked"biological mechanisms underlying beneficial plant-microbe associations.展开更多
Human and animal hairs have been used in forensic investigations for over a century.Hair is stable under adverse natural conditions;hence,it is often recovered at the crime scene,and it is necessary to determine wheth...Human and animal hairs have been used in forensic investigations for over a century.Hair is stable under adverse natural conditions;hence,it is often recovered at the crime scene,and it is necessary to determine whether the hair is of human or animal origin.Morphological and genetic characteristics are useful to differentiate human hair from animal hair.In the present study,we analyzed the distinguishing characteristics of hair of various species.In addition,we explore species identification by cytochrome c oxidase I mitochondrial gene analysis.We confirm that both the microscopic and molecular analyses of hairs are useful in forensic investigations.展开更多
The anti-hair loss mechanism of Aquilaria sinensis leaf extract(ASE)has been studied by using metabolomics and network pharmacology.Metabolomics was utilized to comprehensively identify the active constituents of ASE,...The anti-hair loss mechanism of Aquilaria sinensis leaf extract(ASE)has been studied by using metabolomics and network pharmacology.Metabolomics was utilized to comprehensively identify the active constituents of ASE,and the network pharmacology was used to elucidate their anti-hair loss mechanism,which was verified by molecular docking technology.572 active compounds were identified from the ASE by metabolomics methods,where there are 1447 corresponding targets and 492 targets related to hair loss,totaling 88 targets.20 core active substances were identified by constructing a network between common targets and active substances,which include vanillic acid,chorionic acid,caffeic acid and apigenin.The five key targets of TNF,TP53,IL6,PPARG,and EGFR were screened out by the PPI network analysis on 88 common targets.The GO and KEGG pathway enrichment analysis showed that the inflammation,hormone balance,cell growth,proliferation,apoptosis,and oxidative stress are involved.Molecular docking studies have confirmed the high binding affinity between core active compounds and key targets.The drug similarity assessment on these core compounds suggested that they have the potential to be used as potential hair loss treatment drugs.This study elucidates the complex molecular mechanism of ASE in treating hair loss,and provides a reference for the future applications in hair care products.展开更多
Objective This study aimed to comprehensively investigate the potential protective effects and underlying mechanisms of taurine against dihydrotestosterone(DHT)-induced androgenetic alopecia(AGA)in male C57BL/6 mice,w...Objective This study aimed to comprehensively investigate the potential protective effects and underlying mechanisms of taurine against dihydrotestosterone(DHT)-induced androgenetic alopecia(AGA)in male C57BL/6 mice,with a focus on hair follicle cycle modulation,cellular proliferation/apoptosis,and key related signaling pathways.Methods Six-week-old female C57BL/6 mice were initially used to assess the hair growth-promoting potential of taurine.After acclimatization,they were randomly assigned to three groups(n=8):control(regular drinking water),taurine(drinking water containing 1%taurine),and minoxidil(topical 2%minoxidil,positive control).For the AGA study,male C57BL/6 mice were randomly divided into five groups(n=8):control(physiological saline),DHT(model group,1 mg/d DHT),DHT+low-dose taurine(1 mg/d DHT+2 mg/d taurine),DHT+high-dose taurine(1 mg/d DHT+10 mg/d taurine),and DHT+minoxidil(positive control,1 mg/d DHT+topical 2%minoxidil).One day before treatment initiation,dorsal hair was shaved with scissors,and residual hair was removed using a depilatory cream.DHT and taurine were administered via daily intraperitoneal injection.Hair regrowth was assessed by photographing the depilated area at regular intervals and quantified using a four-point grading system(0-3).Dorsal skin samples were collected on day 14 for histological analysis(H&E staining),immunofluorescence staining(Ki67 for proliferation,TUNEL for apoptosis),ELISA(DHT quantification),RT-qPCR,and Western blot analysis to evaluate the expression of key genes and proteins(androgen receptor(AR),transforming growth factor(TGF)‑β1,TGF‑β2,Dickkopf-1(DKK1)).Results In female mice,taurine supplementation significantly accelerated hair growth,with effects comparable to minoxidil.This was evidenced by an earlier transition from pink(telogen)to black(anagen)skin and increased hair growth scores.Histological analysis showed that taurine increased hair follicle count and dermal thickness.Immunofluorescence confirmed enhanced keratinocyte proliferation in the hair matrix.In the DHTinduced AGA model,DHT significantly extended the telogen phase,inhibited hair growth,increased skin DHT content,and induced hair follicle miniaturization.Taurine treatment,particularly at the high dose,effectively counteracted these effects:it promoted the telogen-to-anagen transition and improved hair growth scores.Histomorphometric analysis showed that taurine significantly restored DHT-induced reductions in dermal thickness,hair follicle count,hair bulb depth,and follicle size.Taurine treatment also reduced apoptosis and promoted the proliferation of hair follicle cells,as demonstrated by Ki67 and TUNEL assays.Crucially,RT-qPCR and Western blot analyses revealed that DHT significantly up-regulated the expression of AR,TGF‑β1,TGF‑β2,and DKK1 at both mRNA and protein levels in dorsal skin.Taurine administration markedly down-regulated the expression of these pathogenic factors,bringing them closer to the levels observed in the control group.Conclusion Taurine demonstrates significant efficacy in alleviating DHT-induced AGA in male C57BL/6 mice.Its protective effects are mediated through multi-faceted mechanisms.(1)Promoting hair follicle cycle progression:it accelerates the transition from telogen to anagen,counteracting DHT-induced prolongation of the telogen phase.(2)Modulating cellular dynamics:it stimulates the proliferation of hair matrix keratinocytes and reduces DHT-induced apoptosis within hair follicle cells.(3)Suppressing androgen-driven pathogenic pathways:it downregulates the expression of critical molecules in the AGA pathway,including AR,the cytokines TGF-β1 and TGF-β2,and the Wnt pathway inhibitor DKK1.Given its favorable safety profile and multi-targeted action,taurine emerges as a promising novel therapeutic candidate or adjunct for treating AGA.Further investigation into its clinical potential and precise molecular mechanisms is warranted.This study provides a robust preclinical foundation for considering taurine supplementation or topical application in hair loss management strategies.展开更多
BACKGROUND Exosome-based therapies represent a promising approach for hair regeneration.Unlike conventional treatments such as minoxidil and finasteride,exosomes deliver bioactive cargo that can stimulate dermal papil...BACKGROUND Exosome-based therapies represent a promising approach for hair regeneration.Unlike conventional treatments such as minoxidil and finasteride,exosomes deliver bioactive cargo that can stimulate dermal papilla cells,enhance angiogenesis,and modulate inflammatory pathways.However,variability in exosome sources,isolation techniques,and dosing protocols limits their clinical translation.AIM To synthesize findings from in vitro,preclinical and clinical studies,and to evaluate the efficacy,mechanisms,and challenges associated with exosome-based hair restoration therapies.METHODS A literature search was conducted using multiple databases(PubMed/Medline,Embase,Scopus,and Web of Science)employing terms for exosomes and hair regeneration for articles published in English to February 2025,following Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.RESULTS A total of 27 studies(three in vitro,three pre-clinical,18 with both in vitro and preclinical component and three clinical)met the pre-defined search and inclusion criteria and were included in this review.CONCLUSION Exosome-based therapies hold immense promise for hair regeneration by leveraging their ability to modulate key signaling pathways and enhance hair follicle regeneration.While in vitro and preclinical studies demonstrate consistent efficacy across diverse exosome sources,methodological heterogeneity and a limited number of clinical studies warrant further clinical research to realize their full clinical potential for hair regeneration.展开更多
基金Supported by National Special Fund for Forestry Research in the Public Interest(201004094)~~
文摘[Objective] The paper was to compare the infrared spectra of straight guard hairs of leopard cat and golden cat. [Method] The straight guard hairs of leopard cat and golden cat were detected and analyzed by FTIR （Fourier Transform Infrared Spectroscopy）. [Result] There was significant interspecific difference in the infrared spectra and second derivative spectra for the middle part of guard hair. An evident M-shaped bimodal absorption peak appeared in golden cat at 648 and 654 cm-1, respectively, while did not appear in leopard cat. The second derivative spec-tra of golden cat at wave numbers from 709 to 763 cm -1 were mainly unimodal peaks with strong peak intensity, while that of leopard cat mainly was M-shaped bi-modal absorption peak with weak peak intensity. It indicated that there was obvious difference in the structure of protein side chain in guard hairs of these two animals. [Conclusion] The FTIR analysis showed great application foreground in the study of animal hairs for interspecific identification.
文摘The taxonomic status of long-tailed field mouse (Apodemus orestes) is still uncertain up to now.Some scholars regarded it as a subspecies or a synonym of dragon field mouse (A.draco),while other scholars considered it a valid species.In the study,five specimens of adult long-tailed field mouse,dragon field mouse and Chevrier's field mouse (A.chevrieri) (as a contrast) were chosen respectively.After treated,with the eyepiece micrometer in the inverted microscope,we made measurements of the widths of hairs and medullas and then calculated the medullary indexes of straight guard hairs from around the mouth,head,back,abdomen and forelimb of each species.The results indicate that,viewing at each of the five parts and the mixture of the five parts,there are no significant differences between A.orestes and A.draco,Significant differences can be found between A.orestes & A.chevrieri and A.draco & A.chevrieri though.The standpoint that A.orestes was listed as a valid species is not supported by this study.
基金sponspored by research opening fund of State Key Laboratory of Environmental Geochemistry,Guiyang,Guizhou Province,China with grant No.SKLEG2017910。
文摘In recent times,there had been reported cases of Pb poisoning in Anka gold mining area,Northwest Nigeria.Therefore,this study was carried out to determine the extent of bioaccumulation of heavy metals in the hairs and nails of children in the area.Forty samples(twenty nails and twenty hairs)samples were collected from ten boys and ten girls of ages 5–9 residing in the area.To ascertain the sources of heavy metals in children,15 soils samples,15 groundwater samples,5 samples of mine tailings,and 5 plants samples were collected.Hair and nails of the subjects were collected using internationally acceptable techniques.All samples were kept in uncontaminated ziplock bags prior to laboratory preparation and analysis.The samples were cleaned using nonionic detergent(triton X-100)and deionized water.The hairs and nails were digested with 10 mL of 6:1 mixture of nitric acid and perchloric acid.The soils,mine tailings,and plants were air-dried at room temperature,sieved,and chemically digested using the aqua regia method.The concentrations of metals in all the samples were determined using highperformance liquid chromatography–inductively coupled plasma–mass spectrometry.Statistical analysis was employed to unravel potential sources of metals in the media.Results showed that heavy metals in children of the area are above results from similar studies and pathological ranges for heavy metals in hairs and nails.Also,heavy metals in environmental media are above the recommended standards.Multivariate analysis showed that the metals are mainly from mining and other anthropogenic sources.Results of correlation between heavy metals in hairs and nails with those in geological samples revealed that heavy metal that bioaccumulates in the children of this area are mostly from contaminated environmental media.It is recommended that complete remediation and effective health education be carried out in the area.
文摘In polymorphic mammalian species that display multiple color forms, those with dark, or melanic pelage would be prone to overheating, especially if they live in warm climates, because their fur absorbs solar energy at a higher rate. However, experimental studies indicate that certain physical properties of fur of dark individuals appear to prevent, or minimize heat stress, although it is not clear what properties do so. Here, we tested the possibility that black-furred individuals simply have shorter or thinner hair fibers, which would create a lighter （in terms of weight） coat or one that allows greater air flow for evaporative coo- ling. We examined museum specimens of eastern fox squirrels Sciurus niger, a species native to the United States and one that displays brown, grey or all-black pelage color, and used image analysis procedures to quantify hairs from the dorsal surface and tail. From examination of 43 specimens （19 brown, 9 black and 15 grey）, and 1,720 hairs, we found no significant difference in hair lengths across color morphs, but significant differences in hair fiber widths. Black squirrels had thinner body hairs than other forms （7% thinner）, but thicker tail hairs （9% thicker） than the others. Given that the dorsal surface would be directly exposed to solar radiation, we interpret this to be an adaptation to prevent heat stress during the day. The thicker tail hairs may be an adapta- tion for nighttime thermoregulation, since squirrels sleep with their tails wrapped around their bodies. These results add to a growing literature body of the functional significance of mammalian pelage [Current Zoology 57 （6）： 731-736, 2011].
文摘The contents of total and methyl mercury in scalp hair samples of 1179 fishermenliving at a typical Hg-polluted region in Northeast China and 27 lying-in womenand their new born babies in Beijing have been determined by illstrumental neutronactivation analysis, gas chromatography (electron coupling) and other techniqlles.Only 18 of all fishermen have the Hg contents above 5 ig/g, which indicates that theHg pollution there has been substantially alleviated. The longitudinal Hg patternsof the lying-in women show a gradually lowering tendency during pregnant period.Further, the Hg contents of the new-born babies are generally above or close to those oftheir mothers, confirming the mechanism that the methyl Hg, an organic species of Hgwith high toxicity, is readily able to penetrate the placental barrier and accumulatedin fetus. Thus, the mercury poison hajs occurred at the early stage of pregnancy.
文摘The presumed hairs of Holy Maria-Magdalena are studied here for mineral particles found on their surfaces, by the techniques of scanning electron microscopy coupled with energy dispersive X-ray. Exploration by these techniques of the hair surfaces allows us to observe and study some marble fragments that can originate from the walls of the sarcophagus in which Maria-Magdalena’s remains were kept. These new findings support the authenticity of the hair as traditionally reported in the French “tradition des Saints de Provence”.
基金supported by the National Natural Science Foundation of China(Grant Nos.42288201&41922011)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB26000000)the Fundamental Research Funds for the Central Universities(Grant No.0206-14380219)。
文摘Mammalian hair,as a key feature related to endothermy,physical protection,and camouflage,has a long geohistorical record that dates back even to the Mesozoic.However,the limited information on the taphonomy of hair hinders the understanding of its evolutionary significance in deep time.To address this,we conducted taphonomic experiments to simulate the transformation process of black hair.The changes in the morphological structure,microscopic characteristics,and chemical composition of hair during the simulated fossilization process were documented by scanning electron microscopy,Fourier transform infrared(FTIR)spectroscopy,and Raman spectroscopy.Our results revealed that damage to the morphology of hair began at a mild temperature(150–175℃),and hair transformed into a fluid-like mass at a relatively high temperature(200℃).In addition,the morphological structure of melanosomes had relatively greater preservation potential than keratins did,and the microscopic features of melanosomes were persistently stable.The Raman and FTIR spectra indicated that the characteristic melanin and keratin peaks changed as the temperature increased.Although the chemical signals were not lost completely,the variations in the characteristic amide bands in the FTIR spectra indicate that the keratins severely degraded at high temperatures(>200℃),whereas the characteristic melanin bands in the Raman spectra suggested that melanin signals were still recognizable,even at high temperatures(>200℃).These results were confirmed by principal component analysis(PCA)and principal component analysis linear discriminant analysis(PCA–LDA).In addition,the Raman signals of all the samples in the simulated experiments were distinguished from the signals of common geological carbonaceous materials(humic acid),which suggested that Raman spectroscopy can be used to detect melanin in fossils.
文摘Take care of your hair to help it stay clean,strong and healthy.Wash your hair when it gets dirty,but not too often.For most people,that means every two to three days.People with oily hair wash it every one to two days.Use a brush or comb to keep your hair neat and smooth.It's also important to be gentle so you don't pull or break your hair.Never go to bed with wet hair.It can break easily when you sleep.Dry it before bed!
基金supported by the National Natural Science Foundation of China,No.81571211(to FL)the Natural Science Foundation of Shanghai,No.22ZR1476800(to CH)。
文摘Peripheral nerve defect repair is a complex process that involves multiple cell types;perineurial cells play a pivotal role.Hair follicle neural crest stem cells promote perineurial cell proliferation and migration via paracrine signaling;however,their clinical applications are limited by potential risks such as tumorigenesis and xenogeneic immune rejection,which are similar to the risks associated with other stem cell transplantations.The present study therefore focuses on small extracellular vesicles derived from hair follicle neural crest stem cells,which preserve the bioactive properties of the parent cells while avoiding the transplantation-associated risks.In vitro,small extracellular vesicles derived from hair follicle neural crest stem cells significantly enhanced the proliferation,migration,tube formation,and barrier function of perineurial cells,and subsequently upregulated the expression of tight junction proteins.Furthermore,in a rat model of sciatic nerve defects bridged with silicon tubes,treatment with small extracellular vesicles derived from hair follicle neural crest stem cells resulted in higher tight junction protein expression in perineurial cells,thus facilitating neural tissue regeneration.At 10 weeks post-surgery,rats treated with small extracellular vesicles derived from hair follicle neural crest stem cells exhibited improved nerve function recovery and reduced muscle atrophy.Transcriptomic and micro RNA analyses revealed that small extracellular vesicles derived from hair follicle neural crest stem cells deliver mi R-21-5p,which inhibits mothers against decapentaplegic homolog 7 expression,thereby activating the transforming growth factor-β/mothers against decapentaplegic homolog signaling pathway and upregulating hyaluronan synthase 2 expression,and further enhancing tight junction protein expression.Together,our findings indicate that small extracellular vesicles derived from hair follicle neural crest stem cells promote the proliferation,migration,and tight junction protein formation of perineurial cells.These results provide new insights into peripheral nerve regeneration from the perspective of perineurial cells,and present a novel approach for the clinical treatment of peripheral nerve defects.
基金supported by the National Natural Science Foundation of China(Grant nos.52005355 and 52005356)the Natural Science Foundation of Jiangsu Province(BK2020881).
文摘Mechanosensors,as the core component of a proprioceptive system,can detect many types of mechanical signals in their surroundings,such as force signals,displacement signals,and vibration signals.It is understandable that the development of an all-new mechanosensory structure that can be widely used is highly desirable.This is because it can markedly improve the detection performance of mechanosensors.Coincidentally,in nature,optimized microscale trigger hairs of Venus flytrap are ingeniously used as a mechanosensory structure.These trigger hairs are utilized for tactile mechanosensilla to efficiently detect external mechanical stimuli.Biological trigger hair-based mechanosensilla offer an all-new bio-inspired strategy.This strategy utilizes the notch structure and variable stiffness to enhance the perceptual performance of mechanosensors.In this study,the structure-performance-application coupling relationship of trigger hair-based mechanosensors is explored through experiment and analysis.An artificial trigger hair-based mechanosensor is developed by mimicking the deformation properties of the Venus flytrap trigger hair.This bio-inspired mechanosensor shows excellent performance in terms of mechanical stability,response time,and sensitivity to mechanical signals.
文摘From June 7-10 hair and beauty specialists from 20 countries in Asia gathered in Beijing to take part in the 1994 ⅩⅧ Asian Hairstyling and Make-up Competition. This was the first time the event was held in China. At the same time an international cosmetic, hair and skin care products oriental beauty exposition also was taking place. Throughout history men and women have paid attention to physical beauty, both in the West and the East,
基金This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB27020102)the National Natural Science Foundation of China(91635301,31570262,and 31770292).
文摘The genetic identities of Ca2+ channels in root hair (RH) tips essential for constitutive RH growth have remained elusive for decades. Here, we report the identification and characterization of three cyclicnucleotide-gated channel (CNGC) family members, CNGC5, CNGC6, and CNGC9, as Ca2+ channels essential for constitutive RH growth in Arabidopsis. We found that the cngc5-1cngc6-2cngc9-1 triple mutant(designated shrh1) showed significantly shorter and branching RH phenotypes as compared with thewild type. The defective RH growth phenotype of shrh1 could be rescued by either the expression ofCNGC5, CNGC6, or CNGC9 single gene or by the supply of high external Ca2+, but could not be rescuedby external K+ supply. Cytosolic Ca2+ imaging and patch-clamp data in HEK293T cells showed that thesethree CNGCs all function as Ca2+-permeable channels. Cytosolic Ca2+ imaging in growing RHs furthershowed that the Ca2+ gradients and their oscillation in RH tips were dramatically attenuated in shrh1compared with those in the wild type. Phenotypic analysis revealed that these three CNGCs are Ca2+ channels essential for constitutive RH growth, with different roles in RHs from the conditional player CNGC14.Moreover, we found that these three CNGCs are involved in auxin signaling in RHs. Taken together, ourstudy identified CNGC5, CNGC6, and CNGC9 as three key Ca2+ channels essential for constitutive RHgrowth and auxin signaling in Arabidopsis.
基金supported in part by a doctoral grant from the Algerian Ministry of Higher Education and Scientific Research(“bourse d’excellence du gouvernement algérien”to IM)by an ERANET EU Arimnet2 grant(no.618127)(to HS)by the French Institut National de Recherche pour l’Agriculture,l’Alimentation et l’Environnement(INRAE grant“Phenopili”from Biologie et Amélioration des Plantes Department)(to HS).
文摘The availability in the soil of potassium(K^(+)),a poorly mobile macronutrient required in large quantities for plant growth,is generally suboptimal for crop production in the absence of fertilization,making improvement of the ability of crops to adapt to K^(+)deficiency stress a major issue.Increasing the uptake capacity of the root system is among the main strategies to achieve this goal.Here,we report an integrative approach to examine the effect of K^(+)deficiency on the development of young plant entire root system,including root hairs which are known to provide a significant contribution to the uptake of poorly mobile nutrients such as K^(+),in two genetically distant wheat varieties.A rhizobox-type methodology was developed to obtain highly-resolved images of root and root hairs,allowing to describe global root and root hair traits over the whole root system via image analysis procedures.The two wheat varieties responded differently to the K^(+)shortage:Escandia,a wheat ancestor,reduced shoot biomass in condition of K^(+)shortage and substantially increased the surface area of its root system,specifically by increasing the total root hair area.Oued Zenati,a landrace,conversely appeared unresponsive to the K^(+)shortage but was shown to constitutively express,independently of the external K^(+)availability,favorable traits to cope with reduced K^(+)availability,among which a high total root hair area.Thus,valuable information on root system adaptation to K^(+)deficiency was provided by global analyses including root hairs,which should also be relevant for other nutrient stresses.
基金Project supported by the National Natural Science Foundation of China.
文摘The coupled SU(5) Einstein-Yang-Mills-Higgs system of fields is investigated. A familyof static spherically symmetric and stationary axisymmetric black hole solutions is obtained.Our result shows that the black hole can carry not only the abelian electric and magneticcharges but also the non-Abelian SU(3)_c color charge.
基金the Netherlands Organization of Scientific Research through ALW Topsector Grant no.831.14.001(E.H.V.)a postdoctoral fellowship from the Jane Coffin Childs Memorial Fund for Medical Research(L.M.L.)+8 种基金the NIH(5R01-GM-043778),the NSF(MCB-06-18304),the Gordon and Betty Moore Foundation and the Howard Hughes Medical Institute(P.N.B.)a postdoctoral fellowship from the Research Foundation Flanders(FWO 12B8116N)(R.d.J.)the NWO Green II Grant no.ALWGR.2017.002(R.d.J.)the Novo Nordisk Foundation Grant no.NNF19SA0059362(R.d.J.)the China Scholarship Council(CSC)scholarship no.201908320054(J.Z.)scholarship no.202006990074(J.Y.)the Technology Foundation Perspective Program Back2Roots grant no.14219(C.M.J.P.)the ERC Advanced Grant no.269072 of the European Research Council(C.M.J.P.)the NWO Gravitation Grant no.024.004.014(1.A.S.and C.M.J.).
文摘Growth-and health-promoting bacteria can boost crop productivity in a sustainable way.Pseudomonas simiae WCS417is sucha bacterium that efficiently colonizes roots,modifiesthe architecture of the root systemto increase its size,and induces systemic resistance to make plants more resistant to pests and pathogens.Our previous work suggested that WCS417-induced phenotypes are controlled by root cell-type-specific mechanisms.However,it remains unclear how WCS417 affects these mechanisms.In this study,we transcriptionally profiled five Arabidopsis thaliana root cell types following WCS417 colonization.We found that the cortex and endodermis have the most differentially expressed genes,even though they are not in direct contact with this epiphytic bacterium.Many of these genes are associated with reduced cell wall biogenesis,and mutant analysis suggests that this downregulation facilitates WCS417-driven root architectural changes.Furthermore,we observed elevated expression of suberin biosynthesis genes and increased deposition of suberin in the endodermis of WCS417-colonized roots.Using an endodermal barrier mutant,we showed the importance of endodermal barrier integrity for optimal plant-beneficial bacterium association.Comparison of the transcriptome profiles in the two epidermal cell types that are in direct contact with WcS417-trichoblasts that form root hairs and atrichoblasts that do not-implies a difference in potential for defense gene activation.While both cell types respond to WCS417,trichoblasts displayed both higher basal and WCS417-dependent activation of defense-related genes compared with atrichoblasts.This suggests that root hairs may activate root immunity,a hypothesis that is supported by differential immune responses in root hair mutants.Taken together,these results highlight the strength of cell-type-specific transcriptional profiling to uncover"masked"biological mechanisms underlying beneficial plant-microbe associations.
文摘Human and animal hairs have been used in forensic investigations for over a century.Hair is stable under adverse natural conditions;hence,it is often recovered at the crime scene,and it is necessary to determine whether the hair is of human or animal origin.Morphological and genetic characteristics are useful to differentiate human hair from animal hair.In the present study,we analyzed the distinguishing characteristics of hair of various species.In addition,we explore species identification by cytochrome c oxidase I mitochondrial gene analysis.We confirm that both the microscopic and molecular analyses of hairs are useful in forensic investigations.
文摘The anti-hair loss mechanism of Aquilaria sinensis leaf extract(ASE)has been studied by using metabolomics and network pharmacology.Metabolomics was utilized to comprehensively identify the active constituents of ASE,and the network pharmacology was used to elucidate their anti-hair loss mechanism,which was verified by molecular docking technology.572 active compounds were identified from the ASE by metabolomics methods,where there are 1447 corresponding targets and 492 targets related to hair loss,totaling 88 targets.20 core active substances were identified by constructing a network between common targets and active substances,which include vanillic acid,chorionic acid,caffeic acid and apigenin.The five key targets of TNF,TP53,IL6,PPARG,and EGFR were screened out by the PPI network analysis on 88 common targets.The GO and KEGG pathway enrichment analysis showed that the inflammation,hormone balance,cell growth,proliferation,apoptosis,and oxidative stress are involved.Molecular docking studies have confirmed the high binding affinity between core active compounds and key targets.The drug similarity assessment on these core compounds suggested that they have the potential to be used as potential hair loss treatment drugs.This study elucidates the complex molecular mechanism of ASE in treating hair loss,and provides a reference for the future applications in hair care products.
基金supported by grants from The National Natural Science Foundation of China(31772690)the Natural Science Foundation of Shanxi Province(201701D121106)PhD Research Startup Foundation of Changzhi Medical College(BS202308)。
文摘Objective This study aimed to comprehensively investigate the potential protective effects and underlying mechanisms of taurine against dihydrotestosterone(DHT)-induced androgenetic alopecia(AGA)in male C57BL/6 mice,with a focus on hair follicle cycle modulation,cellular proliferation/apoptosis,and key related signaling pathways.Methods Six-week-old female C57BL/6 mice were initially used to assess the hair growth-promoting potential of taurine.After acclimatization,they were randomly assigned to three groups(n=8):control(regular drinking water),taurine(drinking water containing 1%taurine),and minoxidil(topical 2%minoxidil,positive control).For the AGA study,male C57BL/6 mice were randomly divided into five groups(n=8):control(physiological saline),DHT(model group,1 mg/d DHT),DHT+low-dose taurine(1 mg/d DHT+2 mg/d taurine),DHT+high-dose taurine(1 mg/d DHT+10 mg/d taurine),and DHT+minoxidil(positive control,1 mg/d DHT+topical 2%minoxidil).One day before treatment initiation,dorsal hair was shaved with scissors,and residual hair was removed using a depilatory cream.DHT and taurine were administered via daily intraperitoneal injection.Hair regrowth was assessed by photographing the depilated area at regular intervals and quantified using a four-point grading system(0-3).Dorsal skin samples were collected on day 14 for histological analysis(H&E staining),immunofluorescence staining(Ki67 for proliferation,TUNEL for apoptosis),ELISA(DHT quantification),RT-qPCR,and Western blot analysis to evaluate the expression of key genes and proteins(androgen receptor(AR),transforming growth factor(TGF)‑β1,TGF‑β2,Dickkopf-1(DKK1)).Results In female mice,taurine supplementation significantly accelerated hair growth,with effects comparable to minoxidil.This was evidenced by an earlier transition from pink(telogen)to black(anagen)skin and increased hair growth scores.Histological analysis showed that taurine increased hair follicle count and dermal thickness.Immunofluorescence confirmed enhanced keratinocyte proliferation in the hair matrix.In the DHTinduced AGA model,DHT significantly extended the telogen phase,inhibited hair growth,increased skin DHT content,and induced hair follicle miniaturization.Taurine treatment,particularly at the high dose,effectively counteracted these effects:it promoted the telogen-to-anagen transition and improved hair growth scores.Histomorphometric analysis showed that taurine significantly restored DHT-induced reductions in dermal thickness,hair follicle count,hair bulb depth,and follicle size.Taurine treatment also reduced apoptosis and promoted the proliferation of hair follicle cells,as demonstrated by Ki67 and TUNEL assays.Crucially,RT-qPCR and Western blot analyses revealed that DHT significantly up-regulated the expression of AR,TGF‑β1,TGF‑β2,and DKK1 at both mRNA and protein levels in dorsal skin.Taurine administration markedly down-regulated the expression of these pathogenic factors,bringing them closer to the levels observed in the control group.Conclusion Taurine demonstrates significant efficacy in alleviating DHT-induced AGA in male C57BL/6 mice.Its protective effects are mediated through multi-faceted mechanisms.(1)Promoting hair follicle cycle progression:it accelerates the transition from telogen to anagen,counteracting DHT-induced prolongation of the telogen phase.(2)Modulating cellular dynamics:it stimulates the proliferation of hair matrix keratinocytes and reduces DHT-induced apoptosis within hair follicle cells.(3)Suppressing androgen-driven pathogenic pathways:it downregulates the expression of critical molecules in the AGA pathway,including AR,the cytokines TGF-β1 and TGF-β2,and the Wnt pathway inhibitor DKK1.Given its favorable safety profile and multi-targeted action,taurine emerges as a promising novel therapeutic candidate or adjunct for treating AGA.Further investigation into its clinical potential and precise molecular mechanisms is warranted.This study provides a robust preclinical foundation for considering taurine supplementation or topical application in hair loss management strategies.
文摘BACKGROUND Exosome-based therapies represent a promising approach for hair regeneration.Unlike conventional treatments such as minoxidil and finasteride,exosomes deliver bioactive cargo that can stimulate dermal papilla cells,enhance angiogenesis,and modulate inflammatory pathways.However,variability in exosome sources,isolation techniques,and dosing protocols limits their clinical translation.AIM To synthesize findings from in vitro,preclinical and clinical studies,and to evaluate the efficacy,mechanisms,and challenges associated with exosome-based hair restoration therapies.METHODS A literature search was conducted using multiple databases(PubMed/Medline,Embase,Scopus,and Web of Science)employing terms for exosomes and hair regeneration for articles published in English to February 2025,following Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.RESULTS A total of 27 studies(three in vitro,three pre-clinical,18 with both in vitro and preclinical component and three clinical)met the pre-defined search and inclusion criteria and were included in this review.CONCLUSION Exosome-based therapies hold immense promise for hair regeneration by leveraging their ability to modulate key signaling pathways and enhance hair follicle regeneration.While in vitro and preclinical studies demonstrate consistent efficacy across diverse exosome sources,methodological heterogeneity and a limited number of clinical studies warrant further clinical research to realize their full clinical potential for hair regeneration.
