目的:探讨扶正益补颗粒联合HAART治疗气血亏虚型HIV感染者的临床疗效及对免疫系统(T淋巴细胞亚群)的影响。方法:选取100例于2022年7月~11月到昆明市第三人民医院就诊的气血亏虚型HIV感染者。采用随机数字表法将HIV患者随机分为中西药组...目的:探讨扶正益补颗粒联合HAART治疗气血亏虚型HIV感染者的临床疗效及对免疫系统(T淋巴细胞亚群)的影响。方法:选取100例于2022年7月~11月到昆明市第三人民医院就诊的气血亏虚型HIV感染者。采用随机数字表法将HIV患者随机分为中西药组与西药组,每组各50例。西药组给予HAART治疗方案;中西药组在HAART的基础上加用扶正益补颗粒;疗程均为24周。观察两组临床疗效,比较治疗前后两组患者中医证候积分、HIV病毒载量、T淋巴细胞亚群、IFN-γ、IL-4水平及不良反应发生率。结果:治疗后,中西药组在缓解乏力、气短、神疲、懒言、面色淡白或萎黄及纳呆症状的疗效优于西药组(P P +、CD4+/CD8+均较治疗前显著升高显著(P P +显著高于西药组(P +均较治疗前降低(P γ水平均显著升高(P P Objective: To explore the clinical efficacy and impact on the immune system (T lymphocyte subpopulations) of Fuzheng Yibu Granules combined with HAART in the treatment of HIV-infected people with deficiency of qi and blood. Methods: A total of 100 HIV-infected individuals who fulfilled the diagnostic criteria for HIV infection accompanied by qi and blood deficiency were enrolled in this study and received treatment at the Third People’s Hospital of Kunming from July 2022 to November 2022. The participants were randomly allocated into two groups: the Chinese and Western medicine group and the Western medicine group, with 50 individuals in each group. The Western medicine group was given the HAART treatment;the Chinese and Western medicine group was given Fuzheng Yibu Granules on the basis of HAART. The treatment course was 24 weeks. The therapeutic effects of the two groups were observed, and the TCM syndrome scores, HIV viral load, T lymphocyte subsets, IFN-γ, IL-4 levels, and the incidence of adverse reactions before and after treatment were compared between the two groups. Results: After treatment, the Chinese and Western medicine group was superior to the Western medicine group in alleviating symptoms such as fatigue, shortness of breath, mental fatigue, reluctance to speak, pale or sallow complexion, and anorexia (P P + and CD4+/CD8+ in both groups were significantly increased compared with those before treatment (P P + in the Chinese and Western medicine group was significantly higher than that in the Western medicine group (P + in both groups was decreased compared with that before treatment (P γ in both groups were significantly increased (P P < 0.01). Conclusion: The combination of Fuzheng Yibu Granules and HAART can significantly improve the clinical symptoms of HIV-infected people with deficiency of qi and blood, regulate the Th1/Th2 cell balance, improve the immune function of patients, and has no obvious toxic effects.展开更多
高效抗逆转录病毒治疗(HAART)是目前治疗HIV/AIDS最为有效的方法。通过多种抗逆转录病毒药物的联合应用,HAART能够有效抑制病毒复制,从而显著改善患者的预后。然而,长期接受HAART治疗可能会对患者的多项实验室指标产生影响,包括血常规...高效抗逆转录病毒治疗(HAART)是目前治疗HIV/AIDS最为有效的方法。通过多种抗逆转录病毒药物的联合应用,HAART能够有效抑制病毒复制,从而显著改善患者的预后。然而,长期接受HAART治疗可能会对患者的多项实验室指标产生影响,包括血常规、肝功能、肾功能、血脂和血糖等。这些影响与药物种类、治疗方案、患者个体差异以及合并症等多种因素密切相关。本文还探讨了HAART不良反应的监测与应对策略,并展望了未来的研究方向。通过深入探索这些研究方向,有望进一步优化HAART治疗方案,提高HIV/AIDS患者的治疗效果和生活质量。High efficiency antiretroviral therapy (HAART) is currently the most effective method for treating HIV/AIDS. Through the combination of multiple antiretroviral drugs, HAART can effectively inhibit virus replication, thereby significantly improving the prognosis of patients. However, long-term treatment with HAART may have an impact on multiple laboratory indicators of patients, including blood routine, liver function, kidney function, blood lipids, and blood glucose. These effects are closely related to various factors such as drug types, treatment plans, individual patient differences, and comorbidities. This article also explores the monitoring and response strategies for adverse reactions of HAART, and looks forward to future research directions. By exploring these research directions in depth, it is expected to further optimize the HAART treatment plan and improve the treatment efficacy and quality of life of HIV/AIDS patients.展开更多
文摘目的:探讨扶正益补颗粒联合HAART治疗气血亏虚型HIV感染者的临床疗效及对免疫系统(T淋巴细胞亚群)的影响。方法:选取100例于2022年7月~11月到昆明市第三人民医院就诊的气血亏虚型HIV感染者。采用随机数字表法将HIV患者随机分为中西药组与西药组,每组各50例。西药组给予HAART治疗方案;中西药组在HAART的基础上加用扶正益补颗粒;疗程均为24周。观察两组临床疗效,比较治疗前后两组患者中医证候积分、HIV病毒载量、T淋巴细胞亚群、IFN-γ、IL-4水平及不良反应发生率。结果:治疗后,中西药组在缓解乏力、气短、神疲、懒言、面色淡白或萎黄及纳呆症状的疗效优于西药组(P P +、CD4+/CD8+均较治疗前显著升高显著(P P +显著高于西药组(P +均较治疗前降低(P γ水平均显著升高(P P Objective: To explore the clinical efficacy and impact on the immune system (T lymphocyte subpopulations) of Fuzheng Yibu Granules combined with HAART in the treatment of HIV-infected people with deficiency of qi and blood. Methods: A total of 100 HIV-infected individuals who fulfilled the diagnostic criteria for HIV infection accompanied by qi and blood deficiency were enrolled in this study and received treatment at the Third People’s Hospital of Kunming from July 2022 to November 2022. The participants were randomly allocated into two groups: the Chinese and Western medicine group and the Western medicine group, with 50 individuals in each group. The Western medicine group was given the HAART treatment;the Chinese and Western medicine group was given Fuzheng Yibu Granules on the basis of HAART. The treatment course was 24 weeks. The therapeutic effects of the two groups were observed, and the TCM syndrome scores, HIV viral load, T lymphocyte subsets, IFN-γ, IL-4 levels, and the incidence of adverse reactions before and after treatment were compared between the two groups. Results: After treatment, the Chinese and Western medicine group was superior to the Western medicine group in alleviating symptoms such as fatigue, shortness of breath, mental fatigue, reluctance to speak, pale or sallow complexion, and anorexia (P P + and CD4+/CD8+ in both groups were significantly increased compared with those before treatment (P P + in the Chinese and Western medicine group was significantly higher than that in the Western medicine group (P + in both groups was decreased compared with that before treatment (P γ in both groups were significantly increased (P P < 0.01). Conclusion: The combination of Fuzheng Yibu Granules and HAART can significantly improve the clinical symptoms of HIV-infected people with deficiency of qi and blood, regulate the Th1/Th2 cell balance, improve the immune function of patients, and has no obvious toxic effects.
文摘高效抗逆转录病毒治疗(HAART)是目前治疗HIV/AIDS最为有效的方法。通过多种抗逆转录病毒药物的联合应用,HAART能够有效抑制病毒复制,从而显著改善患者的预后。然而,长期接受HAART治疗可能会对患者的多项实验室指标产生影响,包括血常规、肝功能、肾功能、血脂和血糖等。这些影响与药物种类、治疗方案、患者个体差异以及合并症等多种因素密切相关。本文还探讨了HAART不良反应的监测与应对策略,并展望了未来的研究方向。通过深入探索这些研究方向,有望进一步优化HAART治疗方案,提高HIV/AIDS患者的治疗效果和生活质量。High efficiency antiretroviral therapy (HAART) is currently the most effective method for treating HIV/AIDS. Through the combination of multiple antiretroviral drugs, HAART can effectively inhibit virus replication, thereby significantly improving the prognosis of patients. However, long-term treatment with HAART may have an impact on multiple laboratory indicators of patients, including blood routine, liver function, kidney function, blood lipids, and blood glucose. These effects are closely related to various factors such as drug types, treatment plans, individual patient differences, and comorbidities. This article also explores the monitoring and response strategies for adverse reactions of HAART, and looks forward to future research directions. By exploring these research directions in depth, it is expected to further optimize the HAART treatment plan and improve the treatment efficacy and quality of life of HIV/AIDS patients.
