A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,...A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,6 receptors.This identifies their potential threat to public health.However,our understanding of the molecular basis for the switch of receptor preference is still limited.In this study,we employed the random forest algorithm to identify the potentially key amino acid sites within hemagglutinin(HA),which are associated with the receptor binding ability of H9N2 avian influenza virus(AIV).Subsequently,these sites were further verified by receptor binding assays.A total of 12 substitutions in the HA protein(N158D,N158S,A160 N,A160D,A160T,T163I,T163V,V190T,V190A,D193 N,D193G,and N231D)were predicted to prefer binding toα-2,6 receptors.Except for the V190T substitution,the other substitutions were demonstrated to display an affinity for preferential binding toα-2,6 receptors by receptor binding assays.Especially,the A160T substitution caused a significant upregulation of immune-response genes and an increased mortality rate in mice.Our findings provide novel insights into understanding the genetic basis of receptor preference of the H9N2 AIV.展开更多
This paper proposes an efficient method for designing accurate structure-specified mixed H2/H∞ optimal controllers for systems with uncertainties and disturbance using particle swarm (PSO) algorithm. It is designed t...This paper proposes an efficient method for designing accurate structure-specified mixed H2/H∞ optimal controllers for systems with uncertainties and disturbance using particle swarm (PSO) algorithm. It is designed to find a suitable controller that minimizes the performance index of error signal subject to an unequal constraint on the norm of the closed-loop system. Although the mixed H2/H∞ for the output feedback approach control is considered as a robust and optimal control technique, the design process normally comes up with a complex and non-convex optimization problem, which is difficult to solve by the conventional optimization methods. The PSO can efficiently solve design problems of multi-input-multi-output (MIMO) optimal control systems, which is very suitable for practical engineering designs. It is used to search for parameters of a structure-specified controller, which satisfies mixed performance index. The simulation and experimental results show high feasibility, robustness and practical value compared with the conventional proportional-integral-derivative (PID) and proportional-Integral (PI) controller, and the proposed algorithm is also more efficient compared with the genetic algorithm (GA).展开更多
Aqueous E pH Diagram is an essential tool for analyzing hydrometallurgical and corrosion processes. Due to the requirements for environmental protection and energy saving in recent years, waste water processing a...Aqueous E pH Diagram is an essential tool for analyzing hydrometallurgical and corrosion processes. Due to the requirements for environmental protection and energy saving in recent years, waste water processing and hydrometallurgical process of concentrate have been greatly developed. The construction of E pH diagrams has turned to multi component systems. However, there are some limits in plotting such diagrams. There is only one diagram for one multi component system, which can not reflect the truth of the aqueous reaction. In the paper, a new computation method is proposed to construct E pH diagrams. Component activity term is used to determine the boundary of stable areas. For the multi component systems, different atom ratios of elements have been taken into account. M S H 2O system is chosen to study since it is of importance in metallurgical solution. Compared with conventional methods, the algorithm is simple and conforms to real conditions.展开更多
In view of the existence of uncertainties such as system model and disturbance signal in the electric power steering （EPS） system, and the demand for system dynamic performance, the mixed H2/H∞, controller based on...In view of the existence of uncertainties such as system model and disturbance signal in the electric power steering （EPS） system, and the demand for system dynamic performance, the mixed H2/H∞, controller based on genetic algorithm is proposed. In order to obtain satisfactory steering feel, robust performance and steering stability, models of EPS system and a two-degree- of-freedom car are set up, then the state space model and the augmented matrixes are built. The H∞, method is introduced to minimize the effect of disturbances on the outputs, and the H2 method is applied to optimizing the system performance based on genetic algorithm. The simulation results show that the modified mixed H2/H∞ controller, which synthesizes the advantage of H2 control and Ha, control, has better robust performance and robust stability. The designed controller can attenuate the noises and disturbances caused by road random motivation, torque sensor measurement and model parameter uncertainty, enabling the driver to obtain satisfactory road feel.展开更多
This study aimed to specialise a directional H^(2)(DH^(2))compression to matrices arising from the discontinuous Galerkin(DG)discretisation of the hypersingular equation in acoustics.The significantfinding is an algor...This study aimed to specialise a directional H^(2)(DH^(2))compression to matrices arising from the discontinuous Galerkin(DG)discretisation of the hypersingular equation in acoustics.The significantfinding is an algorithm that takes a DG stiffness matrix andfinds a near-optimal DH^(2) approximation for low and high-frequency problems.We introduced the necessary special optimisations to make this algorithm more efficient in the case of a DG stiffness matrix.Moreover,an automatic parameter tuning strategy makes it easy to use and versatile.Numerical comparisons with a classical Boundary Element Method(BEM)show that a DG scheme combined with a DH^(2) gives better computational efficiency than a classical BEM in the case of high-order finite elements and hp heterogeneous meshes.The results indicate that DG is suitable for an auto-adaptive context in integral equations.展开更多
In this paper,two numerical schemes for the multi-term fractional mixed diffusion and diffusion-wave equation(of order a,with 0<a<2)are developed to solve the initial value problem.Firstly,we study a direct nume...In this paper,two numerical schemes for the multi-term fractional mixed diffusion and diffusion-wave equation(of order a,with 0<a<2)are developed to solve the initial value problem.Firstly,we study a direct numerical scheme that uses quadratic Charles Hermite and Newton(H2N2)interpolation polynomials approximations in the temporal direction and finite element discretization in the spatial direction.We prove the stability of the direct numerical scheme by the energy method and obtain a priori error estimate of the scheme with an accuracy of order 3a.In order to improve computational efficiency,a new fast numerical scheme based on H2N2 interpolation and an efficient sum-of-exponentials approximation for the kernels is proposed.Numerical examples confirm the error estimation results and the validity of the fast scheme.展开更多
基金supported by the National Natural Science Foundation of China(32273037 and 32102636)the Guangdong Major Project of Basic and Applied Basic Research(2020B0301030007)+4 种基金Laboratory of Lingnan Modern Agriculture Project(NT2021007)the Guangdong Science and Technology Innovation Leading Talent Program(2019TX05N098)the 111 Center(D20008)the double first-class discipline promotion project(2023B10564003)the Department of Education of Guangdong Province(2019KZDXM004 and 2019KCXTD001).
文摘A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,6 receptors.This identifies their potential threat to public health.However,our understanding of the molecular basis for the switch of receptor preference is still limited.In this study,we employed the random forest algorithm to identify the potentially key amino acid sites within hemagglutinin(HA),which are associated with the receptor binding ability of H9N2 avian influenza virus(AIV).Subsequently,these sites were further verified by receptor binding assays.A total of 12 substitutions in the HA protein(N158D,N158S,A160 N,A160D,A160T,T163I,T163V,V190T,V190A,D193 N,D193G,and N231D)were predicted to prefer binding toα-2,6 receptors.Except for the V190T substitution,the other substitutions were demonstrated to display an affinity for preferential binding toα-2,6 receptors by receptor binding assays.Especially,the A160T substitution caused a significant upregulation of immune-response genes and an increased mortality rate in mice.Our findings provide novel insights into understanding the genetic basis of receptor preference of the H9N2 AIV.
文摘This paper proposes an efficient method for designing accurate structure-specified mixed H2/H∞ optimal controllers for systems with uncertainties and disturbance using particle swarm (PSO) algorithm. It is designed to find a suitable controller that minimizes the performance index of error signal subject to an unequal constraint on the norm of the closed-loop system. Although the mixed H2/H∞ for the output feedback approach control is considered as a robust and optimal control technique, the design process normally comes up with a complex and non-convex optimization problem, which is difficult to solve by the conventional optimization methods. The PSO can efficiently solve design problems of multi-input-multi-output (MIMO) optimal control systems, which is very suitable for practical engineering designs. It is used to search for parameters of a structure-specified controller, which satisfies mixed performance index. The simulation and experimental results show high feasibility, robustness and practical value compared with the conventional proportional-integral-derivative (PID) and proportional-Integral (PI) controller, and the proposed algorithm is also more efficient compared with the genetic algorithm (GA).
文摘Aqueous E pH Diagram is an essential tool for analyzing hydrometallurgical and corrosion processes. Due to the requirements for environmental protection and energy saving in recent years, waste water processing and hydrometallurgical process of concentrate have been greatly developed. The construction of E pH diagrams has turned to multi component systems. However, there are some limits in plotting such diagrams. There is only one diagram for one multi component system, which can not reflect the truth of the aqueous reaction. In the paper, a new computation method is proposed to construct E pH diagrams. Component activity term is used to determine the boundary of stable areas. For the multi component systems, different atom ratios of elements have been taken into account. M S H 2O system is chosen to study since it is of importance in metallurgical solution. Compared with conventional methods, the algorithm is simple and conforms to real conditions.
基金supported by the National Natural Science Foundation of China (Grant Nos.51005115 and 51005248)the Science Fund of State Key Laboratory of Automotive Safety and Energy (Grant No.KF11201)
文摘In view of the existence of uncertainties such as system model and disturbance signal in the electric power steering （EPS） system, and the demand for system dynamic performance, the mixed H2/H∞, controller based on genetic algorithm is proposed. In order to obtain satisfactory steering feel, robust performance and steering stability, models of EPS system and a two-degree- of-freedom car are set up, then the state space model and the augmented matrixes are built. The H∞, method is introduced to minimize the effect of disturbances on the outputs, and the H2 method is applied to optimizing the system performance based on genetic algorithm. The simulation results show that the modified mixed H2/H∞ controller, which synthesizes the advantage of H2 control and Ha, control, has better robust performance and robust stability. The designed controller can attenuate the noises and disturbances caused by road random motivation, torque sensor measurement and model parameter uncertainty, enabling the driver to obtain satisfactory road feel.
文摘This study aimed to specialise a directional H^(2)(DH^(2))compression to matrices arising from the discontinuous Galerkin(DG)discretisation of the hypersingular equation in acoustics.The significantfinding is an algorithm that takes a DG stiffness matrix andfinds a near-optimal DH^(2) approximation for low and high-frequency problems.We introduced the necessary special optimisations to make this algorithm more efficient in the case of a DG stiffness matrix.Moreover,an automatic parameter tuning strategy makes it easy to use and versatile.Numerical comparisons with a classical Boundary Element Method(BEM)show that a DG scheme combined with a DH^(2) gives better computational efficiency than a classical BEM in the case of high-order finite elements and hp heterogeneous meshes.The results indicate that DG is suitable for an auto-adaptive context in integral equations.
基金supported by the State Key Program of the National Natural Science Foundation of China(No.11931003)by the Grants(Nos.41974133 and 12271233).
文摘In this paper,two numerical schemes for the multi-term fractional mixed diffusion and diffusion-wave equation(of order a,with 0<a<2)are developed to solve the initial value problem.Firstly,we study a direct numerical scheme that uses quadratic Charles Hermite and Newton(H2N2)interpolation polynomials approximations in the temporal direction and finite element discretization in the spatial direction.We prove the stability of the direct numerical scheme by the energy method and obtain a priori error estimate of the scheme with an accuracy of order 3a.In order to improve computational efficiency,a new fast numerical scheme based on H2N2 interpolation and an efficient sum-of-exponentials approximation for the kernels is proposed.Numerical examples confirm the error estimation results and the validity of the fast scheme.
