针对含光伏(photovoltaic,PV)、电动汽车(electric vehicle,EV)及家庭电器负荷的智能社区,以车入户(vehicle to home,V2H)的形式将EV纳入家庭需求响应框架,利用EV的双向输能特性并考虑EV充/放电带来的电池容量退化成本,协同PV、电网的...针对含光伏(photovoltaic,PV)、电动汽车(electric vehicle,EV)及家庭电器负荷的智能社区,以车入户(vehicle to home,V2H)的形式将EV纳入家庭需求响应框架,利用EV的双向输能特性并考虑EV充/放电带来的电池容量退化成本,协同PV、电网的实时电价和用户需求的可容忍时延,基于Lyapunov优化理论提出随机环境下V2H用户的EV充/放电调度策略和每户家庭的负荷响应策略,最小化家庭用户的长期平均购电成本。并提出一种智能社区在线能量交易方案,旨在最小化智能社区总的购电成本、最大限度提高社区能源利用率。理论分析和仿真结果表明,所提算法无需实时电价、PV出力、用户负荷需求的先验概率信息,仅基于当前系统状态就可使优化目标趋于最优值,实现家庭用户的能量调度和家庭用户之间的能量共享,减少家庭购电成本,提高用户之间能量交易的灵活性。展开更多
The medical fungus Hirsutella sinensis has been used as a Chinese folk health supplement because of its immunomodulatory properties.Our previous studies established the antifibrotic action of Hirsutella sinensis mycel...The medical fungus Hirsutella sinensis has been used as a Chinese folk health supplement because of its immunomodulatory properties.Our previous studies established the antifibrotic action of Hirsutella sinensis mycelium(HSM)in the lung.The epithelial–mesenchymal transition(EMT)is involved in the pathogenesis of idiopathic pulmonary fibrosis.The present study investigates the role of HSM in mediating EMT during the development of pulmonary fibrosis.HSM significantly inhibits bleomycin(BLM)-induced pulmonary fibrosis by blocking the EMT.In addition,the expression levels of midkine are increased in the lungs of the BLM-induced group.Further analysis of the results indicates that the mRNA level of midkine correlated positively with EMT.HSM markedly abrogates the transforming growth factorβ-induced EMT-like phenotype and behavior in vitro.The activation of midkine related signaling pathway is ameliorated following HSM treatment,whereas this extract also caused an effective attenuation of the induction of EMT(caused by midkine overexpression)in vitro.Results further confirm that oral medication of HSM disrupted the midkine pathway in vivo.Overall,findings suggest that the midkine pathway and the regulation of the EMT may be considered novel candidate therapeutic targets for the antifibrotic effects caused by HSM.展开更多
背景:H型血管(CD31hiEmcnhi)因独特的功能为深入理解血管介导的骨代谢调控机制提供了新的视角和切入点,引发了骨科学研究范式从“骨本位”向“骨-血管整合”的重要转变。目的:基于H型血管领域的文献数据进行可视化分析,探讨该领域的研...背景:H型血管(CD31hiEmcnhi)因独特的功能为深入理解血管介导的骨代谢调控机制提供了新的视角和切入点,引发了骨科学研究范式从“骨本位”向“骨-血管整合”的重要转变。目的:基于H型血管领域的文献数据进行可视化分析,探讨该领域的研究热点和前沿趋势。方法:系统检索CNKI和Web of Science核心合集中与H型血管相关的中英文文献,文献检索时限为2014-2024年。采用CiteSpace 6.2.R4信息可视化软件对文献的发表国家、作者、机构、关键词、时间线视图等进行可视化分析。结果与结论:①共纳入中文文献59篇、英文文献185篇。自2014年提出H型血管概念以来,相关研究文献数量逐年增加,中国在该领域的研究处于领先地位,主要研究机构包括南方医科大学、四川大学和上海交通大学等。关键词分析揭示,当前研究热点主要集中在H型血管的生成与调控机制、H型血管在骨生成和骨重塑过程中的作用以及H型血管与骨质代谢相关疾病的关系;此外,出现“诱导膜”“软骨修复”“中医药”等新兴关键词,表明研究正在向多样化和多学科交叉的方向发展。②H型血管在骨骼疾病的发生发展中发挥着关键作用,相关研究对深入理解骨组织的生理与病理过程具有重要意义。未来应进一步探讨H型血管在不同疾病背景下的具体作用机制,推动基础研究成果的临床转化,为骨骼疾病的预防和治疗提供新的思路与策略。展开更多
文摘针对含光伏(photovoltaic,PV)、电动汽车(electric vehicle,EV)及家庭电器负荷的智能社区,以车入户(vehicle to home,V2H)的形式将EV纳入家庭需求响应框架,利用EV的双向输能特性并考虑EV充/放电带来的电池容量退化成本,协同PV、电网的实时电价和用户需求的可容忍时延,基于Lyapunov优化理论提出随机环境下V2H用户的EV充/放电调度策略和每户家庭的负荷响应策略,最小化家庭用户的长期平均购电成本。并提出一种智能社区在线能量交易方案,旨在最小化智能社区总的购电成本、最大限度提高社区能源利用率。理论分析和仿真结果表明,所提算法无需实时电价、PV出力、用户负荷需求的先验概率信息,仅基于当前系统状态就可使优化目标趋于最优值,实现家庭用户的能量调度和家庭用户之间的能量共享,减少家庭购电成本,提高用户之间能量交易的灵活性。
基金the Six Talent Peaks Project in Jiangsu Province(No.YY-021)the Fundamental Research Funds of the Central Universities(No.021414380342)the Fund of State Key Laboratory of Trauma Burns and Combined Injury(No.SKLKF201602)。
文摘The medical fungus Hirsutella sinensis has been used as a Chinese folk health supplement because of its immunomodulatory properties.Our previous studies established the antifibrotic action of Hirsutella sinensis mycelium(HSM)in the lung.The epithelial–mesenchymal transition(EMT)is involved in the pathogenesis of idiopathic pulmonary fibrosis.The present study investigates the role of HSM in mediating EMT during the development of pulmonary fibrosis.HSM significantly inhibits bleomycin(BLM)-induced pulmonary fibrosis by blocking the EMT.In addition,the expression levels of midkine are increased in the lungs of the BLM-induced group.Further analysis of the results indicates that the mRNA level of midkine correlated positively with EMT.HSM markedly abrogates the transforming growth factorβ-induced EMT-like phenotype and behavior in vitro.The activation of midkine related signaling pathway is ameliorated following HSM treatment,whereas this extract also caused an effective attenuation of the induction of EMT(caused by midkine overexpression)in vitro.Results further confirm that oral medication of HSM disrupted the midkine pathway in vivo.Overall,findings suggest that the midkine pathway and the regulation of the EMT may be considered novel candidate therapeutic targets for the antifibrotic effects caused by HSM.
文摘背景:H型血管(CD31hiEmcnhi)因独特的功能为深入理解血管介导的骨代谢调控机制提供了新的视角和切入点,引发了骨科学研究范式从“骨本位”向“骨-血管整合”的重要转变。目的:基于H型血管领域的文献数据进行可视化分析,探讨该领域的研究热点和前沿趋势。方法:系统检索CNKI和Web of Science核心合集中与H型血管相关的中英文文献,文献检索时限为2014-2024年。采用CiteSpace 6.2.R4信息可视化软件对文献的发表国家、作者、机构、关键词、时间线视图等进行可视化分析。结果与结论:①共纳入中文文献59篇、英文文献185篇。自2014年提出H型血管概念以来,相关研究文献数量逐年增加,中国在该领域的研究处于领先地位,主要研究机构包括南方医科大学、四川大学和上海交通大学等。关键词分析揭示,当前研究热点主要集中在H型血管的生成与调控机制、H型血管在骨生成和骨重塑过程中的作用以及H型血管与骨质代谢相关疾病的关系;此外,出现“诱导膜”“软骨修复”“中医药”等新兴关键词,表明研究正在向多样化和多学科交叉的方向发展。②H型血管在骨骼疾病的发生发展中发挥着关键作用,相关研究对深入理解骨组织的生理与病理过程具有重要意义。未来应进一步探讨H型血管在不同疾病背景下的具体作用机制,推动基础研究成果的临床转化,为骨骼疾病的预防和治疗提供新的思路与策略。
