Osyris lanceolata is heavily and illegally exploited in East Africa for its essential oils, yet little is known about its population status and ecological requirements. This study examined its population structure and...Osyris lanceolata is heavily and illegally exploited in East Africa for its essential oils, yet little is known about its population status and ecological requirements. This study examined its population structure and environmental factors influencing its distribution in the semi-arid Karamoja sub-region, Uganda. We surveyed 388 plots (5 m radius) at different altitudes, recording life stages, stem diameters, and regeneration patterns, and analyzed soil samples. Multivariate analyses, including Canonical Correspondence Analysis (CCA), Detrended Correspondence Analysis (DCA), Non-metric Multidimensional Scaling (NMDS), and Multiple Regression Modeling (MRM), identified key environmental factors affecting its distribution. Findings show that O. lanceolata populations in Moroto, Nakapiripirit, and Amudat districts are severely degraded due to overexploitation. The species is primarily regenerating through coppicing rather than seedlings, with an exploitation intensity of 56.6%. Population densities are low, distribution is irregular, and sustainable harvesting is not viable. Soil properties, particularly Ca2+, N, P, K+, Na+, and organic matter, significantly influence its abundance. Conservation efforts should focus on identifying suitable provenances for genetic preservation and plantation establishment. Areas with at least 9 trees per hectare in Moroto, Nakapiripirit, and Amudat could serve as potential sites for ex-situ plantations. Further research should explore how biotic interactions, genetic diversity, and morphology affect oil yield and quality to support restoration, breeding, and domestication initiatives.展开更多
Following the publication of Zeng et al.(2023),an inadvertent error was recently identified in Figure 1B and Supplementary Figure S3.To ensure the accuracy and integrity of our published work,we formally request a cor...Following the publication of Zeng et al.(2023),an inadvertent error was recently identified in Figure 1B and Supplementary Figure S3.To ensure the accuracy and integrity of our published work,we formally request a correction to address this issue and apologize for any confusion this error may have caused.For details,please refer to the modified Supplementary Materials.展开更多
Craniometaphyseal dysplasia(CMD),a rare craniotubular disorder,occurs in an autosomal dominant(AD)or autosomal recessive(AR)form.CMD is characterized by hyperostosis of craniofacial bones and metaphyseal flaring of lo...Craniometaphyseal dysplasia(CMD),a rare craniotubular disorder,occurs in an autosomal dominant(AD)or autosomal recessive(AR)form.CMD is characterized by hyperostosis of craniofacial bones and metaphyseal flaring of long bones.Many patients with CMD suffer from neurological symptoms.The pathogenesis of CMD is not fully understood.展开更多
Objective: To study the pharmacokinetics of native r SAK in rabbit's femoral artery thrombosis model, the “lytic circle' method was used to determine plasma levels of r SAK. Methods: Thirty New Zealand rabb...Objective: To study the pharmacokinetics of native r SAK in rabbit's femoral artery thrombosis model, the “lytic circle' method was used to determine plasma levels of r SAK. Methods: Thirty New Zealand rabbits were randomly assigned to the control (saline 10 ml, 30 min), r SAK low dose (0.25 mg/kg, 30 min), medial dose (0.50 mg/kg, 30 min), high dose (1.00 mg/kg, 30 min), single bolus (0.50 mg/kg, 2 min) and conjunctive therapy (initiated with heparin 200 U/kg, followed by infusion of r SAK 0.50 mg/kg for 30 min, and subsequently infused heparin 50 U/(kg·h) to endpoint) groups. The right femoral artery thrombosis model in rabbit was made by balloon injury, then the thrombolytic agents were infused through parallel ear vein and the blood samples were collected pre thrombolysis and at different time post thrombolysis to determine the plasma levels of r SAK by “lytic circle' method, the plasma levels of r SAK were processed by pharmacokinetic computing procedure to fit the model. Results: The plasma levels of r SAK and the diameters of lytic circles showed a pretty good linear correlation under the scope of 2.0×10 4 2.0×10 6 U/L, and the averaged recycle rate was (96.05±11.35)%(RSD =±11.82%).All peak concentration time in each infusion group was 30 min, and the peak concentrations positively correlated with the doses administrated in infusion groups(r=0.999 98, P <0.000 1). In single bolus group, Peak concentration time was 2 min, and the peak concentration reached (5.16±1.02) mg/L, which was significant higher than that in the same dose r SAK infusion group ( P <0.01). In conjunctive therapy group, the peak concentration showed no significant difference from that in the same dose r SAK infusion group ( P >0.05). The plasma levels of r SAK fit in two compartment model as processed by pharmacokinetic computing procedure in each group. Conclusion: The “lytic circle' method is a simple, practical and reliable method to determine the plasma level of r SAK, and the pharmacokinetics of native r SAK infusion fits in two compartment model in rabbit's femoral artery thrombosis model.展开更多
This paper examines the performance of an atmospheric general circulation model (AGCM) developed at the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of ...This paper examines the performance of an atmospheric general circulation model (AGCM) developed at the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics (LASG/IAP). It is a spectral model truncated at R42(2.8125°long×1.66°lat) resolution and with nine vertical levels, and referred to as R42L9/LASG hereafter. It is also the new version of atmospheric component model R15L9 of the global ocean-atmosphere-land system (GOALS/LASG). A 40-year simulation in which the model is forced with the climatological monthly mean sea surface temperature is compared with the 40-year (1958-97) U.S. National Center for Environmental Prediction (NGEP) global reanalysis and the 22-year (1979-2000) Xie-Arkin monthly precipitation climatology. The mean DJF and JJA geographical distributions of precipitation, sea level pressure, 500-hPa geopotential height, 850-hPa and 200-hPa zonal wind, and other fields averaged for the last 30-year integration of the R42L9 model are analyzed. Results show that the model reproduces well the observed basic patterns, particularly precipitation over the East Asian region. Comparing the new model with R15L9/LASG, the old version with coarse resolution (nearly 7.5°long×4.5°lat), shows an obvious improvement in the simulation of regional climate, especially precipitation. The weaknesses in simulation and future improvements of the model are also discussed.展开更多
Repeated-batch and continuous production of L-lactic acid by immobilized Rhizopusoryzae with calcium alginate entrapment method in a three-phase fluidized-bed bioreactor was stud-ied.The operation conditions were opti...Repeated-batch and continuous production of L-lactic acid by immobilized Rhizopusoryzae with calcium alginate entrapment method in a three-phase fluidized-bed bioreactor was stud-ied.The operation conditions were optimized.The productivity based on total reactor volume wasabout 3 times higher than that with free cells in a traditional stirred tank bioreactor.A mathemat-ical model was proposed and the model predictions were in good agreement with the experimentaldat.展开更多
In this paper,we study the approximate solutions for some of nonlinear Biomathematics models via the e-epidemic SI1I2R model characterizing the spread of viruses in a computer network and SIR childhood disease model.T...In this paper,we study the approximate solutions for some of nonlinear Biomathematics models via the e-epidemic SI1I2R model characterizing the spread of viruses in a computer network and SIR childhood disease model.The reduced differential transforms method(RDTM)is one of the interesting methods for finding the approximate solutions for nonlinear problems.We apply the RDTM to discuss the analytic approximate solutions to the SI1I2R model for the spread of virus HCV-subtype and SIR childhood disease model.We discuss the numerical results at some special values of parameters in the approximate solutions.We use the computer software package such as Mathematical to find more iteration when calculating the approximate solutions.Graphical results and discussed quantitatively are presented to illustrate behavior of the obtained approximate solutions.展开更多
Urban planning has become a widely concern for minimizing the negative effects of urban expansion on terrestrial ecosystems. We developed an interdisciplinary modeling framework to evaluate the effectiveness and short...Urban planning has become a widely concern for minimizing the negative effects of urban expansion on terrestrial ecosystems. We developed an interdisciplinary modeling framework to evaluate the effectiveness and shortcomings of urban expansion management strategies. A three-step method was applied to Yinchuan Plain in the northwestern of China, including(1)analyzing the relationship between landscape pattern and ecosystem service values through mathematical statistics;(2) predicting landscape pattern and ecosystem services change under different scenarios based on cellular automaton model(SLEUTH-3r model); and(3) designing and validating optimized scenario through integrating historical analysis experiments and future multi-comparison suggestions. Results have suggested that landscape composition and configuration can significantly affect regional ecosystem service values, especially the connectivity and shape of landscape. Compact urban growth policy and medium environment protection policy are the appropriate setting for urban expansion plan. Optimization validation of the combined designed scenario implied the reliability of this method. Our results highlighted the significance of integrating application of landscape pattern analysis, ecosystem service value evaluation,model simulation and multi-scenario prediction in urban planning.展开更多
文摘Osyris lanceolata is heavily and illegally exploited in East Africa for its essential oils, yet little is known about its population status and ecological requirements. This study examined its population structure and environmental factors influencing its distribution in the semi-arid Karamoja sub-region, Uganda. We surveyed 388 plots (5 m radius) at different altitudes, recording life stages, stem diameters, and regeneration patterns, and analyzed soil samples. Multivariate analyses, including Canonical Correspondence Analysis (CCA), Detrended Correspondence Analysis (DCA), Non-metric Multidimensional Scaling (NMDS), and Multiple Regression Modeling (MRM), identified key environmental factors affecting its distribution. Findings show that O. lanceolata populations in Moroto, Nakapiripirit, and Amudat districts are severely degraded due to overexploitation. The species is primarily regenerating through coppicing rather than seedlings, with an exploitation intensity of 56.6%. Population densities are low, distribution is irregular, and sustainable harvesting is not viable. Soil properties, particularly Ca2+, N, P, K+, Na+, and organic matter, significantly influence its abundance. Conservation efforts should focus on identifying suitable provenances for genetic preservation and plantation establishment. Areas with at least 9 trees per hectare in Moroto, Nakapiripirit, and Amudat could serve as potential sites for ex-situ plantations. Further research should explore how biotic interactions, genetic diversity, and morphology affect oil yield and quality to support restoration, breeding, and domestication initiatives.
文摘Following the publication of Zeng et al.(2023),an inadvertent error was recently identified in Figure 1B and Supplementary Figure S3.To ensure the accuracy and integrity of our published work,we formally request a correction to address this issue and apologize for any confusion this error may have caused.For details,please refer to the modified Supplementary Materials.
基金supported by NIH/NIDCR grant R01DE025664 to IPC.
文摘Craniometaphyseal dysplasia(CMD),a rare craniotubular disorder,occurs in an autosomal dominant(AD)or autosomal recessive(AR)form.CMD is characterized by hyperostosis of craniofacial bones and metaphyseal flaring of long bones.Many patients with CMD suffer from neurological symptoms.The pathogenesis of CMD is not fully understood.
文摘Objective: To study the pharmacokinetics of native r SAK in rabbit's femoral artery thrombosis model, the “lytic circle' method was used to determine plasma levels of r SAK. Methods: Thirty New Zealand rabbits were randomly assigned to the control (saline 10 ml, 30 min), r SAK low dose (0.25 mg/kg, 30 min), medial dose (0.50 mg/kg, 30 min), high dose (1.00 mg/kg, 30 min), single bolus (0.50 mg/kg, 2 min) and conjunctive therapy (initiated with heparin 200 U/kg, followed by infusion of r SAK 0.50 mg/kg for 30 min, and subsequently infused heparin 50 U/(kg·h) to endpoint) groups. The right femoral artery thrombosis model in rabbit was made by balloon injury, then the thrombolytic agents were infused through parallel ear vein and the blood samples were collected pre thrombolysis and at different time post thrombolysis to determine the plasma levels of r SAK by “lytic circle' method, the plasma levels of r SAK were processed by pharmacokinetic computing procedure to fit the model. Results: The plasma levels of r SAK and the diameters of lytic circles showed a pretty good linear correlation under the scope of 2.0×10 4 2.0×10 6 U/L, and the averaged recycle rate was (96.05±11.35)%(RSD =±11.82%).All peak concentration time in each infusion group was 30 min, and the peak concentrations positively correlated with the doses administrated in infusion groups(r=0.999 98, P <0.000 1). In single bolus group, Peak concentration time was 2 min, and the peak concentration reached (5.16±1.02) mg/L, which was significant higher than that in the same dose r SAK infusion group ( P <0.01). In conjunctive therapy group, the peak concentration showed no significant difference from that in the same dose r SAK infusion group ( P >0.05). The plasma levels of r SAK fit in two compartment model as processed by pharmacokinetic computing procedure in each group. Conclusion: The “lytic circle' method is a simple, practical and reliable method to determine the plasma level of r SAK, and the pharmacokinetics of native r SAK infusion fits in two compartment model in rabbit's femoral artery thrombosis model.
文摘This paper examines the performance of an atmospheric general circulation model (AGCM) developed at the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics (LASG/IAP). It is a spectral model truncated at R42(2.8125°long×1.66°lat) resolution and with nine vertical levels, and referred to as R42L9/LASG hereafter. It is also the new version of atmospheric component model R15L9 of the global ocean-atmosphere-land system (GOALS/LASG). A 40-year simulation in which the model is forced with the climatological monthly mean sea surface temperature is compared with the 40-year (1958-97) U.S. National Center for Environmental Prediction (NGEP) global reanalysis and the 22-year (1979-2000) Xie-Arkin monthly precipitation climatology. The mean DJF and JJA geographical distributions of precipitation, sea level pressure, 500-hPa geopotential height, 850-hPa and 200-hPa zonal wind, and other fields averaged for the last 30-year integration of the R42L9 model are analyzed. Results show that the model reproduces well the observed basic patterns, particularly precipitation over the East Asian region. Comparing the new model with R15L9/LASG, the old version with coarse resolution (nearly 7.5°long×4.5°lat), shows an obvious improvement in the simulation of regional climate, especially precipitation. The weaknesses in simulation and future improvements of the model are also discussed.
基金Supported by the National Natural Science Foundation of China.
文摘Repeated-batch and continuous production of L-lactic acid by immobilized Rhizopusoryzae with calcium alginate entrapment method in a three-phase fluidized-bed bioreactor was stud-ied.The operation conditions were optimized.The productivity based on total reactor volume wasabout 3 times higher than that with free cells in a traditional stirred tank bioreactor.A mathemat-ical model was proposed and the model predictions were in good agreement with the experimentaldat.
文摘In this paper,we study the approximate solutions for some of nonlinear Biomathematics models via the e-epidemic SI1I2R model characterizing the spread of viruses in a computer network and SIR childhood disease model.The reduced differential transforms method(RDTM)is one of the interesting methods for finding the approximate solutions for nonlinear problems.We apply the RDTM to discuss the analytic approximate solutions to the SI1I2R model for the spread of virus HCV-subtype and SIR childhood disease model.We discuss the numerical results at some special values of parameters in the approximate solutions.We use the computer software package such as Mathematical to find more iteration when calculating the approximate solutions.Graphical results and discussed quantitatively are presented to illustrate behavior of the obtained approximate solutions.
基金supported by the National Natural Science Foundation of China [Grant number 41371176]the Fundamental Research Funds for the Central Universities[Grant number lzujbky_2017_it91]
文摘Urban planning has become a widely concern for minimizing the negative effects of urban expansion on terrestrial ecosystems. We developed an interdisciplinary modeling framework to evaluate the effectiveness and shortcomings of urban expansion management strategies. A three-step method was applied to Yinchuan Plain in the northwestern of China, including(1)analyzing the relationship between landscape pattern and ecosystem service values through mathematical statistics;(2) predicting landscape pattern and ecosystem services change under different scenarios based on cellular automaton model(SLEUTH-3r model); and(3) designing and validating optimized scenario through integrating historical analysis experiments and future multi-comparison suggestions. Results have suggested that landscape composition and configuration can significantly affect regional ecosystem service values, especially the connectivity and shape of landscape. Compact urban growth policy and medium environment protection policy are the appropriate setting for urban expansion plan. Optimization validation of the combined designed scenario implied the reliability of this method. Our results highlighted the significance of integrating application of landscape pattern analysis, ecosystem service value evaluation,model simulation and multi-scenario prediction in urban planning.
