Pain is a complex physiological and psychological activity,involving at least three dimensions,including pain sensation,pain emotion,and pain cognition.Acupuncture can clearly relieve the pain sensation of patients an...Pain is a complex physiological and psychological activity,involving at least three dimensions,including pain sensation,pain emotion,and pain cognition.Acupuncture can clearly relieve the pain sensation of patients and improve pain emotion and pain cognition induced by pain;acupuncture participates in the multi-dimensional regulation of pain through brain regions of the limbic system such as anterior cingulate cortex(ACC),amygdala(AMY),and hippocampus.By analyzing relevant literature,it has been found that the regulation of acupuncture on pain emotion is mainly related to the activation of pertinent opioid receptors in the ACC,the decrease of the expression of extracellular signal-regulated kinase(ERK),and the promotion of the expression of glutamic acid(Glu)A1,metabotropic glutamate receptor-1(mGluR1),andγ-aminobutyric acid aminobutyric acid(GABA)B2 protein in the AMY.The regulation of acupuncture on pain cognition is mainly related to the elevation of the expression of protein kinase A(PKA)and phospho-p38 mitogen-activated protein kinase(phospho-p38 MAPK)and the inhibition of cyclic adenosine monophosphate(cAMP)/PKA/cAMP response element-binding protein(CREB)signaling pathway in the ACC.展开更多
基金This work was supported by 2021 Scientific Planning Project of Gansu Province(2021年甘肃省科技计划项目No.21JR1RA266)Project of National Natural Science Foundation of China(国家自然科学基金项目,No.81460744).
文摘Pain is a complex physiological and psychological activity,involving at least three dimensions,including pain sensation,pain emotion,and pain cognition.Acupuncture can clearly relieve the pain sensation of patients and improve pain emotion and pain cognition induced by pain;acupuncture participates in the multi-dimensional regulation of pain through brain regions of the limbic system such as anterior cingulate cortex(ACC),amygdala(AMY),and hippocampus.By analyzing relevant literature,it has been found that the regulation of acupuncture on pain emotion is mainly related to the activation of pertinent opioid receptors in the ACC,the decrease of the expression of extracellular signal-regulated kinase(ERK),and the promotion of the expression of glutamic acid(Glu)A1,metabotropic glutamate receptor-1(mGluR1),andγ-aminobutyric acid aminobutyric acid(GABA)B2 protein in the AMY.The regulation of acupuncture on pain cognition is mainly related to the elevation of the expression of protein kinase A(PKA)and phospho-p38 mitogen-activated protein kinase(phospho-p38 MAPK)and the inhibition of cyclic adenosine monophosphate(cAMP)/PKA/cAMP response element-binding protein(CREB)signaling pathway in the ACC.
