Two novel 2,5-diphenyl oxazole derivatives,named gymnothecaoxazoles A（1） and B（2）,were isolated from the whole parts of endemic medicinal plant of Gymnotheca chinensis（Saururaceae）.The structures of the new comp...Two novel 2,5-diphenyl oxazole derivatives,named gymnothecaoxazoles A（1） and B（2）,were isolated from the whole parts of endemic medicinal plant of Gymnotheca chinensis（Saururaceae）.The structures of the new compounds were elucidated by extensive NMR and MS data,and the structure of compound 1was further confirmed by X-ray crystal diffraction analysis.展开更多
Two new eupodienone lignans, named gymnothelignan T （1） and gymnothelignan U （2） were isolated from the whole plants of endemic medicinal plant of Gymnotheca chinensis （Saururaceae）. The structures of the new co...Two new eupodienone lignans, named gymnothelignan T （1） and gymnothelignan U （2） were isolated from the whole plants of endemic medicinal plant of Gymnotheca chinensis （Saururaceae）. The structures of the new compounds were elucidated by means of HRMS, 1D and 2D NMR. Compound I was tested for cytotoxic activity in HCT15, HCT116, A549, MCF-7 and HepG2 cells and exhibited no appreciable activity against these tested cell lines with IC50 values above 50 μmol/L.展开更多
Two new biphenyl butyl neolignan derivatives,named gymnothebutyllignans A（1） and B（2）,were isolated from the whole parts of endemic medicinal plant of Gymnotheca involucrata（Saururaceae）.The structures of the ne...Two new biphenyl butyl neolignan derivatives,named gymnothebutyllignans A（1） and B（2）,were isolated from the whole parts of endemic medicinal plant of Gymnotheca involucrata（Saururaceae）.The structures of the new compounds were elucidated by extensive NMR and MS data,and the absolutely configuration of compound 1 was confirmed by X-ray crystal diffraction analysis.展开更多
基金financially supported by grants from the National Natural Sciences Foundation (Nos. 21572219 and 21302180) of China
文摘Two novel 2,5-diphenyl oxazole derivatives,named gymnothecaoxazoles A（1） and B（2）,were isolated from the whole parts of endemic medicinal plant of Gymnotheca chinensis（Saururaceae）.The structures of the new compounds were elucidated by extensive NMR and MS data,and the structure of compound 1was further confirmed by X-ray crystal diffraction analysis.
基金financially supported by the grant from the National Natural Sciences Foundation of China (No. 30973634)
文摘Two new eupodienone lignans, named gymnothelignan T （1） and gymnothelignan U （2） were isolated from the whole plants of endemic medicinal plant of Gymnotheca chinensis （Saururaceae）. The structures of the new compounds were elucidated by means of HRMS, 1D and 2D NMR. Compound I was tested for cytotoxic activity in HCT15, HCT116, A549, MCF-7 and HepG2 cells and exhibited no appreciable activity against these tested cell lines with IC50 values above 50 μmol/L.
基金financially supported by grants from the National Natural Sciences Foundation of China(No.31560102)
文摘Two new biphenyl butyl neolignan derivatives,named gymnothebutyllignans A（1） and B（2）,were isolated from the whole parts of endemic medicinal plant of Gymnotheca involucrata（Saururaceae）.The structures of the new compounds were elucidated by extensive NMR and MS data,and the absolutely configuration of compound 1 was confirmed by X-ray crystal diffraction analysis.
文摘目的建立鉴别鱼腥草Houttuynia cordata与百部还魂Gymnotheca chinensis的特异性PCR方法。方法采集不同产地的鱼腥草与百部还魂样品各8份,所有样品提取总DNA。通过对其mat K片段进行扩增、测序,进行同源比对后根据其变异位点设计特异鉴别引物,建立特异PCR鉴别方法,并通过加入SYBR Green I染料法对2种中药进行快速检测。另外,构建多重PCR体系,只经一个PCR反应,就能对鱼腥草与百部还魂进行快速分子鉴定。结果所构建特异PCR与多重PCR体系均能产生鱼腥草185 bp的特异鉴别条带,百部还魂389 bp的特异鉴别条带,SYBR Green I染料可进行快速检测方法。结论建立的鱼腥草与百部还魂2种中药的快速PCR鉴别方法简便、可靠。
