Currently,available conventional options for diabetes mellitus have certain limitations of their own,and options from medicinal plants with antihyperglycemic activities are being searched to meet the need.Antidiabetic...Currently,available conventional options for diabetes mellitus have certain limitations of their own,and options from medicinal plants with antihyperglycemic activities are being searched to meet the need.Antidiabetic properties of Tmospora cordifolia are highly appreciated in Ayurveda and even in recent modern researches.Several studies on its extracts(viz,immunemodulatory.anti-hyperglycemic.antioxidant,adaptogenic.hepatoprotective.hormone regulator etc.) and isolated phytoconstituents(like tinosporin,berberine.jatrorrhizine etc.) have reported that it is a preventive and curative antidiabetic herb,which are substantiated by clinical trials.Scattered information pertaining to antidiabetic potential of Tmospora is reported.Present review encompasses(i) in-depth information of reported antidiabetic activities of the plant in light of available experimental and clinical studies,and(ii) understanding on the possible mechanism of its action in combating the complex pathology of diabetes.展开更多
Tinospora cordifolia(Guduchi or Gurjo),a herbaceous vine or climbing deciduous shrub,is consider as an important medicine in the Ayurvedic system of medication,which is available in India,China,Myanmar,Bangladesh and ...Tinospora cordifolia(Guduchi or Gurjo),a herbaceous vine or climbing deciduous shrub,is consider as an important medicine in the Ayurvedic system of medication,which is available in India,China,Myanmar,Bangladesh and Srilanka.Menispermaceae is the family of this compound.T.cordifolia have a variety of properties to treat various ailments such as fevers,jaundice,diabetes,dysentery,urinary infections,and skin diseases.This compound has been subjected to many chemicals,pharmacological,pre-clinical,or clinical investigations and some new therapeutic potential effects have been indicated.This review aims to summarize the critical information concerning in areas of chemical constituents,chemical structure,and pharmacokinetic activities such as anti-diabetic,anticancer,immune-modulatory,antivirus(especially in silico study about COVID-19),antioxidant,antimicrobial,hepatoprotective and its effect on cardiovascular and neurological disorders as well as rheumatoid arthritis.This traditional herb needs more experimental study on the clinical,pre-clinical study,and clinical efficacy of these compounds for the prevention and treatment of COVID-19 and needs large-scale clinical studies to prove the clinical efficacy of this compound,especially in stress-related diseases and other neuronal disorders.展开更多
基金Supported by Institute of Post Graduate Teaching and Research in Ayurveda,Gujarat Ayurved University,Jamnagar,Gujarat,India
文摘Currently,available conventional options for diabetes mellitus have certain limitations of their own,and options from medicinal plants with antihyperglycemic activities are being searched to meet the need.Antidiabetic properties of Tmospora cordifolia are highly appreciated in Ayurveda and even in recent modern researches.Several studies on its extracts(viz,immunemodulatory.anti-hyperglycemic.antioxidant,adaptogenic.hepatoprotective.hormone regulator etc.) and isolated phytoconstituents(like tinosporin,berberine.jatrorrhizine etc.) have reported that it is a preventive and curative antidiabetic herb,which are substantiated by clinical trials.Scattered information pertaining to antidiabetic potential of Tmospora is reported.Present review encompasses(i) in-depth information of reported antidiabetic activities of the plant in light of available experimental and clinical studies,and(ii) understanding on the possible mechanism of its action in combating the complex pathology of diabetes.
文摘Tinospora cordifolia(Guduchi or Gurjo),a herbaceous vine or climbing deciduous shrub,is consider as an important medicine in the Ayurvedic system of medication,which is available in India,China,Myanmar,Bangladesh and Srilanka.Menispermaceae is the family of this compound.T.cordifolia have a variety of properties to treat various ailments such as fevers,jaundice,diabetes,dysentery,urinary infections,and skin diseases.This compound has been subjected to many chemicals,pharmacological,pre-clinical,or clinical investigations and some new therapeutic potential effects have been indicated.This review aims to summarize the critical information concerning in areas of chemical constituents,chemical structure,and pharmacokinetic activities such as anti-diabetic,anticancer,immune-modulatory,antivirus(especially in silico study about COVID-19),antioxidant,antimicrobial,hepatoprotective and its effect on cardiovascular and neurological disorders as well as rheumatoid arthritis.This traditional herb needs more experimental study on the clinical,pre-clinical study,and clinical efficacy of these compounds for the prevention and treatment of COVID-19 and needs large-scale clinical studies to prove the clinical efficacy of this compound,especially in stress-related diseases and other neuronal disorders.
