The growth trajectory of hailstones within clouds has remained elusive due to the inability to trace them directly,impeding the comprehension of their underlying growth mechanisms.This study investigated hailstone ver...The growth trajectory of hailstones within clouds has remained elusive due to the inability to trace them directly,impeding the comprehension of their underlying growth mechanisms.This study investigated hailstone vertical growth trajectories by detecting the stable isotope signatures(2H and 18O compositions)of different shells in 27 hailstones from 9hailstorms,which allowed us to capture the ambient temperature during hailstone growth.The vertical growth trajectories were obtained by comparing the isotopic compositions of water condensate in clouds,derived from the Adiabatic Model,with those measured in hailstones.Although hailstone growth was primarily observed in the–10°C to–30°C temperature layer,the embryo formation height and subsequent growth trajectories significantly varied among hailstones.Embryos formed over a wide range of temperatures(–8.7°C to–33.4°C);four originated at temperatures above–15°C and 16originated at temperatures below–20°C,suggesting ice nuclei composed of bioproteins and mineral dust,respectively.Among the 27 measured hailstones,3 exhibited minimal vertical movement,16 exhibited a monotonic rise or fall,and the remaining 8 exhibited alternating up-down trajectories;only one experienced“recycling”during up-down drifting.Trajectory analysis revealed that similar-sized hailstones from a single storm tended to form at similar heights,whereas those larger than 25 mm in diameter exhibited at least one period of upward growth.Vertical trajectories derived from isotopic analysis were corroborated by radar hydrometeor observations.展开更多
The asymmetric semi-circular bend(ASCB)specimen has been proposed to investigate the cracking behavior in different geo and construction materials and attracted the attention of researchers due to its advantages.Howev...The asymmetric semi-circular bend(ASCB)specimen has been proposed to investigate the cracking behavior in different geo and construction materials and attracted the attention of researchers due to its advantages.However,there are few studies on the fracture toughness determination of rock materials.In this work,a series of fracture tests were performed with the ASCB specimens made of granite.The onset of fracture,crack initiation angle and crack propagating trajectory was analyzed in detail combined with several mixed mode fracture criteria.The influence of the crack length on the mode Ⅰ/Ⅱ fracture toughness was studied.A comparison between the fracture toughness ratios predicted by varying criteria and experimental results was conducted.The relationship between experimentally determined crack initiation angles and curves of the generalized maximum tangential stress(GMTS)criterion was obtained.The fracture process of the specimen was recorded with the high-speed camera.The shortcomings of the ASCB specimens for the fracture toughness determination of rock materials were discussed.The results may provide a reference for analysis of mixed mode I and II fracture behavior of brittle materials.展开更多
This study aimed to investigate whether fetal growth trajectories(FGTs)could predict early childhood development,indicate intrauterine metabolic changes,and explore potential optimal and suboptimal FGTs.FGTs were deve...This study aimed to investigate whether fetal growth trajectories(FGTs)could predict early childhood development,indicate intrauterine metabolic changes,and explore potential optimal and suboptimal FGTs.FGTs were developed by using an unsupervised machine-learning approach.Children’s neurodevelopment,anthropometry,and respiratory outcomes in thefirst 6 years of life were assessed at different ages.In a subgroup of participants,we conducted a metabolomics analysis of cord blood to reveal the metabolic features of FGTs.We identified 6 FGTs:early decelerating,early decelerating with late catch-up growth,early accelerating,early accelerating with late medium growth,late decelerating,and late accelerating.The early accelerating with late medium growth pattern might be the optimal FGT due to its associations with better psychomotor development,mental development,intelligence quotient,and lung function and a lower risk of behaviour and respiratory problems.Compared with the optimal FGT,early decelerating and late decelerating FGTs were associated with poor neurodevelopment and lung function,while early accelerating FGT was associated with more severe autistic symptoms,poor lung function,and increased risks of overweight/obesity.Metabolic alterations were enriched in amino acid metabolism for early decelerating and late decelerating FGTs,whereas altered metabolites were enriched in lipid metabolism for early accelerating FGT.Thesefindings suggest that FGTs are predictors of early life development and may indicate intrauterine adaptive metabolism.The discovery of optimal and suboptimal FGTs provides potential clues for the early identification and intervention of fetal origin dysplasia or disease,but further research on related mechanisms is still needed.展开更多
The connections between urinary organophosphate ester(OPE)metabolites and child growth have been identified in prior research,but there is currently a dearth of epidemiological evidence regarding the sex-specific impa...The connections between urinary organophosphate ester(OPE)metabolites and child growth have been identified in prior research,but there is currently a dearth of epidemiological evidence regarding the sex-specific impact of OPEs on child growth trajectories.This study enrolled 804 maternal-child pairs,and five OPE congeners were quantified in maternal serum during pregnancy.In this study,the impact of prenatal OPE exposure on child growth trajectories was assessed using linear mixed-effect models and a group-based trajectory model(GBTM),with consideration given to sex-specific effects.Fetuses were frequently exposed to OPEs in utero,and tris(2-butoxyethel)phosphate(TBEP)exhibited the highest concentration levels in maternal serum.Among male children,an increase of 2.72 ng/g lipid in TBEP concentration was associated with a 0.11-unit increase in head circumference-for-age z-score(HCAZ),and the effect was mainly concentrated at 1 and 2 months of age.Among female children,an increase of 2.72 ng/g lipid in tris(2-chloro-1-(chloromethyl)ethyl)phosphate(TDCPP)concentration was associated with a 0.15-unit increase in length-for-age z-score(LAZ)and a 0.14-unit increase in weight-for-age z-score(WAZ),and the effects were mainly concentrated at 9 months of age.For HCAZ trajectories,higher prenatal TBEP exposure was associated with higher odds for the fast growth group in male children.For the LAZ and WAZ trajectories,higher prenatal TDCPP exposure was associated with higher odds for the fast growth group in female children.The trajectory analysis approach provided insight into the complex associations between OPE exposure and child growth.展开更多
Prenatal ozone(O3)exposure may disrupt normal offspring growth.However,epidemiological evidence that prenatal O3 exposure affects the physical development of offspring early in life is far from adequate.A total of 490...Prenatal ozone(O3)exposure may disrupt normal offspring growth.However,epidemiological evidence that prenatal O3 exposure affects the physical development of offspring early in life is far from adequate.A total of 4909 maternal-child pairs from the Shanghai Maternal-Child Pairs Cohort were included.A high-resolution random forest model was utilized to evaluate prenatal exposure levels of O3 based on the home addresses of pregnant women.Group-based trajectory and mixed-effects models were used to assess associations between prenatal Os exposure and physical parameters.Each 10μg/m increase in O3 concentration was associated with 0.084,0.048,and 0.082-unit increases in body mass index(BMI)for age Z score(BAZ),weight for age Z score(WAZ),and weight for length Z score(WLZ),respectively.Specifically,a 10μg/m^(3) increase in O3 concentration was linked to a 1.208-fold and 1.209-fold increase in the elevated-increasing group for the BAZ and WLZ trajectories,respectively.Moreover,each 10μg/m^(3) increases in prenatal O3 was associated with a 1.396-fold and 0.786-fold increase in the risk of BAZ and length for age Z score(LAZ)accelerated growth,respectively.Furthermore,a 10μg/m^(3) increase in prenatal Og was linked to a 1.355-fold increase in the risk of overweight and obesity(OAO).Our study revealed that prenatal O3 exposure is associated with accelerated BMI gain or decelerated body length gain in the early life of children.Prenatal Os may also increase the risk of OAO in children for the first two years.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.42030607)the Beijing Municipal Science and Technology Commission(Grant No.Z251100004525005)the National Science Foundation/National Center for Atmospheric Research,and NASA(Grant No.80NSSC22M0129)。
文摘The growth trajectory of hailstones within clouds has remained elusive due to the inability to trace them directly,impeding the comprehension of their underlying growth mechanisms.This study investigated hailstone vertical growth trajectories by detecting the stable isotope signatures(2H and 18O compositions)of different shells in 27 hailstones from 9hailstorms,which allowed us to capture the ambient temperature during hailstone growth.The vertical growth trajectories were obtained by comparing the isotopic compositions of water condensate in clouds,derived from the Adiabatic Model,with those measured in hailstones.Although hailstone growth was primarily observed in the–10°C to–30°C temperature layer,the embryo formation height and subsequent growth trajectories significantly varied among hailstones.Embryos formed over a wide range of temperatures(–8.7°C to–33.4°C);four originated at temperatures above–15°C and 16originated at temperatures below–20°C,suggesting ice nuclei composed of bioproteins and mineral dust,respectively.Among the 27 measured hailstones,3 exhibited minimal vertical movement,16 exhibited a monotonic rise or fall,and the remaining 8 exhibited alternating up-down trajectories;only one experienced“recycling”during up-down drifting.Trajectory analysis revealed that similar-sized hailstones from a single storm tended to form at similar heights,whereas those larger than 25 mm in diameter exhibited at least one period of upward growth.Vertical trajectories derived from isotopic analysis were corroborated by radar hydrometeor observations.
基金Projects(52004182,51804110,51904101)supported by the National Natural Science Foundation of ChinaProject(2020JJ5188)supported by the Natural Science Foundation of Hunan Province,China。
文摘The asymmetric semi-circular bend(ASCB)specimen has been proposed to investigate the cracking behavior in different geo and construction materials and attracted the attention of researchers due to its advantages.However,there are few studies on the fracture toughness determination of rock materials.In this work,a series of fracture tests were performed with the ASCB specimens made of granite.The onset of fracture,crack initiation angle and crack propagating trajectory was analyzed in detail combined with several mixed mode fracture criteria.The influence of the crack length on the mode Ⅰ/Ⅱ fracture toughness was studied.A comparison between the fracture toughness ratios predicted by varying criteria and experimental results was conducted.The relationship between experimentally determined crack initiation angles and curves of the generalized maximum tangential stress(GMTS)criterion was obtained.The fracture process of the specimen was recorded with the high-speed camera.The shortcomings of the ASCB specimens for the fracture toughness determination of rock materials were discussed.The results may provide a reference for analysis of mixed mode I and II fracture behavior of brittle materials.
基金supported by the National Natural Science Foundation of China(U21A20397,22236001,42277428)the Program for HUST Academic Frontier Youth Team(2018QYTD12).
文摘This study aimed to investigate whether fetal growth trajectories(FGTs)could predict early childhood development,indicate intrauterine metabolic changes,and explore potential optimal and suboptimal FGTs.FGTs were developed by using an unsupervised machine-learning approach.Children’s neurodevelopment,anthropometry,and respiratory outcomes in thefirst 6 years of life were assessed at different ages.In a subgroup of participants,we conducted a metabolomics analysis of cord blood to reveal the metabolic features of FGTs.We identified 6 FGTs:early decelerating,early decelerating with late catch-up growth,early accelerating,early accelerating with late medium growth,late decelerating,and late accelerating.The early accelerating with late medium growth pattern might be the optimal FGT due to its associations with better psychomotor development,mental development,intelligence quotient,and lung function and a lower risk of behaviour and respiratory problems.Compared with the optimal FGT,early decelerating and late decelerating FGTs were associated with poor neurodevelopment and lung function,while early accelerating FGT was associated with more severe autistic symptoms,poor lung function,and increased risks of overweight/obesity.Metabolic alterations were enriched in amino acid metabolism for early decelerating and late decelerating FGTs,whereas altered metabolites were enriched in lipid metabolism for early accelerating FGT.Thesefindings suggest that FGTs are predictors of early life development and may indicate intrauterine adaptive metabolism.The discovery of optimal and suboptimal FGTs provides potential clues for the early identification and intervention of fetal origin dysplasia or disease,but further research on related mechanisms is still needed.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFC2705004)the National Natural Science Foundation of China(Grant No.82273585)Key Project on Science and Technology Program of Fujian Health Commission(Gran No.2021ZD01002).
文摘The connections between urinary organophosphate ester(OPE)metabolites and child growth have been identified in prior research,but there is currently a dearth of epidemiological evidence regarding the sex-specific impact of OPEs on child growth trajectories.This study enrolled 804 maternal-child pairs,and five OPE congeners were quantified in maternal serum during pregnancy.In this study,the impact of prenatal OPE exposure on child growth trajectories was assessed using linear mixed-effect models and a group-based trajectory model(GBTM),with consideration given to sex-specific effects.Fetuses were frequently exposed to OPEs in utero,and tris(2-butoxyethel)phosphate(TBEP)exhibited the highest concentration levels in maternal serum.Among male children,an increase of 2.72 ng/g lipid in TBEP concentration was associated with a 0.11-unit increase in head circumference-for-age z-score(HCAZ),and the effect was mainly concentrated at 1 and 2 months of age.Among female children,an increase of 2.72 ng/g lipid in tris(2-chloro-1-(chloromethyl)ethyl)phosphate(TDCPP)concentration was associated with a 0.15-unit increase in length-for-age z-score(LAZ)and a 0.14-unit increase in weight-for-age z-score(WAZ),and the effects were mainly concentrated at 9 months of age.For HCAZ trajectories,higher prenatal TBEP exposure was associated with higher odds for the fast growth group in male children.For the LAZ and WAZ trajectories,higher prenatal TDCPP exposure was associated with higher odds for the fast growth group in female children.The trajectory analysis approach provided insight into the complex associations between OPE exposure and child growth.
基金supported by the National Key Research and Development Program of China (Grant 2022YFC2705004)the National Natural Science Foundation of China (Grant 82273585)Fudan University&Minhang Health Joint Venture Cooperation Project (2022FM11).
文摘Prenatal ozone(O3)exposure may disrupt normal offspring growth.However,epidemiological evidence that prenatal O3 exposure affects the physical development of offspring early in life is far from adequate.A total of 4909 maternal-child pairs from the Shanghai Maternal-Child Pairs Cohort were included.A high-resolution random forest model was utilized to evaluate prenatal exposure levels of O3 based on the home addresses of pregnant women.Group-based trajectory and mixed-effects models were used to assess associations between prenatal Os exposure and physical parameters.Each 10μg/m increase in O3 concentration was associated with 0.084,0.048,and 0.082-unit increases in body mass index(BMI)for age Z score(BAZ),weight for age Z score(WAZ),and weight for length Z score(WLZ),respectively.Specifically,a 10μg/m^(3) increase in O3 concentration was linked to a 1.208-fold and 1.209-fold increase in the elevated-increasing group for the BAZ and WLZ trajectories,respectively.Moreover,each 10μg/m^(3) increases in prenatal O3 was associated with a 1.396-fold and 0.786-fold increase in the risk of BAZ and length for age Z score(LAZ)accelerated growth,respectively.Furthermore,a 10μg/m^(3) increase in prenatal Og was linked to a 1.355-fold increase in the risk of overweight and obesity(OAO).Our study revealed that prenatal O3 exposure is associated with accelerated BMI gain or decelerated body length gain in the early life of children.Prenatal Os may also increase the risk of OAO in children for the first two years.
