Eco-friendly Ultra-high-performance liquid chromatography (UHPLC) with green aqueous-organic mobile phase was applied for the simultaneous determination of febuxostat (FEB) and diclofenac (DIC) with the composition of...Eco-friendly Ultra-high-performance liquid chromatography (UHPLC) with green aqueous-organic mobile phase was applied for the simultaneous determination of febuxostat (FEB) and diclofenac (DIC) with the composition of water:ethanol (85:15<span> </span>v/v) utilizing phenomenex Kinetex C<sub>18</sub> column (4.6 × 100 mm 2.6 μm), flow rate 1 ml/min and<b><span> </span></b>UV detection at 280 nm<b><span> </span></b>with linear ranges of 0.4 - 4.0 μg/mL and 0.5 - 5.0 μg/mL for FEB and DIC, respectively. The proposed method was also successfully applied to analyze the two drugs in pharmaceutical dosage form and human plasma. The results obtained were validated and statistically analyzed and found to be in accordance with those given by reported methods. Moreover, the greenness of the developed method is assessed using suitable analytical Eco-Scale and GAPI tools<b><span> </span></b>and comparison with the previously published methods have been carried out to indicate the priority of the proposed method. UHPLC is considered eco-friendly method regarding uses of safe solvents, simple, accurate and short time of analysis.展开更多
A novel electrochemical sensor based on a graphene oxide(GO)/three-dimensional(3D)hierarchical zinc oxide(ZnO)nanocomposite was developed for the efficient determination of the antibiotic drug chloramphenicol(CAP).The...A novel electrochemical sensor based on a graphene oxide(GO)/three-dimensional(3D)hierarchical zinc oxide(ZnO)nanocomposite was developed for the efficient determination of the antibiotic drug chloramphenicol(CAP).The hierarchical ZnO structure consisting of nanosheets was synthesized by a green aqueous solution procedure and then composited with GO through a simple sonochemical method.The synthesized ZnO and GO/ZnO nanomaterials were characterized by scanning electron microscopy(SEM),elemental mapping,X-ray diffraction(XRD),UV-Visible spectroscopy,Fourier transform infrared spectroscopy(FT-IR),and Raman spectroscopy.The electrochemical performance of the prepared GO/ZnO/glassy carbon electrode(GCE)was evaluated using cyclic voltammetry(CV)and differential pulse voltammetry(DPV)techniques.The GO/ZnO/GCE shows a low CAP detection limit of 0.01μM,a high sensitivity of 7.27μAμM^(−1) cm^(−2),and a linear response in the range of 0.2 to 7.2μM.Moreover,it exhibits excellent stability,reproducibility and repeatability.Practicality of the sensor has further been demonstrated with honey,milk and eye drop samples.展开更多
A novel method for fluorination of halopyridazine derivatives with potassium fluoride was performed using a green chemistry procedure, including ionic liquid as an environmentally benign reaction medium and microwave ...A novel method for fluorination of halopyridazine derivatives with potassium fluoride was performed using a green chemistry procedure, including ionic liquid as an environmentally benign reaction medium and microwave irradiation with high yield.展开更多
文摘Eco-friendly Ultra-high-performance liquid chromatography (UHPLC) with green aqueous-organic mobile phase was applied for the simultaneous determination of febuxostat (FEB) and diclofenac (DIC) with the composition of water:ethanol (85:15<span> </span>v/v) utilizing phenomenex Kinetex C<sub>18</sub> column (4.6 × 100 mm 2.6 μm), flow rate 1 ml/min and<b><span> </span></b>UV detection at 280 nm<b><span> </span></b>with linear ranges of 0.4 - 4.0 μg/mL and 0.5 - 5.0 μg/mL for FEB and DIC, respectively. The proposed method was also successfully applied to analyze the two drugs in pharmaceutical dosage form and human plasma. The results obtained were validated and statistically analyzed and found to be in accordance with those given by reported methods. Moreover, the greenness of the developed method is assessed using suitable analytical Eco-Scale and GAPI tools<b><span> </span></b>and comparison with the previously published methods have been carried out to indicate the priority of the proposed method. UHPLC is considered eco-friendly method regarding uses of safe solvents, simple, accurate and short time of analysis.
基金supported by the Ministry of Science and Technology,Taiwan,ROC under the grant MOST 106-2221-E-027-107.
文摘A novel electrochemical sensor based on a graphene oxide(GO)/three-dimensional(3D)hierarchical zinc oxide(ZnO)nanocomposite was developed for the efficient determination of the antibiotic drug chloramphenicol(CAP).The hierarchical ZnO structure consisting of nanosheets was synthesized by a green aqueous solution procedure and then composited with GO through a simple sonochemical method.The synthesized ZnO and GO/ZnO nanomaterials were characterized by scanning electron microscopy(SEM),elemental mapping,X-ray diffraction(XRD),UV-Visible spectroscopy,Fourier transform infrared spectroscopy(FT-IR),and Raman spectroscopy.The electrochemical performance of the prepared GO/ZnO/glassy carbon electrode(GCE)was evaluated using cyclic voltammetry(CV)and differential pulse voltammetry(DPV)techniques.The GO/ZnO/GCE shows a low CAP detection limit of 0.01μM,a high sensitivity of 7.27μAμM^(−1) cm^(−2),and a linear response in the range of 0.2 to 7.2μM.Moreover,it exhibits excellent stability,reproducibility and repeatability.Practicality of the sensor has further been demonstrated with honey,milk and eye drop samples.
文摘A novel method for fluorination of halopyridazine derivatives with potassium fluoride was performed using a green chemistry procedure, including ionic liquid as an environmentally benign reaction medium and microwave irradiation with high yield.
