Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,n...Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,neural oscillatory dynamics,and brain network reorganization remain unclear.This investigation seeks to systematically evaluate the therapeutic potential of rTMS as a non-invasive neuromodulatory intervention through a multimodal framework integrating clinical assessments,molecular profiling,and neurophysiological monitoring.Methods In this prospective double-blind trial,12 AD patients underwent a 14-day protocol of 20 Hz rTMS,with comprehensive multimodal assessments performed pre-and postintervention.Cognitive functioning was quantified using the mini-mental state examination(MMSE)and Montreal cognitive assessment(MOCA),while daily living capacities and neuropsychiatric profiles were respectively evaluated through the activities of daily living(ADL)scale and combined neuropsychiatric inventory(NPI)-Hamilton depression rating scale(HAMD).Peripheral blood biomarkers,specifically Aβ1-40 and phosphorylated tau(p-tau181),were analyzed to investigate the effects of rTMS on molecular metabolism.Spectral power analysis was employed to investigate rTMS-induced modulations of neural rhythms in AD patients,while brain network analyses incorporating topological properties were conducted to examine stimulus-driven network reorganization.Furthermore,systematic assessment of correlations between cognitive scale scores,blood biomarkers,and network characteristics was performed to elucidate cross-modal therapeutic associations.Results Clinically,MMSE and MOCA scores improved significantly(P<0.05).Biomarker showed that Aβ1-40 level increased(P<0.05),contrasting with p-tau181 reduction.Moreover,the levels of Aβ1-40 were positively correlated with MMSE and MOCA scores.Post-intervention analyses revealed significant modulations in oscillatory power,characterized by pronounced reductions in delta(P<0.05)and theta bands(P<0.05),while concurrent enhancements were observed in alpha,beta,and gamma band activities(all P<0.05).Network analysis revealed frequency-specific reorganization:clustering coefficients were significantly decreased in delta,theta,and alpha bands(P<0.05),while global efficiency improvement was exclusively detected in the delta band(P<0.05).The alpha band demonstrated concurrent increases in average nodal degree(P<0.05)and characteristic path length reduction(P<0.05).Further research findings indicate that the changes in the clinical scale HAMD scores before and after rTMS stimulation are negatively correlated with the changes in the blood biomarkers Aβ1-40 and p-tau181.Additionally,the changes in the clinical scales MMSE and MoCA scores were negatively correlated with the changes in the node degree of the alpha frequency band and negatively correlated with the clustering coefficient of the delta frequency band.However,the changes in MMSE scores are positively correlated with the changes in global efficiency of both the delta and alpha frequency bands.Conclusion 20 Hz rTMS targeting dorsolateral prefrontal cortex(DLPFC)significantly improves cognitive function and enhances the metabolic clearance ofβ-amyloid and tau proteins in AD patients.This neurotherapeutic effect is mechanistically associated with rTMS-mediated frequency-selective neuromodulation,which enhances the connectivity of oscillatory networks through improved neuronal synchronization and optimized topological organization of functional brain networks.These findings not only support the efficacy of rTMS as an adjunctive therapy for AD but also underscore the importance of employing multiple assessment methods—including clinical scales,blood biomarkers,and EEG——in understanding and monitoring the progression of AD.This research provides a significant theoretical foundation and empirical evidence for further exploration of rTMS applications in AD treatment.展开更多
In this paper,we obtain a normality criterion for families of meromorphic functions concerning‘wandering’shared functions,which generalizes and improves Montel’s criterion and the related results due to Schwick,Xu-...In this paper,we obtain a normality criterion for families of meromorphic functions concerning‘wandering’shared functions,which generalizes and improves Montel’s criterion and the related results due to Schwick,Xu-Fang,Xu-Qiu,and Grahl-Nevo.Also,a normality relationship between two families is given.展开更多
Defect engineering is a commonly methodology used to enhance the thermoelectric performance of thermoelectric PbTe by improving its electronic transport properties.At the nanoscale,defects can induce quantum tunneling...Defect engineering is a commonly methodology used to enhance the thermoelectric performance of thermoelectric PbTe by improving its electronic transport properties.At the nanoscale,defects can induce quantum tunneling effects that significantly impact the electrical properties of materials.To understand the specific mechanisms underlying the quantum transport properties of PbTe,we employ the non-equilibrium Green's function(NEGF)method to investigate the effects of intrinsic defects(point defects and grain boundaries)on the electronic transport properties of PbTe-based nanodevices from a quantum mechanical perspective.Our results show that the Pb vacancy(VPb)has the highest conduction.The conduction depends on the defect type,chemical potential and bias voltage.The presence of intrinsic point defects introduces impurity levels,facilitating the electron tunneling and leading to an increase in the transmission coefficient,thereby enhancing the electronic transport properties.For PbTe containing grain boundaries,these boundaries suppress the electronic transport properties.The Te occupied twin boundary(Te-TB)exerts a stronger inhibitory effect than the Pb occupied twin boundary(Pb-TB).Nevertheless,the combined effect between twin boundaries and point defects can enhance the electrical properties.Therefore,in order to obtain highly conductive of PbTe materials,a Te-rich synthesis environment should be used to promote the effective formation of Pb vacancy.Our work offers a comprehensive understanding of the impact of defects on electron scattering in thermoelectric materials.展开更多
In this paper,we study a class of Sturm-Liouville problems,where the boundary conditions involve eigenparameters.Firstly,by defining a new inner product which depends on the transmission conditions,we obtain a new Hil...In this paper,we study a class of Sturm-Liouville problems,where the boundary conditions involve eigenparameters.Firstly,by defining a new inner product which depends on the transmission conditions,we obtain a new Hilbert space,on which the concerned operator A is self-adjoint.Then we construct the fundamental solutions to the problem,obtain the necessary and sufficient conditions for eigenvalues,and prove that the eigenvalues are simple.Finally,we investigate Green’s functions of such problem.展开更多
Understanding the effects of point liquid loading on transversely isotropic poroelastic media is crucial for advancing geomechanics and biomechanics, where precise modeling of fluid-structure interactions is essential...Understanding the effects of point liquid loading on transversely isotropic poroelastic media is crucial for advancing geomechanics and biomechanics, where precise modeling of fluid-structure interactions is essential. This paper presents a comprehensive analysis of infinite transversely isotropic poroelasticity under a fluid source, based on Biot's theory, aiming to uncover new and previously unexplored insights in the literature. We begin our study by deriving a general solution for fluid-saturated, transversely isotropic poroelastic materials in terms of harmonic functions that satisfy sixth-order homogeneous partial differential equations, using potential theory and Almansi's theorem. Based on these general solutions and potential functions, we construct a Green's function for a point fluid source, introducing three new harmonic functions with undetermined constants. These constants are determined by enforcing continuity and equilibrium conditions. Substituting these into the general solution yields fundamental solutions for poroelasticity that provide crucial support for a wide range of project problems. Numerical results and comparisons with existing literature are provided to illustrate physical mechanisms through contour plots. Our observations reveal that all components tend to zero in the far field and become singular at the concentrated source. Additionally, the contours exhibit rapid changes near the point fluid source but display gradual variations at a distance from it. These findings highlight the intricate behavior of the system under point liquid loading, offering valuable insights for further research and practical applications.展开更多
Functionally graded materials (FGMs) are innovative materials distinguished by gradual variations in composition and structure, offering exceptional properties for diverse applications. Poly(ionic liquid)s (PILs), mer...Functionally graded materials (FGMs) are innovative materials distinguished by gradual variations in composition and structure, offering exceptional properties for diverse applications. Poly(ionic liquid)s (PILs), merging the characteristics of polymers and ionic liquids, have emerged as viable options for the development of FGMs given their tunable skeleton, ionic conductivity, and compatibility with various functional materials. This review highlights the latest advancements in the design strategies of FGMs based on porous PILs, focusing on single and multi-gradient structures. Furthermore, we also highlight their emerging applications in molecular recognition, sensing, adsorption, separation, and catalysis. By exploring the interplay between porosity, ionic functionality, and gradient architecture, this review offers perspectives on the prospects of PIL-based FGMs for tackling global challenges in energy, environment, and healthcare.展开更多
The numerical simulation of the fluid flow and the flexible rod(s)interaction is more complicated and has lower efficiency due to the high computational cost.In this paper,a semi-resolved model coupling the computatio...The numerical simulation of the fluid flow and the flexible rod(s)interaction is more complicated and has lower efficiency due to the high computational cost.In this paper,a semi-resolved model coupling the computational fluid dynamics and the flexible rod dynamics is proposed using a two-way domain expansion method.The gov-erning equations of the flexible rod dynamics are discretized and solved by the finite element method,and the fluid flow is simulated by the finite volume method.The interaction between fluids and solid rods is modeled by introducing body force terms into the momentum equations.Referred to the traditional semi-resolved numerical model,an anisotropic Gaussian kernel function method is proposed to specify the interactive forces between flu-ids and solid bodies for non-circle rod cross-sections.A benchmark of the flow passing around a single flexible plate with a rectangular cross-section is used to validate the algorithm.Focused on the engineering applications,a test case of a finite patch of cylinders is implemented to validate the accuracy and efficiency of the coupled model.展开更多
We present a method to unify the calculation of Green＇s functions for an electromagnetic（EM） transmitting source embedded in a homogeneous stratified medium.A virtual interface parallel to layer interfaces is intro...We present a method to unify the calculation of Green＇s functions for an electromagnetic（EM） transmitting source embedded in a homogeneous stratified medium.A virtual interface parallel to layer interfaces is introduced through the source location.The potentials for Green＇s function are derived by decomposing the partial wave solutions to Helmholtz＇s equations into upward and downward within boundaries.The amplitudes of the potentials in each stratum are obtained recursively from the initial amplitudes at the source level.The initial amplitudes are derived by coupling with the transmitting sources and following the discontinuity of the tangential electric and magnetic fields at the source interface.Only the initial terms are related to the transmitting sources and thus need to be modified for different transmitters,whereas the kernel connected with the stratified media stays unchanged.Hence,the present method can be easily applied to EM transmitting sources with little modification.The application of the proposed method to the marine controlled-source electromagnetic method（MCSEM） demonstrates its simplicity and flexibility.展开更多
RpoS protein is a σ factor of RNA polymerase that can control the expression of a group-specific gene, thus playing a vital role in bacteria. In bacteria, RpoS expression is under strict control and is mainly regulat...RpoS protein is a σ factor of RNA polymerase that can control the expression of a group-specific gene, thus playing a vital role in bacteria. In bacteria, RpoS expression is under strict control and is mainly regulated at three levels： transcription level, translation level and post-translational level. Environmental stress enters bacterial cells through signal transduction and leads to a series of variations in microenvironment, thereby causing changes of regulator and controlling its levels based on the direct and indirect interaction between regulator and RpoS protein. In addition, RpoS protein has played special roles in bacteria, therefore the changes of RpoS protein levels will lead to variations in expression levels of a large number of genes, thereby causing variations of bacterial response to different environmental stress and changes of certain characteristics of bacteria, which provides a new strategy for the control of bacterial diseases in the future. This paper reviewed the recent progress on the regulation of RpoS protein expression and its function in several common bacteria. Due to the functional complexity of RpoS protein, there are still a lot of unknown functions to be further identified.展开更多
s Western Yunnan is located at the boundary of collision or underthrusting zone of Eurasian plate and is influenced by many times tectonic movements. With very complex geological environment and tectonic background, i...s Western Yunnan is located at the boundary of collision or underthrusting zone of Eurasian plate and is influenced by many times tectonic movements. With very complex geological environment and tectonic background, it is one of the seismically active areas. In the paper, the teleseismic records were selected from 16 national, local and mo-bile stations, including 4 very-wide-band mobile stations of PASSCAL. And nearly 2 000 receiver functions were extracted. Two measuring lines are 650 km and 450 km, respectively and across some major tectonic units in Western Yunnan. It is indicated that Nujiang might be a seam characterized by underthrusting. The western and eastern boundaries of Sichuan-Yunnan rhombus block, i.e., Honghe and Xiaojiang faults, might be an erection seam or collision belt. Panxi tectonic zone still has the characteristics of continental rift valley, that is, the surface is hollow and the upper mantle is upwarping. The tectonic situation in Western Yunnan is of certain regulation with the interlacing distribution of orogenic zone and seam. The crustal thickness decreases gradually from the north to the south and the S wave velocity is globally lower here.展开更多
By using integral transform methods, the Green(s functions of horizontal harmonic force applied at the interior of the saturated half-space soil are obtained in the paper. The general solutions of the Biot dynamic equ...By using integral transform methods, the Green(s functions of horizontal harmonic force applied at the interior of the saturated half-space soil are obtained in the paper. The general solutions of the Biot dynamic equations in frequency domain are established through the use of Hankel integral transforms technique. Utilizing the above- mentioned general solutions, and the boundary conditions of the surface of the half-space and the continuous conditions at the plane of the horizontal force, the solutions of the boundary value problem can be determined. By the numerical inverse Hankel transforms method, the Green(s functions of the harmonic horizontal force are obtainable. The degenerate case of the results deduced from this paper agrees well with the known results. Two numerical examples are given in the paper.展开更多
在硬件在回路仿真系统中,模型需与数据采集卡之间进行实时数据的采集和交换,Simulink下Real Time Workspace工具箱提供了与硬件之间的实时数据采集和交换,但是工具箱并不支持市面上所有采集板卡的类型,给用户对采集板卡选型带来一定局...在硬件在回路仿真系统中,模型需与数据采集卡之间进行实时数据的采集和交换,Simulink下Real Time Workspace工具箱提供了与硬件之间的实时数据采集和交换,但是工具箱并不支持市面上所有采集板卡的类型,给用户对采集板卡选型带来一定局限性。因此本文使用Simulink中S-Function模块编写不同采集板卡的硬件驱动,证明只要是数据采集工具箱支持的板卡型号,都可以用S-Function进行模块化硬件驱动编写,解决了Simulink中Real Time Workspace工具箱给用户在使用Simulink建模过程中对板卡选型的局限性这一问题。展开更多
文摘Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,neural oscillatory dynamics,and brain network reorganization remain unclear.This investigation seeks to systematically evaluate the therapeutic potential of rTMS as a non-invasive neuromodulatory intervention through a multimodal framework integrating clinical assessments,molecular profiling,and neurophysiological monitoring.Methods In this prospective double-blind trial,12 AD patients underwent a 14-day protocol of 20 Hz rTMS,with comprehensive multimodal assessments performed pre-and postintervention.Cognitive functioning was quantified using the mini-mental state examination(MMSE)and Montreal cognitive assessment(MOCA),while daily living capacities and neuropsychiatric profiles were respectively evaluated through the activities of daily living(ADL)scale and combined neuropsychiatric inventory(NPI)-Hamilton depression rating scale(HAMD).Peripheral blood biomarkers,specifically Aβ1-40 and phosphorylated tau(p-tau181),were analyzed to investigate the effects of rTMS on molecular metabolism.Spectral power analysis was employed to investigate rTMS-induced modulations of neural rhythms in AD patients,while brain network analyses incorporating topological properties were conducted to examine stimulus-driven network reorganization.Furthermore,systematic assessment of correlations between cognitive scale scores,blood biomarkers,and network characteristics was performed to elucidate cross-modal therapeutic associations.Results Clinically,MMSE and MOCA scores improved significantly(P<0.05).Biomarker showed that Aβ1-40 level increased(P<0.05),contrasting with p-tau181 reduction.Moreover,the levels of Aβ1-40 were positively correlated with MMSE and MOCA scores.Post-intervention analyses revealed significant modulations in oscillatory power,characterized by pronounced reductions in delta(P<0.05)and theta bands(P<0.05),while concurrent enhancements were observed in alpha,beta,and gamma band activities(all P<0.05).Network analysis revealed frequency-specific reorganization:clustering coefficients were significantly decreased in delta,theta,and alpha bands(P<0.05),while global efficiency improvement was exclusively detected in the delta band(P<0.05).The alpha band demonstrated concurrent increases in average nodal degree(P<0.05)and characteristic path length reduction(P<0.05).Further research findings indicate that the changes in the clinical scale HAMD scores before and after rTMS stimulation are negatively correlated with the changes in the blood biomarkers Aβ1-40 and p-tau181.Additionally,the changes in the clinical scales MMSE and MoCA scores were negatively correlated with the changes in the node degree of the alpha frequency band and negatively correlated with the clustering coefficient of the delta frequency band.However,the changes in MMSE scores are positively correlated with the changes in global efficiency of both the delta and alpha frequency bands.Conclusion 20 Hz rTMS targeting dorsolateral prefrontal cortex(DLPFC)significantly improves cognitive function and enhances the metabolic clearance ofβ-amyloid and tau proteins in AD patients.This neurotherapeutic effect is mechanistically associated with rTMS-mediated frequency-selective neuromodulation,which enhances the connectivity of oscillatory networks through improved neuronal synchronization and optimized topological organization of functional brain networks.These findings not only support the efficacy of rTMS as an adjunctive therapy for AD but also underscore the importance of employing multiple assessment methods—including clinical scales,blood biomarkers,and EEG——in understanding and monitoring the progression of AD.This research provides a significant theoretical foundation and empirical evidence for further exploration of rTMS applications in AD treatment.
基金Supported by the National Natural Science Foundation of China(Grant No.11471163)。
文摘In this paper,we obtain a normality criterion for families of meromorphic functions concerning‘wandering’shared functions,which generalizes and improves Montel’s criterion and the related results due to Schwick,Xu-Fang,Xu-Qiu,and Grahl-Nevo.Also,a normality relationship between two families is given.
基金financial support from the National Natural Science Foundation of China(No.12474016)the program of“Distinguished Expert of Taishan Scholar”(No.tstp20221124)+4 种基金the National Natural Science Foundation of China(Nos.52172212,12474017)the Shandong Provincial Science Foundation(ZR2021YQ03)the program for“Young Scientists of Taishan Scholars”(No.tsqn202306184)financial support from the National Natural Science Foundation of China(No.12464034)the Natural Science Foundation of Ningxia,China(No.2024AAC05070)。
文摘Defect engineering is a commonly methodology used to enhance the thermoelectric performance of thermoelectric PbTe by improving its electronic transport properties.At the nanoscale,defects can induce quantum tunneling effects that significantly impact the electrical properties of materials.To understand the specific mechanisms underlying the quantum transport properties of PbTe,we employ the non-equilibrium Green's function(NEGF)method to investigate the effects of intrinsic defects(point defects and grain boundaries)on the electronic transport properties of PbTe-based nanodevices from a quantum mechanical perspective.Our results show that the Pb vacancy(VPb)has the highest conduction.The conduction depends on the defect type,chemical potential and bias voltage.The presence of intrinsic point defects introduces impurity levels,facilitating the electron tunneling and leading to an increase in the transmission coefficient,thereby enhancing the electronic transport properties.For PbTe containing grain boundaries,these boundaries suppress the electronic transport properties.The Te occupied twin boundary(Te-TB)exerts a stronger inhibitory effect than the Pb occupied twin boundary(Pb-TB).Nevertheless,the combined effect between twin boundaries and point defects can enhance the electrical properties.Therefore,in order to obtain highly conductive of PbTe materials,a Te-rich synthesis environment should be used to promote the effective formation of Pb vacancy.Our work offers a comprehensive understanding of the impact of defects on electron scattering in thermoelectric materials.
基金supported by the National Natural Science Foundation of China(No.12461086)the Natural Science Foundation of Hubei Province(No.2022CFC016)。
文摘In this paper,we study a class of Sturm-Liouville problems,where the boundary conditions involve eigenparameters.Firstly,by defining a new inner product which depends on the transmission conditions,we obtain a new Hilbert space,on which the concerned operator A is self-adjoint.Then we construct the fundamental solutions to the problem,obtain the necessary and sufficient conditions for eigenvalues,and prove that the eigenvalues are simple.Finally,we investigate Green’s functions of such problem.
基金supported by the National Natural Science Foundation of China (Grant Nos. 12272269, 11972257,11832014 and 11472193)the Shanghai Pilot Program for Basic Researchthe Shanghai Gaofeng Project for University Academic Program Development。
文摘Understanding the effects of point liquid loading on transversely isotropic poroelastic media is crucial for advancing geomechanics and biomechanics, where precise modeling of fluid-structure interactions is essential. This paper presents a comprehensive analysis of infinite transversely isotropic poroelasticity under a fluid source, based on Biot's theory, aiming to uncover new and previously unexplored insights in the literature. We begin our study by deriving a general solution for fluid-saturated, transversely isotropic poroelastic materials in terms of harmonic functions that satisfy sixth-order homogeneous partial differential equations, using potential theory and Almansi's theorem. Based on these general solutions and potential functions, we construct a Green's function for a point fluid source, introducing three new harmonic functions with undetermined constants. These constants are determined by enforcing continuity and equilibrium conditions. Substituting these into the general solution yields fundamental solutions for poroelasticity that provide crucial support for a wide range of project problems. Numerical results and comparisons with existing literature are provided to illustrate physical mechanisms through contour plots. Our observations reveal that all components tend to zero in the far field and become singular at the concentrated source. Additionally, the contours exhibit rapid changes near the point fluid source but display gradual variations at a distance from it. These findings highlight the intricate behavior of the system under point liquid loading, offering valuable insights for further research and practical applications.
基金support provided by National Natural Science Foundation of China(22471018,22071008,22208018)support provided by the Shenzhen Science and Technology Program(JCYJ20220818100012025).
文摘Functionally graded materials (FGMs) are innovative materials distinguished by gradual variations in composition and structure, offering exceptional properties for diverse applications. Poly(ionic liquid)s (PILs), merging the characteristics of polymers and ionic liquids, have emerged as viable options for the development of FGMs given their tunable skeleton, ionic conductivity, and compatibility with various functional materials. This review highlights the latest advancements in the design strategies of FGMs based on porous PILs, focusing on single and multi-gradient structures. Furthermore, we also highlight their emerging applications in molecular recognition, sensing, adsorption, separation, and catalysis. By exploring the interplay between porosity, ionic functionality, and gradient architecture, this review offers perspectives on the prospects of PIL-based FGMs for tackling global challenges in energy, environment, and healthcare.
基金supported by Shanghai 2021“Science and Technology Innovation Action Plan”:Social Development Science and Technology Research Project(Grant No.21DZ1202703).
文摘The numerical simulation of the fluid flow and the flexible rod(s)interaction is more complicated and has lower efficiency due to the high computational cost.In this paper,a semi-resolved model coupling the computational fluid dynamics and the flexible rod dynamics is proposed using a two-way domain expansion method.The gov-erning equations of the flexible rod dynamics are discretized and solved by the finite element method,and the fluid flow is simulated by the finite volume method.The interaction between fluids and solid rods is modeled by introducing body force terms into the momentum equations.Referred to the traditional semi-resolved numerical model,an anisotropic Gaussian kernel function method is proposed to specify the interactive forces between flu-ids and solid bodies for non-circle rod cross-sections.A benchmark of the flow passing around a single flexible plate with a rectangular cross-section is used to validate the algorithm.Focused on the engineering applications,a test case of a finite patch of cylinders is implemented to validate the accuracy and efficiency of the coupled model.
基金supported by CNSF(Granted No.40874050)Chinese High Technology Project(Granted No.2011YQ05006010)
文摘We present a method to unify the calculation of Green＇s functions for an electromagnetic（EM） transmitting source embedded in a homogeneous stratified medium.A virtual interface parallel to layer interfaces is introduced through the source location.The potentials for Green＇s function are derived by decomposing the partial wave solutions to Helmholtz＇s equations into upward and downward within boundaries.The amplitudes of the potentials in each stratum are obtained recursively from the initial amplitudes at the source level.The initial amplitudes are derived by coupling with the transmitting sources and following the discontinuity of the tangential electric and magnetic fields at the source interface.Only the initial terms are related to the transmitting sources and thus need to be modified for different transmitters,whereas the kernel connected with the stratified media stays unchanged.Hence,the present method can be easily applied to EM transmitting sources with little modification.The application of the proposed method to the marine controlled-source electromagnetic method（MCSEM） demonstrates its simplicity and flexibility.
基金Supported by Science and Technology Program of Shandong Province (No. 2010GHY10501)National Department Public Benefit Research Fond of China (No. 200909020)~~
文摘RpoS protein is a σ factor of RNA polymerase that can control the expression of a group-specific gene, thus playing a vital role in bacteria. In bacteria, RpoS expression is under strict control and is mainly regulated at three levels： transcription level, translation level and post-translational level. Environmental stress enters bacterial cells through signal transduction and leads to a series of variations in microenvironment, thereby causing changes of regulator and controlling its levels based on the direct and indirect interaction between regulator and RpoS protein. In addition, RpoS protein has played special roles in bacteria, therefore the changes of RpoS protein levels will lead to variations in expression levels of a large number of genes, thereby causing variations of bacterial response to different environmental stress and changes of certain characteristics of bacteria, which provides a new strategy for the control of bacterial diseases in the future. This paper reviewed the recent progress on the regulation of RpoS protein expression and its function in several common bacteria. Due to the functional complexity of RpoS protein, there are still a lot of unknown functions to be further identified.
基金State Key Basic Research Development and Programming Project of China (G1998040700).
文摘s Western Yunnan is located at the boundary of collision or underthrusting zone of Eurasian plate and is influenced by many times tectonic movements. With very complex geological environment and tectonic background, it is one of the seismically active areas. In the paper, the teleseismic records were selected from 16 national, local and mo-bile stations, including 4 very-wide-band mobile stations of PASSCAL. And nearly 2 000 receiver functions were extracted. Two measuring lines are 650 km and 450 km, respectively and across some major tectonic units in Western Yunnan. It is indicated that Nujiang might be a seam characterized by underthrusting. The western and eastern boundaries of Sichuan-Yunnan rhombus block, i.e., Honghe and Xiaojiang faults, might be an erection seam or collision belt. Panxi tectonic zone still has the characteristics of continental rift valley, that is, the surface is hollow and the upper mantle is upwarping. The tectonic situation in Western Yunnan is of certain regulation with the interlacing distribution of orogenic zone and seam. The crustal thickness decreases gradually from the north to the south and the S wave velocity is globally lower here.
基金State Natural Science Foundation (59879012) and Doctoral Foundation from State Education Commission (98024832).
文摘By using integral transform methods, the Green(s functions of horizontal harmonic force applied at the interior of the saturated half-space soil are obtained in the paper. The general solutions of the Biot dynamic equations in frequency domain are established through the use of Hankel integral transforms technique. Utilizing the above- mentioned general solutions, and the boundary conditions of the surface of the half-space and the continuous conditions at the plane of the horizontal force, the solutions of the boundary value problem can be determined. By the numerical inverse Hankel transforms method, the Green(s functions of the harmonic horizontal force are obtainable. The degenerate case of the results deduced from this paper agrees well with the known results. Two numerical examples are given in the paper.
文摘在硬件在回路仿真系统中,模型需与数据采集卡之间进行实时数据的采集和交换,Simulink下Real Time Workspace工具箱提供了与硬件之间的实时数据采集和交换,但是工具箱并不支持市面上所有采集板卡的类型,给用户对采集板卡选型带来一定局限性。因此本文使用Simulink中S-Function模块编写不同采集板卡的硬件驱动,证明只要是数据采集工具箱支持的板卡型号,都可以用S-Function进行模块化硬件驱动编写,解决了Simulink中Real Time Workspace工具箱给用户在使用Simulink建模过程中对板卡选型的局限性这一问题。
