This article describes the equilibrium structure of the solar interior plasma (SIP) and solar wind plasma (SWP) in detail under the framework of the gravito-electrostatic sheath (GES) model. This model gives a precise...This article describes the equilibrium structure of the solar interior plasma (SIP) and solar wind plasma (SWP) in detail under the framework of the gravito-electrostatic sheath (GES) model. This model gives a precise definition of the solar surface boundary (SSB), surface origin mechanism of the subsonic SWP, and its supersonic acceleration. Equilibrium parameters like plasma potential, self-gravity, population density, flow, their gradients, and all the relevant inhomogeneity scale lengths are numerically calculated and analyzed as an initial value problem. Physical significance of the structure condition for the SSB is discussed. The plasma oscillation and Jeans time scales are also plotted and compared. In addition, different coupling parameters, and electric current profiles are also numerically studied. The current profiles exhibit an important behavior of directional reversibility, i.e., an electrodynamical transition from negative to positive value. It occurs beyond a few Jeans lengths away from the SSB. The virtual spherical surface lying at the current reversal point, where the net current becomes zero, has the property of a floating surface behavior of the real physical wall. Our investigation indicates that the SWP behaves as an ion current-carrying plasma system. The basic mechanism behind the GES formation and its distinctions from conventional plasma sheath are discussed. The electromagnetic properties of the Sun derived from our model with the most accurate available inputs are compared with those of others. These results are useful as an input element to study the properties of the linear and nonlinear dynamics of various solar plasma waves, oscillations and instabilities.展开更多
Unbonded post-tensioned(PT)concrete systems are widely used in safety-critical structures,yet model-ing practices for prestress implementation and tendon-concrete interaction remain inconsistent.This study investigate...Unbonded post-tensioned(PT)concrete systems are widely used in safety-critical structures,yet model-ing practices for prestress implementation and tendon-concrete interaction remain inconsistent.This study investigates the effects of sheath(duct)implementation and confinement assumptions through nonlinear finite element analysis.Four modeling cases were defined,consisting of an explicit sheath without tendon-concrete confinement(S)and three no-sheath variants with different confinement levels(X,N,A).One-way beams and two-way panels were analyzed,and panel blast responses were validated against experimental results.In both beams and panels,average initial stress levels were similar across models,through local stress concentrations appeared when the sheath was modeled.Under blast loading,these local effects became critical,and the sheath-implemented model reproduced experimental behavior most accurately,whereas non-implemented models deviated.Reduced blast intensity diminished the differences among models,thereby reaffirming that sheath-induced localization and damage propagation are critical factors.These findings highlight the importance of explicit sheath implementation for realistic numerical assessment of unbonded PT structures under extreme loads.展开更多
Chronic cerebral hypoperfusion can lead to neuronal necrosis,trigger inflammatory responses,promote white matter damage,and ultimately result in cognitive impairment.Consequently,chronic cerebral hypoperfusion is an i...Chronic cerebral hypoperfusion can lead to neuronal necrosis,trigger inflammatory responses,promote white matter damage,and ultimately result in cognitive impairment.Consequently,chronic cerebral hypoperfusion is an important factor influencing the onset and progression of vascular dementia.The myelin sheath is a critical component of white matter,and damage and repair of the white matter are closely linked to myelin sheath integrity.This article reviews the role of microglia in vascular dementia,focusing on their effects on myelin sheaths and the potential therapeutic implications.The findings suggest that ischemia and hypoxia cause disruption of the blood-brain barrier and activate microglia,which may worsen blood-brain barrier damage through the release of matrix-degrading enzymes.Microglia-mediated metabolic reprogramming is recognized as an important driver of inflammation.Damage to the blood-brain barrier and subsequent inflammation can lead to myelin injury and accelerate the progression of vascular dementia.Early activation of microglia is a protective response that contributes to the maintenance of blood-brain barrier integrity through sensing,debris-clearing,and defensive mechanisms.However,prolonged activation can trigger a shift in microglia toward the pro-inflammatory M1 phenotype,resulting in myelin damage and cognitive impairment.Triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells 1 have been identified as potential biomarkers for vascular dementia,as both are closely linked to cognitive decline.Although effective clinical treatments for myelin damage in the central nervous system are currently lacking,researchers are actively working to develop targeted therapies.Several drugs,including nimodipine,dopaminergic agents,simvastatin,biotin,and quetiapine,have been evaluated for clinical use in treating microglial and myelin damage.Future research will face challenges in developing targeted therapeutic strategies for vascular dementia,requiring further investigation into the timing,duration,and specific mechanisms of microglial activation,as well as the exploration of new drug combinations and additional therapeutic targets.展开更多
Ethylene response factors(ERFs)are plant transcription agents that play a pivotal role in disease resistance through the ethylene signaling pathway.However,whether and how ERFs regulate resistance to sheath blight(ShB...Ethylene response factors(ERFs)are plant transcription agents that play a pivotal role in disease resistance through the ethylene signaling pathway.However,whether and how ERFs regulate resistance to sheath blight(ShB),caused by Rhizoctonia solani in rice,remains largely unknown.Here,we demonstrated that OsERF7 negatively regulates rice resistance to ShB by inhibiting phytoalexin biosynthesis.Overexpression of OsERF7(OsERF7OE)significantly decreased ShB resistance,whereas knockout of OsERF7(oserf7)enhanced it.Mechanistically,antioxidant enzyme activities are significantly reduced in OsERF7OE plants,but increased in oserf7 plants.Furthermore,transcriptome analysis revealed that oserf7 plants exhibited significant upregulation of pathogenesis-related(PR)and phytoalexin biosynthesis genes upon R.solani infection.Consistently,transcript levels of phytoalexin biosynthesis genes,including OsKSL7,OsKSL8,OsKOL5,and OsCPS4,were significantly elevated in oserf7 plants,but reduced in OsERF7OE plants in response to R.solani infection.Electrophoretic mobility shift assays and dual-luciferase(LUC)reporter assays further confirmed that OsERF7 directly binds to the promoters of OsKSL8,OsKOL5,and OsCPS4,thereby repressing their expression.In summary,our study revealed that OsERF7 negatively regulated rice resistance to ShB primarily by inhibiting phytoalexin biosynthesis.展开更多
Rice sheath blight(RSB)is a major destructive disease impeding rice production.Identifying key germplasm resources with increased resistance remains a challenge.However,the mechanisms underlying disease resistance are...Rice sheath blight(RSB)is a major destructive disease impeding rice production.Identifying key germplasm resources with increased resistance remains a challenge.However,the mechanisms underlying disease resistance are not yet fully understood.Cytochrome P450 monooxygenases(CYP450s)serve biosynthesis and metabolic detoxification functions in plants,but there is limited information about their role in the response induced by RSB.This study demonstrated that CYT02 belongs to the CYP73A100 subfamily and is a typical member of the CYP450s.Overexpression(OE)in rice of the cytochrome P450 monooxygenase cyt02 conferred increased resistance to RSB and increased vegetative tillering.Cyt02 may increase RSB resistance by regulating plant hormone synthesis,regulate reactive oxygen species(ROS)by coordinating the activity of antioxidant enzymes,and initiate phytoalexin synthesis in response to fungal infection.These research findings have laid a foundation for a deeper understanding of the function of cyt02 and offered a potential target gene for breeding rice varieties resistant to sheath blight.展开更多
BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side effects.This case report explores the novel us...BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side effects.This case report explores the novel use of a surgically-initiated rectus sheath block with a catheter-over-needle assembly for pain management in AAA repair.CASE SUMMARY A 67-year-old female with hypertension and previous aortic dissection underwent elective open repair of an infrarenal AAA,which had grown from 3.4 cm to 4.3 cm over 14 months.A rectus sheath block was initiated surgically for postoperative pain control.The patient reported low pain scores and did not require systemic intravenous opioids,enabling early ambulation and discharge on postoperative day seven without complications.By preventing complications of systemic opi-oids,the method indicating a promising direction for postoperative pain management in major vascular surgeries.CONCLUSION Surgically-initiated rectus sheath block as a valuable tool for managing postoperative pain in AAA repair.展开更多
Rice sheath blight is one of the serious rice diseases causing economic losses worldwide.Shenqinmycin,a broad-spectrum microbial metabolite pesticide,inhibits plant pathogens.This study investigated the sensitivity of...Rice sheath blight is one of the serious rice diseases causing economic losses worldwide.Shenqinmycin,a broad-spectrum microbial metabolite pesticide,inhibits plant pathogens.This study investigated the sensitivity of rice sheath blight pathogen to the biological pesticide by treating 45 strains isolated from three northeastern provinces with varying concentrations of Shenqinmycin.The effects on mycelial growth and sclerotial germination of the rice sheath blight pathogens were measured to determine the resistance levels.The results indicated that all tested strains were sensitive to Shenqinmycin,with EC50 values for Rhizoctonia solani ranging from 0.0487 mg·L^(-1) to 0.2348 mg·L^(-1),and a sensitivity baseline of 0.1292 mg·L^(-1).For Rhizoctonias oryzae-sativae,the EC50 values ranged from 0.0517 mg·L^(-1) to 0.1697 mg·L^(-1),with a sensitivity baseline of 0.1163 mg·L^(-1).Shenqinmycin had no effect on the sclerotial germination of either pathogen,suggesting its potential as an effective agent for controlling rice sheath blight.展开更多
Currently,although some progress has been made in infancy-stage rocking-chair aqueous zinc-ion batteries(AZIBs),more discussions have focused only on the different electrochemical performances displayed by different m...Currently,although some progress has been made in infancy-stage rocking-chair aqueous zinc-ion batteries(AZIBs),more discussions have focused only on the different electrochemical performances displayed by different material types rather than the intrinsic ion transport migration electrochemistry.Herein,we for the first time delve into the mechanism of tailoring the solvation sheath and desolvation processes at the electrode/electrolyte interfaces to enhance the structural stabilities in the deep discharge states.In this work,the TiO_(2)front interfaces are induced on electrochemically active but unstable TiSe_(2)host materials to construct unique TiO_(2)/TiSe_(2)-C heterointerfaces.According to X-ray absorption near edge structure(XANES),differential electrochemical mass spectrometry(DEMS),and electrochemical quartz crystal microbalance(EQCM),the intercalated species are transformed from[Zn(H_(2)O)_(6)]^(2+)to[Zn(H_(2)O)_(2)]^(2+)due to the built-in electric fields(BEFs)effects,further accelerating the ion transfer kinetics.Furthermore,owing to the absence of high-energy desolvation solvents released from desolvation processes,hydrogen evolution reaction(HER)energy barriers,Ti-Se bond strength,and structural stabilities are significantly improved,and the initial CE and HER overpotentials of the TiO_(2)/TiSe_(2)-C heterointerfaces increased from 13.76%to 84.7%,and from 1.04 to 1.30 V,respectively,and the H2 precipitation current density even at-1.3 V decreased by 73.2%.This work provides valuable insights into the complex interface electrochemical mechanism of tailoring the solvation sheath and desolvation processes toward rocking-chair zinc-ion batteries.展开更多
Non-traumatic headache is a common presentation in both emergency and outpatient settings,where timely identification of raised intracranial pressure(ICP)is crucial to prevent severe neurological complications.Convent...Non-traumatic headache is a common presentation in both emergency and outpatient settings,where timely identification of raised intracranial pressure(ICP)is crucial to prevent severe neurological complications.Conventional diagnostic methods such as computed tomography and lumbar puncture have important limitations,including invasiveness,delayed availability,and limited sensitivity in certain contexts.Point-of-care ultrasound measurement of the optic nerve sheath diameter(ONSD)has emerged as a rapid,non-invasive tool for detecting elevated ICP at the bedside.The technique is based on the anatomical continuity between the intracranial subarachnoid space and the optic nerve sheath,which expands in response to increased ICP.Evidence from multiple studies and meta-analyses indicates that ONSD measurements above 5.0-5.7 mm in adults strongly correlate with elevated ICP,showing pooled sensitivities and specificities approaching 90%.This modality enables immediate triage,guides urgency of neuroimaging,reduces unnecessary radiation exposure,and can be applied in outpatient and low-resource settings.Despite these advantages,ONSD assessment is subject to operator dependency,variability in threshold values,and reduced accuracy in patients with certain ocular or systemic conditions.Advances in artificial intelligence–assisted measurement,coupled with standardized training protocols,have the potential to improve reproducibility and broaden adoption.Overall,point-of-care ultrasound-based ONSD measurement represents a valuable adjunct in the early evaluation of patients with non-traumatic headache,facilitating faster diagnosis,better resource utilization,and improved patient outcomes.展开更多
In recent years,the prevalence of rice sheath blight caused by Rhizoctonia solani has significantly increased in Heilongjiang Province.Chemical control has become the primary control method.To cope with this,a novel m...In recent years,the prevalence of rice sheath blight caused by Rhizoctonia solani has significantly increased in Heilongjiang Province.Chemical control has become the primary control method.To cope with this,a novel mycelium growth rate method was employed to assess the toxicity of 13 fungicides,including a combination of 45%prochloraz and 125 g·mL^(-1)epoxiconazole,against R.solani.Additionally,the resistance of 99 R.solani strains to thifluzamide across various regions was also evaluated.The findings indicated that 75%trifloxystrobin-tebuconazole exhibited the most effective inhibitory effect,with an effective inhibitory medium concentration(EC50)value of 0.0101μg·mL^(-1).The EC50 values for 20%prothioconazole,125 g·mL^(-1)epoxiconazole,24%thifluzamide,and 50%hexaconazole were all less than 10μg·mL^(-1),indicating a better inhibitory effect on R.solani.The strongest synergistic effect was noted in the mixture of prochloraz and epoxiconazole at a 1:2 ratio,resulting in an EC50 value of 2.9917μg·mL^(-1),and a co-toxicity coefficient of 213.38.Among the 34 strains from Harbin City,the average EC50 value was 196.9341μg·mL^(-1)indicating the highest susceptiblility to thifluzamide.Conversely,15 strains from Shuangyashan City exhibited an average EC50 value of 364.7323μg·mL^(-1),reflecting the lowest sensitivity to thifluzamide.The sensitivity baseline EC50 value for R.solani was 253.8854μg·mL^(-1),with an overall resistance level between 0.1567 and 3.3292,indicating that the resistance level of R.solani in Heilongjiang Province remained low.Therefore,R.solani was still sensitive to thifluzamide in most areas of Heilongjiang Province,but there was a certain risk of resistance in Qitaihe City,which needed to be continuously monitored.At the same time,this study might provide a theoretical foundation for enhancing the prevention and management of the rice sheath blight.展开更多
Solvated zinc ions are prone to undergo desolvation at the electrode/electrolyte interfaces,and unstable H_(2)O molecules within the solvated sheaths tend to trigger hydrogen evolution reaction(HER),further accelerati...Solvated zinc ions are prone to undergo desolvation at the electrode/electrolyte interfaces,and unstable H_(2)O molecules within the solvated sheaths tend to trigger hydrogen evolution reaction(HER),further accelerating interfaces decay.Herein,we propose for the first time a novel strategy to enhance the interfacial stabilities by insitu dynamic reconstruction of weakly solvated Zn2þduring the desolvation processes at heterointerfaces.Theoretical calculations indicate that,due to built-in electric field effects(BEFs),the plating/stripping mechanism shifts from[Zn(H_(2)O)_(6)]_(2)þto[Zn(H_(2)O)_(5)(SO_(4))^(2-)]_(2)þwithout additional electrolyte additives,reducing the solvation ability of H_(2)O,enhancing the competitive coordination of SO_(4)^(2-),essentially eliminating the undesirable side effects of anodes.Hence,symmetric cells can operate stably for 3000 h(51.7-times increase in cycle life),and the full cells can operate stably for 5000 cycles(51.5-times increase in cycle life).This study provides valuable insights into the critical design of weakly solvated Zn^(2+) þand desolvation processes at heterointerfaces.展开更多
BACKGROUND The optic nerve sheath diameter(ONSD)measured by ultrasound has emerged as a significant noninvasive method for detecting elevated intracranial pressure(ICP),guiding timely interventions,and monitoring trea...BACKGROUND The optic nerve sheath diameter(ONSD)measured by ultrasound has emerged as a significant noninvasive method for detecting elevated intracranial pressure(ICP),guiding timely interventions,and monitoring treatment response.Previous studies have shown that the baseline ONSD at admission is a prognostic indicator of mortality in adult patients with cerebrovascular events,traumatic brain injury,hepatic encephalopathy,and acute stroke.However,pediatric data on the dynamic changes in ONSD remain limited.AIM To study the association between within-48 hours admission dynamic ONSD changes and mortality in children with clinically relevant elevated ICP.METHODS This single-institution prospective study was performed at a tertiary Children’s Hospital in Vietnam,between November 2023 and August 2024.The primary outcome was in-hospital mortality rate.ONSD data were measured at admission,24 hours,and 48 hours post-admission to pediatric intensive care unit(PICU).Linear mixed-effects models accounting for repeated measures within individuals were used to analyze the association between ONSD changes and in-hospital mortality.RESULTS A total of 69 PICU-admitted children with clinically relevant raised ICP were enrolled and included in the analysis.The median patient age was 6 years(interquartile range:1-12),and males accounted for 54%of all patients.The inhospital mortality rate in children with clinically relevant raised ICP was 23.2%.Traumatic brain injury,sepsisassociated encephalopathy,and septic shock were the main causes of death in this cohort.Linear mixed-effects analysis showed that dynamic variability in ONSD values upon PICU admission and during the first 48 hours later correlated significantly with increased mortality.Nonsurvivors had a 5.3%increase in the mean ONSD at 48 hours compared to baseline levels,while the survivors showed a 5.6%reduction in ONSD.CONCLUSION Serial ultrasound-based ONSD measurements within 48 hours of admission better predicted mortality than baseline data in critically ill children,offering a practical,noninvasive tool for early prognosis in elevated ICP.展开更多
文摘This article describes the equilibrium structure of the solar interior plasma (SIP) and solar wind plasma (SWP) in detail under the framework of the gravito-electrostatic sheath (GES) model. This model gives a precise definition of the solar surface boundary (SSB), surface origin mechanism of the subsonic SWP, and its supersonic acceleration. Equilibrium parameters like plasma potential, self-gravity, population density, flow, their gradients, and all the relevant inhomogeneity scale lengths are numerically calculated and analyzed as an initial value problem. Physical significance of the structure condition for the SSB is discussed. The plasma oscillation and Jeans time scales are also plotted and compared. In addition, different coupling parameters, and electric current profiles are also numerically studied. The current profiles exhibit an important behavior of directional reversibility, i.e., an electrodynamical transition from negative to positive value. It occurs beyond a few Jeans lengths away from the SSB. The virtual spherical surface lying at the current reversal point, where the net current becomes zero, has the property of a floating surface behavior of the real physical wall. Our investigation indicates that the SWP behaves as an ion current-carrying plasma system. The basic mechanism behind the GES formation and its distinctions from conventional plasma sheath are discussed. The electromagnetic properties of the Sun derived from our model with the most accurate available inputs are compared with those of others. These results are useful as an input element to study the properties of the linear and nonlinear dynamics of various solar plasma waves, oscillations and instabilities.
基金supported by the Nuclear Safety Research Program through the Korea Foundation of Nuclear Safety(KoFONS)using the financial resource granted by the Nuclear Safety and Security Commission(NSSC)of the Republic of Korea[RS-2025-02310881]the Korea Institute of Energy Technology Evaluation and Planning[KETEP]grant funded by the Ministry of Trade,Industry and Energy(MOTIE)[RS-2025-25447272].
文摘Unbonded post-tensioned(PT)concrete systems are widely used in safety-critical structures,yet model-ing practices for prestress implementation and tendon-concrete interaction remain inconsistent.This study investigates the effects of sheath(duct)implementation and confinement assumptions through nonlinear finite element analysis.Four modeling cases were defined,consisting of an explicit sheath without tendon-concrete confinement(S)and three no-sheath variants with different confinement levels(X,N,A).One-way beams and two-way panels were analyzed,and panel blast responses were validated against experimental results.In both beams and panels,average initial stress levels were similar across models,through local stress concentrations appeared when the sheath was modeled.Under blast loading,these local effects became critical,and the sheath-implemented model reproduced experimental behavior most accurately,whereas non-implemented models deviated.Reduced blast intensity diminished the differences among models,thereby reaffirming that sheath-induced localization and damage propagation are critical factors.These findings highlight the importance of explicit sheath implementation for realistic numerical assessment of unbonded PT structures under extreme loads.
基金supported by the Natural Science Foundation of Beijing,No.7232279(to XW)the National Natural Science Foundation of China,No.U21A20400(to QW)Key Project of Beijing University of Chinese Medicine,Nos.2022-JYB-JBZR-004(to XW),2024-JYB-JBZD-043(to CL).
文摘Chronic cerebral hypoperfusion can lead to neuronal necrosis,trigger inflammatory responses,promote white matter damage,and ultimately result in cognitive impairment.Consequently,chronic cerebral hypoperfusion is an important factor influencing the onset and progression of vascular dementia.The myelin sheath is a critical component of white matter,and damage and repair of the white matter are closely linked to myelin sheath integrity.This article reviews the role of microglia in vascular dementia,focusing on their effects on myelin sheaths and the potential therapeutic implications.The findings suggest that ischemia and hypoxia cause disruption of the blood-brain barrier and activate microglia,which may worsen blood-brain barrier damage through the release of matrix-degrading enzymes.Microglia-mediated metabolic reprogramming is recognized as an important driver of inflammation.Damage to the blood-brain barrier and subsequent inflammation can lead to myelin injury and accelerate the progression of vascular dementia.Early activation of microglia is a protective response that contributes to the maintenance of blood-brain barrier integrity through sensing,debris-clearing,and defensive mechanisms.However,prolonged activation can trigger a shift in microglia toward the pro-inflammatory M1 phenotype,resulting in myelin damage and cognitive impairment.Triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells 1 have been identified as potential biomarkers for vascular dementia,as both are closely linked to cognitive decline.Although effective clinical treatments for myelin damage in the central nervous system are currently lacking,researchers are actively working to develop targeted therapies.Several drugs,including nimodipine,dopaminergic agents,simvastatin,biotin,and quetiapine,have been evaluated for clinical use in treating microglial and myelin damage.Future research will face challenges in developing targeted therapeutic strategies for vascular dementia,requiring further investigation into the timing,duration,and specific mechanisms of microglial activation,as well as the exploration of new drug combinations and additional therapeutic targets.
基金supported by the National Natural Science Foundation of China(Grant Nos.32200430 and 32272110)Jiangsu Province Higher Vocational College Teacher Professional Leader High-End Training Program,China(Grant No.2023GRFX083)+2 种基金China Postdoctoral Science Foundation(Grant No.2022M712700)Jiangsu Funding Program for Excellent Postdoctoral Talent,China(Grant No.2022ZB628)a Project Funded by Priority Academic Program Development of Jiangsu Higher Education Institutions,China.
文摘Ethylene response factors(ERFs)are plant transcription agents that play a pivotal role in disease resistance through the ethylene signaling pathway.However,whether and how ERFs regulate resistance to sheath blight(ShB),caused by Rhizoctonia solani in rice,remains largely unknown.Here,we demonstrated that OsERF7 negatively regulates rice resistance to ShB by inhibiting phytoalexin biosynthesis.Overexpression of OsERF7(OsERF7OE)significantly decreased ShB resistance,whereas knockout of OsERF7(oserf7)enhanced it.Mechanistically,antioxidant enzyme activities are significantly reduced in OsERF7OE plants,but increased in oserf7 plants.Furthermore,transcriptome analysis revealed that oserf7 plants exhibited significant upregulation of pathogenesis-related(PR)and phytoalexin biosynthesis genes upon R.solani infection.Consistently,transcript levels of phytoalexin biosynthesis genes,including OsKSL7,OsKSL8,OsKOL5,and OsCPS4,were significantly elevated in oserf7 plants,but reduced in OsERF7OE plants in response to R.solani infection.Electrophoretic mobility shift assays and dual-luciferase(LUC)reporter assays further confirmed that OsERF7 directly binds to the promoters of OsKSL8,OsKOL5,and OsCPS4,thereby repressing their expression.In summary,our study revealed that OsERF7 negatively regulated rice resistance to ShB primarily by inhibiting phytoalexin biosynthesis.
基金supported by the Sichuan Province International Science and Technology Innovation Cooperation(2024YFHZ0299)the Project of Science and Technology Department of Sichuan Province(2022YFH0031)Chengdu Science and Technology Bureau(2024-YF05-02168-SN).
文摘Rice sheath blight(RSB)is a major destructive disease impeding rice production.Identifying key germplasm resources with increased resistance remains a challenge.However,the mechanisms underlying disease resistance are not yet fully understood.Cytochrome P450 monooxygenases(CYP450s)serve biosynthesis and metabolic detoxification functions in plants,but there is limited information about their role in the response induced by RSB.This study demonstrated that CYT02 belongs to the CYP73A100 subfamily and is a typical member of the CYP450s.Overexpression(OE)in rice of the cytochrome P450 monooxygenase cyt02 conferred increased resistance to RSB and increased vegetative tillering.Cyt02 may increase RSB resistance by regulating plant hormone synthesis,regulate reactive oxygen species(ROS)by coordinating the activity of antioxidant enzymes,and initiate phytoalexin synthesis in response to fungal infection.These research findings have laid a foundation for a deeper understanding of the function of cyt02 and offered a potential target gene for breeding rice varieties resistant to sheath blight.
基金Supported by the Taichung Veterans General Hospital,No.TCVGH-1125401B.
文摘BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side effects.This case report explores the novel use of a surgically-initiated rectus sheath block with a catheter-over-needle assembly for pain management in AAA repair.CASE SUMMARY A 67-year-old female with hypertension and previous aortic dissection underwent elective open repair of an infrarenal AAA,which had grown from 3.4 cm to 4.3 cm over 14 months.A rectus sheath block was initiated surgically for postoperative pain control.The patient reported low pain scores and did not require systemic intravenous opioids,enabling early ambulation and discharge on postoperative day seven without complications.By preventing complications of systemic opi-oids,the method indicating a promising direction for postoperative pain management in major vascular surgeries.CONCLUSION Surgically-initiated rectus sheath block as a valuable tool for managing postoperative pain in AAA repair.
基金Supported by the Green Plant Protection Project(213010801)the Heilongjiang Provincial Key R&D Program Projects(20232X02B0502)。
文摘Rice sheath blight is one of the serious rice diseases causing economic losses worldwide.Shenqinmycin,a broad-spectrum microbial metabolite pesticide,inhibits plant pathogens.This study investigated the sensitivity of rice sheath blight pathogen to the biological pesticide by treating 45 strains isolated from three northeastern provinces with varying concentrations of Shenqinmycin.The effects on mycelial growth and sclerotial germination of the rice sheath blight pathogens were measured to determine the resistance levels.The results indicated that all tested strains were sensitive to Shenqinmycin,with EC50 values for Rhizoctonia solani ranging from 0.0487 mg·L^(-1) to 0.2348 mg·L^(-1),and a sensitivity baseline of 0.1292 mg·L^(-1).For Rhizoctonias oryzae-sativae,the EC50 values ranged from 0.0517 mg·L^(-1) to 0.1697 mg·L^(-1),with a sensitivity baseline of 0.1163 mg·L^(-1).Shenqinmycin had no effect on the sclerotial germination of either pathogen,suggesting its potential as an effective agent for controlling rice sheath blight.
基金supported by the National Natural Science Foundation of China(51977097).
文摘Currently,although some progress has been made in infancy-stage rocking-chair aqueous zinc-ion batteries(AZIBs),more discussions have focused only on the different electrochemical performances displayed by different material types rather than the intrinsic ion transport migration electrochemistry.Herein,we for the first time delve into the mechanism of tailoring the solvation sheath and desolvation processes at the electrode/electrolyte interfaces to enhance the structural stabilities in the deep discharge states.In this work,the TiO_(2)front interfaces are induced on electrochemically active but unstable TiSe_(2)host materials to construct unique TiO_(2)/TiSe_(2)-C heterointerfaces.According to X-ray absorption near edge structure(XANES),differential electrochemical mass spectrometry(DEMS),and electrochemical quartz crystal microbalance(EQCM),the intercalated species are transformed from[Zn(H_(2)O)_(6)]^(2+)to[Zn(H_(2)O)_(2)]^(2+)due to the built-in electric fields(BEFs)effects,further accelerating the ion transfer kinetics.Furthermore,owing to the absence of high-energy desolvation solvents released from desolvation processes,hydrogen evolution reaction(HER)energy barriers,Ti-Se bond strength,and structural stabilities are significantly improved,and the initial CE and HER overpotentials of the TiO_(2)/TiSe_(2)-C heterointerfaces increased from 13.76%to 84.7%,and from 1.04 to 1.30 V,respectively,and the H2 precipitation current density even at-1.3 V decreased by 73.2%.This work provides valuable insights into the complex interface electrochemical mechanism of tailoring the solvation sheath and desolvation processes toward rocking-chair zinc-ion batteries.
文摘Non-traumatic headache is a common presentation in both emergency and outpatient settings,where timely identification of raised intracranial pressure(ICP)is crucial to prevent severe neurological complications.Conventional diagnostic methods such as computed tomography and lumbar puncture have important limitations,including invasiveness,delayed availability,and limited sensitivity in certain contexts.Point-of-care ultrasound measurement of the optic nerve sheath diameter(ONSD)has emerged as a rapid,non-invasive tool for detecting elevated ICP at the bedside.The technique is based on the anatomical continuity between the intracranial subarachnoid space and the optic nerve sheath,which expands in response to increased ICP.Evidence from multiple studies and meta-analyses indicates that ONSD measurements above 5.0-5.7 mm in adults strongly correlate with elevated ICP,showing pooled sensitivities and specificities approaching 90%.This modality enables immediate triage,guides urgency of neuroimaging,reduces unnecessary radiation exposure,and can be applied in outpatient and low-resource settings.Despite these advantages,ONSD assessment is subject to operator dependency,variability in threshold values,and reduced accuracy in patients with certain ocular or systemic conditions.Advances in artificial intelligence–assisted measurement,coupled with standardized training protocols,have the potential to improve reproducibility and broaden adoption.Overall,point-of-care ultrasound-based ONSD measurement represents a valuable adjunct in the early evaluation of patients with non-traumatic headache,facilitating faster diagnosis,better resource utilization,and improved patient outcomes.
基金Supported by the Green Plant Protection Project(213010801)the Heilongjiang Province Key Research and Development Plan Project(20232X02 B0502)the Natural Science Foundation of Heilongjiang Province(LH2022C022)。
文摘In recent years,the prevalence of rice sheath blight caused by Rhizoctonia solani has significantly increased in Heilongjiang Province.Chemical control has become the primary control method.To cope with this,a novel mycelium growth rate method was employed to assess the toxicity of 13 fungicides,including a combination of 45%prochloraz and 125 g·mL^(-1)epoxiconazole,against R.solani.Additionally,the resistance of 99 R.solani strains to thifluzamide across various regions was also evaluated.The findings indicated that 75%trifloxystrobin-tebuconazole exhibited the most effective inhibitory effect,with an effective inhibitory medium concentration(EC50)value of 0.0101μg·mL^(-1).The EC50 values for 20%prothioconazole,125 g·mL^(-1)epoxiconazole,24%thifluzamide,and 50%hexaconazole were all less than 10μg·mL^(-1),indicating a better inhibitory effect on R.solani.The strongest synergistic effect was noted in the mixture of prochloraz and epoxiconazole at a 1:2 ratio,resulting in an EC50 value of 2.9917μg·mL^(-1),and a co-toxicity coefficient of 213.38.Among the 34 strains from Harbin City,the average EC50 value was 196.9341μg·mL^(-1)indicating the highest susceptiblility to thifluzamide.Conversely,15 strains from Shuangyashan City exhibited an average EC50 value of 364.7323μg·mL^(-1),reflecting the lowest sensitivity to thifluzamide.The sensitivity baseline EC50 value for R.solani was 253.8854μg·mL^(-1),with an overall resistance level between 0.1567 and 3.3292,indicating that the resistance level of R.solani in Heilongjiang Province remained low.Therefore,R.solani was still sensitive to thifluzamide in most areas of Heilongjiang Province,but there was a certain risk of resistance in Qitaihe City,which needed to be continuously monitored.At the same time,this study might provide a theoretical foundation for enhancing the prevention and management of the rice sheath blight.
基金financially supported by the National Natural Science Foundation of China(51977097).
文摘Solvated zinc ions are prone to undergo desolvation at the electrode/electrolyte interfaces,and unstable H_(2)O molecules within the solvated sheaths tend to trigger hydrogen evolution reaction(HER),further accelerating interfaces decay.Herein,we propose for the first time a novel strategy to enhance the interfacial stabilities by insitu dynamic reconstruction of weakly solvated Zn2þduring the desolvation processes at heterointerfaces.Theoretical calculations indicate that,due to built-in electric field effects(BEFs),the plating/stripping mechanism shifts from[Zn(H_(2)O)_(6)]_(2)þto[Zn(H_(2)O)_(5)(SO_(4))^(2-)]_(2)þwithout additional electrolyte additives,reducing the solvation ability of H_(2)O,enhancing the competitive coordination of SO_(4)^(2-),essentially eliminating the undesirable side effects of anodes.Hence,symmetric cells can operate stably for 3000 h(51.7-times increase in cycle life),and the full cells can operate stably for 5000 cycles(51.5-times increase in cycle life).This study provides valuable insights into the critical design of weakly solvated Zn^(2+) þand desolvation processes at heterointerfaces.
文摘BACKGROUND The optic nerve sheath diameter(ONSD)measured by ultrasound has emerged as a significant noninvasive method for detecting elevated intracranial pressure(ICP),guiding timely interventions,and monitoring treatment response.Previous studies have shown that the baseline ONSD at admission is a prognostic indicator of mortality in adult patients with cerebrovascular events,traumatic brain injury,hepatic encephalopathy,and acute stroke.However,pediatric data on the dynamic changes in ONSD remain limited.AIM To study the association between within-48 hours admission dynamic ONSD changes and mortality in children with clinically relevant elevated ICP.METHODS This single-institution prospective study was performed at a tertiary Children’s Hospital in Vietnam,between November 2023 and August 2024.The primary outcome was in-hospital mortality rate.ONSD data were measured at admission,24 hours,and 48 hours post-admission to pediatric intensive care unit(PICU).Linear mixed-effects models accounting for repeated measures within individuals were used to analyze the association between ONSD changes and in-hospital mortality.RESULTS A total of 69 PICU-admitted children with clinically relevant raised ICP were enrolled and included in the analysis.The median patient age was 6 years(interquartile range:1-12),and males accounted for 54%of all patients.The inhospital mortality rate in children with clinically relevant raised ICP was 23.2%.Traumatic brain injury,sepsisassociated encephalopathy,and septic shock were the main causes of death in this cohort.Linear mixed-effects analysis showed that dynamic variability in ONSD values upon PICU admission and during the first 48 hours later correlated significantly with increased mortality.Nonsurvivors had a 5.3%increase in the mean ONSD at 48 hours compared to baseline levels,while the survivors showed a 5.6%reduction in ONSD.CONCLUSION Serial ultrasound-based ONSD measurements within 48 hours of admission better predicted mortality than baseline data in critically ill children,offering a practical,noninvasive tool for early prognosis in elevated ICP.
