Background:Glutamate(GLU)is one of the most important excitatory neurotransmitters in central nervous system(CNS).GLU is involved in many CNS diseases,which is well reported that it is closely related to the infectiou...Background:Glutamate(GLU)is one of the most important excitatory neurotransmitters in central nervous system(CNS).GLU is involved in many CNS diseases,which is well reported that it is closely related to the infectious diseases in CNS.Brain abscess is a common disease in CNS.GLU chemical exchange saturation transfer MRI(GLUCEST)is used to explore the changes of glutamate concentration in the brain abscess models.Methods:Firstly,a SD rat brain abscess model was established by using Staphylococcus aureus in the right frontal lobe of SD rats.Secondly,imaging of normal SD rats and brain abscess rats were obtained in Agilent 7.0T animal magnetic resonance scanner respectively.Finally,all data are processed on Matlab.Results:GLUCEST clearly delineated brain abscess at Z spectra.The CEST map of the brain abscess rats showed that the glutamate CEST effect in the lesions was significantly higher than that in the normal SD rats(p<0.05).Conclusions:GLUCEST may provide new insight into brain abscess and help to improve the differential diagnosis.展开更多
Inflammation in central nervous system(CNS)is one of the most severe diseases,and also plays an impellent role in some neurodegenerative diseases.Glutamate(Glu)has been considered relevant to the pathogenesis of neuro...Inflammation in central nervous system(CNS)is one of the most severe diseases,and also plays an impellent role in some neurodegenerative diseases.Glutamate(Glu)has been considered relevant to the pathogenesis of neuroinflammation.In order to diagnose neuroinflammation incipiently and precisely,we review the pathobiological events in the early stages of neuroinflammation,the interactions between Glu and neuroinflammation,and two kinds of magnetic resonance techniques of imaging Glu(chemical exchange saturation transfer and magnetic resonance spectroscopy).展开更多
基金sponsored by the National Natural Science Foundation of China(Grant No.81471730)the Natural Science Foundation of Guangdong Province of China(Grant No.2015A030313444)the Department for Education,Guangdong Government under the Top-tier University Development Scheme for Research and Control of Infectious Diseases.
文摘Background:Glutamate(GLU)is one of the most important excitatory neurotransmitters in central nervous system(CNS).GLU is involved in many CNS diseases,which is well reported that it is closely related to the infectious diseases in CNS.Brain abscess is a common disease in CNS.GLU chemical exchange saturation transfer MRI(GLUCEST)is used to explore the changes of glutamate concentration in the brain abscess models.Methods:Firstly,a SD rat brain abscess model was established by using Staphylococcus aureus in the right frontal lobe of SD rats.Secondly,imaging of normal SD rats and brain abscess rats were obtained in Agilent 7.0T animal magnetic resonance scanner respectively.Finally,all data are processed on Matlab.Results:GLUCEST clearly delineated brain abscess at Z spectra.The CEST map of the brain abscess rats showed that the glutamate CEST effect in the lesions was significantly higher than that in the normal SD rats(p<0.05).Conclusions:GLUCEST may provide new insight into brain abscess and help to improve the differential diagnosis.
基金supported in part by the National Natural Science Foundation of China(Grant No.81471730)the National High Technology Research and Development Program(863 Program)of China(Program No.2014AA021101)the Natural Science Foundation of Guangdong Province of China(Grant No.2015A030313444).
文摘Inflammation in central nervous system(CNS)is one of the most severe diseases,and also plays an impellent role in some neurodegenerative diseases.Glutamate(Glu)has been considered relevant to the pathogenesis of neuroinflammation.In order to diagnose neuroinflammation incipiently and precisely,we review the pathobiological events in the early stages of neuroinflammation,the interactions between Glu and neuroinflammation,and two kinds of magnetic resonance techniques of imaging Glu(chemical exchange saturation transfer and magnetic resonance spectroscopy).
