This article presents research focused on developing and scientifically substantiating a technology for producing environmentally friendly glued structures fromwood treated through a two-stage process.Themethodology i...This article presents research focused on developing and scientifically substantiating a technology for producing environmentally friendly glued structures fromwood treated through a two-stage process.Themethodology involves preliminary thermal modification followed by high-frequency low-temperature plasma treatment.Thermal modification enhances performance characteristics such as resistance to rot,lowers hygroscopicity,and increases dimensional stability.However,it can diminish the adhesive properties of wood,complicating the bonding process.To address this challenge,the study introduces high-frequency low-temperature plasma treatment,which activates the wood surface,improving wettability and adhesion while minimizing glue consumption.Experimental results indicate that plasma treatment reduces the contact angle by 46%and adhesive consumption during bonding by 24%,thereby enhancing the environmental friendliness of the glued structures.Furthermore,this dual treatment process increases the shear strength of adhesive joints by 22.7%and bending strength of glued beams by 66.6%,demonstrating a 30%lower carbon footprint compared to conventional methods.The findings affirm the efficacy of this technology in producing building materials,particularly glued beams for large-span structures.展开更多
探究2型糖尿病(diabetes mellitus type 2,T2DM)患者血清C肽、糖化血红蛋白(glycosylated hemoglobin,HbA1c)以及葡萄糖(glucose,GLU)水平表达及其同并发症发生风险的相关性。选取甘肃省陇南市第一人民医院(2024年1月—2025年4月)收治的...探究2型糖尿病(diabetes mellitus type 2,T2DM)患者血清C肽、糖化血红蛋白(glycosylated hemoglobin,HbA1c)以及葡萄糖(glucose,GLU)水平表达及其同并发症发生风险的相关性。选取甘肃省陇南市第一人民医院(2024年1月—2025年4月)收治的180例T2DM患者为观察组,根据是否发生并发症分为非并发症组(50例)和并发症组(130例)。同时选取同期体检的180例健康人群为对照组。对比C肽、HbA1c、GLU水平,并经Spearman相关性分析C肽、HbA1c、GLU水平与T2DM患者并发症发生风险的相关性。结果显示,观察组血清C肽水平低于对照组,HbA1c水平、GLU高于对照组(P<0.05)。并发症组血清C肽水平低于非并发症组,HbA1c水平、GLU高于非并发症组(P<0.05)。HbA1c、GLU水平与T2DM患者并发症的发生风险呈正相关,C肽水平与T2DM患者并发症的发生风险呈负相关(P<0.05)。研究发现,通过监测血清C肽、HbA1c以及GLU水平,可评估T2DM患者的并发症发生风险。展开更多
OBJECTIVE: To investigate the antiepileptic effects of Chaihushugan decoction(CHSGD) in rats with pentylenetetrazole(PTZ)-induced seizures and to discuss the impact of CHSGD on glutamate metabolism, a hypothesized und...OBJECTIVE: To investigate the antiepileptic effects of Chaihushugan decoction(CHSGD) in rats with pentylenetetrazole(PTZ)-induced seizures and to discuss the impact of CHSGD on glutamate metabolism, a hypothesized underlying mechanism of seizure reduction.METHODS: Fifty Wistar rats were divided randomly into either control(n = 10) or experimental(n = 40)groups. Rats in the control group were administered physiological saline intraperitoneally. A subconvulsive dose of PTZ(35 mg/kg) was administered intraperitoneally to rats in the experimental group to induce seizures. The fully PTZ-kindled rats were then randomly divided into five subgroups(n = 8 each) based on the following treatment categories: physiological saline, VPA(200 mg/kg), CHSGD(2.5 g/kg), CHSGD(5 g/kg), or CHSGD(10 g/kg),administered orally once per day, respectively. On day 28 following initiation of drug treatment, seizures were monitored. The rats were then sacrificed, and hippocampal dissections were performed for subsequent studies.RESULTS: CHSGD significantly prolonged the latency of myoclonic, clonic, and tonic seizures, while decreasing overall seizure rates in the kindled rats.The measured concentrations of 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-d-glucose(2-NBDG) and glutamate were significantly lower in the hippocampi of kindled rats in groups treated with CHSGD compared with those treated with PTZ alone. In addition, CHSGD was found to up-regulate both the expression of glutamate transporter-1(GLT-1) protein and the activity of glutamine synthetase(GS) in the hippocampi of kindled rats.CONCLUSION: These results suggest that CHSGD has antiepileptic effects on PTZ-induced seizures.The results further suggest an increase in glutamate metabolism at the synaptic cleft is a putative underlying mechanism of seizure reduction.展开更多
基金funded by the Technostart competition,Agreement No.12-22(2-22)dated 01 February 2022.
文摘This article presents research focused on developing and scientifically substantiating a technology for producing environmentally friendly glued structures fromwood treated through a two-stage process.Themethodology involves preliminary thermal modification followed by high-frequency low-temperature plasma treatment.Thermal modification enhances performance characteristics such as resistance to rot,lowers hygroscopicity,and increases dimensional stability.However,it can diminish the adhesive properties of wood,complicating the bonding process.To address this challenge,the study introduces high-frequency low-temperature plasma treatment,which activates the wood surface,improving wettability and adhesion while minimizing glue consumption.Experimental results indicate that plasma treatment reduces the contact angle by 46%and adhesive consumption during bonding by 24%,thereby enhancing the environmental friendliness of the glued structures.Furthermore,this dual treatment process increases the shear strength of adhesive joints by 22.7%and bending strength of glued beams by 66.6%,demonstrating a 30%lower carbon footprint compared to conventional methods.The findings affirm the efficacy of this technology in producing building materials,particularly glued beams for large-span structures.
文摘探究2型糖尿病(diabetes mellitus type 2,T2DM)患者血清C肽、糖化血红蛋白(glycosylated hemoglobin,HbA1c)以及葡萄糖(glucose,GLU)水平表达及其同并发症发生风险的相关性。选取甘肃省陇南市第一人民医院(2024年1月—2025年4月)收治的180例T2DM患者为观察组,根据是否发生并发症分为非并发症组(50例)和并发症组(130例)。同时选取同期体检的180例健康人群为对照组。对比C肽、HbA1c、GLU水平,并经Spearman相关性分析C肽、HbA1c、GLU水平与T2DM患者并发症发生风险的相关性。结果显示,观察组血清C肽水平低于对照组,HbA1c水平、GLU高于对照组(P<0.05)。并发症组血清C肽水平低于非并发症组,HbA1c水平、GLU高于非并发症组(P<0.05)。HbA1c、GLU水平与T2DM患者并发症的发生风险呈正相关,C肽水平与T2DM患者并发症的发生风险呈负相关(P<0.05)。研究发现,通过监测血清C肽、HbA1c以及GLU水平,可评估T2DM患者的并发症发生风险。
基金Supported by Guangdong Natural Science Foundation(The effects of "Treatment from Gan"on Regulation of A-type Potassium Channels by KChIP/Kv4 in the pathomechanism of Refractory Epilepsy,No.2014A030310052)National Natural Science Foundation of China(Study on Regulation of A-type Potassium Channels by KChIP/Kv4 in the Pathomechanism of Refractory Epilepsy and the Effects of "Treatment from Gan",No.81503564)
文摘OBJECTIVE: To investigate the antiepileptic effects of Chaihushugan decoction(CHSGD) in rats with pentylenetetrazole(PTZ)-induced seizures and to discuss the impact of CHSGD on glutamate metabolism, a hypothesized underlying mechanism of seizure reduction.METHODS: Fifty Wistar rats were divided randomly into either control(n = 10) or experimental(n = 40)groups. Rats in the control group were administered physiological saline intraperitoneally. A subconvulsive dose of PTZ(35 mg/kg) was administered intraperitoneally to rats in the experimental group to induce seizures. The fully PTZ-kindled rats were then randomly divided into five subgroups(n = 8 each) based on the following treatment categories: physiological saline, VPA(200 mg/kg), CHSGD(2.5 g/kg), CHSGD(5 g/kg), or CHSGD(10 g/kg),administered orally once per day, respectively. On day 28 following initiation of drug treatment, seizures were monitored. The rats were then sacrificed, and hippocampal dissections were performed for subsequent studies.RESULTS: CHSGD significantly prolonged the latency of myoclonic, clonic, and tonic seizures, while decreasing overall seizure rates in the kindled rats.The measured concentrations of 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-d-glucose(2-NBDG) and glutamate were significantly lower in the hippocampi of kindled rats in groups treated with CHSGD compared with those treated with PTZ alone. In addition, CHSGD was found to up-regulate both the expression of glutamate transporter-1(GLT-1) protein and the activity of glutamine synthetase(GS) in the hippocampi of kindled rats.CONCLUSION: These results suggest that CHSGD has antiepileptic effects on PTZ-induced seizures.The results further suggest an increase in glutamate metabolism at the synaptic cleft is a putative underlying mechanism of seizure reduction.
