The world today is facing turbulence and change,and global development is at a crossroads.At this critical juncture,President Xi Jinping put forth the Global Development Initiative(GDI)with the theme“implementing the...The world today is facing turbulence and change,and global development is at a crossroads.At this critical juncture,President Xi Jinping put forth the Global Development Initiative(GDI)with the theme“implementing the 2030 Sustainable Development Agenda for more robust,greener and healthier global development”at the 76th General Assembly of the United Nations,which sheds light on the direction of global development.The GDI,proposed by China,has galvanized support from the international community as an international public goods to promote common development.Following the historical trends of human development,the GDI breaks through the limitations of the hegemonic stability theory and the free-riding curse to expand and innovate the theoretical perception of international public goods with the right approach to principles and interests.With a people-oriented approach and the basic principles of green and innovative development,the GDI both addresses urgent challenges and attaches importance to enhancing development capabilities and creating supporting conditions to offer a holistic solution to global challenges.Through the implementation of multiple pathways under international cooperation,the GDI will build a consensus on global development,increase the momentum of global development,and play an important role in creating a community with a shared future for mankind.展开更多
BACKGROUND Xia–Gibbs syndrome(XGS,OMIM:615829),caused by mutations within the ATHook DNA-binding motif-containing protein 1(AHDC1)gene(OMIM:615790),located on the short arm of chromosome 1 within the cytogenetic band...BACKGROUND Xia–Gibbs syndrome(XGS,OMIM:615829),caused by mutations within the ATHook DNA-binding motif-containing protein 1(AHDC1)gene(OMIM:615790),located on the short arm of chromosome 1 within the cytogenetic band 1p36.11,contains five noncoding 5 exons,a single 4.9-kb coding exon,and a noncoding 3 exon.CASE SUMMARY In this case report,we diagnosed and treated a 6-mo-old girl with XGS.The primary clinical symptoms included global developmental delay,hypotonia,and mild dysmorphic features.Using high-throughput whole-exosome sequencing to sequence the patient and her parents,and the results showed a novel frameshift mutation of c.1155dupG(p.Arg386Alafs*3)in the AHDC1 gene.The paternal gene was wild type.CONCLUSION This report extends the mutation spectrum of the AHDC1 gene to provide the diagnostic basis for genetic counseling in families with XGS.展开更多
With the increasing demand for VAS from the subscribers, mobile operators are making efforts to create more services to promote the continuous development of the non-voice service application. The following three mobi...With the increasing demand for VAS from the subscribers, mobile operators are making efforts to create more services to promote the continuous development of the non-voice service application. The following three mobile VASes are becoming the development focus of operators.展开更多
China’s Global Development Initiative(GDI)and Global Security Initiative(GSI)symbolize the important innovations,in theory and in practice,resulting from President Xi Jinping Thought on Diplomacy in recent years.Both...China’s Global Development Initiative(GDI)and Global Security Initiative(GSI)symbolize the important innovations,in theory and in practice,resulting from President Xi Jinping Thought on Diplomacy in recent years.Both initiatives were proposed by President Xi Jinping,who has been standing with the people and supporting laws for the development of human society.These initiatives disseminate Chinese wisdom and inputs in responding to the questions posed by the world,by our times,and by history,thus having a significant impact on China’s peaceful development,as well as on global prosperity and progress.Presently,the once-in-a-century changes that shape the world today are evolving rapidly,and the international security situation is undergoing complex transformations.To address urgent issues and make new contributions to global peace and development,it is crucial to systematically study and deeply reflect on the GDI and the GSI and seek synergy between the two.展开更多
Human development is now in the throes of the worst situation since the end of the Second World War,just like falling into a swamp,beset by the difficulties of regional conflicts,economic recession,food crisis,spread ...Human development is now in the throes of the worst situation since the end of the Second World War,just like falling into a swamp,beset by the difficulties of regional conflicts,economic recession,food crisis,spread of viruses and climate change.展开更多
Net capital flows to developing countries fell 20 percent in 2009 to $598 billion and were a little over half the 2007 peak of $1.11 trillion. This is according to a new comprehensive dataset
As China concludes the suc-cessful implementation of the 14th Five-Year Plan(2021-25)and enters the decisive stage of building a modern socialist country,it does so with a powerful legacy that has shaped its developme...As China concludes the suc-cessful implementation of the 14th Five-Year Plan(2021-25)and enters the decisive stage of building a modern socialist country,it does so with a powerful legacy that has shaped its development for more than seven decades.展开更多
Global developmental delay/intellectual disability(GDD/ID)with a prevalence of 1%e3%represents one of the biggest medical and social challenges in our society.^(1)Genetic factors are the main causes of GDD/ID and earl...Global developmental delay/intellectual disability(GDD/ID)with a prevalence of 1%e3%represents one of the biggest medical and social challenges in our society.^(1)Genetic factors are the main causes of GDD/ID and early diagnosis is crucial to improving the prognosis of GDD/ID children.^(2)Chromosomal microarray analysis,as a first-tier clinical test,^(3)remains limited because of the insufficient to detect small variations while whole exome sequencing(WES)can detect both single-nucleotide variants(SNVs)and copy-number variants(CNVs),effectively improving the diagnostic yield of GDD/ID.展开更多
Today,the world is undergoing extremely rapid and profound changes.The Two Sessions held each March in Beijing provide an excellent opportunity to review the changes taking place in the world,reflect on the path China...Today,the world is undergoing extremely rapid and profound changes.The Two Sessions held each March in Beijing provide an excellent opportunity to review the changes taking place in the world,reflect on the path China has taken,its achievements and challenges,and evaluate future steps.展开更多
Ports,the core hub of global supply chains,serve as vital links in the economic and trade exchanges among countries.Efficient,safe,green and smart ports are essential for the smooth operation of global trade.Recently,...Ports,the core hub of global supply chains,serve as vital links in the economic and trade exchanges among countries.Efficient,safe,green and smart ports are essential for the smooth operation of global trade.Recently,ISO established ISO/TC 8/SC 27,Ports and terminals,the secretariat of which is held by China.This is a big breakthrough of China’s participation in the international standardization activities in the area of transportation.展开更多
Importance:Understanding the significance of motor skills in promoting physical fitness(PF)can offer valuable insights for devising comprehensive intervention and clinical rehabilitation programs for children with glo...Importance:Understanding the significance of motor skills in promoting physical fitness(PF)can offer valuable insights for devising comprehensive intervention and clinical rehabilitation programs for children with global developmental delay(GDD).However,it remains unclear whether fundamental motor skills(FMS)can improve the PF of children with GDD.Objective:To investigate the correlation between FMS and PF in children with GDD.Methods:A total of 180 children with GDD and 180 typically developing(TD)children aged 3-5 years were selected.All participants completed the Gesell Developmental Schedule,FMS,and PF tests at Beijing Children’s Hospital between September 2022 and August 2023.Partial correlation and regression analyses were performed to examine the relationship between FMS and PF.Results:Children with GDD had significantly lower FMS and PF scores compared to TD children(P<0.05).No significant differences were found between males and females with GDD in FMS and PF score(P>0.05).A more severe developmental delay was associated with lower FMS and PF scores.The correlation coefficients between individual FMS items and individual PF items,as well as the total PF score,ranged from 0.20 to 0.56.Regression analysis indicated that manual dexterity(β=0.241,P=0.029)and body balance(β=0.399,P=0.001)significantly predicted the total PF score.Interpretation:In children with GDD,both FMS and PF are underdeveloped.Focusing on motor skills development is vital for promoting their PF.展开更多
Modern urbanization and industrial revolution,good and easy transportation and communication systems,sophisticated exploration and exploitation technology of hidden mineral resources are the indicators of development ...Modern urbanization and industrial revolution,good and easy transportation and communication systems,sophisticated exploration and exploitation technology of hidden mineral resources are the indicators of development activities.It is now well recognized worldwide that without development activities upgrading of living standard and sustainability of a society can not be achieved.展开更多
On September 1,2025,President Xi Jinping solemnly proposed the Global Governance Initiative(GGI)at the“Shanghai Cooperation Organization Plus”Meeting.Following the Global Development Initiative(GDI),the Global Secur...On September 1,2025,President Xi Jinping solemnly proposed the Global Governance Initiative(GGI)at the“Shanghai Cooperation Organization Plus”Meeting.Following the Global Development Initiative(GDI),the Global Security Initiative(GSI),and the Global Civilization Initiative(GCI).展开更多
By analyzing the distribution of global oil and gas fields and the reasons why some oil and gas fields are not in production, the distribution characteristics of oil and gas remaining recoverable reserves and their ye...By analyzing the distribution of global oil and gas fields and the reasons why some oil and gas fields are not in production, the distribution characteristics of oil and gas remaining recoverable reserves and their year-on-year changes, the distribution characteristics of oil and gas production and their year-on-year changes, and the development potential of oil and gas to be tapped in 2021, this paper sorts out systematically the current status and characteristics of global oil and gas development, summaries the major trends of global oil and gas development, puts forward enlightenment for international oil and gas cooperation. In 2021, oil and gas fields were widely distributed, the number of non-producing oil and gas fields was large;the whole oil and gas remaining recoverable reserves declined slightly, unconventional oil and gas remaining recoverable reserves dropped significantly;the overall oil and gas production continuously increased, the outputs of key resource-host countries kept year-on-year growth;undeveloped oilfields had abundant reserves and great development potential. Combined with global oil and gas geopolitics, oil and gas industry development trends, oil and gas investment intensity, and the tracking and judgment of hotspot fields, the major trends of global oil and gas development in 2021 are summarized. On this basis, the four aspects of enlightenment and suggestions for international oil and gas cooperation and development strategies are put forward: attach great importance to the obligation of marine abandonment to ensure high-quality and long-term benefit development of offshore oil and gas;adhere to the principle of not going to dangerous and chaotic places, strengthen the concentration of oil and gas assets, and establish multi stable supply bases;based on the multi-scenario demand of natural gas, realize the transformation from integrated collaboration to full oil and gas industry chain development;increase the acquisition of high-quality large-scale assets, and pay attention to the continuous optimization of the shareholding ratio of projects at different stages.展开更多
Accurate software cost estimation in Global Software Development(GSD)remains challenging due to reliance on historical data and expert judgments.Traditional models,such as the Constructive Cost Model(COCOMO II),rely h...Accurate software cost estimation in Global Software Development(GSD)remains challenging due to reliance on historical data and expert judgments.Traditional models,such as the Constructive Cost Model(COCOMO II),rely heavily on historical and accurate data.In addition,expert judgment is required to set many input parameters,which can introduce subjectivity and variability in the estimation process.Consequently,there is a need to improve the current GSD models to mitigate reliance on historical data,subjectivity in expert judgment,inadequate consideration of GSD-based cost drivers and limited integration of modern technologies with cost overruns.This study introduces a novel hybrid model that synergizes the COCOMO II with Artificial Neural Networks(ANN)to address these challenges.The proposed hybrid model integrates additional GSD-based cost drivers identified through a systematic literature review and further vetted by industry experts.This article compares the effectiveness of the proposedmodelwith state-of-the-artmachine learning-basedmodels for software cost estimation.Evaluating the NASA 93 dataset by adopting twenty-six GSD-based cost drivers reveals that our hybrid model achieves superior accuracy,outperforming existing state-of-the-artmodels.The findings indicate the potential of combining COCOMO II,ANN,and additional GSD-based cost drivers to transform cost estimation in GSD.展开更多
This paper presents an analysis of four aspects,including the distribution and production of global oil and gas fields,the distribution and changes of remaining recoverable reserves,the differences in oil and gas prod...This paper presents an analysis of four aspects,including the distribution and production of global oil and gas fields,the distribution and changes of remaining recoverable reserves,the differences in oil and gas production between regions/countries,and the development potentials of oil and gas fields unproduced and to be produced in 2023.On this basis,the situation and characteristics of global oil and gas development are expounded,and the trend of global oil and gas development is summarized.In 2023,upstream oil and gas production landscape is expanding,and the number of oil and gas fields in production is increasing significantly;oil and gas recoverable reserves increased year-on-year,driven by significant contributions from new discoveries and reserve re-estimates;the overall oil and gas production grew continuously,with notable contributions from new projects coming online and capacity expansion efforts;and the oil and gas fields unproduced or to be produced,especially large onshore conventional oil fields and economically challenging offshore gas fields,host abundant recoverable reserves.From the perspectives of reshaping oil and gas production areas due to the pandemic and Russia-Ukraine conflicts,geopolitical crises,capital expenditure structures in petroleum exploration and development,and the proactive layout of oil and gas associated resources,the trend of global oil and gas development in 2023 was analyzed systematically.The enlightenment and suggestions in four aspects are proposed for Chinese oil companies to focus on core businesses and clarify development strategies in the post-pandemic era and the context of energy transition:The global oil and gas landscape is undergoing profound adjustments,and it is essential to grasp development trends,especially in core businesses;upstream business exhibits a strong potential,and emerging fields are considered as new growth poles;the prospects for tight/shale oil and gas are promising,and new pathways to ensure national energy security are explored;cutting-edge breakthroughs are achieved in emerging industries of strategic importance,and a comprehensive energy collaboration system for supply security is established.展开更多
文摘The world today is facing turbulence and change,and global development is at a crossroads.At this critical juncture,President Xi Jinping put forth the Global Development Initiative(GDI)with the theme“implementing the 2030 Sustainable Development Agenda for more robust,greener and healthier global development”at the 76th General Assembly of the United Nations,which sheds light on the direction of global development.The GDI,proposed by China,has galvanized support from the international community as an international public goods to promote common development.Following the historical trends of human development,the GDI breaks through the limitations of the hegemonic stability theory and the free-riding curse to expand and innovate the theoretical perception of international public goods with the right approach to principles and interests.With a people-oriented approach and the basic principles of green and innovative development,the GDI both addresses urgent challenges and attaches importance to enhancing development capabilities and creating supporting conditions to offer a holistic solution to global challenges.Through the implementation of multiple pathways under international cooperation,the GDI will build a consensus on global development,increase the momentum of global development,and play an important role in creating a community with a shared future for mankind.
基金Supported by National Administration of Traditional Chinese Medicine,No.2019XZZX-EK002.
文摘BACKGROUND Xia–Gibbs syndrome(XGS,OMIM:615829),caused by mutations within the ATHook DNA-binding motif-containing protein 1(AHDC1)gene(OMIM:615790),located on the short arm of chromosome 1 within the cytogenetic band 1p36.11,contains five noncoding 5 exons,a single 4.9-kb coding exon,and a noncoding 3 exon.CASE SUMMARY In this case report,we diagnosed and treated a 6-mo-old girl with XGS.The primary clinical symptoms included global developmental delay,hypotonia,and mild dysmorphic features.Using high-throughput whole-exosome sequencing to sequence the patient and her parents,and the results showed a novel frameshift mutation of c.1155dupG(p.Arg386Alafs*3)in the AHDC1 gene.The paternal gene was wild type.CONCLUSION This report extends the mutation spectrum of the AHDC1 gene to provide the diagnostic basis for genetic counseling in families with XGS.
文摘With the increasing demand for VAS from the subscribers, mobile operators are making efforts to create more services to promote the continuous development of the non-voice service application. The following three mobile VASes are becoming the development focus of operators.
基金supported by the National Social Science Fund of China,entitled"Study on the Path of Globalization and the Building of a Human Community with a Shared Future amid Changes Unseen in a Century"(Grant No.21&ZD172).
文摘China’s Global Development Initiative(GDI)and Global Security Initiative(GSI)symbolize the important innovations,in theory and in practice,resulting from President Xi Jinping Thought on Diplomacy in recent years.Both initiatives were proposed by President Xi Jinping,who has been standing with the people and supporting laws for the development of human society.These initiatives disseminate Chinese wisdom and inputs in responding to the questions posed by the world,by our times,and by history,thus having a significant impact on China’s peaceful development,as well as on global prosperity and progress.Presently,the once-in-a-century changes that shape the world today are evolving rapidly,and the international security situation is undergoing complex transformations.To address urgent issues and make new contributions to global peace and development,it is crucial to systematically study and deeply reflect on the GDI and the GSI and seek synergy between the two.
文摘Human development is now in the throes of the worst situation since the end of the Second World War,just like falling into a swamp,beset by the difficulties of regional conflicts,economic recession,food crisis,spread of viruses and climate change.
文摘Net capital flows to developing countries fell 20 percent in 2009 to $598 billion and were a little over half the 2007 peak of $1.11 trillion. This is according to a new comprehensive dataset
文摘As China concludes the suc-cessful implementation of the 14th Five-Year Plan(2021-25)and enters the decisive stage of building a modern socialist country,it does so with a powerful legacy that has shaped its development for more than seven decades.
基金supported by the Shanghai Municipal Commission of Science and Technology Research Project(China)(No.19JC1411001)the National Key Research and Development Program from the Ministry of Science and Technology of the People’s Republic of China(No.2021YFC2700800)+4 种基金the National Natural Science Foundation of China(No.31972880,32170615,31611130035,31371274)the National Key Research and Development Plan for Stem Cell and Transformation Research(China)(No.2017YFA0104202)the Collaborative Innovation Center Project Construction for Shanghai Women and Children’s Health,the Open Research Fund of National Health Commission Key Laboratory of Birth Defects Prevention&Henan Key Laboratory of Population Defects Prevention(China)(No.ZD202309)The Medical Science and Technology Research Program Project of Henan Province,China(No.LHGJ20230368)the Postdoctoral Research Fund of the Third Affiliated Hospital of Zhengzhou University(No.BSH20230101).
文摘Global developmental delay/intellectual disability(GDD/ID)with a prevalence of 1%e3%represents one of the biggest medical and social challenges in our society.^(1)Genetic factors are the main causes of GDD/ID and early diagnosis is crucial to improving the prognosis of GDD/ID children.^(2)Chromosomal microarray analysis,as a first-tier clinical test,^(3)remains limited because of the insufficient to detect small variations while whole exome sequencing(WES)can detect both single-nucleotide variants(SNVs)and copy-number variants(CNVs),effectively improving the diagnostic yield of GDD/ID.
文摘Today,the world is undergoing extremely rapid and profound changes.The Two Sessions held each March in Beijing provide an excellent opportunity to review the changes taking place in the world,reflect on the path China has taken,its achievements and challenges,and evaluate future steps.
文摘Ports,the core hub of global supply chains,serve as vital links in the economic and trade exchanges among countries.Efficient,safe,green and smart ports are essential for the smooth operation of global trade.Recently,ISO established ISO/TC 8/SC 27,Ports and terminals,the secretariat of which is held by China.This is a big breakthrough of China’s participation in the international standardization activities in the area of transportation.
文摘Importance:Understanding the significance of motor skills in promoting physical fitness(PF)can offer valuable insights for devising comprehensive intervention and clinical rehabilitation programs for children with global developmental delay(GDD).However,it remains unclear whether fundamental motor skills(FMS)can improve the PF of children with GDD.Objective:To investigate the correlation between FMS and PF in children with GDD.Methods:A total of 180 children with GDD and 180 typically developing(TD)children aged 3-5 years were selected.All participants completed the Gesell Developmental Schedule,FMS,and PF tests at Beijing Children’s Hospital between September 2022 and August 2023.Partial correlation and regression analyses were performed to examine the relationship between FMS and PF.Results:Children with GDD had significantly lower FMS and PF scores compared to TD children(P<0.05).No significant differences were found between males and females with GDD in FMS and PF score(P>0.05).A more severe developmental delay was associated with lower FMS and PF scores.The correlation coefficients between individual FMS items and individual PF items,as well as the total PF score,ranged from 0.20 to 0.56.Regression analysis indicated that manual dexterity(β=0.241,P=0.029)and body balance(β=0.399,P=0.001)significantly predicted the total PF score.Interpretation:In children with GDD,both FMS and PF are underdeveloped.Focusing on motor skills development is vital for promoting their PF.
文摘Modern urbanization and industrial revolution,good and easy transportation and communication systems,sophisticated exploration and exploitation technology of hidden mineral resources are the indicators of development activities.It is now well recognized worldwide that without development activities upgrading of living standard and sustainability of a society can not be achieved.
文摘On September 1,2025,President Xi Jinping solemnly proposed the Global Governance Initiative(GGI)at the“Shanghai Cooperation Organization Plus”Meeting.Following the Global Development Initiative(GDI),the Global Security Initiative(GSI),and the Global Civilization Initiative(GCI).
基金Scientific Research and Technology Development Project(2021DJ3205)。
文摘By analyzing the distribution of global oil and gas fields and the reasons why some oil and gas fields are not in production, the distribution characteristics of oil and gas remaining recoverable reserves and their year-on-year changes, the distribution characteristics of oil and gas production and their year-on-year changes, and the development potential of oil and gas to be tapped in 2021, this paper sorts out systematically the current status and characteristics of global oil and gas development, summaries the major trends of global oil and gas development, puts forward enlightenment for international oil and gas cooperation. In 2021, oil and gas fields were widely distributed, the number of non-producing oil and gas fields was large;the whole oil and gas remaining recoverable reserves declined slightly, unconventional oil and gas remaining recoverable reserves dropped significantly;the overall oil and gas production continuously increased, the outputs of key resource-host countries kept year-on-year growth;undeveloped oilfields had abundant reserves and great development potential. Combined with global oil and gas geopolitics, oil and gas industry development trends, oil and gas investment intensity, and the tracking and judgment of hotspot fields, the major trends of global oil and gas development in 2021 are summarized. On this basis, the four aspects of enlightenment and suggestions for international oil and gas cooperation and development strategies are put forward: attach great importance to the obligation of marine abandonment to ensure high-quality and long-term benefit development of offshore oil and gas;adhere to the principle of not going to dangerous and chaotic places, strengthen the concentration of oil and gas assets, and establish multi stable supply bases;based on the multi-scenario demand of natural gas, realize the transformation from integrated collaboration to full oil and gas industry chain development;increase the acquisition of high-quality large-scale assets, and pay attention to the continuous optimization of the shareholding ratio of projects at different stages.
文摘Accurate software cost estimation in Global Software Development(GSD)remains challenging due to reliance on historical data and expert judgments.Traditional models,such as the Constructive Cost Model(COCOMO II),rely heavily on historical and accurate data.In addition,expert judgment is required to set many input parameters,which can introduce subjectivity and variability in the estimation process.Consequently,there is a need to improve the current GSD models to mitigate reliance on historical data,subjectivity in expert judgment,inadequate consideration of GSD-based cost drivers and limited integration of modern technologies with cost overruns.This study introduces a novel hybrid model that synergizes the COCOMO II with Artificial Neural Networks(ANN)to address these challenges.The proposed hybrid model integrates additional GSD-based cost drivers identified through a systematic literature review and further vetted by industry experts.This article compares the effectiveness of the proposedmodelwith state-of-the-artmachine learning-basedmodels for software cost estimation.Evaluating the NASA 93 dataset by adopting twenty-six GSD-based cost drivers reveals that our hybrid model achieves superior accuracy,outperforming existing state-of-the-artmodels.The findings indicate the potential of combining COCOMO II,ANN,and additional GSD-based cost drivers to transform cost estimation in GSD.
基金Supported by the Petro China Scientific Research and Technology Development Project(2023SC0105)。
文摘This paper presents an analysis of four aspects,including the distribution and production of global oil and gas fields,the distribution and changes of remaining recoverable reserves,the differences in oil and gas production between regions/countries,and the development potentials of oil and gas fields unproduced and to be produced in 2023.On this basis,the situation and characteristics of global oil and gas development are expounded,and the trend of global oil and gas development is summarized.In 2023,upstream oil and gas production landscape is expanding,and the number of oil and gas fields in production is increasing significantly;oil and gas recoverable reserves increased year-on-year,driven by significant contributions from new discoveries and reserve re-estimates;the overall oil and gas production grew continuously,with notable contributions from new projects coming online and capacity expansion efforts;and the oil and gas fields unproduced or to be produced,especially large onshore conventional oil fields and economically challenging offshore gas fields,host abundant recoverable reserves.From the perspectives of reshaping oil and gas production areas due to the pandemic and Russia-Ukraine conflicts,geopolitical crises,capital expenditure structures in petroleum exploration and development,and the proactive layout of oil and gas associated resources,the trend of global oil and gas development in 2023 was analyzed systematically.The enlightenment and suggestions in four aspects are proposed for Chinese oil companies to focus on core businesses and clarify development strategies in the post-pandemic era and the context of energy transition:The global oil and gas landscape is undergoing profound adjustments,and it is essential to grasp development trends,especially in core businesses;upstream business exhibits a strong potential,and emerging fields are considered as new growth poles;the prospects for tight/shale oil and gas are promising,and new pathways to ensure national energy security are explored;cutting-edge breakthroughs are achieved in emerging industries of strategic importance,and a comprehensive energy collaboration system for supply security is established.
