Primary salivary gland-type carcinoma of the nasopharynx is a rare malignancy with aggressive clinical behavior and poor prognosis. Few cases have been reported in the literature. We report the case of a salivary glan...Primary salivary gland-type carcinoma of the nasopharynx is a rare malignancy with aggressive clinical behavior and poor prognosis. Few cases have been reported in the literature. We report the case of a salivary gland-type carcinoma of the nasopharynx diagnosed in a 70-year-old woman managed in department of radiotherapy at Hassan II University Hospital in Morocco. The patient received a total of 70 Gy of radiations, which were divided into 2 Gy per session during 7 weeks. Follow-up was performed regularly, including nasal endoscopic examination and nasopharyngeal CT. Evolution was marked by disease control after 12 months of follow-up. The aim of this work is to show the rarity of this entity, describe clinical, radiological and histological features and finally discuss the treatment management.展开更多
目的:胃底腺型肿瘤异型性小,与胃底腺息肉及正常胃底腺黏膜鉴别困难。研究发现CyclinD1在胃底腺型肿瘤中特异性高表达,可能成为鉴别诊断胃底腺型肿瘤与胃底腺息肉及正常胃底腺黏膜的标志物。本研究旨在通过分析CyclinD1在胃底腺型肿瘤...目的:胃底腺型肿瘤异型性小,与胃底腺息肉及正常胃底腺黏膜鉴别困难。研究发现CyclinD1在胃底腺型肿瘤中特异性高表达,可能成为鉴别诊断胃底腺型肿瘤与胃底腺息肉及正常胃底腺黏膜的标志物。本研究旨在通过分析CyclinD1在胃底腺型肿瘤中的表达特征,探讨其病理诊断价值。方法:收集佛山市第二人民医院病理科2020年1月至2025年6月经病理诊断为胃底腺型肿瘤的肿瘤组织标本10例、胃底腺息肉标本13例、正常胃底腺黏膜标本15例。采用免疫组织化学EnVision法检测胃底腺型肿瘤、胃底腺息肉及正常胃底腺黏膜中CyclinD1的表达水平。采用受试者操作特征曲线(receiver operating characteristic,ROC)评估CyclinD1对于鉴别诊断胃底腺型肿瘤与正常胃底腺黏膜及胃底腺息肉的效能。结果:10例胃底腺型肿瘤中有9例CyclinD1表达呈阳性,而胃底腺息肉只有1例(1/13)CyclinD1表达呈阳性,15例正常胃底腺黏膜CyclinD1表达均为阴性。ROC曲线显示:CyclinD1诊断胃底腺型肿瘤的曲线下面积(area under the curve,AUC)为0.950(95%置信区间0.838~1.062,P<0.01),最佳临界值为0.900,敏感度为90%,特异度为100%。结论:CyclinD1在胃底腺型肿瘤中呈现弥漫性强阳性表达,而在胃底腺息肉和正常胃底腺黏膜中少量表达或不表达,提示CyclinD1可作为诊断胃底腺型肿瘤的可靠标志物,可用于鉴别胃底腺型肿瘤与胃底腺息肉及正常胃底腺黏膜。展开更多
目的探讨胃底腺癌(gastric adenocarcinoma of the fundic gland type,GA-FG)的临床特点、内镜特征、病理学特点。方法回顾性分析我院2016年3月~2019年3月11例胃底腺癌的临床内镜病理资料。临床特点包括性别、年龄、症状等;内镜特征包...目的探讨胃底腺癌(gastric adenocarcinoma of the fundic gland type,GA-FG)的临床特点、内镜特征、病理学特点。方法回顾性分析我院2016年3月~2019年3月11例胃底腺癌的临床内镜病理资料。临床特点包括性别、年龄、症状等;内镜特征包括部位、内镜下长径、色泽和形态等;病理资料包括长径、浸润深度、幽门螺杆菌(Helicobacter pylori,HP)感染等。结果以60岁以上的老年人(8/11)居多,无特异临床表现。病灶多为位于胃上部(8/11)的隆起型病灶(10/11),长径均≤1 cm。4处病灶浸润黏膜下层。多数(9/11)Ki67≤10%,大部分(10/11)HP阴性。结论胃底腺癌是一种罕见的肿瘤,临床症状不典型,内镜见胃上部隆起型小病灶时需考虑该病可能,确诊需要依靠病理检查。展开更多
文摘Primary salivary gland-type carcinoma of the nasopharynx is a rare malignancy with aggressive clinical behavior and poor prognosis. Few cases have been reported in the literature. We report the case of a salivary gland-type carcinoma of the nasopharynx diagnosed in a 70-year-old woman managed in department of radiotherapy at Hassan II University Hospital in Morocco. The patient received a total of 70 Gy of radiations, which were divided into 2 Gy per session during 7 weeks. Follow-up was performed regularly, including nasal endoscopic examination and nasopharyngeal CT. Evolution was marked by disease control after 12 months of follow-up. The aim of this work is to show the rarity of this entity, describe clinical, radiological and histological features and finally discuss the treatment management.
文摘目的:胃底腺型肿瘤异型性小,与胃底腺息肉及正常胃底腺黏膜鉴别困难。研究发现CyclinD1在胃底腺型肿瘤中特异性高表达,可能成为鉴别诊断胃底腺型肿瘤与胃底腺息肉及正常胃底腺黏膜的标志物。本研究旨在通过分析CyclinD1在胃底腺型肿瘤中的表达特征,探讨其病理诊断价值。方法:收集佛山市第二人民医院病理科2020年1月至2025年6月经病理诊断为胃底腺型肿瘤的肿瘤组织标本10例、胃底腺息肉标本13例、正常胃底腺黏膜标本15例。采用免疫组织化学EnVision法检测胃底腺型肿瘤、胃底腺息肉及正常胃底腺黏膜中CyclinD1的表达水平。采用受试者操作特征曲线(receiver operating characteristic,ROC)评估CyclinD1对于鉴别诊断胃底腺型肿瘤与正常胃底腺黏膜及胃底腺息肉的效能。结果:10例胃底腺型肿瘤中有9例CyclinD1表达呈阳性,而胃底腺息肉只有1例(1/13)CyclinD1表达呈阳性,15例正常胃底腺黏膜CyclinD1表达均为阴性。ROC曲线显示:CyclinD1诊断胃底腺型肿瘤的曲线下面积(area under the curve,AUC)为0.950(95%置信区间0.838~1.062,P<0.01),最佳临界值为0.900,敏感度为90%,特异度为100%。结论:CyclinD1在胃底腺型肿瘤中呈现弥漫性强阳性表达,而在胃底腺息肉和正常胃底腺黏膜中少量表达或不表达,提示CyclinD1可作为诊断胃底腺型肿瘤的可靠标志物,可用于鉴别胃底腺型肿瘤与胃底腺息肉及正常胃底腺黏膜。
文摘目的探讨胃底腺癌(gastric adenocarcinoma of the fundic gland type,GA-FG)的临床特点、内镜特征、病理学特点。方法回顾性分析我院2016年3月~2019年3月11例胃底腺癌的临床内镜病理资料。临床特点包括性别、年龄、症状等;内镜特征包括部位、内镜下长径、色泽和形态等;病理资料包括长径、浸润深度、幽门螺杆菌(Helicobacter pylori,HP)感染等。结果以60岁以上的老年人(8/11)居多,无特异临床表现。病灶多为位于胃上部(8/11)的隆起型病灶(10/11),长径均≤1 cm。4处病灶浸润黏膜下层。多数(9/11)Ki67≤10%,大部分(10/11)HP阴性。结论胃底腺癌是一种罕见的肿瘤,临床症状不典型,内镜见胃上部隆起型小病灶时需考虑该病可能,确诊需要依靠病理检查。
