Investigating the formation and evolution of coarse-grained deposits in modern lakes and the relevant controlling conditions is indispensable to the prediction of reservoir sandbodies, disaster prediction,and limnolog...Investigating the formation and evolution of coarse-grained deposits in modern lakes and the relevant controlling conditions is indispensable to the prediction of reservoir sandbodies, disaster prediction,and limnological research. The source-to-sink system of coarse-grained deposits in Lake Chenghai, a deep,scarped Late Quaternary lake, was investigated in this study based on 62 outcrops, Advanced Land Observing Satellite(ALOS) digital elevation model(DEM) data, and regional geological survey data. The findings include the following:(1) the source areas of coarse-grained deposits in Lake Chenghai were lithologically classified into carbonate source areas, basaltic source areas and siliciclastic source areas, and were geomorphically categorized as scarp type or confluence type. Subaqueous colluvial aprons have formed downstream of the carbonate source areas and scarp-type basaltic source areas, while Gilbert-type deltas have formed downstream of siliciclastic source areas and confluence-type basaltic source areas.(2) The formation and evolution of coarse-grained deposits are controlled by the sediment flux that evolves in synchrony with the geomorphic evolution of the source areas and the sink regimes. Scarps represent the initial landform of the source areas.Source material rolls off or slides down scarps or forms small-scale debris flows before entering the lake. The source material initially formed subaqueous colluvial apron(synonymous with subaqueous fans) where sufficient space was present to accommodate sediments and the basement angle exceeded than the natural angle of repose. As weathering and denudation have progressed, the initial scarps have transformed into confluencetype slopes, and the source material has formed medium-and large-scale debris flows that have entered the lake, resulting in an increase in sediment flux. Consequently, the subaqueous colluvial aprons have rapidly grown and developed subaerial deposits, which have evolved into larger-scale Gilbert-type deltas that overlie the initial aprons.(3) The morphology and distribution of coarse-grained deposits vary in response to differences in quantity and composition of materials from different source areas, which resulting from different rates of weathering and denudation and different sediment input regimes. Firstly, the size and surface slope angle of a subaqueous colluvial apron from a carbonate source are smaller than those of a subaqueous colluvial apron of basaltic origin. Secondly, a Gilbert-type delta from a basaltic source features a greater slope angle and a thicker topset than does a Gilbert-type delta of siliciclastic origin, and the latter exhibits a longer foreset and a thicker bottomset than in the former. Thirdly, the sizes of subaqueous colluvial aprons are not strongly correlated with the sizes of the source areas, while the sizes of Gilbert-type deltas are.展开更多
We conducted a field campaign to investigate the chemical composition,sources,and light absorption of submicron aerosols(PM_(1))from early 2022 in Nanjing,China.The average concentration of PM_(1) was 31μg m^(−3),org...We conducted a field campaign to investigate the chemical composition,sources,and light absorption of submicron aerosols(PM_(1))from early 2022 in Nanjing,China.The average concentration of PM_(1) was 31μg m^(−3),organics(33%)constituted the largest fraction,followed by nitrate(30%),sulfate(18%),ammonium(15%),chloride(3%),and rBC(2%).Four organic aerosol(OA)subcomponents were identified,including two primary OA(POA)and two secondary OA(SOA).The less-oxidized SOA(LO-OOA)contributes the most to the total OA mass(59%).LO-OOA is tightly correlated with the tracer ion C_(2)H_(4)O_(2)^(+)from levoglucosan,and another aged biomass-burning derived species,K_(3)SO_(4)^(+),suggesting it was likely influenced by aged biomass-burning OA.Our study also revealed that fireworks during the Spring Festival have a detrimental impact on air quality,contributing to secondary formation and accumulation under static winter meteorological conditions,prolonging the pollution duration.Also,LO-OOA was found to have the strongest light-absorbing ability.Our results highlight that the light absorption of LO-OOA can mainly be attributed to the C_(x)H_(y)N^(+) family,increased with the double-bond equivalent value.The more-oxidized SOA(MO-OOA)exhibited a negligible light absorption and was strongly correlated with daytime photochemical processes,implying a light-bleaching effect.This study enhances our understanding of the regional contribution of biomass combustion and fireworks to PM_(1) pollution in Nanjing,a typical megacity in the Yangtze River Delta region,during winter,aiding in the development of strategies for long-term air quality improvement in the region.展开更多
Gamma delta(γδ)T cells and invariant natural killer T(iNKT)cells are unconventional T cells with limited T cell receptor(TCR)diversity.Both can recognize lipid or non-peptide antigens,often through cluster of differ...Gamma delta(γδ)T cells and invariant natural killer T(iNKT)cells are unconventional T cells with limited T cell receptor(TCR)diversity.Both can recognize lipid or non-peptide antigens,often through cluster of differentiation 1d(CD1d),rapidly produce cytokines,express natural killer(NK)cell markers,and are mainly found in mucosal and barrier tissues.Acting as a bridge between innate and adaptive immunity,they show great promise for cancer immunotherapy.DevelopingγδT and iNKT cells for treatment involves shared features like thymic origin,MHC-independent recognition,rapid cytotoxicity,low graft-vs.-host disease(GvHD)risk,ex vivo expansion,and genetic modification,making them suitable for adoptive cell therapies.While their mechanisms are similar,iNKT cells rely on CD1d-mediated antigen presentation,provided by CD1d-expressing antigen-presenting cells(APCs)or engineered cell lines,to activate their invariant TCR and expand effectively.Chimeric antigen receptors(CAR)-induced functional activations make these cell types viable alternatives to conventional cell-based or CAR-T therapies with additional safety benefits.Early clinical trials have shown encouraging results,and their completion will confirm their potential for future treatments.This review explores the biology and mechanisms ofγδT and iNKT cells,focusing on how APCs,cytokines,feeder cells,and CARs contribute to boosting their cytotoxic function,cytokine production,and expansion,enhancing their promise as cancer immunotherapies.It also explores the advancements and challenges in developingγδT and iNKT cell-based immunotherapies,with preclinical and early clinical outcomes offering promising insights.展开更多
随着数字音源的普及,数模转换器(Digital to Analog Converter, DAC)成为音频设备中不可或缺的元件,其精度往往决定着整个系统的信号保真度。基于此,利用噪声整形技术对用于高精度音频DAC的Sigma-Delta调制器进行设计和现场可编程门阵列...随着数字音源的普及,数模转换器(Digital to Analog Converter, DAC)成为音频设备中不可或缺的元件,其精度往往决定着整个系统的信号保真度。基于此,利用噪声整形技术对用于高精度音频DAC的Sigma-Delta调制器进行设计和现场可编程门阵列(Field Programmable Gate Array, FPGA)实现。通过搭建测试系统,测试结果表明,所设计的Sigma-Delta调制器在输入信号为1 411.2 kHz采样频率、1 kHz频率、0 dBFS(Full Scale)幅度的正弦信号条件下,其输出信噪比(Signal to Noise Ratio, SNR)可达107.4 dB;当输入信号频率在音频频带内时(输入信号幅度为0dBFS),其输出SNR稳定保持在104 dB以上;并可用于WAV音乐播放器中。展开更多
基金the National Natural Science Foundation of China (Grant No. 42172115,41972099, 42102153)the China Postdoctoral Science Foundation (Grant No. 2021M693500)the National Major Science and Technology Projects of China(Grant No. 2017ZX05009-002, 2017ZX05072-002)。
文摘Investigating the formation and evolution of coarse-grained deposits in modern lakes and the relevant controlling conditions is indispensable to the prediction of reservoir sandbodies, disaster prediction,and limnological research. The source-to-sink system of coarse-grained deposits in Lake Chenghai, a deep,scarped Late Quaternary lake, was investigated in this study based on 62 outcrops, Advanced Land Observing Satellite(ALOS) digital elevation model(DEM) data, and regional geological survey data. The findings include the following:(1) the source areas of coarse-grained deposits in Lake Chenghai were lithologically classified into carbonate source areas, basaltic source areas and siliciclastic source areas, and were geomorphically categorized as scarp type or confluence type. Subaqueous colluvial aprons have formed downstream of the carbonate source areas and scarp-type basaltic source areas, while Gilbert-type deltas have formed downstream of siliciclastic source areas and confluence-type basaltic source areas.(2) The formation and evolution of coarse-grained deposits are controlled by the sediment flux that evolves in synchrony with the geomorphic evolution of the source areas and the sink regimes. Scarps represent the initial landform of the source areas.Source material rolls off or slides down scarps or forms small-scale debris flows before entering the lake. The source material initially formed subaqueous colluvial apron(synonymous with subaqueous fans) where sufficient space was present to accommodate sediments and the basement angle exceeded than the natural angle of repose. As weathering and denudation have progressed, the initial scarps have transformed into confluencetype slopes, and the source material has formed medium-and large-scale debris flows that have entered the lake, resulting in an increase in sediment flux. Consequently, the subaqueous colluvial aprons have rapidly grown and developed subaerial deposits, which have evolved into larger-scale Gilbert-type deltas that overlie the initial aprons.(3) The morphology and distribution of coarse-grained deposits vary in response to differences in quantity and composition of materials from different source areas, which resulting from different rates of weathering and denudation and different sediment input regimes. Firstly, the size and surface slope angle of a subaqueous colluvial apron from a carbonate source are smaller than those of a subaqueous colluvial apron of basaltic origin. Secondly, a Gilbert-type delta from a basaltic source features a greater slope angle and a thicker topset than does a Gilbert-type delta of siliciclastic origin, and the latter exhibits a longer foreset and a thicker bottomset than in the former. Thirdly, the sizes of subaqueous colluvial aprons are not strongly correlated with the sizes of the source areas, while the sizes of Gilbert-type deltas are.
基金support from the Natural Science Foundation of Jiangsu Province(Grant No.BK20240036)the National Natural Science Foundation of China(Grant Nos.U24A20515,22276099,and 22361162668)Guangxi Key Research and Development Program,China(Grant No.Guike AB24010074)。
文摘We conducted a field campaign to investigate the chemical composition,sources,and light absorption of submicron aerosols(PM_(1))from early 2022 in Nanjing,China.The average concentration of PM_(1) was 31μg m^(−3),organics(33%)constituted the largest fraction,followed by nitrate(30%),sulfate(18%),ammonium(15%),chloride(3%),and rBC(2%).Four organic aerosol(OA)subcomponents were identified,including two primary OA(POA)and two secondary OA(SOA).The less-oxidized SOA(LO-OOA)contributes the most to the total OA mass(59%).LO-OOA is tightly correlated with the tracer ion C_(2)H_(4)O_(2)^(+)from levoglucosan,and another aged biomass-burning derived species,K_(3)SO_(4)^(+),suggesting it was likely influenced by aged biomass-burning OA.Our study also revealed that fireworks during the Spring Festival have a detrimental impact on air quality,contributing to secondary formation and accumulation under static winter meteorological conditions,prolonging the pollution duration.Also,LO-OOA was found to have the strongest light-absorbing ability.Our results highlight that the light absorption of LO-OOA can mainly be attributed to the C_(x)H_(y)N^(+) family,increased with the double-bond equivalent value.The more-oxidized SOA(MO-OOA)exhibited a negligible light absorption and was strongly correlated with daytime photochemical processes,implying a light-bleaching effect.This study enhances our understanding of the regional contribution of biomass combustion and fireworks to PM_(1) pollution in Nanjing,a typical megacity in the Yangtze River Delta region,during winter,aiding in the development of strategies for long-term air quality improvement in the region.
文摘Gamma delta(γδ)T cells and invariant natural killer T(iNKT)cells are unconventional T cells with limited T cell receptor(TCR)diversity.Both can recognize lipid or non-peptide antigens,often through cluster of differentiation 1d(CD1d),rapidly produce cytokines,express natural killer(NK)cell markers,and are mainly found in mucosal and barrier tissues.Acting as a bridge between innate and adaptive immunity,they show great promise for cancer immunotherapy.DevelopingγδT and iNKT cells for treatment involves shared features like thymic origin,MHC-independent recognition,rapid cytotoxicity,low graft-vs.-host disease(GvHD)risk,ex vivo expansion,and genetic modification,making them suitable for adoptive cell therapies.While their mechanisms are similar,iNKT cells rely on CD1d-mediated antigen presentation,provided by CD1d-expressing antigen-presenting cells(APCs)or engineered cell lines,to activate their invariant TCR and expand effectively.Chimeric antigen receptors(CAR)-induced functional activations make these cell types viable alternatives to conventional cell-based or CAR-T therapies with additional safety benefits.Early clinical trials have shown encouraging results,and their completion will confirm their potential for future treatments.This review explores the biology and mechanisms ofγδT and iNKT cells,focusing on how APCs,cytokines,feeder cells,and CARs contribute to boosting their cytotoxic function,cytokine production,and expansion,enhancing their promise as cancer immunotherapies.It also explores the advancements and challenges in developingγδT and iNKT cell-based immunotherapies,with preclinical and early clinical outcomes offering promising insights.
