In the present paper, the therapeutic effects of point-injection and electro-acupuncture(EA) were compared in 100 patients of coronary heart disease with abnormal increases of indexes ofblood rheology. Results indicat...In the present paper, the therapeutic effects of point-injection and electro-acupuncture(EA) were compared in 100 patients of coronary heart disease with abnormal increases of indexes ofblood rheology. Results indicated that after one therapeutic course, the increases of indexes of bloodrheology were reduced in Geshu-ligustrazine group, Geshu-saline group, Geshu-EA group and Feishu-ligustrazine group (P【0. 05 - 0. 01 ) and there was no this action in Feishu-EA group. Among them,the Geshu-EA group had the best therapeutic effect.展开更多
Ojective:To explored the effectiveness and safety of acupuncture at back-shu points of five zang and Geshu(BL 17)for bipolar depression,and its mechanism from the aspect of the anti-inflammatory response.Background:Bi...Ojective:To explored the effectiveness and safety of acupuncture at back-shu points of five zang and Geshu(BL 17)for bipolar depression,and its mechanism from the aspect of the anti-inflammatory response.Background:Bipolar disorder is a very common,often misdiagnosed mental disorder strongly associated with comorbidity,disability,and premature mortality.Bipolar depression(ie,depressive episode in bipolar disorder)is poorly responsive to available treatments.Acupuncture at back-shu points of five zang and Geshu(BL 17),a prescription from Dr.Leting Wang,is a popular therapy for depression in China.Its effectiveness and safety for bipolar depression are yet to be verified by clinical studies.Methods:The study is a single-center,prospective,randomized controlled trial involving 72 patients diagnosed with bipolar depression.Participants will be randomized either to the study group or the control group in a 1:1 ratio.All participants will receive mood stabilizer therapy.In addition,the study group will receive acupuncture therapy at back-shu points of five zang and Geshu(BL 17),three times per week.The control group will orally take the antidepressant bupropion.Observation and intervention will last for 8 consecutive weeks.Outcome measurements include Hamilton Depression Rating Scale-17,Hamilton Anxiety Rating Scale,Clinical Global Impression Scale,Young Manic Rating Scale,Treatment Emergent Symptom Scale,serum levels of anti-inflammatory cytokines[interleukin-4(IL-40),IL-10,and transforming growth factor–β,pro-inflammatory cytokines(IL-1β,IL-6,and tumor necrosis factor–α),brain-derived neurotrophic factor,and C-reactive protein.Assessments will be conducted at baseline,first,second,fourth,and eighth weeks after randomization.Safety assessments will be performed throughout the study.Discussion:The results of this study are expected to verify the effectiveness and safety of acupuncture at back-shu points of five zang and Geshu(BL 17)for bipolar depression,and explore its therapeutic mechanisms from the point of anti-inflammation.展开更多
文摘In the present paper, the therapeutic effects of point-injection and electro-acupuncture(EA) were compared in 100 patients of coronary heart disease with abnormal increases of indexes ofblood rheology. Results indicated that after one therapeutic course, the increases of indexes of bloodrheology were reduced in Geshu-ligustrazine group, Geshu-saline group, Geshu-EA group and Feishu-ligustrazine group (P【0. 05 - 0. 01 ) and there was no this action in Feishu-EA group. Among them,the Geshu-EA group had the best therapeutic effect.
基金funded by the Beijing Municipal Administration of Hospitals Incubating Program(No.PZ2022032).
文摘Ojective:To explored the effectiveness and safety of acupuncture at back-shu points of five zang and Geshu(BL 17)for bipolar depression,and its mechanism from the aspect of the anti-inflammatory response.Background:Bipolar disorder is a very common,often misdiagnosed mental disorder strongly associated with comorbidity,disability,and premature mortality.Bipolar depression(ie,depressive episode in bipolar disorder)is poorly responsive to available treatments.Acupuncture at back-shu points of five zang and Geshu(BL 17),a prescription from Dr.Leting Wang,is a popular therapy for depression in China.Its effectiveness and safety for bipolar depression are yet to be verified by clinical studies.Methods:The study is a single-center,prospective,randomized controlled trial involving 72 patients diagnosed with bipolar depression.Participants will be randomized either to the study group or the control group in a 1:1 ratio.All participants will receive mood stabilizer therapy.In addition,the study group will receive acupuncture therapy at back-shu points of five zang and Geshu(BL 17),three times per week.The control group will orally take the antidepressant bupropion.Observation and intervention will last for 8 consecutive weeks.Outcome measurements include Hamilton Depression Rating Scale-17,Hamilton Anxiety Rating Scale,Clinical Global Impression Scale,Young Manic Rating Scale,Treatment Emergent Symptom Scale,serum levels of anti-inflammatory cytokines[interleukin-4(IL-40),IL-10,and transforming growth factor–β,pro-inflammatory cytokines(IL-1β,IL-6,and tumor necrosis factor–α),brain-derived neurotrophic factor,and C-reactive protein.Assessments will be conducted at baseline,first,second,fourth,and eighth weeks after randomization.Safety assessments will be performed throughout the study.Discussion:The results of this study are expected to verify the effectiveness and safety of acupuncture at back-shu points of five zang and Geshu(BL 17)for bipolar depression,and explore its therapeutic mechanisms from the point of anti-inflammation.
