Background Genitourinary cancers constitute a significant portion of the global cancer burden and have emerged as a prominent cause of cancer-related mortality.However,there remains a paucity of up-to-date statistical...Background Genitourinary cancers constitute a significant portion of the global cancer burden and have emerged as a prominent cause of cancer-related mortality.However,there remains a paucity of up-to-date statistical analyses that meticulously examine the global and national shifts in the epidemiology of genitourinary cancers.Our study aimed to provide a comprehensive understanding of the global distribution and progression of genitourinary cancers through analyses of the recently updated 2021 Global Burden of Disease(GBD)database.Methods This study presented the incidence,mortality,disability-adjusted life years(DALYs),and their respective age-standardized rates for four genitourinary cancers(bladder,kidney,prostate,and testicular cancers)by sex,age,and location from 1990 to 2021.Estimates for these data were presented with their 95%uncertainty intervals(UIs).Estimated annual percentage changes(EAPCs)and Bayesian Age-Period-Cohort(BAPC)models were utilized to further quantify the temporal dynamics of age-standardized rates(ASRs)in genitourinary cancers.Countries and territories were categorized according to socio-demographic index(SDI)quintiles.Results Globally,with the exception of a sustained decline in age-standardized incidence rates(ASIRs)for bladder cancer(EAPC=−0.36%),the ASIRs for kidney,prostate,and testicular cancers demonstrated an upward trend from 1990 to 2021(EAPC=0.53%,0.20%,and 1.43%,respectively).In terms of geographical regions,High-income North America had the highest ASIRs for both bladder(13.98 per 100,000 persons[95%UI,12.96 to 14.61])and prostate(47.02 per 100,000 persons[95%UI,44.47 to 49.04])cancers.Southern Latin America recorded the highest ASIRs for kidney(13.44 per 100,000 persons[95%UI,12.27 to 14.73])and testicular(4.98 per 100,000 persons[95%UI,4.33 to 5.72])cancers.Additionally,Central Europe(1.25%[95%CI,1.12%to 1.38%]),East Asia(2.40%[95%CI,2.21%to 2.59%]),Eastern Europe(3.74%[95%CI,3.55%to 3.92%]),and the Caribbean(5.52%[95%CI,4.32%to 6.74%])exhibited the highest EAPCs for bladder,kidney,prostate,and testicular cancers,respectively.Unlike the ASIRs,age-standardized mortality rates(ASMRs)and age-standardized DALYs rates(ASDRs)showed a downward trend over time in all types of genitourinary cancers.The disease burdens of bladder,kidney,and prostate cancers were primarily distributed among older men,while testicular cancer mainly occurred in young men.Smoking remained the primary risk factor for bladder cancer.Meanwhile,high fasting plasma glucose and high body-mass index exerted increasingly significant impacts on bladder and kidney cancers,respectively,during the study period.Projections to 2050 suggest that the global burdens of genitourinary cancers are expected to decline to varying degrees.However,regional disparities in genitourinary cancer burdens are projected to persist.Conclusions Although the results demonstrate a marginal decline in ASRs caused by genitourinary cancers,they still impose a considerable global burden and result in numerous deaths.Our study obtained and analyzed the latest epidemiological data of genitourinary cancers from the GBD 2021,offering valuable information for national healthcare professionals and policymakers to optimize resource allocation,manage costs more efficiently,and develop practical healthcare policies.展开更多
Objective:Recent randomised controlled trials underestimated the incidence of genitourinary (GU) complications occurring more than 5 years following pelvic radiotherapy. This study aimed to determine the burden of tre...Objective:Recent randomised controlled trials underestimated the incidence of genitourinary (GU) complications occurring more than 5 years following pelvic radiotherapy. This study aimed to determine the burden of treatment at a single institution from late GU complications after pelvic radiotherapy.Methods:A prospective study of all presentations for GU complications following pelvic radiotherapy at a tertiary urology department between November 2018 and November 2019 was performed. Subgroup analyses was performed on patients with prostate cancer (PCa) with late toxicity to compare patient demographics, radiotherapy, complications, and management factors.Results:There were 117 hospital encounters involving 46 patients with a 56.4% repeat encounter rate. Patients with PCa were the predominant group (n=39, 84.8%). External beam radiotherapy was the most common treatment modality (n=41, 89.1%). The median time from radiotherapy to encounter was 8 (range 0–23) years. Radiation-induced haemorrhagic cystitis was the most common presentation (n=70, 59.8%). Forty-four (42.7%) encounters for GU toxicity were managed operatively and 33 (32.0%) involved a non-operative procedure. Nine patients required packed red cell transfusion, with a total of 154 units transfused. Patients with PCa who presented with late GU toxicity had higher median Radiotherapy Oncology Group grades (p=0.020), proportion of emergency admissions (p=0.047), and frequency of clot urinary retention (p<0.001).Conclusion:There is a high burden of elective and emergency urology workload attributed to late pelvic radiation toxicity. Late GU toxicity occurring ≥5 years after radiotherapy is common and often more severe.展开更多
Liver transplantation is as a crucial therapeutic option for patients with end-stage liver disease,but the persistent organ shortage emphasizes a need to explore unconventional donor sources,including individuals with...Liver transplantation is as a crucial therapeutic option for patients with end-stage liver disease,but the persistent organ shortage emphasizes a need to explore unconventional donor sources,including individuals with a history of malignan-cies.This review investigates the viability of liver donation from individuals with current or past genitourinary malignancies,focusing on renal,prostate and urinary bladder cancers.The rising incidence of urogenital malignancies among potential donors is thought to result from increasing donor age.Analysis of transmission risks reveals low rates of donor-derived cancer transmission,partic-ularly for early-stage renal and prostate cancers.Recipients with a history of genitourinary malignancy pose complex challenges regarding post-transplant immunosuppression and cancer recurrence.Nonetheless,the evidence suggests acceptable outcomes can be achieved with careful patient selection and tailored management strategies.Recommendations for pre-transplant evaluation and post-transplant surveillance are discussed,highlighting the need for individualized approaches in this patient population.Further prospective studies are warranted to refine guidelines and optimize outcomes in liver transplantation for patients with genitourinary malignancies.展开更多
Objective:We performed a population-based analysis focusing on primary extranodal lymphoma of either testis,kidney,bladder or prostate(PGUL).Methods:We identified all cases of localized testis,renal,bladder and prosta...Objective:We performed a population-based analysis focusing on primary extranodal lymphoma of either testis,kidney,bladder or prostate(PGUL).Methods:We identified all cases of localized testis,renal,bladder and prostate primary lymphomas(PL)versus primary testis,kidney,bladder and prostate cancers within the Surveillance,Epidemiology,and End Results database(1998e2015).Estimated annual proportion change methodology(EAPC),multivariable logistic regression models,cumulative incidence plots and multivariable competing risks regression models were used.Results:The rates of testis-PL,renal-PL,bladder-PL and prostate-PL were 3.04%,0.22%,0.18%and 0.01%,respectively.Patients with PGUL were older and more frequently Caucasian.Annual rates significantly decreased for renal-PL(EAPC:5.6%;pZ0.004)and prostate-PL(EAPC:3.6%;pZ0.03).In multivariable logistic regression models,older ager independently predicted testis-PL(odds ratio[OR]:16.4;p<0.001)and renal-PL(OR:3.5;p<0.001),while female gender independently predicted bladder-PL(OR:5.5;p<0.001).In surgically treated patients,cumulative incidence plots showed significantly higher 10-year cancer-specific mortality(CSM)rates for testis-PL,renal-PL and prostate-PL versus their primary genitourinary tumors.In multivariable competing risks regression models,only testis-PL(hazard ratio[HR]:16.7;p<0.001)and renal-PL(HR:2.52;p<0.001)independently predicted higher CSM rates.Conclusion:PGUL rates are extremely low and on the decrease in kidney and prostate but stable in testis and bladder.Relative to primary genitourinary tumors,PGUL are associated with worse CSM for testis-PL and renal-PL but not for bladder-PL and prostate-PL,even after adjustment for other-cause mortality.展开更多
The predictive factors of prognosis and treatment strategies for small-cell carcinoma （SCC） of the urinary tract are controversial. This study was aimed to investigate the clinical experience and management of patie...The predictive factors of prognosis and treatment strategies for small-cell carcinoma （SCC） of the urinary tract are controversial. This study was aimed to investigate the clinical experience and management of patients with SCC of the urinary tract. We collected data of patients who were diagnosed with genitourinary SCC （GSCC） between 2002 and 2013 and were treated in the Fudan University Shanghai Cancer Center. A total of 18 patients were diagnosed with GSCC of which 10 originated from the prostate, seven from the bladder and one from the adrenal gland. The mean follow-up time was 15.5 months and progression-free survival （PFS） was 9.3 months. Primary tumor resection was attempted in 13 of 18 patients （72.2%） in whom radical surgery was performed in six of 14 （42.9%） limited disease patients. Most of the patients （13, 72.2%） received cisplatin-based chemotherapy. Patients who had normal lactic dehydrogenase （LDH） levels showed a significantly higher median PFS and overall survival （OS） compared with patients with high LDH levels （P = 0,030, P = 0.010）. Patients with limited disease treated with a radical operation experienced a non-significant （P = 0,211） longer PFS compared with patients who were not treated, but this reached statistical significance after analyzing OS （P = 0.211, P = 0.039）. Our patients showed a poor prognosis as reported previously. Serum LDH levels beyond the normal range indicate a poor prognosis. For GSCC patients who are diagnosed with limited disease, radical surgery is strongly recommended along with cisplatin-based chemotherapy,展开更多
There is increasing attention about managing the adverse effects of adjuvant therapy(Chemotherapy and anti-estrogen treatment)for breast cancer survivors(BCSs).Vulvovaginal atrophy(VVA),caused by decreased levels of c...There is increasing attention about managing the adverse effects of adjuvant therapy(Chemotherapy and anti-estrogen treatment)for breast cancer survivors(BCSs).Vulvovaginal atrophy(VVA),caused by decreased levels of circulating estrogen to urogenital receptors,is commonly experienced by this patients.Women receiving antiestrogen therapy,specifically aromatase inhibitors,often suffer from vaginal dryness,itching,irritation,dyspareunia,and dysuria,collectively known as genitourinary syndrome of menopause(GSM),that it can in turn lead to pain,discomfort,impairment of sexual function and negatively impact on multiple domains of quality of life(QoL).The worsening of QoL in these patients due to GSM symptoms can lead to discontinuation of hormone adjuvant therapies and therefore must be addressed properly.The diagnosis of VVA is confirmed through patient-reported symptoms and gynecological examination of external structures,introitus,and vaginal mucosa.Systemic estrogen treatment is contraindicated in BCSs.In these patients,GSM may be prevented,reduced and managed in most cases but this requires early recognition and appropriate treatment,but it is normally undertreated by oncologists because of fear of cancer recurrence,specifically when considering treatment with vaginal estrogen therapy(VET)because of unknown levels of systemic absorption of estradiol.Lifestyle modifications and nonhormonal treatments(vaginal moisturizers,lubricants,and gels)are the first-line treatment for GSM both in healthy women as BCSs,but when these are not effective for symptom relief,other options can be considered,such as VET,ospemifene,local androgens,intravaginal dehydroepiandrosterone(prasterone),or laser therapy(erbium or CO2 Laser).The present data suggest that these therapies are effective for VVA in BCSs;however,safety remains controversial and a there is a major concern with all of these treatments.We review current evidence for various nonpharmacologic and pharmacologic therapeutic modalities for GSM in BCSs and highlight the substantial gaps in the evidence for safe and effective therapies and the need for future research.We include recommendations for an approach to the management of GSM in women at high risk for breast cancer,women with estrogen-receptor positive breast cancers,women with triplenegative breast cancers,and women with metastatic disease.展开更多
BACKGROUND The effect of low ligation(LL)vs high ligation(HL)of the inferior mesenteric artery(IMA)on functional outcomes during sigmoid colon and rectal cancer surgery,including urinary,sexual,and bowel function,is s...BACKGROUND The effect of low ligation(LL)vs high ligation(HL)of the inferior mesenteric artery(IMA)on functional outcomes during sigmoid colon and rectal cancer surgery,including urinary,sexual,and bowel function,is still controversial.AIM To assess the effect of LL of the IMA on genitourinary function and defecation after colorectal cancer(CRC)surgery.METHODS EMBASE,PubMed,Web of Science,and the Cochrane Library were systematically searched to retrieve studies describing sigmoid colon and rectal cancer surgery in order to compare outcomes following LL and HL.A total of 14 articles,including 4750 patients,were analyzed using Review Manager 5.3 software.Dichotomous results are expressed as odds ratios(ORs)with 95%confidence intervals(CIs)and continuous outcomes are expressed as weighted mean differences(WMDs)with 95%CIs.RESULTS LL resulted in a significantly lower incidence of nocturnal bowel movement(OR=0.73,95%CI:0.55 to 0.97,P=0.03)and anastomotic stenosis(OR=0.31,95%CI:0.16 to 0.62,P=0.0009)compared with HL.The risk of postoperative urinary dysfunction,however,did not differ significantly between the two techniques.The meta-analysis also showed no significant differences between LL and HL in terms of anastomotic leakage,postoperative complications,total lymph nodes harvested,blood loss,operation time,tumor recurrence,mortality,5-year overall survival rate,or 5-year disease-free survival rate.CONCLUSION Since LL may result in better bowel function and a reduced rate of anastomotic stenosis following CRC surgeries,we suggest that LL be preferred over HL.展开更多
Object:Corona virus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which leads to acute respiratory infection symptoms.SARS-CoV-2 infection is not always limited to the ...Object:Corona virus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which leads to acute respiratory infection symptoms.SARS-CoV-2 infection is not always limited to the respiratory tract,and renal infection and dysfunction have been shown to be specific risk factors for death.In addition,COVID-19 has a higher incidence,severity and mortality in men than women.This disparity is due to biological rather than comorbid or behavioral sex differences.Because the male reproductive system is unique,the function of sex hormones in COVID-19 infection may explain the differences between males and females.Understanding these factors will provide appropriate prevention measures and adequate triage strategies and guide the drug discovery process.Methods:An electronic search was completed in PubMed,ARXIV,MEDRXIV and BIORXIV.The most relevant articles were systematically reviewed.In addition,single cell RNA sequencing analysis of tissue samples from human cell landscape was conducted.Results:The influence of SARS-CoV-2 on the urogenital system,the possibility of urinary tract transmission and the functions of sex hormones were discussed in this review.Conclusion:Corona viruses can invade the genitourinary system,causing urological symptoms.Identifying the potential genitourinary organ impairments and protecting them from damage are necessary.Since sex hormones have potential as specific drugs,the gonadal hormones substitution therapy should be considered in both sexes in the COVID-19 pandemic.展开更多
The genitourinary tract can be affected by several pathologies which require repair or replacement to recover biological functions.Current therapeutic strategies are challenged by a growing shortage of adequate tissue...The genitourinary tract can be affected by several pathologies which require repair or replacement to recover biological functions.Current therapeutic strategies are challenged by a growing shortage of adequate tissues.Therefore,new options must be considered for the treatment of patients,with the use of stem cells(SCs)being attractive.Two different strategies can be derived from stem cell use:Cell therapy and tissue therapy,mainly through tissue engineering.The recent advances using these approaches are described in this review,with a focus on stromal/mesenchymal cells found in adipose tissue.Indeed,the accessibility,high yield at harvest as well as anti-fibrotic,immunomodulatory and proangiogenic properties make adipose-derived stromal/SCs promising alternatives to the therapies currently offered to patients.Finally,an innovative technique allowing tissue reconstruction without exogenous material,the self-assembly approach,will be presented.Despite advances,more studies are needed to translate such approaches from the bench to clinics in urology.For the 21st century,cell and tissue therapies based on SCs are certainly the future of genitourinary regenerative medicine.展开更多
The primary approaches to treat cancerous diseases include drug treatment,surgical procedures,biotherapy,and radiation therapy.Chemotherapy has been the primary treatment for cancer for a long time,but its main drawba...The primary approaches to treat cancerous diseases include drug treatment,surgical procedures,biotherapy,and radiation therapy.Chemotherapy has been the primary treatment for cancer for a long time,but its main drawback is that it kills cancerous cells along with healthy ones,leading to deadly adverse health effects.However,genitourinary cancer has become a concern in recent years as it is more common in middle-aged people.So,researchers are trying to find possible therapeutic options from natural small molecules due to the many drawbacks associated with chemotherapy and other radiation-based therapies.Plenty of research was conducted regarding genitourinary cancer to determine the promising role of natural small molecules.So,this review focused on natural small molecules along with their potential therapeutic targets in the case of genitourinary cancers such as prostate cancer,renal cancer,bladder cancer,testicular cancer,and so on.Also,this review states some ongoing or completed clinical evidence in this regard.展开更多
Objective:The novel coronavirus(severe acute respiratory syndrome coronavirus 2)has been spreading worldwide since December 2019,posing a serious danger to human health and socioeconomic development.A large number of ...Objective:The novel coronavirus(severe acute respiratory syndrome coronavirus 2)has been spreading worldwide since December 2019,posing a serious danger to human health and socioeconomic development.A large number of clinical trials have revealed that coronavirus disease 2019(COVID-19)results in multi-organ damage including the urogenital system.This study aimed to explore the potential mechanisms of genitourinary damage associated with COVID-19 infection through bioinformatics and molecular simulation analysis.Methods:We used multiple publicly available databases to explore the expression patterns of angiotensin-converting enzyme 2(ACE2),transmembrane serine protease 2(TMPRSS2),and CD147 in major organs in the healthy and disease-specific populations,particularly the genitourinary organs.Single-cell RNA sequencing was used to analyze the cell-specific expression patterns of ACE2,TMPRSS2,CD147,cytokine receptors,and cytokine interacting proteins in genitourinary organs,such as the bladder,kidney,prostate,and testis.Additionally,gene set enrichmentanalysis was used to investigate the relationship between testosterone levels and COVID-19 vulnerability in patients with prostate cancer.Results:The results revealed that ACE2,TMPRSS2,and CD147 were highly expressed in normal urogenital organs.Then,they were also highly expressed in multiple tumors and chronic kidney diseases.Additionally,ACE2,TMPRSS2,and CD147 were significantly expressed in a range of cells in urogenital organs according to single-cell RNA sequencing.Cytokine receptors and cytokine interacting proteins,especially CCL2,JUN,and TIMP1,were commonly highly expressed in urogenital organs.Finally,gene set enrichment analysis results showed that high testosterone levels in prostate cancer patients were significantly related to the JAK-STAT signaling pathway and the Toll-like receptor signaling pathway which were associated with COVID-19.Conclusion:Our study provides new insights into the potential mechanisms of severe acute respiratory syndrome coronavirus 2 damage to urogenital organs from multiple perspectives,which may draw the attention of urologists to COVID-19 and contribute to the development of targeted drugs.展开更多
Bladder,kidney,prostate and testicular carcinoma are the top four genitourinary cancers in China.Here we analyzed mRNA and miRNA expression profiles of carcinomas of the bladder(TCC),kidney(ccRCC)and testis(TGCT)to un...Bladder,kidney,prostate and testicular carcinoma are the top four genitourinary cancers in China.Here we analyzed mRNA and miRNA expression profiles of carcinomas of the bladder(TCC),kidney(ccRCC)and testis(TGCT)to uncover their specific regulatory mechanisms.The gene expression profiles of GSE31617 were downloaded from GEO database,which contained 27 samples,including 10 TCC,7 TGCT and 10 ccRCC.Specific up-and downregulated differentially expressed genes(DEGs)and differentially expressed microRNAs(DEmiRNAs)of each cancer were selected and target genes of DEmiRNAs were predicted.Gene interaction network of the shared genes and target genes of DEmiRNAs of each cancer was predicted by STRING and constructed by Cytoscape.In each cancer,we build regulatory networks of hub genes selected and conducted GO analysis of enriched genes.Furthermore,we chose four hub genes(SALL4,RHEB,CDC42 and TNN)for survival analysis in OncoLnc database,and they all had effects on the survival rate of another genitourinary cancer-kidney renal clear cell carcinoma(KIRC).In conclusion,the present study indicated that the identified hub genes promote our understanding of molecular mechanisms underlying the development of three genitourinary cancers,and might be used as molecular targets and diagnostic biomarkers for the treatment of them.展开更多
Background: Genitourinary syndrome of menopause (GSM) is the new term for vulvovaginal atrophy (VVA). The condition is relevant in more than 50% of women, having an adverse impact on quality of life and sexual relatio...Background: Genitourinary syndrome of menopause (GSM) is the new term for vulvovaginal atrophy (VVA). The condition is relevant in more than 50% of women, having an adverse impact on quality of life and sexual relationships. Objective: To assess the efficacy and safety of a new type of non-ablative laser, Solid State Vaginal Laser (SSVL), for vaginal tissue regeneration and rejuvenation. Method: Eighty participants with GSM symptoms were treated with a total of 4 treatments in about two months (every 15 - 20 days) of a non-ablative SSVL (LASEmaR 1500TM-EUFOTON). A cumulative intensity of GSM symptoms using a 10-cm VAS (dryness and/or burning and/or dyspareunia), the vaginal health index (VHI), the Female Sexual Function Index (FSFI) were evaluated. Urinary Incontinence Short Form (ICIQ-UI SF) and vaginal bioptic samples were also collected. Results: Improvement following the SSVL was observed on VHIS, VVA symptoms and sexual female function. This finding was also ratified by the improvement of vaginal histological features. After the SSVL treatment, almost all patients (91%) affected by urinary incontinence obtained the complete remission of symptoms. Conclusion: The objective evaluation of VHIS, FSFI and ICIQ-UI SF scores and the histological results indicates a real favorable effect of SSVL on GSM and on urinary incontinence.展开更多
Aim of the Work: The present wok aims to assess how to reach the optimum diagnosis of the nature and the complications of lower genitourinary tract cyst in male patient using different radiological imaging modalities....Aim of the Work: The present wok aims to assess how to reach the optimum diagnosis of the nature and the complications of lower genitourinary tract cyst in male patient using different radiological imaging modalities. Patients and Methods: 1000 male patients were evaluated with pelvic ultrasound and if lower genitourinary tract cysts were present, the patients were further subjected to either trans-rectal ultrasound (TRUS), TRUS guided aspiration for presence of spermatozoa, TRUS guided seminal vesiculography or CT urography in order to reach the origin of the cyst and the complications of its presence. Results: 14 cases were detected with lower genitourinary tract cysts among our patients with an overall incidence 1.4%;among them 3 patients with mid line prostatic cysts showed normal seminal analysis;1 patient with prostatic cyst was infertile;3 patients were detected with infravesical cysts after transurethral resection prostatectomy;2 cases with small retention cysts were associated with benign prostatic hyperplasia;1 case was detected with prostatic abscess;1 patient was detected with unilateral ureterocele;1 patient was detected with large pelvi abdominal unilateral seminal vesicle cyst;1 patient was with unilateral ejaculatory duct cyst;1 patient with small cystic dilation of prostatic urethra was associated with urethral stone.展开更多
BACKGROUND Trauma is a major cause of morbidity globally and the sixth leading cause of death,accounting for 10%of all mortalities.The genitourinary trauma is estimated for approximately 10%of all patients presenting ...BACKGROUND Trauma is a major cause of morbidity globally and the sixth leading cause of death,accounting for 10%of all mortalities.The genitourinary trauma is estimated for approximately 10%of all patients presenting with trauma,and the kidney is the most injured genitourinary organ globally.However,there is a paucity of data on genitourinary injury from the Sub-Saharan,and there may be variations from common genitourinary organs injured in developed nations.AIM To provide insight on the epidemiology and management of genitourinary trauma in Sub-Saharan Africa with recommendations based on international guidelines.METHODS A thorough literature search of genitourinary trauma was conducted using PubMed,Google Scholar and African Journal Online.RESULTS A total of 30 studies from the Sub-Saharan region were eligible for the study and reviewed for epidemiology,biodata,types of injury,mechanisms of injury,treatment and follow-up.After evaluating 21904 patients presenting with urological emergencies,approximately 6.6%of cases were due to genitourinary trauma.The commonest injury was urethral 42.9%(22.2-62.2%)followed by injury to the external genitalia(penis,scrotum,testes)25.1%(8.8-67.7%).CONCLUSION Genitourinary injury in Sub-Saharan Africa is underreported,and the presence of more trauma registries,trained urologists and trauma facilities could improve the overall standard of care as well as providing data for research and development in the field.展开更多
Submission deadline:31 October 2025 UroPrecision is delighted to announce a special issue on Liquid Biopsy in Genitourinary(GU)Oncology,focusing on prostate,renal,and bladder cancers.This issue,led by Dr.Shidong Jia,D...Submission deadline:31 October 2025 UroPrecision is delighted to announce a special issue on Liquid Biopsy in Genitourinary(GU)Oncology,focusing on prostate,renal,and bladder cancers.This issue,led by Dr.Shidong Jia,Dr.Liang Cheng,and Dr.Joshua Linscott,will highlight the latest advancements in liquid biopsy technologies and their clinical applications,including diagnosis,prognosis,treatment monitoring,and drug development for GU malignancies.展开更多
Submission deadline:31 October 2025 UroPrecision is delighted to announce a special issue on Liquid Biopsy in Genitourinary(GU)Oncology,focusing on prostate,renal,and bladder cancers.This issue,led by Dr.Shidong Jia,D...Submission deadline:31 October 2025 UroPrecision is delighted to announce a special issue on Liquid Biopsy in Genitourinary(GU)Oncology,focusing on prostate,renal,and bladder cancers.This issue,led by Dr.Shidong Jia,Dr.Liang Cheng,and Dr.Joshua Linscott,will highlight the latest advancements in liquid biopsy technologies and their clinical applications,including diagnosis,prognosis,treatment monitoring,and drug development for GU malignancies.展开更多
Male genitourinary dysfunction causes serious physical or mental distress,such as infertility and psychological harm,which leads to impaired quality of life.Current conventional treatments involving drug therapy,surgi...Male genitourinary dysfunction causes serious physical or mental distress,such as infertility and psychological harm,which leads to impaired quality of life.Current conventional treatments involving drug therapy,surgical repair,and tissue grafting have a limited effect on recovering the function and fertility of the genitourinary organs.To address these limitations,various biomaterials have been explored,with collagen-based materials increasingly gaining attention for reconstructing the male genitourinary system due to their superior biocompatibility,biodegradability,low antigenicity,biomimetic 3D matrix characteristics,hemostatic efficacy,and tissue regeneration capabilities.This review covers the recent biomedical applications of collagen-based materials including treatment of erectile dysfunction,premature ejaculation,penile girth enlargement,prostate cancer,Peyronie’s disease,chronic kidney disease,etc.Although there are relatively few clinical trials,the promising results of the existing studies on animal models reveal a bright future for collagen-based materials in the treatment of male genitourinary diseases.展开更多
Objective To assess relationships between cold spells and genitourinary hospitalization risk.Methods Hospitalization records for genitourinary system diseases(GUDs)from 16 districts in Beijing(2013–2018)were analyzed...Objective To assess relationships between cold spells and genitourinary hospitalization risk.Methods Hospitalization records for genitourinary system diseases(GUDs)from 16 districts in Beijing(2013–2018)were analyzed.Cold spells were defined based on varying intensity thresholds.A two-stage analytical method was employed:first,generalized linear models assessed district-specific associations between cold spells and hospitalizations;second,random-effects meta-analysis aggregated the districtlevel results.Subgroup analyses were performed by admission type(emergency vs.outpatient),age,and sex.Results A total of 271,579 GUD-related hospitalizations were recorded.Cold spells(p1day2,daily mean temperature below the 1st percentiles of the daily mean temperature distribution from January 1,2013,to December 31,2018,lasting for two or more consecutive days)were linked to a significant rise in hospitalization risks:1.43(95%CI:1.32–1.56)for all GUDs,1.35(95%CI:1.23–1.49)for urinary system diseases,and 1.46(95%CI:1.28–1.67)for renal failure,when compared to non-cold spell days.Emergency admissions showed higher risk increases than outpatient admissions.Conclusion Extreme cold spells significantly elevate hospitalization risks for GUDs.This highlights the urgent need for targeted public health interventions to mitigate cold-related health impacts,especially for vulnerable populations.展开更多
ECharles Osterberg。Dr.Osterberg is a board-certified urologist with fellowship training in male genitourinary reconstruction.He moved to Austin(TX,USA)in 2016 to join the University of Texas-Dell Medical School as As...ECharles Osterberg。Dr.Osterberg is a board-certified urologist with fellowship training in male genitourinary reconstruction.He moved to Austin(TX,USA)in 2016 to join the University of Texas-Dell Medical School as Associate Professor of Surgery.Dr.Osterberg specializes in reconstructive urology,genitourinary trauma,prosthetics,and robotic surgery.After serving as the Chief of Urology at Dell-Seton Medical Center-the main teaching hospital for Dell Medical School for 7 years,Dr.Osterberg transitioned his practice to Urology Austin,an affiliate of Urology America.At his new practice,he and his team have performed hundreds of complex urologic reconstructions and urethral stricture surgeries.展开更多
基金funded by the National Natural Science Foundation of China(grant numbers:82202877 and 8237110369)the Natural Science Foundation of Guangdong Province of China(grant number:2024A1515010599)Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(grant number:XMLX202134).
文摘Background Genitourinary cancers constitute a significant portion of the global cancer burden and have emerged as a prominent cause of cancer-related mortality.However,there remains a paucity of up-to-date statistical analyses that meticulously examine the global and national shifts in the epidemiology of genitourinary cancers.Our study aimed to provide a comprehensive understanding of the global distribution and progression of genitourinary cancers through analyses of the recently updated 2021 Global Burden of Disease(GBD)database.Methods This study presented the incidence,mortality,disability-adjusted life years(DALYs),and their respective age-standardized rates for four genitourinary cancers(bladder,kidney,prostate,and testicular cancers)by sex,age,and location from 1990 to 2021.Estimates for these data were presented with their 95%uncertainty intervals(UIs).Estimated annual percentage changes(EAPCs)and Bayesian Age-Period-Cohort(BAPC)models were utilized to further quantify the temporal dynamics of age-standardized rates(ASRs)in genitourinary cancers.Countries and territories were categorized according to socio-demographic index(SDI)quintiles.Results Globally,with the exception of a sustained decline in age-standardized incidence rates(ASIRs)for bladder cancer(EAPC=−0.36%),the ASIRs for kidney,prostate,and testicular cancers demonstrated an upward trend from 1990 to 2021(EAPC=0.53%,0.20%,and 1.43%,respectively).In terms of geographical regions,High-income North America had the highest ASIRs for both bladder(13.98 per 100,000 persons[95%UI,12.96 to 14.61])and prostate(47.02 per 100,000 persons[95%UI,44.47 to 49.04])cancers.Southern Latin America recorded the highest ASIRs for kidney(13.44 per 100,000 persons[95%UI,12.27 to 14.73])and testicular(4.98 per 100,000 persons[95%UI,4.33 to 5.72])cancers.Additionally,Central Europe(1.25%[95%CI,1.12%to 1.38%]),East Asia(2.40%[95%CI,2.21%to 2.59%]),Eastern Europe(3.74%[95%CI,3.55%to 3.92%]),and the Caribbean(5.52%[95%CI,4.32%to 6.74%])exhibited the highest EAPCs for bladder,kidney,prostate,and testicular cancers,respectively.Unlike the ASIRs,age-standardized mortality rates(ASMRs)and age-standardized DALYs rates(ASDRs)showed a downward trend over time in all types of genitourinary cancers.The disease burdens of bladder,kidney,and prostate cancers were primarily distributed among older men,while testicular cancer mainly occurred in young men.Smoking remained the primary risk factor for bladder cancer.Meanwhile,high fasting plasma glucose and high body-mass index exerted increasingly significant impacts on bladder and kidney cancers,respectively,during the study period.Projections to 2050 suggest that the global burdens of genitourinary cancers are expected to decline to varying degrees.However,regional disparities in genitourinary cancer burdens are projected to persist.Conclusions Although the results demonstrate a marginal decline in ASRs caused by genitourinary cancers,they still impose a considerable global burden and result in numerous deaths.Our study obtained and analyzed the latest epidemiological data of genitourinary cancers from the GBD 2021,offering valuable information for national healthcare professionals and policymakers to optimize resource allocation,manage costs more efficiently,and develop practical healthcare policies.
文摘Objective:Recent randomised controlled trials underestimated the incidence of genitourinary (GU) complications occurring more than 5 years following pelvic radiotherapy. This study aimed to determine the burden of treatment at a single institution from late GU complications after pelvic radiotherapy.Methods:A prospective study of all presentations for GU complications following pelvic radiotherapy at a tertiary urology department between November 2018 and November 2019 was performed. Subgroup analyses was performed on patients with prostate cancer (PCa) with late toxicity to compare patient demographics, radiotherapy, complications, and management factors.Results:There were 117 hospital encounters involving 46 patients with a 56.4% repeat encounter rate. Patients with PCa were the predominant group (n=39, 84.8%). External beam radiotherapy was the most common treatment modality (n=41, 89.1%). The median time from radiotherapy to encounter was 8 (range 0–23) years. Radiation-induced haemorrhagic cystitis was the most common presentation (n=70, 59.8%). Forty-four (42.7%) encounters for GU toxicity were managed operatively and 33 (32.0%) involved a non-operative procedure. Nine patients required packed red cell transfusion, with a total of 154 units transfused. Patients with PCa who presented with late GU toxicity had higher median Radiotherapy Oncology Group grades (p=0.020), proportion of emergency admissions (p=0.047), and frequency of clot urinary retention (p<0.001).Conclusion:There is a high burden of elective and emergency urology workload attributed to late pelvic radiation toxicity. Late GU toxicity occurring ≥5 years after radiotherapy is common and often more severe.
文摘Liver transplantation is as a crucial therapeutic option for patients with end-stage liver disease,but the persistent organ shortage emphasizes a need to explore unconventional donor sources,including individuals with a history of malignan-cies.This review investigates the viability of liver donation from individuals with current or past genitourinary malignancies,focusing on renal,prostate and urinary bladder cancers.The rising incidence of urogenital malignancies among potential donors is thought to result from increasing donor age.Analysis of transmission risks reveals low rates of donor-derived cancer transmission,partic-ularly for early-stage renal and prostate cancers.Recipients with a history of genitourinary malignancy pose complex challenges regarding post-transplant immunosuppression and cancer recurrence.Nonetheless,the evidence suggests acceptable outcomes can be achieved with careful patient selection and tailored management strategies.Recommendations for pre-transplant evaluation and post-transplant surveillance are discussed,highlighting the need for individualized approaches in this patient population.Further prospective studies are warranted to refine guidelines and optimize outcomes in liver transplantation for patients with genitourinary malignancies.
文摘Objective:We performed a population-based analysis focusing on primary extranodal lymphoma of either testis,kidney,bladder or prostate(PGUL).Methods:We identified all cases of localized testis,renal,bladder and prostate primary lymphomas(PL)versus primary testis,kidney,bladder and prostate cancers within the Surveillance,Epidemiology,and End Results database(1998e2015).Estimated annual proportion change methodology(EAPC),multivariable logistic regression models,cumulative incidence plots and multivariable competing risks regression models were used.Results:The rates of testis-PL,renal-PL,bladder-PL and prostate-PL were 3.04%,0.22%,0.18%and 0.01%,respectively.Patients with PGUL were older and more frequently Caucasian.Annual rates significantly decreased for renal-PL(EAPC:5.6%;pZ0.004)and prostate-PL(EAPC:3.6%;pZ0.03).In multivariable logistic regression models,older ager independently predicted testis-PL(odds ratio[OR]:16.4;p<0.001)and renal-PL(OR:3.5;p<0.001),while female gender independently predicted bladder-PL(OR:5.5;p<0.001).In surgically treated patients,cumulative incidence plots showed significantly higher 10-year cancer-specific mortality(CSM)rates for testis-PL,renal-PL and prostate-PL versus their primary genitourinary tumors.In multivariable competing risks regression models,only testis-PL(hazard ratio[HR]:16.7;p<0.001)and renal-PL(HR:2.52;p<0.001)independently predicted higher CSM rates.Conclusion:PGUL rates are extremely low and on the decrease in kidney and prostate but stable in testis and bladder.Relative to primary genitourinary tumors,PGUL are associated with worse CSM for testis-PL and renal-PL but not for bladder-PL and prostate-PL,even after adjustment for other-cause mortality.
文摘The predictive factors of prognosis and treatment strategies for small-cell carcinoma （SCC） of the urinary tract are controversial. This study was aimed to investigate the clinical experience and management of patients with SCC of the urinary tract. We collected data of patients who were diagnosed with genitourinary SCC （GSCC） between 2002 and 2013 and were treated in the Fudan University Shanghai Cancer Center. A total of 18 patients were diagnosed with GSCC of which 10 originated from the prostate, seven from the bladder and one from the adrenal gland. The mean follow-up time was 15.5 months and progression-free survival （PFS） was 9.3 months. Primary tumor resection was attempted in 13 of 18 patients （72.2%） in whom radical surgery was performed in six of 14 （42.9%） limited disease patients. Most of the patients （13, 72.2%） received cisplatin-based chemotherapy. Patients who had normal lactic dehydrogenase （LDH） levels showed a significantly higher median PFS and overall survival （OS） compared with patients with high LDH levels （P = 0,030, P = 0.010）. Patients with limited disease treated with a radical operation experienced a non-significant （P = 0,211） longer PFS compared with patients who were not treated, but this reached statistical significance after analyzing OS （P = 0.211, P = 0.039）. Our patients showed a poor prognosis as reported previously. Serum LDH levels beyond the normal range indicate a poor prognosis. For GSCC patients who are diagnosed with limited disease, radical surgery is strongly recommended along with cisplatin-based chemotherapy,
文摘There is increasing attention about managing the adverse effects of adjuvant therapy(Chemotherapy and anti-estrogen treatment)for breast cancer survivors(BCSs).Vulvovaginal atrophy(VVA),caused by decreased levels of circulating estrogen to urogenital receptors,is commonly experienced by this patients.Women receiving antiestrogen therapy,specifically aromatase inhibitors,often suffer from vaginal dryness,itching,irritation,dyspareunia,and dysuria,collectively known as genitourinary syndrome of menopause(GSM),that it can in turn lead to pain,discomfort,impairment of sexual function and negatively impact on multiple domains of quality of life(QoL).The worsening of QoL in these patients due to GSM symptoms can lead to discontinuation of hormone adjuvant therapies and therefore must be addressed properly.The diagnosis of VVA is confirmed through patient-reported symptoms and gynecological examination of external structures,introitus,and vaginal mucosa.Systemic estrogen treatment is contraindicated in BCSs.In these patients,GSM may be prevented,reduced and managed in most cases but this requires early recognition and appropriate treatment,but it is normally undertreated by oncologists because of fear of cancer recurrence,specifically when considering treatment with vaginal estrogen therapy(VET)because of unknown levels of systemic absorption of estradiol.Lifestyle modifications and nonhormonal treatments(vaginal moisturizers,lubricants,and gels)are the first-line treatment for GSM both in healthy women as BCSs,but when these are not effective for symptom relief,other options can be considered,such as VET,ospemifene,local androgens,intravaginal dehydroepiandrosterone(prasterone),or laser therapy(erbium or CO2 Laser).The present data suggest that these therapies are effective for VVA in BCSs;however,safety remains controversial and a there is a major concern with all of these treatments.We review current evidence for various nonpharmacologic and pharmacologic therapeutic modalities for GSM in BCSs and highlight the substantial gaps in the evidence for safe and effective therapies and the need for future research.We include recommendations for an approach to the management of GSM in women at high risk for breast cancer,women with estrogen-receptor positive breast cancers,women with triplenegative breast cancers,and women with metastatic disease.
文摘BACKGROUND The effect of low ligation(LL)vs high ligation(HL)of the inferior mesenteric artery(IMA)on functional outcomes during sigmoid colon and rectal cancer surgery,including urinary,sexual,and bowel function,is still controversial.AIM To assess the effect of LL of the IMA on genitourinary function and defecation after colorectal cancer(CRC)surgery.METHODS EMBASE,PubMed,Web of Science,and the Cochrane Library were systematically searched to retrieve studies describing sigmoid colon and rectal cancer surgery in order to compare outcomes following LL and HL.A total of 14 articles,including 4750 patients,were analyzed using Review Manager 5.3 software.Dichotomous results are expressed as odds ratios(ORs)with 95%confidence intervals(CIs)and continuous outcomes are expressed as weighted mean differences(WMDs)with 95%CIs.RESULTS LL resulted in a significantly lower incidence of nocturnal bowel movement(OR=0.73,95%CI:0.55 to 0.97,P=0.03)and anastomotic stenosis(OR=0.31,95%CI:0.16 to 0.62,P=0.0009)compared with HL.The risk of postoperative urinary dysfunction,however,did not differ significantly between the two techniques.The meta-analysis also showed no significant differences between LL and HL in terms of anastomotic leakage,postoperative complications,total lymph nodes harvested,blood loss,operation time,tumor recurrence,mortality,5-year overall survival rate,or 5-year disease-free survival rate.CONCLUSION Since LL may result in better bowel function and a reduced rate of anastomotic stenosis following CRC surgeries,we suggest that LL be preferred over HL.
文摘Object:Corona virus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which leads to acute respiratory infection symptoms.SARS-CoV-2 infection is not always limited to the respiratory tract,and renal infection and dysfunction have been shown to be specific risk factors for death.In addition,COVID-19 has a higher incidence,severity and mortality in men than women.This disparity is due to biological rather than comorbid or behavioral sex differences.Because the male reproductive system is unique,the function of sex hormones in COVID-19 infection may explain the differences between males and females.Understanding these factors will provide appropriate prevention measures and adequate triage strategies and guide the drug discovery process.Methods:An electronic search was completed in PubMed,ARXIV,MEDRXIV and BIORXIV.The most relevant articles were systematically reviewed.In addition,single cell RNA sequencing analysis of tissue samples from human cell landscape was conducted.Results:The influence of SARS-CoV-2 on the urogenital system,the possibility of urinary tract transmission and the functions of sex hormones were discussed in this review.Conclusion:Corona viruses can invade the genitourinary system,causing urological symptoms.Identifying the potential genitourinary organ impairments and protecting them from damage are necessary.Since sex hormones have potential as specific drugs,the gonadal hormones substitution therapy should be considered in both sexes in the COVID-19 pandemic.
基金Supported by the‘Fonds de Recherche du Québec-Santé(FRQS)(C.C.)the Canadian Institutes of Health Research(to S.B.as PI and J.F.as co-PI),No.258229the Quebec Cell,Tissue and Gene Therapy Network-ThéCell(a thematic network supported by the FRQS).
文摘The genitourinary tract can be affected by several pathologies which require repair or replacement to recover biological functions.Current therapeutic strategies are challenged by a growing shortage of adequate tissues.Therefore,new options must be considered for the treatment of patients,with the use of stem cells(SCs)being attractive.Two different strategies can be derived from stem cell use:Cell therapy and tissue therapy,mainly through tissue engineering.The recent advances using these approaches are described in this review,with a focus on stromal/mesenchymal cells found in adipose tissue.Indeed,the accessibility,high yield at harvest as well as anti-fibrotic,immunomodulatory and proangiogenic properties make adipose-derived stromal/SCs promising alternatives to the therapies currently offered to patients.Finally,an innovative technique allowing tissue reconstruction without exogenous material,the self-assembly approach,will be presented.Despite advances,more studies are needed to translate such approaches from the bench to clinics in urology.For the 21st century,cell and tissue therapies based on SCs are certainly the future of genitourinary regenerative medicine.
基金the Deanship of Scientific Research at King Khalid University for funding this work through the Large Research Group Project under grant number RGP.02/339/44.
文摘The primary approaches to treat cancerous diseases include drug treatment,surgical procedures,biotherapy,and radiation therapy.Chemotherapy has been the primary treatment for cancer for a long time,but its main drawback is that it kills cancerous cells along with healthy ones,leading to deadly adverse health effects.However,genitourinary cancer has become a concern in recent years as it is more common in middle-aged people.So,researchers are trying to find possible therapeutic options from natural small molecules due to the many drawbacks associated with chemotherapy and other radiation-based therapies.Plenty of research was conducted regarding genitourinary cancer to determine the promising role of natural small molecules.So,this review focused on natural small molecules along with their potential therapeutic targets in the case of genitourinary cancers such as prostate cancer,renal cancer,bladder cancer,testicular cancer,and so on.Also,this review states some ongoing or completed clinical evidence in this regard.
文摘Objective:The novel coronavirus(severe acute respiratory syndrome coronavirus 2)has been spreading worldwide since December 2019,posing a serious danger to human health and socioeconomic development.A large number of clinical trials have revealed that coronavirus disease 2019(COVID-19)results in multi-organ damage including the urogenital system.This study aimed to explore the potential mechanisms of genitourinary damage associated with COVID-19 infection through bioinformatics and molecular simulation analysis.Methods:We used multiple publicly available databases to explore the expression patterns of angiotensin-converting enzyme 2(ACE2),transmembrane serine protease 2(TMPRSS2),and CD147 in major organs in the healthy and disease-specific populations,particularly the genitourinary organs.Single-cell RNA sequencing was used to analyze the cell-specific expression patterns of ACE2,TMPRSS2,CD147,cytokine receptors,and cytokine interacting proteins in genitourinary organs,such as the bladder,kidney,prostate,and testis.Additionally,gene set enrichmentanalysis was used to investigate the relationship between testosterone levels and COVID-19 vulnerability in patients with prostate cancer.Results:The results revealed that ACE2,TMPRSS2,and CD147 were highly expressed in normal urogenital organs.Then,they were also highly expressed in multiple tumors and chronic kidney diseases.Additionally,ACE2,TMPRSS2,and CD147 were significantly expressed in a range of cells in urogenital organs according to single-cell RNA sequencing.Cytokine receptors and cytokine interacting proteins,especially CCL2,JUN,and TIMP1,were commonly highly expressed in urogenital organs.Finally,gene set enrichment analysis results showed that high testosterone levels in prostate cancer patients were significantly related to the JAK-STAT signaling pathway and the Toll-like receptor signaling pathway which were associated with COVID-19.Conclusion:Our study provides new insights into the potential mechanisms of severe acute respiratory syndrome coronavirus 2 damage to urogenital organs from multiple perspectives,which may draw the attention of urologists to COVID-19 and contribute to the development of targeted drugs.
文摘Bladder,kidney,prostate and testicular carcinoma are the top four genitourinary cancers in China.Here we analyzed mRNA and miRNA expression profiles of carcinomas of the bladder(TCC),kidney(ccRCC)and testis(TGCT)to uncover their specific regulatory mechanisms.The gene expression profiles of GSE31617 were downloaded from GEO database,which contained 27 samples,including 10 TCC,7 TGCT and 10 ccRCC.Specific up-and downregulated differentially expressed genes(DEGs)and differentially expressed microRNAs(DEmiRNAs)of each cancer were selected and target genes of DEmiRNAs were predicted.Gene interaction network of the shared genes and target genes of DEmiRNAs of each cancer was predicted by STRING and constructed by Cytoscape.In each cancer,we build regulatory networks of hub genes selected and conducted GO analysis of enriched genes.Furthermore,we chose four hub genes(SALL4,RHEB,CDC42 and TNN)for survival analysis in OncoLnc database,and they all had effects on the survival rate of another genitourinary cancer-kidney renal clear cell carcinoma(KIRC).In conclusion,the present study indicated that the identified hub genes promote our understanding of molecular mechanisms underlying the development of three genitourinary cancers,and might be used as molecular targets and diagnostic biomarkers for the treatment of them.
文摘Background: Genitourinary syndrome of menopause (GSM) is the new term for vulvovaginal atrophy (VVA). The condition is relevant in more than 50% of women, having an adverse impact on quality of life and sexual relationships. Objective: To assess the efficacy and safety of a new type of non-ablative laser, Solid State Vaginal Laser (SSVL), for vaginal tissue regeneration and rejuvenation. Method: Eighty participants with GSM symptoms were treated with a total of 4 treatments in about two months (every 15 - 20 days) of a non-ablative SSVL (LASEmaR 1500TM-EUFOTON). A cumulative intensity of GSM symptoms using a 10-cm VAS (dryness and/or burning and/or dyspareunia), the vaginal health index (VHI), the Female Sexual Function Index (FSFI) were evaluated. Urinary Incontinence Short Form (ICIQ-UI SF) and vaginal bioptic samples were also collected. Results: Improvement following the SSVL was observed on VHIS, VVA symptoms and sexual female function. This finding was also ratified by the improvement of vaginal histological features. After the SSVL treatment, almost all patients (91%) affected by urinary incontinence obtained the complete remission of symptoms. Conclusion: The objective evaluation of VHIS, FSFI and ICIQ-UI SF scores and the histological results indicates a real favorable effect of SSVL on GSM and on urinary incontinence.
文摘Aim of the Work: The present wok aims to assess how to reach the optimum diagnosis of the nature and the complications of lower genitourinary tract cyst in male patient using different radiological imaging modalities. Patients and Methods: 1000 male patients were evaluated with pelvic ultrasound and if lower genitourinary tract cysts were present, the patients were further subjected to either trans-rectal ultrasound (TRUS), TRUS guided aspiration for presence of spermatozoa, TRUS guided seminal vesiculography or CT urography in order to reach the origin of the cyst and the complications of its presence. Results: 14 cases were detected with lower genitourinary tract cysts among our patients with an overall incidence 1.4%;among them 3 patients with mid line prostatic cysts showed normal seminal analysis;1 patient with prostatic cyst was infertile;3 patients were detected with infravesical cysts after transurethral resection prostatectomy;2 cases with small retention cysts were associated with benign prostatic hyperplasia;1 case was detected with prostatic abscess;1 patient was detected with unilateral ureterocele;1 patient was detected with large pelvi abdominal unilateral seminal vesicle cyst;1 patient was with unilateral ejaculatory duct cyst;1 patient with small cystic dilation of prostatic urethra was associated with urethral stone.
文摘BACKGROUND Trauma is a major cause of morbidity globally and the sixth leading cause of death,accounting for 10%of all mortalities.The genitourinary trauma is estimated for approximately 10%of all patients presenting with trauma,and the kidney is the most injured genitourinary organ globally.However,there is a paucity of data on genitourinary injury from the Sub-Saharan,and there may be variations from common genitourinary organs injured in developed nations.AIM To provide insight on the epidemiology and management of genitourinary trauma in Sub-Saharan Africa with recommendations based on international guidelines.METHODS A thorough literature search of genitourinary trauma was conducted using PubMed,Google Scholar and African Journal Online.RESULTS A total of 30 studies from the Sub-Saharan region were eligible for the study and reviewed for epidemiology,biodata,types of injury,mechanisms of injury,treatment and follow-up.After evaluating 21904 patients presenting with urological emergencies,approximately 6.6%of cases were due to genitourinary trauma.The commonest injury was urethral 42.9%(22.2-62.2%)followed by injury to the external genitalia(penis,scrotum,testes)25.1%(8.8-67.7%).CONCLUSION Genitourinary injury in Sub-Saharan Africa is underreported,and the presence of more trauma registries,trained urologists and trauma facilities could improve the overall standard of care as well as providing data for research and development in the field.
文摘Submission deadline:31 October 2025 UroPrecision is delighted to announce a special issue on Liquid Biopsy in Genitourinary(GU)Oncology,focusing on prostate,renal,and bladder cancers.This issue,led by Dr.Shidong Jia,Dr.Liang Cheng,and Dr.Joshua Linscott,will highlight the latest advancements in liquid biopsy technologies and their clinical applications,including diagnosis,prognosis,treatment monitoring,and drug development for GU malignancies.
文摘Submission deadline:31 October 2025 UroPrecision is delighted to announce a special issue on Liquid Biopsy in Genitourinary(GU)Oncology,focusing on prostate,renal,and bladder cancers.This issue,led by Dr.Shidong Jia,Dr.Liang Cheng,and Dr.Joshua Linscott,will highlight the latest advancements in liquid biopsy technologies and their clinical applications,including diagnosis,prognosis,treatment monitoring,and drug development for GU malignancies.
基金supported by grants from the National Natural Science Foundation of China(Grant No.82305302,22208228)China Postdoctoral Science Foundation(Grant No.2022M722295)Key Research and Development Project of Sichuan Science and Technology Plan Projects(Grant No.2022YFS0380).
文摘Male genitourinary dysfunction causes serious physical or mental distress,such as infertility and psychological harm,which leads to impaired quality of life.Current conventional treatments involving drug therapy,surgical repair,and tissue grafting have a limited effect on recovering the function and fertility of the genitourinary organs.To address these limitations,various biomaterials have been explored,with collagen-based materials increasingly gaining attention for reconstructing the male genitourinary system due to their superior biocompatibility,biodegradability,low antigenicity,biomimetic 3D matrix characteristics,hemostatic efficacy,and tissue regeneration capabilities.This review covers the recent biomedical applications of collagen-based materials including treatment of erectile dysfunction,premature ejaculation,penile girth enlargement,prostate cancer,Peyronie’s disease,chronic kidney disease,etc.Although there are relatively few clinical trials,the promising results of the existing studies on animal models reveal a bright future for collagen-based materials in the treatment of male genitourinary diseases.
基金supported by the National Natural Science Foundation of China(Grant Nos.92043301,41907367,41961134033)the National High-level Talents Special Support Plan of China for Young Talents.
文摘Objective To assess relationships between cold spells and genitourinary hospitalization risk.Methods Hospitalization records for genitourinary system diseases(GUDs)from 16 districts in Beijing(2013–2018)were analyzed.Cold spells were defined based on varying intensity thresholds.A two-stage analytical method was employed:first,generalized linear models assessed district-specific associations between cold spells and hospitalizations;second,random-effects meta-analysis aggregated the districtlevel results.Subgroup analyses were performed by admission type(emergency vs.outpatient),age,and sex.Results A total of 271,579 GUD-related hospitalizations were recorded.Cold spells(p1day2,daily mean temperature below the 1st percentiles of the daily mean temperature distribution from January 1,2013,to December 31,2018,lasting for two or more consecutive days)were linked to a significant rise in hospitalization risks:1.43(95%CI:1.32–1.56)for all GUDs,1.35(95%CI:1.23–1.49)for urinary system diseases,and 1.46(95%CI:1.28–1.67)for renal failure,when compared to non-cold spell days.Emergency admissions showed higher risk increases than outpatient admissions.Conclusion Extreme cold spells significantly elevate hospitalization risks for GUDs.This highlights the urgent need for targeted public health interventions to mitigate cold-related health impacts,especially for vulnerable populations.
文摘ECharles Osterberg。Dr.Osterberg is a board-certified urologist with fellowship training in male genitourinary reconstruction.He moved to Austin(TX,USA)in 2016 to join the University of Texas-Dell Medical School as Associate Professor of Surgery.Dr.Osterberg specializes in reconstructive urology,genitourinary trauma,prosthetics,and robotic surgery.After serving as the Chief of Urology at Dell-Seton Medical Center-the main teaching hospital for Dell Medical School for 7 years,Dr.Osterberg transitioned his practice to Urology Austin,an affiliate of Urology America.At his new practice,he and his team have performed hundreds of complex urologic reconstructions and urethral stricture surgeries.
