Background: Tuberculosis (TB) is an infectious disease and it is a public health concern due to the endemic nature of the disease. Nigeria’s health systems still rely heavily on out-dated tuberculosis diagnostic test...Background: Tuberculosis (TB) is an infectious disease and it is a public health concern due to the endemic nature of the disease. Nigeria’s health systems still rely heavily on out-dated tuberculosis diagnostic tests;including sputum smear microscopy and chest radiography. This necessitated the urgent need to explore a more reliable, effective method that can rapidly enhance simultaneous detection of Mycobacterium tuberculosis (MTB) and rifampicin (RIF) resistance. Aims: We evaluated the prevalence of MTB and rifampicin resistance and the influence of socio-demographic factors. Methods: A longitudinal, descriptive study that employs the Xpert MTB/RIF automated molecular method for rapid detection of rifampicin resistance. Secondary data were collected from the medical record from March 2017 to December 2018. Primary data were collected by direct clinical observations and analysis with gene expert machine from January 2019-March 2019. Results: Study populations were 1893 subjects pooled as secondary data at the Gene Expert laboratory, with a mean age of 44.92 years and were categorized based on sex, 1125 (59.4%) males and 768 (40.6%) females respectively. The MTB detected were 117 (15.7%) for males while 76 (9.9%) were positive for females. 948 (84.3%) were negative for males and 692 (90.1%) negative for females. Also, the categories for age were grouped into three but the older age groups (29 - 54) and (55 - 80) were more vulnerable to MTB having a p = 0.506 which is statistically non-significant;only 14 (5.5%) have RIF while 239 (94.5%) do not have RIF resistance strains. Logistic regression analysis of MTB detected showed a significant association (p < 0.05) for sex and a non-significant association (p > 0.05) for age. The prevalence rate for RIF Resistance is 5.53%, there is a statistical difference p = 0.001 between RIF Resistance and MTB in Ilorin. Conclusion: The utilization of validated molecular technique for MTB strain identification has shown stronger epidemiological impetus for an improved care management outcome specifically in resources limited areas.展开更多
伴睾丸核蛋白(nuclear protein in testis,NUT)基因重排的中线癌又称NUT癌,是一种罕见的高度侵袭性肿瘤,根据NUT中线癌家族成员1(NUT midline carcinoma family member 1,NUTM1)基因发生重排或突变定义。常规治疗方法对NUT癌效果欠佳,...伴睾丸核蛋白(nuclear protein in testis,NUT)基因重排的中线癌又称NUT癌,是一种罕见的高度侵袭性肿瘤,根据NUT中线癌家族成员1(NUT midline carcinoma family member 1,NUTM1)基因发生重排或突变定义。常规治疗方法对NUT癌效果欠佳,绝大多数患者预后差。现阶段对该基因变异的认识不足是制约NUT癌诊治取得进展的主要障碍。目前在临床实践中缺乏针对NUT癌临床特征、诊断及治疗方法的标准化指南,限制了临床医师对该疾病的充分认识。为了给临床医师提供更加明确规范的诊断参考依据,中国抗癌协会肿瘤基因诊断专业委员会中线(NUT)癌基因诊断工作组及中国抗癌协会肿瘤标志专业委员会组织了临床、病理、分子检测和生物信息分析等领域专家,综合国内外NUT癌临床应用的共识指南、重要文献及临床实践经验,共同制定了本共识,对NUT癌临床诊疗给出专家组意见,期望为临床医师提供NUT癌诊疗指导意见,降低NUT癌误诊率,提高治疗效果和预后。展开更多
文摘Background: Tuberculosis (TB) is an infectious disease and it is a public health concern due to the endemic nature of the disease. Nigeria’s health systems still rely heavily on out-dated tuberculosis diagnostic tests;including sputum smear microscopy and chest radiography. This necessitated the urgent need to explore a more reliable, effective method that can rapidly enhance simultaneous detection of Mycobacterium tuberculosis (MTB) and rifampicin (RIF) resistance. Aims: We evaluated the prevalence of MTB and rifampicin resistance and the influence of socio-demographic factors. Methods: A longitudinal, descriptive study that employs the Xpert MTB/RIF automated molecular method for rapid detection of rifampicin resistance. Secondary data were collected from the medical record from March 2017 to December 2018. Primary data were collected by direct clinical observations and analysis with gene expert machine from January 2019-March 2019. Results: Study populations were 1893 subjects pooled as secondary data at the Gene Expert laboratory, with a mean age of 44.92 years and were categorized based on sex, 1125 (59.4%) males and 768 (40.6%) females respectively. The MTB detected were 117 (15.7%) for males while 76 (9.9%) were positive for females. 948 (84.3%) were negative for males and 692 (90.1%) negative for females. Also, the categories for age were grouped into three but the older age groups (29 - 54) and (55 - 80) were more vulnerable to MTB having a p = 0.506 which is statistically non-significant;only 14 (5.5%) have RIF while 239 (94.5%) do not have RIF resistance strains. Logistic regression analysis of MTB detected showed a significant association (p < 0.05) for sex and a non-significant association (p > 0.05) for age. The prevalence rate for RIF Resistance is 5.53%, there is a statistical difference p = 0.001 between RIF Resistance and MTB in Ilorin. Conclusion: The utilization of validated molecular technique for MTB strain identification has shown stronger epidemiological impetus for an improved care management outcome specifically in resources limited areas.
文摘伴睾丸核蛋白(nuclear protein in testis,NUT)基因重排的中线癌又称NUT癌,是一种罕见的高度侵袭性肿瘤,根据NUT中线癌家族成员1(NUT midline carcinoma family member 1,NUTM1)基因发生重排或突变定义。常规治疗方法对NUT癌效果欠佳,绝大多数患者预后差。现阶段对该基因变异的认识不足是制约NUT癌诊治取得进展的主要障碍。目前在临床实践中缺乏针对NUT癌临床特征、诊断及治疗方法的标准化指南,限制了临床医师对该疾病的充分认识。为了给临床医师提供更加明确规范的诊断参考依据,中国抗癌协会肿瘤基因诊断专业委员会中线(NUT)癌基因诊断工作组及中国抗癌协会肿瘤标志专业委员会组织了临床、病理、分子检测和生物信息分析等领域专家,综合国内外NUT癌临床应用的共识指南、重要文献及临床实践经验,共同制定了本共识,对NUT癌临床诊疗给出专家组意见,期望为临床医师提供NUT癌诊疗指导意见,降低NUT癌误诊率,提高治疗效果和预后。
