G-protein coupled receptor kinase 4(GRK4)gene plays a core role in renal dopamine D1 receptor function for handing renal sodium excretion,the rs1801058 T variant has~50%frequency in the general East Asian population b...G-protein coupled receptor kinase 4(GRK4)gene plays a core role in renal dopamine D1 receptor function for handing renal sodium excretion,the rs1801058 T variant has~50%frequency in the general East Asian population but lacks functional evidence for salt-sensitivity.In this prospective study,we identified rs1801058 genotypes by sequencing in hypertensives patients and analyzed the variant's effects on blood pressure response to acute salt loading in 150 newly diagnosed hypertension patients.Our data indicated that there were no statistically significant difference in blood pressure changes between the overall rs1801058 genotype groups.Carriers of the C allele showed a significant rise in heart rate change according to acute saline loading.Among patients age≤40year,T allele carriers showed higher changes in systolic blood pressure(SBP),diastolic blood pressure(DBP),mean arterial pressure(MAP),and heart rate(HR)than C allele carriers when diuretic shrinkage.GRK4 single rs1801058 polymorphism cannot directly explain salt sensitivity in the Chinese hypertension patients.展开更多
Background G-protein–coupled receptor kinases (GRKs) play important roles in cardiac hypertrophy and heart failure. The role of GRK4 in hypertension has been well demonstrated, but little is known in cardiac ischemic...Background G-protein–coupled receptor kinases (GRKs) play important roles in cardiac hypertrophy and heart failure. The role of GRK4 in hypertension has been well demonstrated, but little is known in cardiac ischemic injury. In the present study, we explore if and how GRK4 regulates cardiomyocyte autophagy and influence the prognosis of myocardial infarction (MI).展开更多
文摘G-protein coupled receptor kinase 4(GRK4)gene plays a core role in renal dopamine D1 receptor function for handing renal sodium excretion,the rs1801058 T variant has~50%frequency in the general East Asian population but lacks functional evidence for salt-sensitivity.In this prospective study,we identified rs1801058 genotypes by sequencing in hypertensives patients and analyzed the variant's effects on blood pressure response to acute salt loading in 150 newly diagnosed hypertension patients.Our data indicated that there were no statistically significant difference in blood pressure changes between the overall rs1801058 genotype groups.Carriers of the C allele showed a significant rise in heart rate change according to acute saline loading.Among patients age≤40year,T allele carriers showed higher changes in systolic blood pressure(SBP),diastolic blood pressure(DBP),mean arterial pressure(MAP),and heart rate(HR)than C allele carriers when diuretic shrinkage.GRK4 single rs1801058 polymorphism cannot directly explain salt sensitivity in the Chinese hypertension patients.
文摘Background G-protein–coupled receptor kinases (GRKs) play important roles in cardiac hypertrophy and heart failure. The role of GRK4 in hypertension has been well demonstrated, but little is known in cardiac ischemic injury. In the present study, we explore if and how GRK4 regulates cardiomyocyte autophagy and influence the prognosis of myocardial infarction (MI).
