Background: Little is known about the nature of metaistasis to small cervical lymph nodes(SCLNS) in the patients with nasopharyngeal carcinoma(NPC)examined by using 18-fluoro-2-deoxy-glucose(^(18)F-FDG) positron emiss...Background: Little is known about the nature of metaistasis to small cervical lymph nodes(SCLNS) in the patients with nasopharyngeal carcinoma(NPC)examined by using 18-fluoro-2-deoxy-glucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT).The present study aimed to evaluate the diagnostic values of PET/CT in identifying metastasis in SCLNs in NPC patients.Methods: Magnetic resonance images(MRI) and PET/CT scans for 470 patients with newly diagnosed, non-distant metastatic NPC were analyzed. Metastatic rates of SCLNs were defined by the positive number of SCLNs on PET/CT scans and total number of SCLNs on MRI scans. Receiver operating characteristic curve was applied to compare PET/CT-determined stage with MRI-determined stage.Results: In total, 2082 SCLNs were identified, with 808(38.8%) ≥ 5 and < 6 mm in diameter(group A), 526(25.3%)≥ 6 and < 7 mm in diameter(group B),374(18.0%)≥ 7 and < 8 mm in diameter(group C), 237(11.4%) ≥8 and<9 mm in diameter(group D),and 137(6.5%) ≥ 9 and <10 mm in diameter(group E).The overall metastatic rates examined by using PET/CT for groups A, B,C,D, and E were 3.5%, 8.0%, 31.3%, 60.0%, and 83.9%, respectively(P< 0.001). In level IV/Vb, the metastatic rate for nodes ≥ 8 mm was 84.6%. PET/CT examination resulted in modification of N category and overall stage for 135(28.7%) and 46(9.8%) patients, respectively. The areas under curve of MRIdetermined and PET/CT-determined overall stage were 0.659 and 0.704 for predicting overall survival, 0.661 and 0.711 for predicting distant metastasis-free survival, and 0.636 and 0.663 for predicting disease-free survival.Conclusions: PET/CT was more effective than MRI in identifying metastatic SCLNs, and the radiologic diagnostic criteria for metastatic lymph nodes in level IV/Vb should be re-defined.展开更多
Metal phosphides have shown great application potential as anode for sodium-ion batteries(NIBs)owing to high theoretical capacity,suitable operation voltage and abundant resource.Unfortunately,the application of NiP_(...Metal phosphides have shown great application potential as anode for sodium-ion batteries(NIBs)owing to high theoretical capacity,suitable operation voltage and abundant resource.Unfortunately,the application of NiP_(2) anode is severely impeded by low practical capacity and fast capacity decay due to the huge volume variation and low reactivity of internal phosphorus(P)component towards Na^(+).Herein,electronic structure modulation of NiP_(2) via heteroatoms doping and introducing vacancies defects to enhance Na+adsorption sites and diffusion kinetics is successfully attempted.The as-synthesized three-dimensional(3D)bicontinuous carbon matrix decorated with well-dispersed fluorine(F)-doped NiP_(2) nanoparticles(F-NiP_(2)@carbon nanosheets)delivers a high reversible capacity(585 mAh·g^(−1) at 0.1 A·g^(−1))and excellent long cycling stability(244 mAh·g^(−1) over 1,000 cycles at 2 A·g^(−1))when tested as anode in NIBs.Density functional theory(DFT)calculations reveal that F doping in NiP_(2) induces the formation of P vacancies with increased Na+adsorption energy and accelerates the alloying of internal P component.The F-NiP_(2)@carbon nanosheets//Na_(3)V_(2)(PO_(4))_(3) full cell is evaluated showing stable long cycling life.The heteroatoms doping-induced dual defects strategy opens up a new way of metal phosphides for sodium storage.展开更多
基金supported by grants from the Science and Technology Project of Guangzhou City,China(No.14570006)the Planned Science and Technology Project of Guangdong Province,China(No.2013B020400004)
文摘Background: Little is known about the nature of metaistasis to small cervical lymph nodes(SCLNS) in the patients with nasopharyngeal carcinoma(NPC)examined by using 18-fluoro-2-deoxy-glucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT).The present study aimed to evaluate the diagnostic values of PET/CT in identifying metastasis in SCLNs in NPC patients.Methods: Magnetic resonance images(MRI) and PET/CT scans for 470 patients with newly diagnosed, non-distant metastatic NPC were analyzed. Metastatic rates of SCLNs were defined by the positive number of SCLNs on PET/CT scans and total number of SCLNs on MRI scans. Receiver operating characteristic curve was applied to compare PET/CT-determined stage with MRI-determined stage.Results: In total, 2082 SCLNs were identified, with 808(38.8%) ≥ 5 and < 6 mm in diameter(group A), 526(25.3%)≥ 6 and < 7 mm in diameter(group B),374(18.0%)≥ 7 and < 8 mm in diameter(group C), 237(11.4%) ≥8 and<9 mm in diameter(group D),and 137(6.5%) ≥ 9 and <10 mm in diameter(group E).The overall metastatic rates examined by using PET/CT for groups A, B,C,D, and E were 3.5%, 8.0%, 31.3%, 60.0%, and 83.9%, respectively(P< 0.001). In level IV/Vb, the metastatic rate for nodes ≥ 8 mm was 84.6%. PET/CT examination resulted in modification of N category and overall stage for 135(28.7%) and 46(9.8%) patients, respectively. The areas under curve of MRIdetermined and PET/CT-determined overall stage were 0.659 and 0.704 for predicting overall survival, 0.661 and 0.711 for predicting distant metastasis-free survival, and 0.636 and 0.663 for predicting disease-free survival.Conclusions: PET/CT was more effective than MRI in identifying metastatic SCLNs, and the radiologic diagnostic criteria for metastatic lymph nodes in level IV/Vb should be re-defined.
基金the National Natural Science Foundation of China(Nos.22005201 and 22005292)the Natural Science Foundation of Guangdong(No.2020A1515010840)Shenzhen Government’s Plan of Science and Technology(Nos.JCYJ20200109105803806 and RCYX20200714114535052).
文摘Metal phosphides have shown great application potential as anode for sodium-ion batteries(NIBs)owing to high theoretical capacity,suitable operation voltage and abundant resource.Unfortunately,the application of NiP_(2) anode is severely impeded by low practical capacity and fast capacity decay due to the huge volume variation and low reactivity of internal phosphorus(P)component towards Na^(+).Herein,electronic structure modulation of NiP_(2) via heteroatoms doping and introducing vacancies defects to enhance Na+adsorption sites and diffusion kinetics is successfully attempted.The as-synthesized three-dimensional(3D)bicontinuous carbon matrix decorated with well-dispersed fluorine(F)-doped NiP_(2) nanoparticles(F-NiP_(2)@carbon nanosheets)delivers a high reversible capacity(585 mAh·g^(−1) at 0.1 A·g^(−1))and excellent long cycling stability(244 mAh·g^(−1) over 1,000 cycles at 2 A·g^(−1))when tested as anode in NIBs.Density functional theory(DFT)calculations reveal that F doping in NiP_(2) induces the formation of P vacancies with increased Na+adsorption energy and accelerates the alloying of internal P component.The F-NiP_(2)@carbon nanosheets//Na_(3)V_(2)(PO_(4))_(3) full cell is evaluated showing stable long cycling life.The heteroatoms doping-induced dual defects strategy opens up a new way of metal phosphides for sodium storage.
