An orthotropic functionally graded piezoelectric rectangular plate with arbitrarily distributed material properties was studied, which is simply supported and grounded（electrically） on its four lateral edges. The st...An orthotropic functionally graded piezoelectric rectangular plate with arbitrarily distributed material properties was studied, which is simply supported and grounded（electrically） on its four lateral edges. The state equations of the functionally graded piezoelectric material were obtained using the state-space approach, and a Peano-Baker series solution was obtained for the coupled electroelastic fi elds of the functionally graded piezoelectric plate subjected to mechanical and electric loading on its upper and lower surfaces. The influence of different distributions of material properties on the structural response of the plate was studied using the obtained solutions.展开更多
Three-dimensional elasticity solutions for static bending of thick functionally graded plates are presented using a hybrid semi-analytical approach-the state-space based differential quadrature method （SSDQM）. The p...Three-dimensional elasticity solutions for static bending of thick functionally graded plates are presented using a hybrid semi-analytical approach-the state-space based differential quadrature method （SSDQM）. The plate is generally supported at four edges for which the two-way differential quadrature method is used to solve the in-plane variations of the stress and displacement fields numerically. An approximate laminate model （ALM） is exploited to reduce the inhomogeneous plate into a multi-layered laminate, thus applying the state space method to solve analytically in the thickness direction. Both the convergence properties of SSDQM and ALM are examined. The SSDQM is validated by comparing the numerical results with the exact solutions reported in the literature. As an example, the Mori-Tanaka model is used to predict the effective bulk and shear moduli. Effects of gradient index and aspect ratios on the bending behavior of functionally graded thick plates are investigated.展开更多
OBJECTIVE:To systematically assess the safety and effectiveness of Compound E’jiao Jiang(复方阿胶浆,CEJ)for treating leukopenia.METHODS:Four English and four Chinese databases were searched for randomized controlled ...OBJECTIVE:To systematically assess the safety and effectiveness of Compound E’jiao Jiang(复方阿胶浆,CEJ)for treating leukopenia.METHODS:Four English and four Chinese databases were searched for randomized controlled trials(RCTs)on CEJ for treating leukopenia up to July 1,2024.Two researchers independently screened the studies and extracted necessary data.Methodological quality and risk of bias were assessed using the Cochrane risk-of-bias tool.Articles eligible for Meta-analysis were analyzed using RevMan.RESULTS:A total of 28 RCTs involving 2041 participants were included,with 1034 in the experimental group and 1007 in the control group.The Meta-analysis showed a significant effect of CEJ in treating leukopenia caused by tumor and immune diseases(three RCTs)[risk ratio(RR)=1.17,95%confidence interval(CI)(1.08,1.27),P=0.0002,I^(2)=35%].The combination of CEJ and Western Medicine showed superior results in terms of white blood cell(WBC)counts(fifteen RCTs)[mean difference(MD)=1.12,95%CI(0.83,1.42),P<0.00001,I^(2)=88%],Karnofsky Performance Status(KPS)levels(seven RCTs)[RR=1.39,95%CI(1.25,1.55),P<0.00001,I^(2)=36%],and mitigation of bone marrow toxicity(eleven RCTs)[RR=0.61,95%CI(0.54,0.69),P<0.00001,I^(2)=24%]compared to Western Medicine alone.Adverse events mainly included gastrointestinal and digestive reactions associated with chemotherapy drugs.CONCLUSION:CEJ alone or in combination with Western Medicine for treating leukopenia caused by tumor and immune diseases improved WBC counts,clinical efficacy,and quality of life.It also reduced bone marrow toxicity-induced leukopenia,enhanced the efficacy of chemotherapy while reducing its toxicity,and alleviated symptoms.No significant adverse events were reported in the RCTs,indicating favorable efficacy and safety.The Grading of Recommendations Assessment,Development and Evaluation assessment indicated a low level of evidence for CEJ in improving leukocyte elevation efficacy,KPS levels,and myelosuppressive toxicity.Therefore,large-scale,high-quality,rigorous multicenter double-blind controlled trials are recommended to strengthen the evidence level.展开更多
OBJECTIVE:To systematically evaluate the efficacy and safety of Chinese herbal medicine(CHM) combined with conventional Western Medicine(CWM) on acute exacerbation of chronic obstructive pulmonary disease(AECOPD) base...OBJECTIVE:To systematically evaluate the efficacy and safety of Chinese herbal medicine(CHM) combined with conventional Western Medicine(CWM) on acute exacerbation of chronic obstructive pulmonary disease(AECOPD) based on high-quality randomized placebocontrolled trials.METHODS:We searched PubMed,Embase,Cochrane Library,China National Knowledge Infrastructure Database,Chinese Biomedical Literature Database,China Science and Technology Journal Database,and Wanfang databases for randomized placebo-controlled trials of CHM treatment for AECOPD from inception to June 4,2021.The Cochrane Collaboration’s tool and the Grading of Recommendations,Assessment,Development and Evaluation were used to assess the risk of bias and the evidence quality of the included studies.Revman 5.3 software was used for Meta-analysis.RESULTS:A total of 9 trials involving 1591 patients were included.The Meta-analysis showed that based on CWM treatment,CHM group had significant advantages over the placebo group in ameliorating clinical total effective rate [RR = 1.29,95% CI(1.07,1.56),P = 0.007,low quality] and TCM symptom scores [MD =-2.99,95% CI(-4.46,-1.53),P < 0.0001,moderate quality],improving arterial blood gas results [PaO_(2):MD = 4.51,95% CI(1.97,7.04),P = 0.0005,moderate quality;PaCO_(2):MD =-2.87,95% CI(-4.28,-1.46),P < 0.0001,moderate quality],reducing CAT scores [MD =-2.08,95% CI(-2.85,-1.31),P < 0.000 01,moderate quality],length of hospitalization [MD =-1.87,95% CI(-3.33,-0.42),P = 0.01,moderate quality],and acute exacerbation rate [RR = 0.60,95% CI(0.43,0.83),P = 0.002,moderate quality].No serious CHM-related adverse events were reported.CONCLUSIONS:The current evidence indicates that CHM is an effective and well-tolerated adjunct therapy for AECOPD patients receiving CWM.However,considering the high heterogeneity,this conclusion requires confirmation.展开更多
基金Funded by the National Natural Science Foundation of China(Nos.11102136 and 41362016)the Open Project of Guangxi Key Laboratory of Disaster Prevention and Structural Safety(No.2013ZDK09)
文摘An orthotropic functionally graded piezoelectric rectangular plate with arbitrarily distributed material properties was studied, which is simply supported and grounded（electrically） on its four lateral edges. The state equations of the functionally graded piezoelectric material were obtained using the state-space approach, and a Peano-Baker series solution was obtained for the coupled electroelastic fi elds of the functionally graded piezoelectric plate subjected to mechanical and electric loading on its upper and lower surfaces. The influence of different distributions of material properties on the structural response of the plate was studied using the obtained solutions.
基金Project supported by the National Natural Science Foundation of China(Nos.51108412,11472244,and 11202186)the National Basic Research Program of China(973 Program)(No.2013CB035901)+1 种基金the Fundamental Research Funds for the Central Universities(No.2014QNA4017)the Zhejiang Provincial Natural Science Foundation of China(No.LR13A020001)
文摘Three-dimensional elasticity solutions for static bending of thick functionally graded plates are presented using a hybrid semi-analytical approach-the state-space based differential quadrature method （SSDQM）. The plate is generally supported at four edges for which the two-way differential quadrature method is used to solve the in-plane variations of the stress and displacement fields numerically. An approximate laminate model （ALM） is exploited to reduce the inhomogeneous plate into a multi-layered laminate, thus applying the state space method to solve analytically in the thickness direction. Both the convergence properties of SSDQM and ALM are examined. The SSDQM is validated by comparing the numerical results with the exact solutions reported in the literature. As an example, the Mori-Tanaka model is used to predict the effective bulk and shear moduli. Effects of gradient index and aspect ratios on the bending behavior of functionally graded thick plates are investigated.
基金Supported by The Qihuang Scholars Support Program of the National Administration of Traditional Chinese Medicinet:2021 Qihuang Scholars Support Project(National Chinese Medicine Teaching Letter[2022]6)National Traditional Medicine Administration's Project for Establishing National Famous and Elderly Traditional Medicine Transmission Workshops:Xie Yanming National Famous Traditional Chinese Medicine Expert Transmission Studio(National Chinese Medicine Education Letter[2022]75)。
文摘OBJECTIVE:To systematically assess the safety and effectiveness of Compound E’jiao Jiang(复方阿胶浆,CEJ)for treating leukopenia.METHODS:Four English and four Chinese databases were searched for randomized controlled trials(RCTs)on CEJ for treating leukopenia up to July 1,2024.Two researchers independently screened the studies and extracted necessary data.Methodological quality and risk of bias were assessed using the Cochrane risk-of-bias tool.Articles eligible for Meta-analysis were analyzed using RevMan.RESULTS:A total of 28 RCTs involving 2041 participants were included,with 1034 in the experimental group and 1007 in the control group.The Meta-analysis showed a significant effect of CEJ in treating leukopenia caused by tumor and immune diseases(three RCTs)[risk ratio(RR)=1.17,95%confidence interval(CI)(1.08,1.27),P=0.0002,I^(2)=35%].The combination of CEJ and Western Medicine showed superior results in terms of white blood cell(WBC)counts(fifteen RCTs)[mean difference(MD)=1.12,95%CI(0.83,1.42),P<0.00001,I^(2)=88%],Karnofsky Performance Status(KPS)levels(seven RCTs)[RR=1.39,95%CI(1.25,1.55),P<0.00001,I^(2)=36%],and mitigation of bone marrow toxicity(eleven RCTs)[RR=0.61,95%CI(0.54,0.69),P<0.00001,I^(2)=24%]compared to Western Medicine alone.Adverse events mainly included gastrointestinal and digestive reactions associated with chemotherapy drugs.CONCLUSION:CEJ alone or in combination with Western Medicine for treating leukopenia caused by tumor and immune diseases improved WBC counts,clinical efficacy,and quality of life.It also reduced bone marrow toxicity-induced leukopenia,enhanced the efficacy of chemotherapy while reducing its toxicity,and alleviated symptoms.No significant adverse events were reported in the RCTs,indicating favorable efficacy and safety.The Grading of Recommendations Assessment,Development and Evaluation assessment indicated a low level of evidence for CEJ in improving leukocyte elevation efficacy,KPS levels,and myelosuppressive toxicity.Therefore,large-scale,high-quality,rigorous multicenter double-blind controlled trials are recommended to strengthen the evidence level.
基金Supported by the National Natural Science:Research on Key Technology of Outcome Measurement and Evaluation of Syndrome Differentiation and Treatment Based on Clinical Trials of COPD (No. 81830116)the Chinese Medicine Inheritance and Innovation “Hundred and Ten Million” Talent ProjectChief Scientist of Qi-Huang Project [(2020) No. 219]the Zhong-yuan Scholars and Scientists Project (No. 2018204)。
文摘OBJECTIVE:To systematically evaluate the efficacy and safety of Chinese herbal medicine(CHM) combined with conventional Western Medicine(CWM) on acute exacerbation of chronic obstructive pulmonary disease(AECOPD) based on high-quality randomized placebocontrolled trials.METHODS:We searched PubMed,Embase,Cochrane Library,China National Knowledge Infrastructure Database,Chinese Biomedical Literature Database,China Science and Technology Journal Database,and Wanfang databases for randomized placebo-controlled trials of CHM treatment for AECOPD from inception to June 4,2021.The Cochrane Collaboration’s tool and the Grading of Recommendations,Assessment,Development and Evaluation were used to assess the risk of bias and the evidence quality of the included studies.Revman 5.3 software was used for Meta-analysis.RESULTS:A total of 9 trials involving 1591 patients were included.The Meta-analysis showed that based on CWM treatment,CHM group had significant advantages over the placebo group in ameliorating clinical total effective rate [RR = 1.29,95% CI(1.07,1.56),P = 0.007,low quality] and TCM symptom scores [MD =-2.99,95% CI(-4.46,-1.53),P < 0.0001,moderate quality],improving arterial blood gas results [PaO_(2):MD = 4.51,95% CI(1.97,7.04),P = 0.0005,moderate quality;PaCO_(2):MD =-2.87,95% CI(-4.28,-1.46),P < 0.0001,moderate quality],reducing CAT scores [MD =-2.08,95% CI(-2.85,-1.31),P < 0.000 01,moderate quality],length of hospitalization [MD =-1.87,95% CI(-3.33,-0.42),P = 0.01,moderate quality],and acute exacerbation rate [RR = 0.60,95% CI(0.43,0.83),P = 0.002,moderate quality].No serious CHM-related adverse events were reported.CONCLUSIONS:The current evidence indicates that CHM is an effective and well-tolerated adjunct therapy for AECOPD patients receiving CWM.However,considering the high heterogeneity,this conclusion requires confirmation.
