In recent years,the incidence and mortality rates of pancreatic cancer have been steadily increasing,and conventional therapies have shown a high degree of tolerance.There-fore,the search for new therapeutic targets r...In recent years,the incidence and mortality rates of pancreatic cancer have been steadily increasing,and conventional therapies have shown a high degree of tolerance.There-fore,the search for new therapeutic targets remains a key issue in current research.Mitochon-drial glutamic-oxaloacetic transaminase 2(GOT2)is an important component of the malate-aspartate shuttle system,which plays an important role in the maintenance of cellular redox balance and amino acid metabolism,and has the potential to become a promising target for anti-cancer therapy.In this paper,we will elaborate on the metabolic and immune effects of GOT2 in pancreatic cancer based on existing studies,with a view to opening up new avenues for the treatment of pancreatic cancer.展开更多
基金supported by the National Natural Science Foundation of China(No.31972890 to Q.Y.)the Department of Science and Technology of Jilin Province,China(No.20230101139JC to Q.Y.).
文摘In recent years,the incidence and mortality rates of pancreatic cancer have been steadily increasing,and conventional therapies have shown a high degree of tolerance.There-fore,the search for new therapeutic targets remains a key issue in current research.Mitochon-drial glutamic-oxaloacetic transaminase 2(GOT2)is an important component of the malate-aspartate shuttle system,which plays an important role in the maintenance of cellular redox balance and amino acid metabolism,and has the potential to become a promising target for anti-cancer therapy.In this paper,we will elaborate on the metabolic and immune effects of GOT2 in pancreatic cancer based on existing studies,with a view to opening up new avenues for the treatment of pancreatic cancer.
