Peptide hormones act through its receptors to regulate a various of physiological processes,including energy metabolism,growth and sleep.The famous helical peptides with important role in maintaining energy metabolic ...Peptide hormones act through its receptors to regulate a various of physiological processes,including energy metabolism,growth and sleep.The famous helical peptides with important role in maintaining energy metabolic balance are glucagon(GCG)and glucagon-like peptide-1(GLP1),which bind to and activate their receptor the Gprotein-coupled receptors(GPCR)GCGR and GLP1R,respectively to regulate blood sugar,food intake and finally body weight.GCG is a gastrointestinal hormone produced in the pancreas,mainly acting opposite to insulin.In response to fasting or acute hypoglycemia,it increases blood glucose by stimulating hepatic gluconeogenesis and glycogen breakdown1.Meanwhile,GCG can affect the energy metabolism and thermogenesis processes of the body2.Studies have shown that exogenous administration of GCG can reduce hepatic triglyceride synthesis and promote hepatic lipolysis3.GLP1 is a hormone primarily produced by intestinal L cells,it binds to its receptor GLP1R expressed mainly on pancreas to enhance insulin secretion in a glucose concentration dependent manner,inhibiting glucagon secretion,and delaying gastric emptying and reduce food intake through central appetite suppression.Thereby,activation of GLP1-GLP1R achieves effects such as lowering blood sugar and weight loss4,5.展开更多
文摘Peptide hormones act through its receptors to regulate a various of physiological processes,including energy metabolism,growth and sleep.The famous helical peptides with important role in maintaining energy metabolic balance are glucagon(GCG)and glucagon-like peptide-1(GLP1),which bind to and activate their receptor the Gprotein-coupled receptors(GPCR)GCGR and GLP1R,respectively to regulate blood sugar,food intake and finally body weight.GCG is a gastrointestinal hormone produced in the pancreas,mainly acting opposite to insulin.In response to fasting or acute hypoglycemia,it increases blood glucose by stimulating hepatic gluconeogenesis and glycogen breakdown1.Meanwhile,GCG can affect the energy metabolism and thermogenesis processes of the body2.Studies have shown that exogenous administration of GCG can reduce hepatic triglyceride synthesis and promote hepatic lipolysis3.GLP1 is a hormone primarily produced by intestinal L cells,it binds to its receptor GLP1R expressed mainly on pancreas to enhance insulin secretion in a glucose concentration dependent manner,inhibiting glucagon secretion,and delaying gastric emptying and reduce food intake through central appetite suppression.Thereby,activation of GLP1-GLP1R achieves effects such as lowering blood sugar and weight loss4,5.
