A facile one-pot procedure has been developed for the synthesis of GL331 in 26% overall yield.In addition,molecular modeling study was carried out to predict the binding site of GL331 with human topoisomerase IIα.The...A facile one-pot procedure has been developed for the synthesis of GL331 in 26% overall yield.In addition,molecular modeling study was carried out to predict the binding site of GL331 with human topoisomerase IIα.The result showed that GL331 exhibited high affinity for the ATPase domain of human topoisomerase IIα and suggested that GL331 probably acts as a competitor of ATP for binding with the human topoisomerase IIα.展开更多
文摘A facile one-pot procedure has been developed for the synthesis of GL331 in 26% overall yield.In addition,molecular modeling study was carried out to predict the binding site of GL331 with human topoisomerase IIα.The result showed that GL331 exhibited high affinity for the ATPase domain of human topoisomerase IIα and suggested that GL331 probably acts as a competitor of ATP for binding with the human topoisomerase IIα.
