Collagen characterization is crucial for disease diagnostics,prevention,and understanding,with growing focus on quantitative analysis at tissue and fibril levels.Numerous models have been developed to quantify structu...Collagen characterization is crucial for disease diagnostics,prevention,and understanding,with growing focus on quantitative analysis at tissue and fibril levels.Numerous models have been developed to quantify structural changes in collagen linked to various pathologies.However,many approaches remain limited to conceptual descriptions or rely on custom software,often requiring programming skills,which re-stricts their clinical application and potential impact.We introduce CollagenFitJ,a plugin for the open-source software platform ImageJ/FIJI,which represents a widely used microscopy image analysis tool.CollagenFitJ makes use of the cylindrical symmetry model for collagen to enable facile quantitative assessment of polarization-resolved second harmonic generation microscopy image stacks.The plugin’s main outputs are collagen structure-related maps(e.g.,orientation and anisotropy of collagen fibrils within the focal volume),which can be accompanied by distribution and randomness maps for a series of structure-related parameters.We describe and validate the use of CollagenFitJ on images acquired on rat-tail tendons,collagen capsules surrounding human thyroid nodules,and mouse colon tumors,using both scanning and widefield second harmonic generation microscopy datasets.The plugin was designed to be user-friendly,requiring little to no experience in image processing and coding to facilitate access for life scientists,medical staff,and microscopy practitioners with limited coding skills or time availability required for coding.展开更多
经天路图是基于三维GIS系统的公路综合设计平台,为了使用户在该软件的使用过程中,准确表达设计理念和思想,需要开发在三维地球场景下的精确绘制图形功能。本文基于中科图新LocaSpaceSDK开发工具包,,使用C#语言在Visual Studio 2019平台...经天路图是基于三维GIS系统的公路综合设计平台,为了使用户在该软件的使用过程中,准确表达设计理念和思想,需要开发在三维地球场景下的精确绘制图形功能。本文基于中科图新LocaSpaceSDK开发工具包,,使用C#语言在Visual Studio 2019平台上开发了基础图元(点、线、多段线、圆、圆弧)绘制功能、特殊点(端点、图元之间的交点、垂足等)捕捉以及正交绘图、延长线追踪等辅助绘图功能。本文介绍了基础绘图功能的研发思路、工具、流程及关键算法,并展示了绘图功能的工程应用。结果表明,本文开发的基础绘图功能可以便捷、快速、准确地帮助用户表达设计理念和思路,提升设计效率。展开更多
Purpose:The interdisciplinary nature and rapid development of the Semantic Web led to the mass publication of RDF data in a large number of widely accepted serialization formats,thus developing out the necessity for R...Purpose:The interdisciplinary nature and rapid development of the Semantic Web led to the mass publication of RDF data in a large number of widely accepted serialization formats,thus developing out the necessity for RDF data processing with specific purposes.The paper reports on an assessment of chief RDF data endpoint challenges and introduces the RDF Adaptor,a set of plugins for RDF data processing which covers the whole life-cycle with high efficiency.Design/methodology/approach:The RDFAdaptor is designed based on the prominent ETL tool—Pentaho Data Integration—which provides a user-friendly and intuitive interface and allows connect to various data sources and formats,and reuses the Java framework RDF4J as middleware that realizes access to data repositories,SPARQL endpoints and all leading RDF database solutions with SPARQL 1.1 support.It can support effortless services with various configuration templates in multi-scenario applications,and help extend data process tasks in other services or tools to complement missing functions.Findings:The proposed comprehensive RDF ETL solution—RDFAdaptor—provides an easy-to-use and intuitive interface,supports data integration and federation over multi-source heterogeneous repositories or endpoints,as well as manage linked data in hybrid storage mode.Research limitations:The plugin set can support several application scenarios of RDF data process,but error detection/check and interaction with other graph repositories remain to be improved.Practical implications:The plugin set can provide user interface and configuration templates which enable its usability in various applications of RDF data generation,multi-format data conversion,remote RDF data migration,and RDF graph update in semantic query process.Originality/value:This is the first attempt to develop components instead of systems that can include extract,consolidate,and store RDF data on the basis of an ecologically mature data warehousing environment.展开更多
基金supported by the Ministry of Research,Innovation and Digitalization,CNCS-UEFISCDI[Grant Nos.RO-NO-2019-0601(MEDYCONAI),PN-III-P4-PCE-2021-0444(RESONANO)]PN-IV-P1-PCE-2023-1137+2 种基金supported in part by IN2SIGHT,European Union’s Horizon 2020(GA.no.964481)by the Research Council of Lithuania(LMTLTAgreement No.P-MIP-23-237).
文摘Collagen characterization is crucial for disease diagnostics,prevention,and understanding,with growing focus on quantitative analysis at tissue and fibril levels.Numerous models have been developed to quantify structural changes in collagen linked to various pathologies.However,many approaches remain limited to conceptual descriptions or rely on custom software,often requiring programming skills,which re-stricts their clinical application and potential impact.We introduce CollagenFitJ,a plugin for the open-source software platform ImageJ/FIJI,which represents a widely used microscopy image analysis tool.CollagenFitJ makes use of the cylindrical symmetry model for collagen to enable facile quantitative assessment of polarization-resolved second harmonic generation microscopy image stacks.The plugin’s main outputs are collagen structure-related maps(e.g.,orientation and anisotropy of collagen fibrils within the focal volume),which can be accompanied by distribution and randomness maps for a series of structure-related parameters.We describe and validate the use of CollagenFitJ on images acquired on rat-tail tendons,collagen capsules surrounding human thyroid nodules,and mouse colon tumors,using both scanning and widefield second harmonic generation microscopy datasets.The plugin was designed to be user-friendly,requiring little to no experience in image processing and coding to facilitate access for life scientists,medical staff,and microscopy practitioners with limited coding skills or time availability required for coding.
文摘经天路图是基于三维GIS系统的公路综合设计平台,为了使用户在该软件的使用过程中,准确表达设计理念和思想,需要开发在三维地球场景下的精确绘制图形功能。本文基于中科图新LocaSpaceSDK开发工具包,,使用C#语言在Visual Studio 2019平台上开发了基础图元(点、线、多段线、圆、圆弧)绘制功能、特殊点(端点、图元之间的交点、垂足等)捕捉以及正交绘图、延长线追踪等辅助绘图功能。本文介绍了基础绘图功能的研发思路、工具、流程及关键算法,并展示了绘图功能的工程应用。结果表明,本文开发的基础绘图功能可以便捷、快速、准确地帮助用户表达设计理念和思路,提升设计效率。
基金This work is supported by“National Social Science Foundation in China”Project(19BTQ061)“Integration and Development on A Next Generation of Open Knowledge Services System and Key Technologies”project(2020XM05).
文摘Purpose:The interdisciplinary nature and rapid development of the Semantic Web led to the mass publication of RDF data in a large number of widely accepted serialization formats,thus developing out the necessity for RDF data processing with specific purposes.The paper reports on an assessment of chief RDF data endpoint challenges and introduces the RDF Adaptor,a set of plugins for RDF data processing which covers the whole life-cycle with high efficiency.Design/methodology/approach:The RDFAdaptor is designed based on the prominent ETL tool—Pentaho Data Integration—which provides a user-friendly and intuitive interface and allows connect to various data sources and formats,and reuses the Java framework RDF4J as middleware that realizes access to data repositories,SPARQL endpoints and all leading RDF database solutions with SPARQL 1.1 support.It can support effortless services with various configuration templates in multi-scenario applications,and help extend data process tasks in other services or tools to complement missing functions.Findings:The proposed comprehensive RDF ETL solution—RDFAdaptor—provides an easy-to-use and intuitive interface,supports data integration and federation over multi-source heterogeneous repositories or endpoints,as well as manage linked data in hybrid storage mode.Research limitations:The plugin set can support several application scenarios of RDF data process,but error detection/check and interaction with other graph repositories remain to be improved.Practical implications:The plugin set can provide user interface and configuration templates which enable its usability in various applications of RDF data generation,multi-format data conversion,remote RDF data migration,and RDF graph update in semantic query process.Originality/value:This is the first attempt to develop components instead of systems that can include extract,consolidate,and store RDF data on the basis of an ecologically mature data warehousing environment.
