妊娠期糖尿病(GDM)是妊娠期间常见的糖代谢异常疾病。本文探讨了吲哚胺2,3-双加氧酶(IDO)与人类白细胞抗原-G (HLA-G)两种免疫调节分子在GDM中的表达及临床意义。本文指明IDO在妊娠期间的活性增加有助于保护胎儿免受母体免疫系统的攻击...妊娠期糖尿病(GDM)是妊娠期间常见的糖代谢异常疾病。本文探讨了吲哚胺2,3-双加氧酶(IDO)与人类白细胞抗原-G (HLA-G)两种免疫调节分子在GDM中的表达及临床意义。本文指明IDO在妊娠期间的活性增加有助于保护胎儿免受母体免疫系统的攻击,但在GDM条件下会造成IDO活性降低。HLA-G通过抑制免疫细胞功能维持母胎间免疫平衡,但GDM会导致血清中可溶性HLA-G水平下降甚至变异。IDO活性降低和HLA-G表达变化提示免疫耐受受损,联合检测这两种分子可为GDM的早期诊断、病情监控及治疗评估提供重要信息。Gestational Diabetes Mellitus (GDM) is a common disorder of glucose metabolism during pregnancy. This article explores the expression and clinical significance of two immunomodulatory molecules, Indoleamine 2,3-Dioxygenase (IDO) and Human Leukocyte Antigen-G (HLA-G), in GDM. It is indicated that the increased activity of IDO during pregnancy helps protect the fetus from maternal immune system attacks, but under GDM conditions, it leads to a reduction in IDO activity. HLA-G maintains immune balance between mother and fetus by inhibiting immune cell function, but GDM causes a decrease or even variation in the levels of soluble HLA-G in the serum. The reduction in IDO activity and changes in HLA-G expression suggest impaired immune tolerance. The combined detection of these two molecules can provide crucial information for the early diagnosis, monitoring, and treatment evaluation of GDM.展开更多
铁死亡是一种新发现的程序性细胞死亡形式,其特征是铁过载及脂质过氧化。越来越多的证据表明,铁死亡与妊娠相关疾病的发生密切相关有关,而抑制铁死亡对于妊娠相关疾病的治疗具有一定作用。本综述总结了铁死亡发生的分子机制及铁死亡在...铁死亡是一种新发现的程序性细胞死亡形式,其特征是铁过载及脂质过氧化。越来越多的证据表明,铁死亡与妊娠相关疾病的发生密切相关有关,而抑制铁死亡对于妊娠相关疾病的治疗具有一定作用。本综述总结了铁死亡发生的分子机制及铁死亡在妊娠相关疾病中的最新研究进展,期望对妊娠相关疾病的诊治带来新的思路。Ferroptosis is a newly discovered form of programmed cell death characterized by iron overload and lipid peroxidation. Accumulating evidence suggests a significant association between ferroptosis and the pathogenesis of pregnancy-related disorders. Studies have shown that inhibiting ferroptosis may offer therapeutic benefits in managing these conditions. This review aims to elucidate molecular mechanisms underlying ferroptosis and to summarize recent advancements in understanding its role in pregnancy-related diseases, thereby providing novel insights for the diagnosis and treatment of such disorders.展开更多
文摘妊娠期糖尿病(GDM)是妊娠期间常见的糖代谢异常疾病。本文探讨了吲哚胺2,3-双加氧酶(IDO)与人类白细胞抗原-G (HLA-G)两种免疫调节分子在GDM中的表达及临床意义。本文指明IDO在妊娠期间的活性增加有助于保护胎儿免受母体免疫系统的攻击,但在GDM条件下会造成IDO活性降低。HLA-G通过抑制免疫细胞功能维持母胎间免疫平衡,但GDM会导致血清中可溶性HLA-G水平下降甚至变异。IDO活性降低和HLA-G表达变化提示免疫耐受受损,联合检测这两种分子可为GDM的早期诊断、病情监控及治疗评估提供重要信息。Gestational Diabetes Mellitus (GDM) is a common disorder of glucose metabolism during pregnancy. This article explores the expression and clinical significance of two immunomodulatory molecules, Indoleamine 2,3-Dioxygenase (IDO) and Human Leukocyte Antigen-G (HLA-G), in GDM. It is indicated that the increased activity of IDO during pregnancy helps protect the fetus from maternal immune system attacks, but under GDM conditions, it leads to a reduction in IDO activity. HLA-G maintains immune balance between mother and fetus by inhibiting immune cell function, but GDM causes a decrease or even variation in the levels of soluble HLA-G in the serum. The reduction in IDO activity and changes in HLA-G expression suggest impaired immune tolerance. The combined detection of these two molecules can provide crucial information for the early diagnosis, monitoring, and treatment evaluation of GDM.
文摘铁死亡是一种新发现的程序性细胞死亡形式,其特征是铁过载及脂质过氧化。越来越多的证据表明,铁死亡与妊娠相关疾病的发生密切相关有关,而抑制铁死亡对于妊娠相关疾病的治疗具有一定作用。本综述总结了铁死亡发生的分子机制及铁死亡在妊娠相关疾病中的最新研究进展,期望对妊娠相关疾病的诊治带来新的思路。Ferroptosis is a newly discovered form of programmed cell death characterized by iron overload and lipid peroxidation. Accumulating evidence suggests a significant association between ferroptosis and the pathogenesis of pregnancy-related disorders. Studies have shown that inhibiting ferroptosis may offer therapeutic benefits in managing these conditions. This review aims to elucidate molecular mechanisms underlying ferroptosis and to summarize recent advancements in understanding its role in pregnancy-related diseases, thereby providing novel insights for the diagnosis and treatment of such disorders.
